CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain by Cheng-Yuan Lai, Ming-Chun Hsieh, Chou-Ming Yeh, Tzer-Bin Lin, Dylan Chou, Hsueh-Hsiao Wang, Kuan-Hung Lin, Jen-Kun Cheng, Po-Sheng Yang, Hsien-Yu Peng

“…Neuropathic pain poses a significant public health challenge, greatly impacting patients' quality of life. Emerging evidence underscores the involvement of epigenetics in dorsal root ganglion (DRG) neurons relevant to pain modulation. …”
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Jinkui Shenqi Pill Combined with Pelvic Floor Biofeedback in Treatment of Postpartum Stress Urinary Incontinence with Kidney-yang Deficiency by Xueqin MIAO, Hongri WANG, Meiyun GAO, Caifeng GUO, Jifen HU, Kunmu ZHANG

“…The pelvic floor muscle myoelectric potential was measured before and after treatment, the urine leakage volume in 1h urine pad test, the Short Form of International Consultation on Incontinence Questionnaire(ICI-Q-SF)scores, calculate the total effective rate and follow up the severity of stress urinary incontinence and ICI-Q-SF questionnaire scores were measured six months after treatment.Results:1) After treatment, the typeⅡmyoelectric potential, typeⅠmyoelectric potential, and typeⅠmuscle endurance potential of the two groups were higher than those before treatment, the difference was statistically significant(<italic>P</italic>&lt;0.05), and the treatment group was higher than the control group, the difference was statistically significant(<italic>P</italic>&lt;0.05).2)The volume of urine leakage in 1 h pad test of the two groups after treatment was less than that before treatment, the difference was statistically significant(<italic>P</italic>&lt;0.05), and the treatment group was significantly less than the control group, the difference was statistically significant(<italic>P</italic>&lt;0.05).3)The ICI-Q-SF questionnaire scores of the two groups after treatment were lower than those before treatment, the differences were statistically significant(<italic>P</italic>&lt;0.05), and the treatment group was significantly lower than the control group, the difference was statistically significant(<italic>P</italic>&lt;0.05).4) The total effective rate of the treatment group(88.60%)was higher than that of the control group(65.80%), the difference was statistically significant(<italic>P</italic>&lt;0.05).5)Follow-up six months later, the degree of stress urinary incontinence and ICI-Q-SF questionnaire scores of the treatment group were lower than those of the control group, and the differences were statistically significant(<italic>P</italic>&lt;0.05).Conclusion:1) Jinkui Shenqi pill combined with pelvic floor biofeedback could enhance the muscle strength of pelvic floor typeⅠand typeⅡmuscles in patients with postpartum stress urinary incontinence with kidney-yang deficiency, improve pelvic floor function recovery, reduce urine leakage, and improve patients'short-term and long-term quality of life, the treatment effect was significant and lasting, and was more effective than pure pelvic floor biofeedback therapy alone;2)The mechanism of Jinkui Shenqi pill in treating postpartum stress urinary incontinence with kidney-yang deficiency may be related to the increase of pelvic floor muscle potential.…”
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Combination of Compound Kushen injection with first-line treatment versus first-line treatment alone for advanced colorectal cancer: a study protocol for a multicenter, openlabel,... by Jingyuan Wu, Yuansha Ge, Guanghui Zhu, Ruike Gao, Xiaoyu Zhu, Ying Zhang, Jie Li

“…Secondary outcomes will be overall survival (OS), 1-year OS rate, 1-year PFS rate, objective response rate,disease control rate, symptoms and quality of life evaluation. Safety outcomes will be incidence of adverse events. …”
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Abnormal dynamic features of cortical microstates for detecting early-stage Parkinson's disease by resting-state electroencephalography: Systematic analysis of the influence of eye... by G. Gimenez-Aparisi, E. Guijarro-Estelles, A. Chornet-Lurbe, D. Cerveró-Albert, Dongmei Hao, Guangfei Li, Y. Ye-Lin

“…Our results suggest that the source-space microstate analysis of resting-state EEG could provide robust biomarkers to detect early-stage PD, which would allow the development of patient-oriented strategies to prevent the disease and improve the patients’ quality of life.…”
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Genetic Biomarkers and Circulating White Blood Cells in Osteoarthritis: A Bioinformatics and Mendelian Randomization Analysis by Yimin Pan, Xiaoshun Sun, Jun Tan, Chao Deng, Changwu Wu, Georg Osterhoff, Nikolas Schopow

“…<b>Background</b>: Osteoarthritis (OA) is a prevalent degenerative joint disease that causes disability and diminishes quality of life. The pathogenesis of OA remains poorly understood, creating an urgent need for biomarkers to aid research, diagnosis, and treatment. …”
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Mixed-methods process evaluation of a proactive approach to healthcare in Parkinson’s disease—ParkProReakt: a protocol of a hybrid efficacy-implementation study by Xinyu Huang, Max Geraedts, Elke Kalbe, Carsten Eggers, David José Pedrosa, Ann-Kristin Folkerts, Marcin Grzegorzek, Marlena van Munster, Johanne Stümpel, Natalie Altschuck, Ingmar Wellach, Hannes Boebinger, Anna Pedrosa, Kati Niemand, Dirk Becker, Nicole Pohlschmidt, Isabel Doblinger, Kristina Schmidt, Daniel Wolferts, Marius Nisslmueller, Gennet Beer, Mohammad Osman Ashraf, Florian Eberhardt, Rebecca Wichartz, Birgit Samans, Volker Gross, Keywan Sohrabi, Linda Kerkemeyer, Uemran Seven, Paulina Olgemoeller, Artur Piet, Mona Irsfeld, Marlena van Munster

“…Introduction People with Parkinson’s disease (PwPD) experience a wide range of motor and non-motor symptoms that have a significant impact on their health and quality of life. Effective care management for PwPD involves monitoring symptoms at home, involving specialised multidisciplinary care providers and enhancing self-management skills. …”
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US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers by Kun Zhou, Holger Strunk, Dobromir Dimitrov, Joan Vidal-Jove, Maria A. Gonzalez-Carmona, Markus Essler, Chengbin Jin, Zhechuan Mei, Hui Zhu, Milka Marinova

“…The underutilized yet promising USgHIFU exhibits the potential to enhance patients’ quality of life by alleviating cancer-related pain. Experts in the field should evaluate this treatment option be evaluated by experts in this field, with this consensus paper potentially serving as a guiding resource for the medical community.Conclusions: US-guided HIFU for advanced pancreatic cancer addresses treatment goals, available options, success rates, and limitations. …”
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Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies by Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

“…Abstract Background Anxiety disorders in older adults have become a prominent public health problem due to their concomitant chronic conditions, reduced quality of life and even death. However, fewer studies have been conducted on differences in anxiety among older individuals in different aged-care models, and the interactive relationship between the influencing factors on anxiety remains unclear. …”
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Nursing of a patient with sudden deafness using Orem self-care mode combined with Traditional Chinese medicine interventions (Orem自理模式联合中医疗法应用于1例突发性聋患者的护理体会)... by SONG Bo (宋波), MEI Xueting (梅雪婷), PEI Xiaolu (裴晓璐), WANG Junge (王俊阁), AI Jianwei (艾建伟), YAN Xinyu (闫新宇), HAN Jinshuai (韩金帅)

“…In response to the problems of affected quality of life, easy occurrence of adverse emotions, and decreased self-care ability of the patient, the Orem self-care mode was used to guide the nursing practice. …”
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Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden by Filipa Sampaio, Alkistis Skalkidou, Gerhard Andersson, Cornelia Weise, Johanna M. Hoppe, Maria Kleinstaeuber, Johan Vegelius, Erika Comasco, Maria Gröndal, Elisavet Kaltsouni, Felicia Sundström, Monica Buhrman

“…Secondary outcomes include treatment effects on quality of life and difficulties in emotion regulation. …”
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The economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study by Banafsheh Darvishi Teli, Meysam Behzadifar, Mania Beiranvand, Aziz Rezapour, Seyed Jafar Ehsanzadeh, Samad Azari, Ahad Bakhtiari, Payam Haghighatfard, Mariano Martini, Maryam Saran, Masoud Behzadifar

“…Comprehensive policies addressing both medical and non-medical expenses are necessary to improve patients’ quality of life and lessen the financial challenges associated with breast cancer in Iran.…”
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Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…Conclusion This study addresses a critical gap in understanding the impact of pre-emptive mTOR inhibitor therapy on neuropsychologic outcomes in young TSC patients, aiming to improve overall patient outcomes and quality of life. EUCT number: 2022–502332-39–00, Registered 22/06/2023, https://euclinicaltrials.eu/search-for-clinical-trials/?…”
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Testing the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial by Andreas Blomqvist, Maria Bäck, Leonie Klompstra, Anna Strömberg, Tiny Jaarsma

“…Although the 1-year survival rate after the first diagnosis is high, physical inactivity and sedentary behavior are associated with increased mortality and negatively impact the health-related quality of life (HR-QoL). ObjectiveWe tested the recruitment frequency, implementation fidelity, and feasibility of outcomes of the Activity Coach app that was developed using an existing mobile health (mHealth) tool, Optilogg, to support older adults with HF to be more physically active and less sedentary. …”
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Psychological factors affecting post-treatment follow-up care in breast cancer patients attending healthcare centers in western Mazandaran (2021-2022) by Zahra Fotokian, Sobhan Rahimi Esbo, Zahra Jannat Alipour, Ali Pourhabib, Fatemeh Ghaffari, Mojtaba Qanbari Qalesari, Shahrbanoo Keyhanian, Mohsen Vakili Sadeghi

“…Background & Aim: Post-treatment follow-up care for breast cancer is crucial in reducing mortality rates, minimizing treatment costs, and enhancing patients' quality of life. This study aims to identify the psychosocial factors affecting post-treatment follow-up care in breast cancer patients. …”
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General practitioner-centered rural obesity management: Design, protocol and baseline data of the German HAPpEN pragmatic trial by Marika Haderer, Reiner Hofmann, Tina Bartelmeß, Laura König, Constanze Betz, Mirna Al Masri, Alisa Bader, Natascha von Schau

“…Primary outcomes include BMI, body weight, waist circumference, heart rate, blood pressure and parameters, while secondary outcomes assess quality of life, wellbeing, health literacy, social interaction, and digital therapy support. …”
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The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…Future research and new therapies may enhance outcomes and reduce health care costs, improving patient quality of life.…”
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Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes by Boyoung Park, Sun-young Kong, Dongju Won, Jong Eun Park, Jun-Kyu Kim, Mi-Ae Jang, Jung-Sook Ha, Kyoung-Bo Kim

“…This study evaluates changes in participant quality of life (QoL), unmet needs and mental health over time based on their genetic variant status.Methods and analysis This prospective cohort study will recruit 1435 patients with suspected hereditary cancer who have undergone BRCA1/2 or next-generation sequencing (NGS) testing. …”
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A nomogram for predicting bladder dysfunction in patients with type 2 diabetes mellitus: a retrospective study by Yingjie Hu, Fengming Hao, Ying Wang, Ling Chen, Lihua Wen, Jue Li, Wei Ren, Wenzhi Cai

“…Background Diabetic bladder dysfunction (DBD) is a common urinary complication in diabetic patients, significantly affecting their overall well-being and quality of life, and placing a considerable burden on healthcare resources. …”
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Prognosis and factors related to severe secondary hyperparathyroidism in long-term peritoneal dialysis patients by Yanmei Li, Xiaonan Feng, Na Chen, Shuhua Song, Min Yu, Yan Wang, Hongxia Zhang, Li Wang, Menghua Chen, Na Tian

“…Secondary hyperparathyroidism (SHPT) can progress to severe SHPT (sSHPT), which affects the survival rate and quality of life of patients. This retrospective cohort study investigated risk factors for sSHPT and the association between SHPT and mortality (all-cause and infection-related) among 771 clinically stable patients (421 male patients; mean age, 51.2 years; median dialysis vintage, 28.3 months) who underwent >3 months of regular peritoneal dialysis (PD) between January 2013 and March 2021. …”
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Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial by Patrick J E Bindels, Arthur M Bohnen, Gijs Elshout, Suzanne G M A Pasmans, Karlijn F van Halewijn

“…Secondary outcomes included the Eczema Area and Severity Index, the Investigators Global Assessment, quality of life (QoL), Patient Global Assessment, Numeric Itch Intensity Score and TCS use.Results The primary outcome showed a significant difference in the POEM scores over 24 weeks of follow-up between the intervention group (n=17) and the control group (n=15) (3.3 vs 9.4, p=0.023). …”
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