Digital screening tool for the assessment of cognitive impairment in unsupervised setting—digiDEM-SCREEN: study protocol for a validation study by Elmar Graessel, Nikolas Dietzel, Hans-Ulrich Prokosch, Peter L Kolominsky-Rabas, Peter Heuschmann, Michael Zeiler, Klaus Kammerer, Ulrich Frick, Rüdiger Pryss

“…Asymptomatic screening of cognitive impairments using neuropsychiatric tests has been proven to efficiently enhance diagnosis rates. Digital screening tools, in particular, provide the advantage of being accessible without spatial or time restrictions. …”
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Neutralizing antibody responses to three XBB protein vaccines in older adults by Guo-Jian Yang, Mei Lu, Rui-Rui Chen, Shuang-Qing Wang, Sheng Wan, Xue-Dong Song, Guo-Ping Cao, Lei Lv, Xue-Juan He, Bing-Dong Zhan, Mai-Juan Ma

“…While COVID-19 vaccines containing XBB subvariants have proven effective in neutralizing new SARS-CoV-2 variants, a gap remains in knowledge regarding neutralizing antibody responses in older adults aged >65 years against these newly emerged variants. …”
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Low expression of TOX predicts poor prognosis of patients with breast cancer in the real world: A retrospective study by Chunlei Tan, Danping Wu, Xiaotian Yang, Shiyuan Zhang, Shuqiang Liu, Boqian Yu, Xiao Yu, Yuting Xiu, Yuanxi Huang

“…Background: TOX is a transcription factor that is implicated in the regulation of T cell exhaustion in tumors. TOX has been proven to have prognostic value in some malignant tumors. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Results: Network analysis identified 129 drugs associated with SCM, which were refined to 14 drug candidates based on strong network predictions, proven anti-infective effects, suitability for ICU use, and minimal side effects. …”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…Tianma Gouteng Granules (TG), a traditional Chinese medicine compound, has been proven to be an effective compound for the treatment of hypertension by traditional Chinese medicine diagnosis, but the target and therapeutic mechanism of TG on hypertension are still unclear. …”
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Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice by Qi Li, Chenyi Wu, Zhenlong Liu, Huiqing Zhang, Yuna Du, Yuxiang Liu, Kuangyu Song, Qiaofa Shi, Rong Li

“…CD38 is one of the well-known regulators of innate immunity, whose dysregulation contributes to sepsis. Many studies have proven that an attenuated Gram-positive bacterium induces sepsis in a CD38-blocking model. …”
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Environment-friendly Ca2+/Cr3+ co-doping LaAlO3 ceramics with excellent infrared radiation performance for energy-saving by Xinglai Yuan, Qinghu Wang, Runke Wu, Shaobai Sang, Yibiao Xu, Xiong Liang, Liping Pan, Bingbing Fan, Yawei Li, Rui Zhang, Jiangtao Li, Olena Volkova

“…Ca2+/Cr3+ co-doped LaAlO3 infrared (IR) ceramics have been proven to be potential energy-saving materials for high-temperature industries because of their high emissivity and high-temperature stability. …”
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Evaluating the implementation of a multicomponent intervention to improve faecal immunochemical test-based (FIT) colorectal cancer screening in primary care by Kamala Adhikari, James Whitworth, Gary F Teare, Muhammad Kashif Mughal, Danica Hignell, Barbara Moysey, Jawad Chishtie

“…Screening has proven effective at reducing the incidence and mortality of colorectal cancer (CRC). …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Against the clinical diagnosis of proven or probable IFDs, the findings show that the LFA system produced a high specificity of 99.4 % while the sensitivity was only moderate at 47.8 % due to the difficulty of extracting fungal DNA from blood samples. …”
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Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury by Yi Kang, Yijie Song, Zhongju Shi, Qiang Li, Yigang Lv, Mengfan Hou, Cui Ding, Jing Xie, Yongfu Lou, Chi Zhang, Huan Jian, Xueying Li, Hengxing Zhou, Shiqing Feng

“…Long noncoding RNAs (lncRNAs) have already been proven to play key roles in different diseases of the CNS. …”
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A Cause of Diarrhea in a Patient with Selective Immunoglobulin A Deficiency by M. I. Gonik, V. S. Shcherbakha, E. Yu. Yuryeva, I. M. Kartavenko, A. S. Tertychny, P. V. Pavlov, A. E. Leonovich, T. L. Lapina, V. T. Ivashkin

“…Despite the absence of antibodies to parietal cells and intrinsic factor, a diagnosis of autoimmune gastritis was established on the basis of histologically confirmed atrophy of the stomach; decrease in serum pepsinogen I and the ratio of pepsinogen I to pepsinogen II, hypergastrinemia; vitamin B12 deficiency; proven autoimmune thyroiditis (antibodies to thyroglobulin and thyroid peroxidase in the diagnostic titre). …”
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Serum Magnesium Level among Acute Myocardial Infarction Patients and Its Correlation with Intra-hospital Complications: A Cross-sectional Single-center Study among Sudanese Patient... by Mohammed Taha, Ayman Azhary, Nooh Mohamed Hajhamed, Waleed Azhary Sir Alkhatim, Salahdeen Ismail Mohammed, Abdullah M Bakheit, Abdallah Elssir Ahmed, Abubakar Abdelbagi

“… Background: Patients with acute myocardial infarction (AMI) frequently have hypomagnesemia, although magnesium (Mg) has proven cardioprotective characteristics. Cardiovascular fatality has been linked to low serum Mg levels; however, the exact mechanism is unknown and results are inconsistent. …”
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Special Staining of the Liquid-Based Cytopathology Test in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients by Yue Hu, Lin Zheng, Deng Pan, Lei Shao, Xianfa Xu, Yiming Yu, Qidong Zhuang, Zaichun Deng, Zhongbo Chen

“…Among 47 possible IPA patients, 25 patients had proven/probable IPA, and 11 patients had other invasive fungal diseases. …”
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A New Approach to Identifying Red Supergiant Stars in Metal-poor Galaxies: A Case Study of NGC 6822 by Zhi-wen Li, Ming Yang, Biwei Jiang, Yi Ren

“…The color–color diagram (CCD) method, specifically using r − z / z − H and J − H / H − K , has proven successful in several studies. However, in metal-poor galaxies, faint RSGs will mix into the dwarf branch in the CCD and would be removed, leading to an incomplete RSG sample. …”
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An assessment of breast cancer HER2, ER, and PR expressions based on mammography using deep learning with convolutional neural networks by Shun Zeng, Hongyu Chen, Rui Jing, Wenzhuo Yang, Ligong He, Tianle Zou, Peng Liu, Bo Liang, Dan Shi, Wenhao Wu, Qiusheng Lin, Zhenyu Ma, Jinhui Zha, Yonghao Zhong, Xianbin Zhang, Guangrui Shao, Peng Gong

“…Mammography of patients with pathologically proven breast cancer was obtained from two centers. …”
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The hypotension prediction index in major abdominal surgery – A prospective randomised clinical trial protocol by Jakub Szrama, Agata Gradys, Zuzanna Nowak, Ashish Lohani, Krzysztof Zwoliński, Tomasz Bartkowiak, Amadeusz Woźniak, Tomasz Koszel, Krzysztof Kusza

“…Previous perioperative goal-directed studies have not proven the benefits of this approach with high certainty. …”
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Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>) by Ye. A. Poluektova, S. Yu. Kuchumova, A. A. Kurbatova, A. A. Sheptulin, O. S. Shifrin, V. T. Ivashkin

“…Careful taking past history and carrying out detailed laboratory and instrumental tool investigation allowed to establish clinical diagnosis in the patient, and pathogenicly proven treatment promoted achievement of disease remission.…”
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The Role of Duodenogastroesophageal Reflux in the Progression of Gastroesophageal Reflux Disease: From Esophagitis to Adenocarcinoma by O. A. Storonova, A. V. Paraskevova, A. A. Makushina

“…The basic therapy for GERD is proton pump inhibitors (PPIs), but up to 40 % of patients do not fully respond to PPI monotherapy, which indicates the need to consider, among the factors in the pathogenesis of GERD, the persistence of weakly acidic and weakly alkaline refluxes, the presence of which can be diagnosed by performing 24-hour impedance-pH monitoring. It has been proven that refluxate is predominantly acidic in nature in 50 % of patients with GERD, acidic with a bile component in 39.7 %, and 10.3 % of patients have bile reflux. …”
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First report of non-marine ostracods (Crustacea, Ostracoda) from the Dahlak Archipelago (Eritrea), with the description of two new species by Giampaolo Rossetti, Ilaria Mazzini, Giorgio Chiozzi, Luca Vecchioni, Federico Marrone

“…Rehydration of dry sediments collected from arid areas where wet periods are short and often unpredictable has proven to be a successful method for describing aquatic invertebrate biodiversity. …”
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Implementing the Kids’ Athletics Program in the System of Increasing the Level of Physical Performance of Youth by Ján Jakubík, Jaroslav Broďáni

“…Conclusions. It has been proven that the “Kids’ Athletics” program, composed of selected disciplines of Kids’ Athletics supplemented by athletic movement games, has a significant impact on a wider range of physical abilities in 8- to 9-year-old children compared to the traditional content of the ISCED 1 state education program. …”
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