Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach by Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah

“…Taken together, melongosides need further attention for more scientific studies as a DENV inhibitory agent, which if proven, in vivo and in clinical trials, can be a useful therapeutic agent against at least DENV-2.…”
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Finding the best column for polar basic analytes across reversed-phase and hydrophilic interaction liquid chromatography by József Simon, Márton Kovács, Pál T. Szabó

“…The resulting best column with the optimal conditions is presented and proven highly efficient for their separation. Significance: A straightforward comparison and ranking system is developed to test multiple chromatographic columns with different stationary phases, from reversed-phase to hydrophilic interaction in gradient elution, seeking the best method for separating polar basic molecules. …”
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Modern possibilities of tear film stability restoration by V.V. Brzheskiy, G.G. Кim, V.А. Bobryshev

“…In vitro and in vivo experiments have proven the possibility of using such modified hyaluronic acid as an artificial tear substitute. …”
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Bioenergy potential of Chlorella vulgaris under the influence of different light conditions in a bubble column photobioreactor by S. Dhanasekar, R. Sathyanathan

“…Moreover, microalgae are proven to be miniature factories that augment the huge potential of biofuel. …”
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Assessment of the safety of priority carcinogenic substances at the level of hygienic regulations in atmospheric air by I.O. Chernychenko, O.M. Lytvychenko, V.F. Babii, O.Ie. Kondratenko, O.P. Rudnytska, D.O. Hlavachek

“…The aim of this work was to assess the risk of carcinogenic substances with a proven danger to humans at the level of current maximum permissible concentrations (MPC). …”
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Detection of Adversarial Attacks Using Deep Learning and Features Extracted From Interpretability Methods in Industrial Scenarios by Angel Luis Perales Gomez, Lorenzo Fernandez Maimo, Alberto Huertas Celdran, Felix J. Garcia Clemente

“…However, the effectiveness of this approach needs to be proven in the field of Anomaly Detection on industrial environments, where adversarial training has critical limitations. …”
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A life stage resolved habitat model for guiding seagrass restoration in coastal lagoons by Sherry Y. Zhai, Michelle Waycott, Ryan Lewis, Emma O’Loughlin, Paul L.A. Erftemeijer, Peisheng Huang, Justin D. Brookes, Claire Sims, Zhenming Zhang, Matthew R. Hipsey

“…Identifying management strategies to guide their recovery has proven complicated due to the complex environmental requirements across life stages. …”
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Ultrasonic-assisted MoS2/GO/TiO2 ceramic coatings: Enhancing anti-friction performance through dual-interface optimization by Ziwei Guo, Yongnan Chen, Nan Wang, Yiku Xu, Qinyang Zhao, Zhimin Hou, Guangrui Gao, Yan Kang, Haifei Zhan

“…Ceramic coatings containing two-dimensional materials (2D materials) provide effective protection for light alloys during wear, significantly improving their anti-friction performance. MoS2 has proven highly effective in enhancing the anti-friction performance of ceramic coatings, particularly when synthesized via plasma electrolytic oxidation (PEO). …”
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Improving Autonomous Vehicle Cognitive Robustness in Extreme Weather With Deep Learning and Thermal Camera Fusion by Mehmood Nawaz, Sheheryar Khan, Muhammad Daud, Muhammad Asim, Ghazanfar Ali Anwar, Ali Raza Shahid, Ho Pui Aaron HO, Tom Chan, Daniel Pak Kong, Wu Yuan

“…In autonomous vehicles (AV), sensor fusion methods have proven to be effective in merging data from multiple sensors and enhancing their perception capabilities. …”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

“…The phenotypic changes induced by CD36 ligands were assessed in vitro by: i) oil red staining, ii) tumorsphere assays, and iii) RT-qPCR.ResultsWe identified an anti-CD36 scFv, called D11, that competes with a commercial anti-CD36 antibody with proven efficacy in disease models. D11 binds to CD36 expressed in the membrane of the cellular models employed and reduces the uptake of CD36 ligands. …”
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Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c... by Louis-Emmanuel Chriqui, Etienne Abdelnour-Berchtold, Edoardo Zanfrini, Severine Devesa-Perez, Michel Gonzalez, Thorsten Krueger, Kim Ellefsen, Alice Destaillats, David Bonnet, Martin Hübner, Hasna Bouchaab, Michal Bassani-Sternberg, Solange Peters, Sabrina Cavin, Jean Y Perentes

“…We plan to determine the safety of such an approach in patients managed for pleural carcinosis. If proven safe, PITHAC could be combined with systemic immunotherapies for the management of cancer. …”
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Cyclophosphamide and mycophenolate mofetil as induction therapy in lupus nephritis by Božić-Majstorović Ljubinka, Popović-Pejičić Snježana, Mrđa Jelena, Mrđa Vladimir, Ovčina Irma

“…Methods: Study included 53 SLE patients with biopsy-proven class III and class IV LN. Twenty-two patients (42 %) were treated with MMF (dosage 2-3 g/day) and 31 patients (58 %) were treated with CYC (0.5 to 1.0 g/m2 in monthly pulses) in a 24-week induction study. …”
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Real-world experiences with brentuximab vedotion-based regimens in systemic anaplastic large cell lymphoma: a multi-center retrospective study by Zhiqiang Zhao, Qinchuan Yu, Liping Su, Jianxia He, Jie Tao, Yanfeng Xi, Yujiao Guo, Yanhong Luo, Lieyang Wang

“…Neurological toxicities were commonly observed but resolved following the completion of treatment.ConclusionBV has proven to be effective and well-tolerated in real-world settings for the treatment of sALCL, reinforcing its potential as a promising option for first-line or subsequent therapy. …”
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Interpretation of COVID-19 Epidemiological Trends in Mexico Through Wastewater Surveillance Using Simple Machine Learning Algorithms for Rapid Decision-Making by Arnoldo Armenta-Castro, Orlando de la Rosa, Alberto Aguayo-Acosta, Mariel Araceli Oyervides-Muñoz, Antonio Flores-Tlacuahuac, Roberto Parra-Saldívar, Juan Eduardo Sosa-Hernández

“…Detection and quantification of disease-related biomarkers in wastewater samples, denominated Wastewater-based Surveillance (WBS), has proven a valuable strategy for studying the prevalence of infectious diseases within populations in a time- and resource-efficient manner, as wastewater samples are representative of all cases within the catchment area, whether they are clinically reported or not. …”
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Surveillance on the coverage of herpes zoster vaccine and post-marketing adverse events in Jiangsu province, China by Xiang Sun, Lei Zhang, Tingting Zhang, Jinning Sun, Yan Xu, Li Liu, Yuan Bao Liu, Ran Hu, YaLi Fu, Zhiguo Wang, Hui Sun

“…Over 55% of AEFIs occurred within 30 minutes post-vaccination , with fever, allergic eruptions, and drowsiness being the most reported systemic symptoms, and redness and induration being the main symptoms at the injection site. Despite the proven safety profile of the HZ vaccine, its coverage remains significantly low among individuals aged 50 years and above in Jiangsu Province, China as of 2023. …”
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Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study by Xin Zhang, Caopei Zheng, Ling Zhang, Yuqing Sun, Ying Liang, Xue Chen, Lijun Pang, Yulin Zhang

“…Methods This was a retrospective cohort study of SLD patients diagnosed with proven or probable IPA at Beijing Youan Hospital, Capital Medical University between January 1, 2012 to January 31, 2023. …”
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THE COLLABORATIVE DESIGNING OF A PERSONALIZED HYBRID LMS USING A VIRTUAL MACHINE IN A CLOUD ENVIRONMENT by Lina Čeponienė, Péter Galambos, Tamás Haidegger, Dariusz Mikulowski, Branislav Mišota, Oliver Moravcik, Enikő Nagy, Mariya P. Shyshkina, Pavel Smolka, Stefan Svetsky

“…In the academic environment, so-called learning management systems (LMSs), especially Moodle in the European Union, have proven suitable for the processing of educational content under e-Learning. …”
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Quantifying the Suitability of Biosignals Acquired During Surgery for Multimodal Analysis by Ennio Idrobo-Avila, Gergo Bognar, Dagmar Krefting, Thomas Penzel, Peter Kovacs, Nicolai Spicher

“…Nevertheless, multimodal analysis is performed successfully in sleep studies since many years as their signals have proven suitable. Hence, this study evaluates the suitability to perform multimodal analysis on a surgery dataset (VitalDB) using a multi-center sleep dataset (SIESTA) as reference. …”
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3D modeling to predict vascular involvement in resectable pancreatic adenocarcinoma by Sguinzi R, Vidal J, Poroes F, Bartolucci DA, Litchinko A, Gossin E, Fingerhut A, Toso C, Buhler L, Egger B

“…A positive delta was defined by the 3D analysis resulting in greater accuracy in predicting vascular involvement as proven intraoperatively or histopathologically. Results: Fourteen PD, one total pancreatectomy, and one exploratory laparotomy were performed. …”
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Beneficial Effect of Fenofibrate in Combination with Silymarin on Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an Animal Model of Metabolic Syndrome by Jan Soukop, Ludmila Kazdová, Martina Hüttl, Hana Malínská, Irena Marková, Olena Oliyarnyk, Denisa Miklánková, Soňa Gurská, Zuzana Rácová, Martin Poruba, Rostislav Večeřa

“…Fenofibrate is an effective hypolipidemic drug, but its benefits for ameliorating disorders associated with hypertriglyceridemia failed to be proven in clinical trials. <b>Methods:</b> To search for possible causes of this situation and possibilities of their favorable influence, we tested the effect of FF monotherapy and the combination of fenofibrate with silymarin on metabolic disorders in a unique model of hereditary hypertriglyceridemic rats (HHTg). …”
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