Mechanisms by which Human Cells Bypass Damaged Bases during DNA Replication after Ultraviolet Irradiation by James E. Cleaver

“…The mechanism of the secondary bypass is unclear, but a number of experiments suggests roles for excision repair to remove damage ahead of replication forks, hRad6/18 proteolysis to clear the blocked forks, and the Rad17-RFC and 9-1-1 complexes to establish a new replication apparatus. …”
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Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan by Shinji Miyata, Hiroshi Kitagawa

“…Finally, we found that increased 6-sulfation accelerated proteolysis of aggrecan by a disintegrin and metalloproteinase domain with thrombospondin motif (ADAMTS) protease. …”
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The Activity of Metalloproteases and Serine Proteases in Various Organs after Leiurus macroctenus Envenomation by Valery Gunas, Oleksandr Maievskyi, Nataliia Raksha, Tetiana Vovk, Oleksiy Savchuk, Serhii Shchypanskyi, Igor Gunas

“…The present study aimed to examine the total proteolysis levels in various organs after Leiurus macroctenus envenomation and evaluate the metalloproteases and serine proteases’ contributions to the total proteolytic activity. …”
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Identification of novel 7-hydroxycoumarin derivatives as ELOC binders with potential to modulate CRL2 complex formation by Yonghyeok Kim, Seon Jeong Baek, Eun-Kyung Yoon, Minhee Choi, Jung-Hoon Kim, Kyungtae Kim, Chi Hoon Park, Byung Il Lee

“…Hydroxyproline-based ligands that mimic VHL substrates have been developed as anchor molecules for proteolysis-targeting chimeras (PROTACs) in TPD. To expand the chemical space for VHL ligands, we conducted fragment screening using VHL–ELOB–ELOC (VBC) proteins. …”
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Differentially Expressed microRNAs in Peritoneal Dialysis Effluent-Derived Exosomes from the Patients with Ultrafiltration Failure by Weifei Wu, Xu Wu, Zhiqun Cheng, Zhenzhen Yang, Minhui Lu, Jing Cheng

“…Functional analyses revealed that these DE-miRNAs were significantly enriched in pathways of cancer, ubiquitin-mediated proteolysis, axon orientation, and the Rap1 and Ras signaling pathways. …”
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Reduced PKC α Activity Induces Senescent Phenotype in Erythrocytes by Rukmini B. Govekar, Poonam D. Kawle, Suresh H. Advani, Surekha M. Zingde

“…The reduction in PKC α activity may be attributed to the known downregulation of PMA-activated PKC α, caused by its membrane translocation and proteolysis. We demonstrate membrane translocation of PKC α in PMA-treated cells to substantiate this inference. …”
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Expression Profiles of Differentially Expressed Circular RNAs and circRNA–miRNA–mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5 by Jing Li, Heng Yang, Huaran Shi, Jihong Zhang, Wei Chen

“…Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the differentially expressed circRNAs were mainly involved in ubiquitin-mediated proteolysis and signaling pathways during CVB5 infection. …”
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Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population by Johannes Lange, Kristin Aaser Lunde, Camilla Sletten, Simon Geir Møller, Ole-Bjørn Tysnes, Guido Alves, Jan Petter Larsen, Jodi Maple-Grødem

“…Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. …”
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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

“…Previously, it was believed that proteolysis by the proteasome required tagging of protein targets with polyubiquitin chains, a pathway called the ubiquitin-proteasome system (UPS). …”
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VE-cadherin cleavage by LasB protease from Pseudomonas aeruginosa facilitates type III secretion system toxicity in endothelial cells. by Guillaume Golovkine, Eric Faudry, Stéphanie Bouillot, Romé Voulhoux, Ina Attrée, Philippe Huber

“…We showed that one of the T2SS effectors, the protease LasB, directly affected VE-cadherin proteolysis, hence promoting cell-cell junction disruption. …”
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Strategies to Identify Recognition Signals and Targets of SUMOylation by Elisa Da Silva-Ferrada, Fernando Lopitz-Otsoa, Valérie Lang, Manuel S. Rodríguez, Rune Matthiesen

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Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: In vitro and in vivo studies by Samaneh Montazeri, Ali Rastegari, Zohreh Mohammadi, Mahboobeh Nazari, Maryam Yousefi, Fatemeh Yazdi Samadi, Somayeh Najafzadeh, Mehdi Aghsami

“…Abstract Epidermal growth factor (EGF) can be efficiently used in wound healing process; but the main obstacle of its clinical use is its susceptibility to proteolysis and maintaining its effective concentration in the site of action. …”
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Chemical, Microbiological, and Functional Characterization of Kefir Produced from Cow’s Milk and Soy Milk by Raúl Ricardo Gamba, Shihori Yamamoto, Mahmoud Abdel-Hamid, Tetsuya Sasaki, Toshihide Michihata, Takashi Koyanagi, Toshiki Enomoto

“…Glutamic acid was majority in both, suggesting that microbial proteolysis leads to an increase in free amino acids including glutamic acid. 108–109 CFU mL−1 LAB, 106–107 CFU mL−1 AAB, and 106–107 CFU mL−1 yeasts were counted in cow’s milk kefir, whereas soy milk kefir contained greatly lower yeasts and AAB. …”
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Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease by Mahdi Bagherpoor Helabad, Irina Matlahov, Raj Kumar, Jan O. Daldrop, Greeshma Jain, Markus Weingarth, Patrick C. A. van der Wel, Markus S. Miettinen

“…A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. …”
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Bioinformatics analysis identifies key secretory protein-encoding differentially expressed genes in adipose tissue of metabolic syndrome by Jiandong Zhou, Yunshan Guo, Xuan Liu, Weijie Yuan

“…GO analyses of these SP-DEGs included proteolysis, angiogenesis, positive regulation of endothelial cell proliferation, immune response, protein processing, positive regulation of neuroblast proliferation, cell adhesion and ER to Golgi vesicle-mediated transport. …”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“… Proteolysis Targeting Chimera (PROTACs) are a brand-new concept of therapeutics that use the ubiquitin-proteasome system for selective degradation of disease-related proteins. …”
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KAI2-dependent signaling controls vegetative reproduction in Marchantia polymorpha through activation of LOG-mediated cytokinin synthesis (14) by Aino Komatsu, Mizuki Fujibayashi, Kazato Kumagai, Hidemasa Suzuki, Yuki Hata, Yumiko Takebayashi, Mikiko Kojima, Hitoshi Sakakibara, Junko Kyozuka

“…Perception of KL by KAI2 triggers MORE AXILLARY GROWTH2 (MAX2)-dependent proteolysis of MpSUPPRESSOR of MORE AXILLALRY GROWTH2 1-LIKE (MpSMXL). …”
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Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro by Miao Liu, Wen-jie Xie, Xu Zhang, Wei Wu, Guang Li, Lu Wang

“…Methods The targets of butyric acid were identified using SwissTargetPrediction database and surface plasmon resonance (SPR). Limited proteolysis mass spectrometry (Lip-MS) was used to further investigate the binding sites of butyric acid with its targets and molecular docking was employed to simulate their binding modes. …”
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Activity trypsin-like proteinases and intestinal mucosa collagen degradation at gastro-intestinal diseases by О. E. Akbasheva, V. A. Burkovskaya, A. E. Dehand, E. I. Beloborodova, L. A. Akimova, E. L. Naumova, E. A. Kvach

“…Activity of elastase- and collagenase-like proteinases was determined, using N-butoxycarbonyl-L-alanine p-nitrophenyl ester (BANE) as substrate.Results. Activation of proteolysis in mucosa of intestine and blood plasma of patients on a background of decrease of activity of proteinase inhibitors and elevation of hydroxyproline contents was revealed. …”
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A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

“…GO enrichment and KEGG pathway analyses suggested that RNF187 may play a role in the pathogenesis of cancer through processes such as "bounding membrane of organelle," "macroautophagy," "proton-transporting V-type ATPase complex," "autophagy," "Ubiquitin mediated proteolysis," "Ferroptosis," "Phagosome," and etc. Conclusion Our inaugural pan-cancer study aims to provide a profound understanding of RNF187 in tumorigenesis across diverse types of tumors.…”
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