Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival by Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng, Wei Huang

“…The study further explored how the HDAC11/IL10 axis enhances mitophagy to promote intracellular S. aureus survival by using HDAC11 overexpression, siRNA, and rapamycin intervention combined with confocal microscopy and flow cytometry. …”
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The Role of Targeted Therapy in Metastatic Renal Cell Carcinoma by Jaya Unnithan, Brian I. Rini

“…The most clinically developed targeted therapies in advanced RCC are those that target the vascular endothelial growth factor (VEGF) ligand or receptor (VEGFR) and therapy directed against the mammalian target of rapamycin (mTOR). Sutent and sorafenib are orally available inhibitors of the VEGFR and platelet derived growth factor receptor (PDGFR). …”
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mTOR Inhibition: From Aging to Autism and Beyond by Matt Kaeberlein

“…The mechanistic target of rapamycin (mTOR) is a highly conserved protein that regulates growth and proliferation in response to environmental and hormonal cues. …”
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Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation by Lu Hu, Lu Hu, Xiaohan Zhang, Xiaohan Zhang, Weiqi Zhang, Weiqi Zhang, Shuai Jin, Shuai Jin, Jie Zhao, Jianming Zheng, Wenli Song, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen

“…The combination of rosiglitazone and rapamycin significantly prolonged graft survival.ConclusionsThis study defined a novel TCMR-associated cytokine gene set that effectively predicts TCMR and identified PPARγ agonists, which prevent TCMR and improve graft survival when combined with rapamycin.…”
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R-loop formation contributes to mTORC1 activation-dependent DNA replication stress induced by p53 deficiency by Li Xiaolei, Yang Cheng, Zhang Xiaohui, Wang Feiyang, Sun Longhua, Zhang Wei, Xu Xinping

“…Interestingly, these effects can be alleviated by rapamycin, an mTORC1 inhibitor. Additionally, rapamycin reduces the abundance of R-loop structures in p53KO cells, which is linked to mTORC1’s regulation of ribonucleotide reductase (RNR) level. …”
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Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo by Bin Wu, Xue Wang, Wei Zhang, Xin Wang, Qi-Miao Wang, Ya-Ju Pang, Yi-Chun Kong

“…The expression of epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), phosphorylated mammalian target of rapamycin (p-mTOR), protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-α (TNF-α) in each group were analyzed by Western blot. …”
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Metformin in the treatment of colorectal cancer and neuroendocrine tumours by Karolina Daniłowska, Natalia Picheta, Barbara I. Krupska, Anna Rudzińska, Oliwia Burdan, Katarzyna Szklener

“…The biguanide works by inhibiting the mammalian target of rapamycin pathway, activating 5’AMP activated protein kinase, and reducing insulin-like growth factor 1. …”
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Promising Response with PI3K Inhibitor for a Patient with Heavily Pretreated PIK3CA Mutation Head-and-Neck Cancer by Ming-Jing Lee, Hsiang-Fong Kao

“…Several pathways have been identified in HNSCC, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. The PI3K/AKT/mTOR pathway is frequently dysregulated in various cancers due to activating mutations or amplification of PIK3CA. …”
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Getah virus triggers ROS-mediated autophagy in mouse Leydig cells by Fengqin Li, Fengqin Li, Fengqin Li, Lishuang Deng, Tong Xu, Lei Xu, Zhiwen Xu, Zhiwen Xu, Siyuan Lai, Siyuan Lai, Yanru Ai, Yanru Ai, Yanqun Wang, Yanqun Wang, Guangwen Yan, Guangwen Yan, Ling Zhu, Ling Zhu

“…Interestingly, the use of rapamycin (Rapa) and 3-Methyladenine (3- MA) led to autophagy change in both infected and uninfected TM3 cells, with no signiffcant alterations in cellular ROS levels. …”
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Everolimus for Compassionate Use in Multiple Basal Cell Carcinomas by Laura Eibenschutz, Delia Colombo, Caterina Catricalà

“…Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been shown to have antineoplastic activity in addition to its use as an immunosuppressive agent for the prevention of organ transplant rejection. …”
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Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases by Yuming Lu, Yifan Wang, Tiantian Ruan, Yihan Wang, Linling Ju, Mengya Zhou, Luyin Liu, Dengfu Yao, Min Yao

“…The activation, differentiation, and function of Tregs are influenced by various metabolic pathways, such as the Mammalian targets of rapamycin (mTOR) pathway and glycolysis. Correspondingly, activated Tregs can reciprocally impact these metabolic pathways. …”
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The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas by Elias A. El Habr, Christos Adamopoulos, Georgia Levidou, Aggeliki A. Saetta, Penelope Korkolopoulou, Christina Piperi

“…Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. …”
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. …”
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Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Medications such as statins, fasudil, rapamycin, and propranolol can alleviate CCM symptoms or hinder its progression by specifically modulating the corresponding targets. …”
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Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy by Olga Doszyn, Tomasz Dulski, Justyna Zmorzynska

“…Here, we present a protocol for the visualization of phosphorylated Rps6, a marker of mechanistic target of rapamycin complex 1 (mTORC1) activity, in the zebrafish brains at 5 days post fertilization (dpf), using whole-mount immunofluorescence and light-sheet microscopy. …”
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Effect of Nitrogen Source and Inorganic Phosphate Concentration on Methanol Utilization and PEX Genes Expression in Pichia pastoris by A. M. Rumjantsev, O. V. Bondareva, M. V. Padkina, E. V. Sambuk

“…Expression of these genes is decreased in media with poor nitrogen sources, such as proline. Addition of rapamycin to the media completely removed repression of AOX1 promoter in media with proline, which allows proposing that Tor-kinase is involved in establishing of nitrogen regulation of this gene. …”
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Using cortical organoids to understand the pathogenesis of malformations of cortical development by Kellen D. Winden, Isabel Gisser, Mustafa Sahin

“…Several genetic pathways have been associated with these disorders from control of cell cycle and cytoskeletal dynamics in global malformations to variants in growth factor signaling pathways, especially those interacting with the mechanistic target of rapamycin (mTOR), in FCDs. Despite advances in understanding these disorders, the underlying developmental pathways that lead to lesion formation and mechanisms through which defects in cortical development cause specific neurological symptoms often remains unclear. …”
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Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance by Ji Won Han, Su-Hyung Park

“…Emerging strategies, including the use of low-dose calcineurin inhibitors with mammalian target of rapamycin inhibitors, adoptive Treg therapy, and low-dose IL-2, aim to enhance Treg function while providing sufficient immunosuppression. …”
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Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management by Laura M. S. Seeber, Ronald P. Zweemer, René H. M. Verheijen, Paul J. van Diest

“…In clinical trials for the treatment of advanced and/or recurrent EC are the topoisomerase I inhibitor Topotecan, mTOR-inhibitor Rapamycin, and angiogenesis inhibitor Bevacizumab. …”
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Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma by J. Martin-Liberal, C. Benson, C. Messiou, C. Fisher, I. Judson

“…The mammalian target of rapamycin (mTOR) pathway has been suggested to play a key role in the mechanisms of hormone resistance. …”
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