Towards a Quantitative Description of Proteolysis: Contribution of Demasking and Hydrolysis Steps to Proteolysis Kinetics of Milk Proteins by Mikhail M. Vorob’ev

Subjects: “…proteolysis mechanisms…”
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Organophosphate esters inhibit enzymatic proteolysis through non-covalent interactions by Zeming Wang, Wei Zhang, Xiaojie Hu, Yanzheng Gao

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The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease by Riya Shanbhag, Guang Shi, Jarungjit Rujiviphat, G. Angus McQuibban

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Theoretical investigation on models of circadian rhythms based on dimerization and proteolysis of PER and TIM by Jifa Jiang, Qiang Liu, Lei Niu

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Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors by Ezequiel J. Tolosa, Lin Yang, Jennifer Ayers-Ringler, Shinichiro Suzuki, Jayapal Reddy Mallareddy, Janet Schaefer-Klein, Mitesh Borad, Farhad Kosari, Amarnath Natarajan, Aaron S. Mansfield

“…These effects depend on dynamin and proteolysis. This application of PROTACs may impact the use of ADCs and provides a rationale to combine these agents in clinical trials.…”
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Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease by Mallory Gough, Catherine Parr-Sturgess, Edward Parkin

“…It is the role of zinc metalloproteinases in this “positive side of proteolysis in Alzheimer's disease” that is discussed in the current paper.…”
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Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. by Marcos V A S Navarro, Peter D Newell, Petya V Krasteva, Debashree Chatterjee, Dean R Madden, George A O'Toole, Holger Sondermann

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Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation by Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li

“…However, the direct identification of a targeted protein remains unexplored for natural occurring compounds. Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

Subjects: “…proteolysis…”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

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Cartilage Oligomeric Matrix Protein (COMP)-Mediated Cell Differentiation to Proteolysis Mechanism Networks from Human Normal Adjacent Tissues to Lung Adenocarcinoma by Lin Wang, Juxiang Huang, Minghu Jiang, Haizhen Diao, Huilei Zhou, Xiaohe Li, Qingchun Chen, Zhenfu Jiang, Haitao Feng, Stefan Wolfl

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A medium-throughput protease assay for screening green plant material by Christina Stonoha-Arther, Andrew Molodchenko, Andrew Molodchenko, Kevin Panke-Buisse

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miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

“…This decline in TREM2 expression was associated with increased proteolysis of TREM2 by a disintegrin and metalloproteases 10 (ADAM10) as well as a disintegrin and metalloproteases 17 (ADAM17), in which ADAM17 was verified as the main cleavage enzyme in terms of TREM2 proteolytic cleavage in hypertensive mice following Pb exposure. …”
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Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor by Algirdas J. Jesaitis, Jeannie Gripentrog, Jovanka M. Voyich

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Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

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Classification of Slovenian Dry-Cured Ham – Kraški pršut – According to Texture Profile by Mateja Lušnic Polak, Tomaž Polak, Mojca Kuhar, Iva Zahija Jazbec, Tadej Kaltnekar, Lea Demšar

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Effect of marination with broccoli (Brassica oleracea var. italica) juice and soy sauce on physicochemical, structural and oxidative properties of beef steak by Ashkan Jebelli Javan, Fatemeh Mirhaj, Nasim Khorshidian, Mehrdad Mohammadi

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Foodborne toxin Aflatoxin B1 induced glomerular podocyte inflammation through proteolysis of RelA, downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway by Jie Zhang, Shuang Yang, Baocai Xu, Zihui Qin, Xinyi Guo, Ben Wei, Qinghua Wu, Kamil Kuca, Tushuai Li, Wenda Wu

“…Our findings indicated that ubiquitin-dependent proteolysis of RelA, downregulation of miR-9, and activation of CXCR4/TXNIP/NLRP3 pathway played an essential role in AFB1-induced glomerular podocyte inflammation. …”
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Virtual screening and directional preparation of xanthine oxidase inhibitory peptides derived from hemp seed protein by Xiaoni Huang, Jiajun Liao, Ping Shi, Xiaodong Pei, Chenghua Wang

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