Association between osteoarthritis and cognitive function: results from the NHANES 2011–2014 and Mendelian randomization study by Kun Zhao, Liuyan Nie, Jingting Zhao, Yankai Dong, Kaixiu Jin, Song Wang, Xiangming Ye

“…Objectives: We aimed to investigate associations between OA and cognitive function using data from the National Health and Nutrition Examination Survey (NHANES) and to investigate the causality using Mendelian randomization (MR). Design: This is a cross-sectional study and MR study. …”
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Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Methods/design This is a single-center, randomized, placebo-controlled clinical phase 2 trial, investigating the clinical superiority of Salovum® given as a food supplement during 5 days to adults with severe TBI (Glasgow Coma Scale (GCS) < 9), admitted to the neurocritical intensive care unit (NICU) at Skane university hospital, Lund, Sweden. …”
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A Randomized Controlled Clinical Trial of Lifestyle Intervention and Pioglitazone for Normalization of Glucose Status in Chinese with Prediabetes by Yingying Luo, Hongyuan Wang, Xianghai Zhou, Cuiqing Chang, Wei Chen, Xiaohui Guo, Jinkui Yang, Linong Ji, Sanjoy K. Paul

“…Materials and Methods. We conducted a randomized, multicenter, 2×2 factorial designed study to examine whether intensive lifestyle intervention and/or pioglitazone could revert prediabetes to normal glucose tolerance. …”
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Associations among immunophenotype, plasma metabolites, and benign prostatic hyperplasia: a mediation Mendelian randomization study by FAN Jiuming, ZHAO Yiqiao, JIA Haichang, WANG Tiankun, HAN Yutong, QIN Zihao, CHEN Ping, ZENG Xiantao

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Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis by Ning Qi, Zhuochen Lyu, Lu Huang, Yun Zhao, Wan Zhang, Xinfeng Zhou, Yang Zhang, Jiasen Cui

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A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease by Limi Huang, Zhiwei Song, Chaosheng Lu, Shenwen Wang, Changsheng Guo, Xin-He Lai, Xin-He Lai, Zhenfeng Zhao

Subjects: “…randomized clinical trial…”
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Evaluation of the Guiding Groove Technique in Periapical Endodontic Surgery: A Single-Blinded Randomized Controlled Trial by Jinghua Sun, Xiaolin Li, Chen Zhang, Benxiang Hou

“…Methods: Subjects with intact labial and buccal bone walls or defects with a maximum diameter of <3 mm, who met the inclusion criteria, were randomized into two groups using www.random.org. The experimental group (n = 15) underwent the “guiding groove” technique, while the control group (n = 15) underwent the traditional bone-removing fenestration. …”
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Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study by Mingyuan Fan, Zhangjun Yun, Jiushu Yuan, Sai Zhang, Hongyan Xie, Dingyi Lu, Haipo Yuan, Hong Gao

“…Abstract Background Considering that the treatment of gout is poor, we performed a Mendelian randomization (MR) study to identify candidate biomarkers and therapeutic targets for gout. …”
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Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials by Li-Chao-Yue Sun, Wen-Shu Li, Wei Chen, Zhao Ren, Chun-Xing Li, Ze Jiang, Le Wang, De-Li Wang, Qing Xie

“…Data on study characteristics, patient demographics, interventions, and outcomes were extracted, and bias risk assessed. A multivariate random-effects model was used for network meta-analysis to derive odds ratios (OR) and 95% confidence intervals (CI).ResultTwelve RCTs were included (10 with tenecteplase, 2 with reteplase) involving 6,633 patients, all compared against 0.9 mg/kg alteplase. …”
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Deconvolution Filtering for Nonlinear Stochastic Systems with Randomly Occurring Sensor Delays via Probability-Dependent Method by Yuqiang Luo, Guoliang Wei, Hamid Reza Karimi, Licheng Wang

“…This paper deals with a robust H∞ deconvolution filtering problem for discrete-time nonlinear stochastic systems with randomly occurring sensor delays. The delayed measurements are assumed to occur in a random way characterized by a random variable sequence following the Bernoulli distribution with time-varying probability. …”
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Evaluating the impact of smoking on the risk of dry eye disease: a two-sample Mendelian randomization study by Kuiliang Yang, Han Zhang, Yujin Wang, Yulin Yan, Zixian Yang, Shanshan Wan, Wanju Yang, Yanning Yang

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Genetic Determinants of Immune Cells and Hepatocellular Carcinoma Risk: A Bioinformatics and Bidirectional Mendelian Randomization Study by Tong WU, Fei GAO, Fei TENG, Qiaoli ZHANG

Subjects: “…mendelian randomization…”
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Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study by Qian Guo, Xinghua Xu, Xiaohui Li, Yang Mao, Shengqiang Li, Yuxin Yao, Xiang Li, Yaxing Li, Jiayue Feng, Yan Shu, Xingli Xu

Subjects: “…Mendelian randomization study…”
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Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies by Aleksandra Hyży, Hanna Rozenek, Ewa Gondek, Mariusz Jaworski

“…Objectives: This review aims to evaluate the effects of antioxidants on the gut microbiome and cognitive function, with a focus on findings from randomized controlled trials (RCTs). Methods: The studies involved human participants across a range of age groups, with interventions encompassing natural antioxidant sources, such as berries, as well as specific antioxidant vitamins. …”
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Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial by Jyoti Mayadev, Dmitriy Zamarin, Wei Deng, Heather A. Lankes, Giulio Pesci, Hayeon Kim, Junzo P. Chino, Barbara Banbury, Ned Sherry, Elad Sharon, Sharad A. Ghamande, Catherine Ferguson, Loren Mell, Laura Holman, Cara Mathews, David O’Malley, Alexander Olawaiye, Elizabeth Hopp, Charles Leath, Larry Copeland, Robert Mannel, Roisin O’Cearbhaill, Carol Aghajanian, Russell J. Schilder

“…Forty patients were randomized, 36 received treatment, and 25 were evaluable for the primary endpoint. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…<h4>Objectives</h4>To assess the effectiveness and efficiency of Asthma-Guidance and Prediction System (A-GPS), an Artificial Intelligence (AI)-assisted CDS tool, in optimizing asthma management through a randomized clinical trial (RCT).<h4>Methods</h4>This was a single-center pragmatic RCT with a stratified randomization design conducted for one year in the primary care pediatric practice of the Mayo Clinic, MN. …”
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Eccentric strengthening vs. conventional therapy in sub-acute stroke survivors: a randomized controlled trial by Kalthoum Belghith, Kalthoum Belghith, Mustapha Zidi, Lhéo Vincent, Lhéo Vincent, Jean-Michel Fedele, Rayan Bou-Serhal, Wael Maktouf

“…Additionally, we aim to explore the effects of ET on the mechanical properties, structural characteristics, and neuromuscular parameters of the plantar flexors. A randomized controlled trial will be conducted, adhering to CONSORT guidelines, with participants assigned to either a Conventional Therapy Group or an Eccentric Training Group. …”
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A Systematic Review of Postoperative Pain Outcome Measurements Utilised in Regional Anesthesia Randomized Controlled Trials by E. Pushpanathan, T. Setty, B. Carvalho, P. Sultan

“…There are few published meta-analyses exploring pain outcome measures utilised in regional anesthesia randomized controlled trials (RCTs), which may be due to heterogeneity in outcomes assessed. …”
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Effect of a Short, Animated Storytelling Video on Transphobia Among US Parents: Randomized Controlled Trial by Doron Amsalem, Merlin Greuel, Shuyan Liu, Andrés Martin, Maya Adam

“…MethodsWe recruited 1267 US parents, through the Prolific Academic (Prolific) online research platform, and randomized them into video intervention or control groups. …”
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Effect of Anodal Transcranial Direct Current Stimulation on Autism: A Randomized Double-Blind Crossover Trial by Anuwat Amatachaya, Narong Auvichayapat, Niramol Patjanasoontorn, Chanyut Suphakunpinyo, Niran Ngernyam, Benchaporn Aree-uea, Keattichai Keeratitanont, Paradee Auvichayapat

“…Twenty patients with autism received 5 consecutive days of both sham and active tDCS stimulation (1 mA) in a randomized double-blind crossover trial over the left dorsolateral prefrontal cortex (F3) for 20 minutes in different orders. …”
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