Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

“…BackgroundDiabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus that manifests as chronic, non-healing wounds that have a significant impact on patients quality of life. Identifying key molecular targets associated with DFUs could help develop targeted therapies to promote wound healing and prevent further complications. …”
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The Effect of a Patient Activation Tailored Intervention on Type 2 Diabetes Self-Management and Clinical Outcomes: A Study from Saudi Arabian Primary Care Settings by Nasser Almutairi, Vinod Gopaldasani, Hassan Hosseinzadeh

“…Collected data included demographics, clinical data, the Patient Activation Measure (PAM), the Summary of Diabetes Self-Care Activities (SDSCA), the diabetes knowledge test (DKT2), the problem area in diabetes test (PAID-5), and the diabetes quality of life test (DQOL). The intervention was tailored based on the participants’ patient activation level. …”
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Diagnosis and Treatment of Low Anterior Resection Syndrome by Masaaki Miyo, Emi Akizuki, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Ichiro Takemasa

“…However, these disorders have been recently termed low anterior resection syndrome (LARS), which is a defecation disorder that occurs following rectal resection and impairs the patient's quality of life (QOL). The LARS score developed by Emmertsen et al., which is a patient-reported outcome measure to evaluate the severity of bowel dysfunction following rectal surgery by scoring the major symptoms of LARS, facilitates the diagnosis and assessment of LARS and enables international comparison and validation through the use of validated scores generated according to the international standards. …”
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Diabetes and Cataracts Development—Characteristics, Subtypes and Predictive Modeling Using Machine Learning in Romanian Patients: A Cross-Sectional Study by Adriana Ivanescu, Simona Popescu, Adina Braha, Bogdan Timar, Teodora Sorescu, Sandra Lazar, Romulus Timar, Laura Gaita

“…Since individuals with diabetes are at an increased risk of developing cataracts, which significantly affects their quality of life, this study aims to identify the most common cataract subtypes in diabetic patients, highlighting the need for proactive screening and early intervention. …”
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Cost‐of‐illness analysis of chronic urticaria clinical management in five countries of Latin America by Jorge Sánchez, Leidy Álvarez, José Ignacio Larco, Luis Ensina, Guillermo Guidos‐Fogelbach, Cesar A. Reyes‐López, German D. Ramon, Karla Robles‐Velasco, Ivan Cherrez‐Ojeda

“…Abstract Introduction Chronic spontaneous urticaria (CSU) is a disease with a high impact on the quality of life of patients. There are some evaluations of the economic cost of the disease in developed countries, but there is little information about the economic cost of the disease in developing countries. …”
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Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…**Methods:** Spanish data from the CHESS II study (2018-2020) on patients' clinical characteristics, health-related quality of life (HRQoL) and hemophilia-related healthcare resource utilization were analyzed. …”
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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model by Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang

“…Abstract Intestinal fibrosis, as a late-stage complication of inflammatory bowel disease (IBD), leads to bowel obstruction and requires surgical intervention, significantly lowering the quality of life of affected patients. SAA3, a highly conserved member of the serum amyloid A (SAA) apolipoprotein family in mice, is synthesized primarily as an acute phase reactant in response to infection, inflammation and trauma. …”
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Nutrition and Physical Therapy in the Prevention and Treatment of Endometriosis by Paulina Krzemińska, Maciej Gołębski, Wojciech Nowak, Jagoda Mikołajczyk, Zuzanna Kukla, Stella Mieruszyńska, Izabela Sadowska, Joanna Kołodziej, Mirosław Sawicki, Jakub Włosiański, Sebastian Musialik

“…Sick women suffering from this condition often have non-specific symptoms, such as pelvic pain and are often associated with the menstrual cycle. can lead to reduced mental, physical, and social well-being and a lower quality of life. There are many factors that predispose to the onset and course of the disease. …”
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Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells by Lauren Frawley, Noam Tomer Taylor, Olivia Sivills, Ella McPhillamy, Timothy Duy To, Yibo Wu, Beek Yoke Chin, Chiew Yen Wong

“…With an incidence rate of about 4.42 cases per 100,000 people annually, ALS severely impacts motor function and quality of life, causing progressive muscle atrophy, spasticity, paralysis, and eventually death. …”
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Integrated Traditional Chinese and western medicine nursing of a patient with COVID-19 complicated with chronic cough (1例新型冠状病毒感染合并慢性咳嗽患者的中西医结合护理体会)... by YANG Xiaoyu (杨肖雨), CAO Hongjing (曹红京), LI Ning (李宁), LI Yueru (李月茹), LI Jing (李静), ZHENG Xinnan (郑鑫楠)

“…In addition, Traditional Chinese Medicine nursing techniques such as dressing aromatherapy, Chinese herbal medicine ointment rubbing, acupoint application, auricular acupoint pressing and five-tone music therapy were carried out to relieve the negative emotion and cough symptoms, and improve patient’s quality of life. (本文总结1例新型冠状病毒感染合并慢性咳嗽患者的中西医结合护理体会。…”
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Family caregiver frailty in adult congenital heart disease is overlooked: A call to action by Arianna Magon, Serena Francesca Flocco, Laura Schianchi, Massimo Chessa, Daniele Ciofi, Salvatore Angileri, Maddalena De Maria, Gianluca Conte, Silvia Favilli, Cristina Arrigoni, Rosario Caruso

“…This perspective calls for immediate action in research and policy to prioritize caregiver well-being in transition care programs, enhancing the quality of life for both caregivers and patients.…”
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Patients’ satisfaction and efficacy of modern conventional hearing aids: A comprehensive analysis of the self-reported user experiences in adult people by Daniele Portelli, Cosimo Galletti, Sabrina Loteta, Leonard Freni, Francesco Ciodaro, Angela Alibrandi, Giuseppe Alberti

“…Objective: Hearing loss is a widespread condition that impacts the quality of life, affecting communication, social interactions, and cognitive functions. …”
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Effects of home-based mirror therapy and cognitive therapeutic exercise on the improvement of the upper extremity functions in patients with severe hemiparesis after a stroke: a pr... by Josefa Gonzalez-Santos, Raul Soto-Camara, Paula Rodriguez-Fernández, Maria Jimenez-Barrios, Jeronimo Gonzalez-Bernal, Carla Collazo-Riobo, Maha Jahouh, Yolanda Bravo-Anguiano, Jose M Trejo-Gabriel-Galan

“…Secondary variables will include cognitive performance, emotional state, quality of life and activities of daily living. During 6 weeks, one of the intervention groups will receive a treatment based on MT and the other one on CTE, both combined with task-oriented training. …”
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Evaluating an implementation programme for medication review with follow-up in community pharmacy using a hybrid effectiveness study design: translating evidence into practice by Fernando Martínez-Martínez, Shalom I Benrimoj, Victoria Garcia-Cardenas, Raquel Varas-Doval, Miguel A Gastelurrutia, Maria Jose Zarzuelo, Beatriz Perez-Escamilla

“…The secondary outcomes were number of medications, non-controlled health problems, emergency visits, hospitalisations and health-related quality of life, which were compared with a previous 6-month cluster RCT.Results 55% of pharmacies reached the implementation phase and 35.6% remained in the testing phase at 12 months. …”
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Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review by Andrei Cretu, Andreea Grosu-Bularda, Eliza-Maria Bordeanu-Diaconescu, Florin-Vlad Hodea, Vladut-Alin Ratoiu, Catalina-Stefania Dumitru, Mihaela-Cristina Andrei, Tiberiu-Paul Neagu, Ioan Lascar, Cristian-Sorin Hariga

“…These strategies aim to optimize both functional recovery and aesthetic outcomes, reducing scarring and improving the quality of life for burn patients. While promising, these emerging techniques require further research and clinical validation to refine their effectiveness and expand their accessibility. …”
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Protocol for prognosticating PPD using EEG changes during labor pain by uterine contractions: a prospective cohort study in the first stage of labor by Yan Wang, Wan-Ying He, Chang’ an A. Zhan, Shi-Lei Pan, Wen Wu, Feng-Xian Li, Hong-Fei Zhang

“…The results from this study may act as a predictor for the development of PPD which may enhance long-term quality of life for the parturient and her offspring. …”
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Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease by Magdalini Kreouzi, Nikolaos Theodorakis, Maria Nikolaou, Georgios Feretzakis, Athanasios Anastasiou, Konstantinos Kalodanis, Aikaterini Sakagianni

“…Clinical trials have demonstrated significant reductions in inflammatory lesions and improved quality-of-life metrics in patients receiving these microbiota-targeted treatments. …”
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Initial ASIA impairment scale and its association with improvement in cervical spinal cord injury by Aman Singh, Somil Jaiswal, Anil Chandra, Amit Srivastava, Suresh Jaiswal, Awadhesh Yadav, B.K. Ojha, Chhitij Srivastava

“… Background: Cervical spinal cord injuries (SCI) are a severe subset of trauma cases, with important impacts on functional abilities and quality of life. Effective management strategies are crucial for improving outcomes. …”
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Orbital lesion (pseudotumor and dacryoadenitis) is a manifestation of systemic sarcoidosis by E.A. Burylova, L.A. Mamaeva, A.S. Berdnikova, O.K. Fedorova

“…Threatened vision loss and poor quality of life are the reasons to prescribe systemic steroids in generalized sarcoidosis. …”
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Remote symptom monitoring with patient-reported outcomes and nudges during lung cancer immunotherapy in China (PRO-NET): protocol for a randomised controlled trial by Ping He, Yanan Luo, Zhenyu Shi, Yiqi Xia, Xiaolong Guan

“…For advanced NSCLC, immunotherapy offers substantial survival benefits but is often accompanied by severe immune-related adverse events symptoms, significantly affecting health-related quality of life (HRQoL). Routinely collection of patient-reported outcomes (PROs) followed by automated alerts has been shown to improve overall survival and HRQoL for cancers. …”
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