Comparative Study on the Clinical Efficacy and Safety of Acitretin and MTX in the Treatment of Pustular Psoriasis by TLR7/MyD88/CXCL16 Pathway by Jiajing Lu, Yu Wang, Ying Li, Yu Gong, Yangfeng Ding, Yuling Shi

“…It can reduce the recurrence rate and improve the quality of life and clinical symptoms. Therefore, a high dose of acitretin is worth popularizing and applying.…”
Get full text

Predictors of Neurological and Functional Recovery in Patients with Moderate to Severe Ischemic Stroke: The EPICA Study by Manuel Murie-Fernández, Mercedes Molleda Marzo

“…Improving our knowledge about the impact of restorative therapies employed in the rehabilitation of a stroke patient may help guide practitioners in prescribing treatment regimen that may lead to better post-stroke recovery and quality of life. Aims. To evaluate the neurological and functional recovery for 3 months after an acute ischemic stroke occurred within previous 3 months. …”
Get full text

Exploring the antiviral potential of shikimic acid against Chikungunya virus through network pharmacology, molecular docking, and in vitro experiments by Jialiang Xin, Xingxing Song, Haohong Zheng, Wenjing Li, Yuyang Qin, Wei Wang, Wei Wang, He Zhang, Guangneng Peng

“…Chikungunya virus (CHIKV) is an arbovirus that can lead to chronic arthritis and significantly diminish the quality of life of patients. Given the expanding global prevalence of CHIKV and the absence of specific antiviral therapies, there is an urgent need to explore effective treatment options. …”
Get full text

Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease by Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen

“…Therefore, dynamic monitoring of these factors associated with risk, timely diagnosis and treatment of ALVDD can delay the progression to symptomatic HF, which is of great importance for reducing CVD mortality, and improving the prognosis and quality of life in CKD patients.…”
Get full text

Children in Vegetative State and Minimally Conscious State: Patients’ Condition and Caregivers’ Burden by A. M. Giovannetti, M. Pagani, D. Sattin, V. Covelli, A. Raggi, S. Strazzer, E. Castelli, A. Trabacca, A. Martinuzzi, M. Leonardi

“…Rehabilitative programs for children with SV and SMC should also provide interventions on surrounding systems: improving the network of psychological support and social assistance may decrease the burden of caregivers and, in turn, improve caring abilities and children quality of life.…”
Get full text

Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based rand... by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

“…Secondary outcomes, measured at quit date, then one, three, six, and 12 months post-quit date, include self-reported continuous abstinence, 7-day point prevalence abstinence, cigarettes smoked per day, withdrawal and urge to smoke, time to (re)lapse, treatment use and compliance, treatment crossover, dual-use, use of other cessation products, change in e-cigarette products, continuation of product use, acceptability, change in health state, health-related quality of life, change in body mass index, adverse events, and cost per quitter. …”
Get full text

Neuropsychological features of patients of reproductive age diagnosed with breast cancer at the stage of surgical treatment using xenon-oxygen therapy by D. A. Rozenko, A. I. Shikhlyarova, L. N. Vaschenko, N. N. Popova, Yu. Yu. Arapova, A. Yu. Ardzha, A. A. Korobov

“…For the final assessment of the physiological and psychological state of the patients, a standardized questionnaires of the quality of life – ESAS, MOS-SF‑36, were used. Statistical data processing was performed using the Statistica 10 software package. …”
Get full text

Higher Physical Activity is Associated with Reduced Lower Urinary Tract Symptoms in Korean Men by Seo Eun Hwang, Jae Moon Yun, Su Hwan Cho, Kyungha Min, Ji Young Kim, Hyuktae Kwon, Jin Ho Park

“…Purpose: Identifying and managing risk factors for lower urinary tract symptoms (LUTS) is crucial because it impacts the quality of life of elderly individuals. Lifestyle factors, including physical activity (PA), and their relationship with LUTS have not been well studied. …”

Efficacy, efficiency and safety of a cardiac telerehabilitation programme using wearable sensors in patients with coronary heart disease: the TELEWEAR-CR study protocol by Andrew Xanthopoulos, Eleni Kapreli, Garyfallia Pepera, Konstantinos I Gourgoulianis, Varsamo Antoniou, Gregory Giamouzis, Constantinos Davos, Ladislav Batalik, Vasileios Stavrou, John Skoularigis

“…Secondary outcomes will be the physical activity, the safety of the exercise intervention (number of adverse events that may occur during the exercise), the quality of life, the training adherence, the anxiety and depression levels, the nicotine dependence and cost-effectiveness. …”
Get full text

Non-Anatomic Reconstruction in Multiligament Knee Injuries: A Functional Approach by Mihai Hurmuz, Cătălin-Adrian Miu, Daniel Ceachir, Romulus-Fabian Tatu, Mihai Andrei, Bogdan Andor, Alexandru Catalin Motofelea, Călin Tudor Hozan

“…The results demonstrated significant improvements across all scoring systems, with enhanced knee stability, reduced pain, and better quality of life. <i>Conclusions</i>: These findings support the feasibility of non-anatomic reconstructions as a practical solution for patients seeking a return to daily activities and recreational sports without the complexity of full anatomic reconstruction.…”
Get full text

Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP) by Li Wang, Yan Zhang, Qiukui Hao, Xiaoyan Chen, Birong Dong, Yan He, Meijuan Chen, Jirong Yue, Xiaochu Wu, Tianyao Zhang, Yan She, Yanling Gao, Yiping Deng

“…Purpose The West China longevity and ageing procedure (WCLAP) cohort study aims to provide guidance for older adults in western China with the aim of improving quality of life, reducing the burden of family care, summarising the characteristics of longevity lifestyles, building a Chinese-longevity-population biobank and exploring the mechanisms underlying population ageing.Participants Since the establishment of the WCLAP research baseline in 2018, a population of 1537 adults aged 80 years and above, living in the community, have been enrolled in the programme as research participants. …”
Get full text

An exploration of desired abstinent and non-abstinent recovery outcomes among people who use methamphetamine by Alex Elswick, Amanda Fallin-Bennett, Karen L. Roper, Evan Batty, Christopher J. McLouth, William Stoops, Hilary L. Surratt, Carrie B. Oser

“…Specific non-abstinent outcomes endorsed as “absolutely essential” by PWUM included: preventing legal trouble (92%), employment stability (82%), improved quality of life (80%), housing stability (78%), improved coping skills (78%), improved relationships (75%), economic/income stability (74%), ability to think clearly (73%), less impulsivity (73%), less depression (71%), less stress (70%), improved hopefulness (70%), and improved sleep (70%). …”
Get full text

Factors involved in maintaining Karnofsky Performance Status (≥ 50%) in glioblastoma, IDH-wildtype patients treated with temozolomide and radiotherapy by Shigeo Ohba, Takao Teranishi, Kazuyasu Matsumura, Masanobu Kumon, Daijiro Kojima, Eiji Fujiwara, Kazutaka Nakao, Kiyonori Kuwahara, Kazuhiro Murayama, Eriel Sandika Pareira, Seiji Yamada, Masahiro Joko, Shunsuke Nakae, Jun Muto, Yuya Nishiyama, Kazuhide Adachi, Hikaru Sasaki, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose

“…Therefore, maintaining KPS ≥ 50% is important to improve the quality of life of patients with glioblastoma, whose median survival is less than 2 years. …”
Get full text

Optimal Timing and Treatment Modalities of Arytenoid Dislocation and Subluxation: A Meta-Analysis by Andrea Frosolini, Valeria Caragli, Giulio Badin, Leonardo Franz, Patrizia Bartolotta, Andrea Lovato, Luca Vedovelli, Elisabetta Genovese, Cosimo de Filippis, Gino Marioni

“…<i>Background and Objective</i>: Arytenoid dislocation (AD) and subluxation (AS) impact vocal fold mobility, potentially affecting the quality of life. Their management, including the timing and modality of treatment, remains a subject of research. …”
Get full text

Systemic therapy a risk factor for glaucoma development and progression by A.M. Getmanova, A.Yu. Brezhnev, A.V. Kuroyedov, V.I. Baranov, A.S. Dvornikov

“…Multimorbidity which is associated with a decline in the quality of life and functional abilities results in the increase in the rate of various physiological disorders and hospital treatment and, therefore, growing healthcare costs. …”
Get full text

Protocol of a randomised controlled phase II clinical trial investigating PREoperative endoscopic injection of BOTulinum toxin into the sphincter of Oddi to reduce postoperative pa... by Phillip Knebel, Thilo Hackert, Markus W Büchler, Thomas Bruckner, Peter Sauer, Markus K Diener, Christine Tjaden, Ulla Klaiber, Pascal Probst, Eike Martin, Steffen Luntz

“…The secondary endpoints comprise further postoperative outcome parameters and quality of life up to 3 months after DP as well as safety and feasibility of the procedure. …”
Get full text

Positron Emission Tomography—Computer Tomography Scan Used as a Monitoring Tool Following Cellular Therapy in Cerebral Palsy and Mental Retardation—A Case Report by Alok Sharma, Hemangi Sane, Amruta Paranjape, Nandini Gokulchandran, Pooja Kulkarni, Anjana Nagrajan, Prerna Badhe

“…Even after lifelong medical and therapeutic management there are residual deficits which affect the quality of life of the patients and their families. We examined a maximally rehabilitated, 20 year old male suffering from CP and Mental Retardation (MR). …”
Get full text

Innovative Diagnostic Approaches and Treatment Strategies for Endometriosis: Current Trends and Future Direction - Review by Wiktoria Domino, Joanna Śnieżna, Wojciech Florczak, Karol Dzwonnik, Urszula Zelik, Jagienka Włodyka, Gabriela Trestka, Maria Przygoda, Jakub Dziewic, Kamila Stępień, Sabina Adamczyk

“…The primary goals of treatment include pain relief, improving the patient's quality of life, preventing disease recurrence, preserving fertility, and reducing the need for surgery. …”
Get full text

Malnutrition among the Elderly in Malaysia and Its Associated Factors: Findings from the National Health and Morbidity Survey 2018 by Mohamad Hasnan Ahmad, Ruhaya Salleh, Cheong Siew Man, Munawara Pardi, Norsyamlina Che Abdul Rahim, Norhafizah Shahril, Mohd Hatta Abdul Mutalib, Suzana Shahar, Noor Ani Ahmad

“…Complex sample multiple logistic regression found that the elderly who lived in a rural area, with no formal or primary level of education, had depression, Instrumental Activity of Daily Living (IADL) dependency, and low quality of life (QoL), were underweight, and had food insecurity and inadequate plain water intake were at a significant risk of malnutrition (malnutrition and at-risk), while Chinese, Bumiputra Sarawak, and BMI more than 25 kgm−2 were found to be protective. …”
Get full text

Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research by Foteini Stefania Koumpa, Diamantis Xylas, Maciej Konopka, Dieter Galea, Kirill Veselkov, Anthony Antoniou, Akash Mehta, Reza Mirnezami

“…Colorectal peritoneal metastases (CPM) are associated with abbreviated survival and significantly impaired quality of life. In patients with CPM, radical multimodality treatment consisting of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated oncological superiority over systemic chemotherapy alone. …”
Get full text