The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies by Randall J. Brezski, David M. Knight, Robert E. Jordan

“…Numerous investigators have provided information on the isotype profiles of the HAH autoantibodies, as well as correlations among protease cleavage patterns and HAH autoantibody reactivity. …”
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Functional Live-Cell Imaging Demonstrates that β-Integrin Promotes Type IV Collagen Degradation by Breast and Prostate Cancer Cells by Mansoureh Sameni, Julie Dosescu, Kenneth M. Yamada, Bonnie F. Sloane, Dora Cavallo-Medved

“…Decreased extracellular matrix degradation also was associated with changes in the constituents of proteolytic pathways: decreases in secretion of the cysteine protease cathepsin B, the matrix metalloproteinase (MMP)-13, and tissue inhibitors of metalloproteinases (TIMP)-1 and 2; a decrease in expression of MMP-14 or membrane type 1 MMP; and an increase in secretion of TIMP-3. …”
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Preservation techniques and their effect on nutritional values and microbial population of brewer’s spent grain: a review by Geberemariyam Terefe

“…Therefore, these problems can be solved by utilizing various preservation methods, including drying (solar, freeze, and oven drying), freezing, ensiling (both alone and in combination with other animal feeds), and additives (Silo-King GPX preservatives, xylanase, carbohydrase (econase) and protease (alcalase), urea and lime, sodium formate, calcium propionate, formic and propionic acids, acetic acid, NaCl, NaOH, HCl, and H2SO4).…”
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Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings by Kevin Peterson, Sabelle Jallow, Sarah L. Rowland-Jones, Thushan I. de Silva

“…Nucleoside analogues alone are not sufficiently potent enough to achieve durable virologic control. Some protease inhibitors, in particular those without ritonavir boosting, are not sufficiently effective against HIV-2. …”
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Evaluation of food digestibility in Nile tilapia fish Oreochromis niloticus given NSP enzymes and organic chromiium by Amelia Oktaviani, Muhammad Agus Suprayudi, Mia Setiawati, Ichsan Achmad Fauzi

“…The results showed that the treatments E1C1 and E0C2 resulted in better total digestibility, energy digestibility, and protein digestibility compared to the control and other treatments. Lipase, protease, and amylase enzymes in tilapia fed with the E1C1 treatment showed significantly higher results (P<0.05) compared to the control. …”
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Analysis of HIV therapy in the liver using optimal control and pharmacokinetics by Hasifa Nampala, Matylda Jabłońska-Sabuka, Martin Singull

“…The optimal controls are presented as therapy efficacy of reverse transcriptase inhibitors (RTIs), integrase inhibitors (INs) and protease inhibitors (PIs). An objective function is defined with an aim to investigate the optimal control strategy that minimises toxicity, viral load and cost of first-line and second-line HIV regimen. …”
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Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation by Aini Vuorinen, Cassandra R. Kennedy, Katherine A. McPhie, William McCarthy, Jonathan Pettinger, J. Mark Skehel, David House, Jacob T. Bush, Katrin Rittinger

“…Abstract Deubiquitinating enzymes (DUBs) are key regulators of cellular homoeostasis, and their dysregulation is associated with several human diseases. The ovarian tumour protease (OTU) family of DUBs are biochemically well-characterised and of therapeutic interest, yet only a few tool compounds exist to study their cellular function and therapeutic potential. …”
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The Immune Response Is Involved in Atherosclerotic Plaque Calcification: Could the RANKL/RANK/OPG System Be a Marker of Plaque Instability? by Fabrizio Montecucco, Sabine Steffens, François Mach

“…These cells play a crucial role in all phases of atherosclerotic plaque formation and complication through cytokine, protease, and prothrombotic factor secretion. The accumulation of inflammatory cells and thus high amounts of soluble mediators are responsible for the evolution of some plaques to instable phenotype which may lead to rupture. …”
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Structure characterization and mechanism of angiotensin I-converting enzyme (ACE) inhibitory peptides modified by plastein reaction derived from tiger nut (Cyperus esculentus) by Junhua Shi, Zhuo Yang, Ming Xu, Guogang Zhao, Yawen Gao, Hongyan Zheng, Ji Feng

“…ACE inhibitory peptide (CLPP, the ACE inhibitory rate is 76.52 ± 1.07%) was obtained by hydrolysis of tiger nut (Cyperus esculentus) protein with alkaline protease. The plastein product (PCLPP, the ACE inhibitory rate is 85 ± 2.33%) was prepared by modifying CLPP with a plastein reaction. …”
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A Review: Application of Bromelain Enzymes in Animal Food Products by Ririn Fatma Nanda, Rini Bahar, Daimon Syukri, Nguyen Ngoc Anh Thu, Anwar Kasim

“…This review focuses on the use of bromelain in various applications in animal products with the latest literature so that it can provide information on what parts of this enzyme can be applied. Bromelain is a protease enzyme found in stems (EC 3.4.22.32), leaves, crowns, fruit skins, fruit flesh (EC 3.4.22.33) and fruit tubers in pineapple. …”
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Improvement of the nutritional value and growth of rotifer (Brachionus plicatilis) by different enrichment period with Bacillus sp. by Sutia Budi, . Zainuddin, Siti Aslamsyah

“…Bacillus sp. is capable of improving the nutrition rotifers to produce vitamins, food detoxication or through enzymatic activity such as protease, lipase, and amylase. This research aimed at observing the influence of the enrichment length of Bacillus sp. on the quality of nutrition and growth of rotifers. …”
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A Review: Application of Bromelain Enzymes in Animal Food Products by Ririn Fatma Nanda, Rini Bahar, Daimon Syukri, Nguyen Ngoc Anh Thu, Anwar Kasim

“…This review focuses on the use of bromelain in various applications in animal products with the latest literature so that it can provide information on what parts of this enzyme can be applied. Bromelain is a protease enzyme found in stems (EC 3.4.22.32), leaves, crowns, fruit skins, fruit flesh (EC 3.4.22.33) and fruit tubers in pineapple. …”
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The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology by Marta Stolarczyk, Bob J. Scholte

“…The ubiquitous transmembrane protease A disintegrin and metalloprotease 17 (ADAM17) forms a functional unit with the EGF receptor (EGFR), in a feedback loop interaction labeled the ADAM17/EGFR axis. …”
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Protective effects of tilapia (Oreochromis niloticus) skin gelatin hydrolysates on osteoporosis rats induced by retinoic acid by Bingtong Liu, Liping Sun, Yongliang Zhuang

“…Tilapia skin gelatin hydrolysates (TSGH) were obtained by complex protease hydrolysis. The amino acid sequences of 50 peptides in TSGH were identified, and most of these peptides were found to contain the -Gly-Pro-sequence. …”
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Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia by Emeline Masse, Philippe Hantson

“…In addition to laboratory changes consistent with disseminated intravascular coagulation, there was also evidence for a low activity of the von Willebrand factor (VWF) cleaving protease ADAMTS13. Later complications included repeated candidemia and bacteraemia despite appropriate therapy; the origin appeared to be diffuse ischemic injury of the gastrointestinal tract. …”
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Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity by Sara Benedé, Leticia Pérez-Rodríguez, David Menchén-Martínez, Elena Molina, Rosina López-Fandiño

“…Additionally, we examined a proteolytically inactivated form of HDM (iHDM) to assess the contribution of HDM protease activity to its adjuvant potential.ResultsBoth HDM and iHDM enhanced allergic responses to EW proteins via the oral route, evidenced by mast cell degranulation in the intestinal tract upon EW challenge. …”
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Iron- Refractory Iron Deficiency Anemia: Review Article by Eman Ahmed Abd -Elmawgood, Mohammed H. Hassan, Dina Hussein Mobark, Nagwan Ibrahim Rashwan

“…This transmembrane serine protease suppresses hepcidin production, an iron regulator (suppressing intestinal absorption of iron). …”
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The Impact of COVID-19 on Gametes and Endometrium: A Narrative Review by Esra Karatas, Ali Can Gunes, Bilal Esat Temiz, Sezcan Mumusoglu, Gurkan Bozdag

“…Whereas the available data suggest that SARS-CoV-2 interferes with various types of molecular pathways in the oocyte, spermatozoa, and endometrium, the lack of co-expression in angiotensin-converting enzyme 2 and transmembrane protease serine 2 in those cell lines theoretically avoid concerns by patients and reproductive endocrinologists. …”
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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. …”
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Xylanase-Producing Microbes and Their Real-World Application by Milan Phuyal, Uttam Budhathoki, Durga Bista, Shailendra Shakya, Rajan Shrestha, Ashwinee Kumar Shrestha

“…The major hemicellulose, Xylan is digested with the help of combination other enzymes such as alpha-amylase, subtilisin, protease, and endo-1,3(4)-β-glucanase along with xylanase. …”
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