A novel nomogram based on the patient’s clinical data and CT signs to predict poor outcomes in AIS patients by Jingyao Yang, Fangfang Deng, Qian Zhang, Zhuyin Zhang, Qinghua Luo, Yeyu Xiao

“…Methods A retrospective analysis was conducted on 161 patients with acute ischemic stroke who underwent mechanical thrombectomy at the Guangzhou Hospital of Integrated Traditional and Western Medicine from January 2019 to June 2023. All patients were randomly assigned to either the training cohort (n = 113) or the validation cohort (n = 48) at a 7:3 ratio. …”
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Niacin alters ruminal microbial composition and metabolites in sheep fed a high-concentrate diet by Zhiqiang Cheng, Jiancheng Liu, Yingying Yu, Wentao Liu, Xiaobin Li, Fengming Li, Changjiang Zang, Kailun Yang

“…This study aimed to investigate the effects of niacin supplementation to a high-concentrate diet (ratio of concentrate supplement to forage = 70:30) on the growth performance, rumen fermentation, rumen microbiota, and metabolomics of sheep. Twelve sheep were randomly divided into two groups: (1) a control group (CON, n = 6) fed a basal diet and (2) a niacin group (NA, n = 6) fed a basal diet supplemented with 130 mg/day niacin for 35 days: days 1–14 were the adaptation period, days 15–35 were the experiment period. …”
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Analysis of Prognostis Factors and Effect of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease by Yiming XU, Honghua SHEN, Jingbo DU, Lei REN

“…All patients were given the treatments: ①Routine medical treatment of COPD, included bronchodilator, hormones and β₂receptor agonist (the patients whose FEV1 accounted for less than 50%of the predicted value and having clinical symptoms were treated with inhaled hormones and β₂receptor agonist), and other expectorant and cough-relieving drugs.②Pulmonary rehabilitation education, included knowledge of COPD, pulmonary rehabilitation idea, smoking cessation, oxygen therapy, rational use of drugs and balanced nutrition, once a month.③Aerobic respiratory exercises, included lip contraction breathing and abdominal breathing training, 5 times a week, 20 minutes each time.④Aerobic exercise training, limited aerobic exercise with different intensity from low to high using randomized block design. All patients completed aerobic exercise of different intensity for 20 weeks, and postoperative life quality, treatment, and survival time of the patients were followed up for 2 years. …”
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Effect and Mechanism of Running on Mouse Emphysema Model Induced by Cigarette Extract by LI Yongrong, XIE Haibin, LI hong, SUN Jie

“…ObjectiveTo observe the effect of running on mouse emphysema model induced by cigarette extract, and to explore its mechanism based on signal transducer and activator of transcription 3 (STAT3).MethodsA total of 40 male C57BL/6 mice were randomly divided into control group, exercise group, emphysema group and emphysema + exercise group, with 10 mice in each group. …”
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Behavior Changes in Quinpirole Obsessive-Compulsive Disorder Rats Treated with 6-Hydroxydopamine and the Corresponding Dopaminergic Compulsive Loop Mechanism by Haowen Zheng, Rui He, Yang Ming, Haiping He, Wei Wang, Ligang Chen, Feilong Gong

“…After model setup, 46 QNP rats were divided randomly into five groups: 6-OHDA anterior limb of internal capsule (AC) stereotactic injection group (QNP+AC group, n = 10), 6-OHDA mediodorsal thalamic nucleus (MD) stereotactic injection group (QNP+MD group, n = 10), 6-OHDA nucleus accumbens (NAC) stereotactic injection group (QNP+NAC group, n = 10), saline stereotactic injection group (QNP+NS-S group, n = 10), and non-surgical group (QNP+Non-S group, n = 6). …”
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Effect of Yao medicine collapse stains combined with wax therapy in the treatment of chronic lumbar muscle strain (瑶药塌渍联合蜡疗治疗慢性腰肌劳损效果观察) by WEI Yingfen (韦英芬), HE Xinghong (何星宏)

“…Methods A total of 138 patients with chronic lumbar muscle strain were selected as the study objects and randomly divided into observation group and control group, with 69 cases in each group. …”
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Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series by Giacomo Savini, Alice Galzignato, Catarina P. Coutinho, Jinhai Huang, Yue Wu, Piero Barboni, João Mendanha Dias, Filomena J. Ribeiro, Domenico Schiano-Lomoriello

“…Methods In a prospective, single-center, non-randomized study, axial length, keratometry, anterior chamber depth, scotopic and photopic pupil diameters, pupil decentration, corneal asphericity, corneal higher-order aberrations (HOAs), coma and spherical aberration were measured preoperatively. …”
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CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor by Tingting Li, Xuan Cai, Xiangning Wang, Xueyan Zhang, Hui Zhang, Biwei Xu, Shiwei Li, Jianyan Hu, Qiang Wu

“…Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeting C/EBP β (LV.shC/EBP β) or control particles (LV.shScrambled). …”
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Understanding Community Health Care Through Problem-Based Learning With Real-Patient Videos: Single-Arm Pre-Post Mixed Methods Study by Kiyoshi Shikino, Kazuyo Yamauchi, Nobuyuki Araki, Ikuo Shimizu, Hajime Kasai, Tomoko Tsukamoto, Hiroshi Tajima, Yu Li, Misaki Onodera, Shoichi Ito

“…MethodsParticipants were 113 fourth-year medical students from Chiba University, engaged in a transition course between preclinical and clinical clerkships from October 24 to November 2, 2023. The students were randomly divided into 16 groups (7-8 participants per group). …”
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Growth performance and gut health of Murrah buffalo calves fed with developed novel synbi- otic formulation by Antony J. Thanippilly, Sachin Kumar, Vinay V. Varada, Nitin Tyagi, Ashish K. Samanta

“…Then, 23 neonatal buffalo calves were selected for 90 days and randomly divided into four groups, with five animals in the control group and six each in the treatment group. …”
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Effect of a refined nursing model based on two-way nursing quality feedback on the postoperative mental resilience of patients with facial vascular malformation (双向质量反馈护理模式对颜面部血管畸形... by BAO Lili (鲍丽丽), QI Jiaxin (齐加新)

“…Methods A total of 165 patients with facial vascular malformation were randomly divided into control group (n = 82) and study group (n = 83). …”
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Dietary supplementation of organic selenium to improve growth performance and protein utilization in African catfish fed with different protein level diets by Giri Maruto Darmawangsa, Muhammad Agus Suprayudi, Nurbambang Priyo Utomo, Julie Ekasari

“… This study aimed to evaluate the effect of organic selenium supplementation on diet with different protein levels on the growth performance and protein utilization of African catfish juvenile. A randomized 2×3 factorial design with two dietary protein levels (27% and 32%) and three dietary selenium (Se) supplementation levels (0 mg/kg, 3 mg/kg, and 6 mg/kg diet) in triplicates were applied in the study. …”
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Effects of heat stress abatement on behavioral response in lactating dairy cows prior to and following an intramammary lipopolysaccharide infusion by T.N. Marins, R.M. Orellana Rivas, Y-C. Chen, V.H.L.R. Melo, Z. Wang, H. Liu, J. Gao, C.G. Savegnago, A.M. Roper, J.K. Bernard, P. Melendez, S. Tao

“…Multiparous mid-lactating Holstein dairy cows (n = 18, parity = 2.4 ± 0.6, DIM = 136 ± 61 d) were randomly assigned to: evaporatively cooled (CL, n = 9) or not cooled (NC, n = 9) for 36 d (average temperature-humidity index = 78.4). …”
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Preliminary study of rubber seed Hevea brasiliensis oil utilization for tilapia diet by Siti Komariyah, Muhammad Agus Suprayudi, Dedi Jusadi

“…Experimental design was set in completely randomized design. Each treatment was done in triplicates. …”
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A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in He... by Lee HW, Kang WY, Park JS, Lee JH, Park JJ, Gwon MR, Yoon YR, Seong SJ

“…Hae Won Lee,1 Woo Youl Kang,2 Ji Seo Park,1 Jae Hwa Lee,1 Jin Ju Park,1 Mi-Ri Gwon,1 Young-Ran Yoon,1 Sook Jin Seong1 1School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; 2Clinical Trial Dossier Evaluation Team, Innovative Products Support Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of KoreaCorrespondence: Young-Ran Yoon, Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongdeok-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-420-4950, +82-53-420-5218, Email yry@knu.ac.kr Sook Jin Seong, Clinical Associate Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongduk-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-200-6351, +82-53-420-5218, Email wintersj@knu.ac.krBackground: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days. …”
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Effectivity of thyroxine and recombinant growth hormone on the growth of Siam-catfish larvae by Agus Oman Sudrajat, Muhammad Muttaqin, . Alimuddin

“…Research was using completely randomized design, with four treatments and five replications; A, control; B, thyroxine hormone (T4) 0.1 mg/L; C, T4 and G (GT) (0.1 mg/L and 10 mg/L); and D, G 10 mg/L. …”
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Pengaruh Cairan Cultur Filtrate Fibroblast (CFF) Terhadap Penyembuhan Luka; Penelitian eksperimental pada Rattus Norvegicus Galur Wistar by Oky Masir, Menkher Manjas, Andani Eka Putra, Salmiah Agus

“…This study used an experimental design method post test only control group design and randomized block design (RBD) by using wistar mice. …”
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Association of genomic predictions for fertility traits with reproductive outcomes in dairy cows under 2 estrus detection and timed artificial insemination programs by D.B. Melo, R.G.S. Bruno, R.S. Bisinotto, F.S. Lima

“…Holstein cows from a single farm were randomly allocated to 2 different programs, the short RepP (n = 982) or long RepP (n = 942). …”
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Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…In LRT plan, high-dose regions for the GTV and D95% exhibited displacements greater than 5 mm from the tumor boundary in 19 randomly scanned sCT sequences under free breathing conditions. …”
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Effect of sun dry brewer spent yeast on chemical composition, in vitro digestibility, and ruminal degradation kinetics of wheat straw by Geberemariyam Terefe, Mulugeta Walelgne, Dereje Fekadu, Getu Kitaw, Mesfin Dejene, Aeimro Kehaliu, Bethlehem Mekonnen, Yohannse Habteyesus

“…Based on these ratios, the experiment was subjected to a completely randomized design with six treatments comprising DBSY0, DBSY10, DBSY20, DBSY30, DBSY40, and DBSY50. …”
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