Effect of Dry Aging on Beef Muscle Proteins by Galina V. Gurinovich, Irina S. Patrakova, Vladislav A. Khrenov, Marina V. Patshina, Antonina I. Shevchenko

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Micellar Casein in Rennin Coagulation, Cheese Dehydration, and Ripening by Elena I. Melnikova, Ekaterina V. Bogdanova, Elena S. Rudnichenko, Mariya S. Chekmareva

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Elucidation of potential relationship between endogenous proteases and key flavor substances in dry-cured pork coppa by Mingming Li, Qiujin Zhu, Chao Qu, Xiaohui Gong, Yunhan Zhang, Xin Zhang, Shouwei Wang

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Non-enzymatic protein targeting agents as a promising strategy for cancer treatment by Madison Ambrose, Jeremy Lee, Aleem Syed, Zamal Ahmed, Guang Peng

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Role of calpain system in meat tenderness: A review by Z.F. Bhat, James D. Morton, Susan L. Mason, Alaa El-Din A. Bekhit

“…Keywords: Aging, Tenderness, Calpains, Proteolysis, Calpain activity, Factors…”
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Identification of Allergenic Tropomyosins with Known and Unknown Sequences in Seafood Products by Marta Godlewska, Piotr Minkiewicz, Małgorzata Darewicz, Anna Iwaniak

“…Several peptides likely to be released during proteolysis can be found in many sequences of proteins from this family. …”
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A Cellular Potts model simulating cell migration on and in matrix environments by Marco Scianna, Luigi Preziosi, Katarina Wolf

“…Our modelprovides a strong correlation of the directionality of migrationwith the topological extracellular matrix distribution and abiphasic dependence of migration on the matrix structure, density,adhesion, and stiffness, and, moreover, simulates that celllocomotion in highly constrained fibrillar obstacles requires thedeformation of the cell's nucleus and/or the activity ofcell-derived proteolysis. In conclusion, we here propose amathematical modeling approach that serves to characterize cellmigration as a biological phenomenon in healthy and diseased tissuesand in engineering applications.…”
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming by Bharathi Suresh, Junwon Lee, Kye-Seong Kim, Suresh Ramakrishna

“…There are two switches: an E3 ubiquitin ligase enzyme that tags ubiquitin molecules to the target proteins for proteolysis and a second enzyme, the deubiquitinating enzyme (DUBs), that performs the opposite action, thereby preventing proteolysis. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…Evolutionary analysis shows the TRMT1 cleavage site is highly conserved in mammals, except in Muroidea, where TRMT1 is likely resistant to cleavage. TRMT1 proteolysis results in reduced tRNA binding and elimination of tRNA methyltransferase activity. …”
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Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action by Humberto Nicastro, Claudia Ribeiro da Luz, Daniela Fojo Seixas Chaves, Luiz Roberto Grassmann Bechara, Vanessa Azevedo Voltarelli, Marcelo Macedo Rogero, Antonio Herbert Lancha

“…The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. …”
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The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Classically, elevated levels of TIMPs are suggested to result in ECM accumulation leading to fibrosis, whereas loss of TIMP responses leads to enhanced matrix proteolysis. Here, we outline the known roles of the most abundant TIMP, TIMP2, in pulmonary diseases but also discuss future perspectives in TIMP2 research that could impact the lungs. …”
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PROTAC technology for prostate cancer treatment by Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka, Wenyi Wei

“…This review explores key biomarkers for PrCa and the latest therapeutic strategies for CRPC with a particular focus on the innovative proteolysis-targeting chimera (PROTAC) technology. This approach offers a novel means of degrading target proteins and we discuss how PROTAC holds potential as effective strategies to combat resistance mechanisms in CRPC.…”
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N-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation... by Nina Germitsch, Tobias Kockmann, Manuela Schnyder, Lucienne Tritten

“…These and further identified cleavage sites suggest direct or indirect activation or proteolysis of complement and coagulation components through A. vasorum ESP, which contains several proteases. …”
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PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers by Nobendu Mukerjee, Dattatreya Mukherjee

“…The increasing incidence of Human Papillomavirus (HPV)-related head and neck cancers, particularly oropharyngeal squamous cell carcinomas, highlights the need for advanced therapeutic options beyond the traditional modalities of surgery, radiation, and chemotherapy, which often lead to significant morbidity and lack specificity in targeting the molecular pathogenesis of the disease. Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. …”
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Single-Molecule Analysis of Alkaline Phosphatase by Douglas B. Craig

“…For alkaline phosphatase, the structural differences have been suggested to be differences in glycosylation, differences due to partial proteolysis, and due to some molecules containing mixtures of active and inactive subunits. …”
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Molecular glue degrader for tumor treatment by Yuhan Hu, Yan Yan, Jiehao Wang, Jiangxue Hou, Quande Lin

“…Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras (PROTAC) is the frontier field in the research and development of antitumor therapy, in which oral drug HP518 Receives FDA Proceed Authorization for its IND Application for Prostate Cancer Treatment. …”
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Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localization by Jasmeet Shergill, Domenico Azarnia Tehran

“…During synaptosomes purification, presynaptic terminals reseal and are protected from proteolysis, while postsynaptic proteins remain susceptible to tryptic cleavage. …”
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Functional Live-Cell Imaging Demonstrates that β-Integrin Promotes Type IV Collagen Degradation by Breast and Prostate Cancer Cells by Mansoureh Sameni, Julie Dosescu, Kenneth M. Yamada, Bonnie F. Sloane, Dora Cavallo-Medved

“…This is the first study to demonstrate through functional live-cell imaging that downregulation of β 1 -integrin expression and function reduces proteolysis of collagen IV by breast and prostate cancer cells.…”
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THE pH TRENDS OF BEEF MEAT DURING TWO AGING PROCESSES by Maria-Cristina Gliga (Colciar), Adriana Paula David, Giorgiana Mihaela Catunescu, Ioana Maria Bodea, Manuel León Camacho, Maria Tofana

“…Thus, the BA breed exhibited a greater decrease in pH compared to RS, which could indicate an advanced proteolysis of proteins.…”
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The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology by Marta Stolarczyk, Bob J. Scholte

“…In airway epithelial cells, ADAM17 sheds multiple soluble signaling proteins by proteolysis, including EGFR ligands such as amphiregulin (AREG), and proinflammatory mediators such as the interleukin 6 coreceptor (IL-6R). …”
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