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Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity
Published 2019-01-01Get full text
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Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes
Published 2015-01-01Get full text
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Unraveling the redox code to improve physiological research in human health and disease
Published 2024-11-01Subjects: Get full text
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Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation
Published 2024-12-01Subjects: Get full text
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The Switching of the Type of a ROS Signal from Mitochondria: The Role of Respiratory Substrates and Permeability Transition
Published 2024-10-01Subjects: Get full text
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SydR, a redox-sensing MarR-type regulator of Sinorhizobium meliloti, is crucial for symbiotic infection of Medicago truncatula roots
Published 2024-12-01Subjects: “…redox signaling…”
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Regulatory roles of NAMPT and NAD+ metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment
Published 2024-12-01“…This study sought to elucidate the regulatory functions of NAMPT and NAD+ metabolism, in conjunction with redox signaling, in the progression of UL, and to explore potential therapeutic strategies targeting these pathways. …”
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2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
Published 2014-01-01“…These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.…”
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Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function
Published 2025-02-01“…Conclusions Our findings suggest that PGRN preserves the vascular contractility via regulating mitophagy flux, mitochondrial activity and dynamics, and redox signaling. Therefore, loss of PGRN function appears as a pivotal risk factor in cardiovascular disease.…”
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Role of gp91phox Homolog Nox1 in Induction of Premalignant Spindle Phenotypes of HPV 16 E6/E7—Immortalized Human Keratinocytes
Published 2010-01-01“…Understanding these mechanisms may provide insight into Nox1 and redox signaling components as potential therapeutic targets to inhibit tumor progression.…”
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Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation
Published 2024-10-01“…This tightly regulated process contributes to MuSC regulation by mediating changes in redox signaling pathways, cell cycle progression, and cell fate decisions. …”
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A system-level model reveals that transcriptional stochasticity is required for hematopoietic stem cell differentiation
Published 2024-12-01“…This regulatory network core integrates key nodes and interactions underlying HSCs differentiation, including transcription factors, metabolic, and redox signaling pathways. We used Boolean, continuous, and stochastic dynamic models to simulate the hypoxic conditions of the HSCs niche, as well as the patterns and temporal sequences of HSCs transitions and differentiation. …”
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The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production
Published 2024-12-01“…Furthermore, they indirectly influence secondary metabolism through intricate signaling pathways, including reactive oxygen species (ROS), metabolites, and redox signaling, which modulate various metabolic processes. …”
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Interplay between energy metabolism and NADPH oxidase-mediated pathophysiology in cardiovascular diseases
Published 2025-01-01“…Among them, NADPH oxidases (NOX), including NOX1-5, are major sources of ROS that mediate redox signaling in both physiological and pathological processes, including fibrosis, hypertrophy, and remodeling. …”
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Dark Anaerobic Conditions Induce a Fast Induction of the Xanthophyll Cycle in <i>Chlamydomonas reinhardtii</i> When Exposed to High Light
Published 2024-11-01“…Conclusions: Our results provide new information on the importance of the redox signaling pathway and highlight the importance of the reductive conditions of the PQ pool in regulating the physiological responses of photosynthetic organisms to stress.…”
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Involvement of a 1-Cys peroxiredoxin in bacterial virulence.
Published 2014-10-01“…LsfA is the first bacterial 1-Cys Prx shown to modulate host immune responses and its characterization will allow a better understanding of the role of redox signaling in host-pathogen interactions.…”
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Potential therapeutic use of millet with broad spectrum anticancer properties: current trends and prospects
Published 2024-12-01“…Plant-based compounds inhibit cancer growth by suppressing mutations, enhancing apoptosis, managing redox signaling, preventing cell division, halting metastasis, lowering oxidative stress, and influencing neovascularization. …”
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