New particle formation dynamics in the central Andes: contrasting urban and mountaintop environments by D. Aliaga, V. A. Sinclair, R. Krejci, R. Krejci, M. Andrade, M. Andrade, P. Artaxo, L. Blacutt, R. Cai, R. Cai, S. Carbone, Y. Gramlich, L. Heikkinen, L. Heikkinen, L. Heikkinen, D. Heslin-Rees, D. Heslin-Rees, W. Huang, W. Huang, V.-M. Kerminen, A. M. Koenig, A. M. Koenig, M. Kulmala, M. Kulmala, M. Kulmala, P. Laj, P. Laj, V. Mardoñez-Balderrama, V. Mardoñez-Balderrama, C. Mohr, C. Mohr, C. Mohr, I. Moreno, P. Paasonen, W. Scholz, K. Sellegri, L. Ticona, G. Uzu, F. Velarde, A. Wiedensohler, D. Worsnop, D. Worsnop, C. Wu, C. Wu, C. Wu, C. Xuemeng, Q. Zha, F. Bianchi

“…CHC at dawn is in an air mass representative of the regional residual layer with minimal local surface influence due to the barren landscape. As the day progresses, upslope winds bring in air masses affected by surface emissions from lower altitudes, which may include anthropogenic or biogenic sources. …”
Get full text

FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy by Liang Zhao, Long Sun, Kaili Fu, Qin Lin, Xiaoyuan Chen, Qicong Luo, Hua Wu, Jianhao Chen, Yangfan Zhou, Yizhen Pang, Guoqiang Su, Haojun Chen

“…Further mechanistic studies have shown that 177Lu-DOTA-2P(FAPI)2 combined with αPD-L1 mAb can reprogram the TME, enhancing antitumor intercellular communication, which activates antitumor-related intercellular contacts such as FasL-Fas interactions between T cells and NK cells with tumor cells and increasing the proportion of infiltrating CD8+ T-cells while reducing regulatory T cells and inhibiting tumor progression. Our research also demonstrates that mature neutrophils play a role in enhancing the efficacy of the combined therapy, as shown in neutrophil-blocking experiments.Conclusions Our study robustly advocates for use of FAP-targeting radiopharmaceuticals, particularly 177Lu-DOTA-2P(FAPI)2, alongside immunotherapy in treating FAP-positive tumors. …”
Get full text

The prognosis and metabolite changes of NSCLC patients receiving first‐line immunotherapy combined chemotherapy in different M1c categories according to 9th edition of TNM classifi... by Liang Zheng, Fang Hu, Wei Nie, Jun Lu, Bo Zhang, Jianlin Xu, Shuyuan Wang, Ying Li, Xiaoxuan Zheng, Wei Zhang, Yinchen Shen, Runbo Zhong, Tianqing Chu, Baohui Han, Hua Zhong, Xueyan Zhang

“…The relationship between metastatic patterns and progression‐free survival (PFS) in patients undergoing combination therapy was analyzed using univariate and multivariate Cox regression models. …”
Get full text

Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis by Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang

“…The degree of GAL8 DNA methylation is related to the progression of atherosclerosis, and its hypomethylation can aggravate atherosclerotic lesions. …”
Get full text

Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

“…Compared with the model group, the high- and low-dose groups of Dracocephalum moldavica L. extract alleviated the progression of pulmonary fibrosis, reduced inflammatory cell infiltration, and attenuated collagen fibre deposition in rats, with a decrease in the protein expression and transcription levels of Col-I and α-SMA (P<0.01), the expression levels of p-PI3K and p-AKT (P<0.001), and the levels of inflammatory factors IL-6 and TNF-α (P<0.05, P<0.001). …”
Get full text

Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…Background and purpose: Abnormal DNA methylation is closely associated with the onset and progression of tumors. This study aimed to investigate the expression of intermediate filament family orphan 1 (IFFO1), a methylation-driven gene (MDG) in pancreatic adenocarcinoma (PAAD), along with its effects on the invasion and metastasis of PAAD cells, as well as its potential as a diagnostic and prognostic biomarker. …”
Get full text

Personalized approach in the management of women with heart failure with preserved ejection fraction and carbohydrate metabolism disorders by L.R. Petrovska, I.O. Kostitska, T.R. Petrovskyy, R.V. Petrovskyy

“…Background. The progression of heart failure (HF) in individuals with carbohydrate metabolism disorders is one of the many fatal complications among comorbid conditions. …”
Get full text

Combined Age with Mean Decrease Rates of Total Bilirubin and MELD Score as a Novel and Simple Clinical Predictor on 90-Day Transplant-Free Mortality in Adult Patients with Acute Li... by Di Jin, Kai Kang, Bing-zhu Yan, Jian-nan Zhang, Jun-bo Zheng, Zhi-hui Wang, Di Wu, Yu-jia Tang, Xin-tong Wang, Qi-qi Lai, Yang Cao, Hong-liang Wang, Yang Gao

“…Acute liver failure (ALF), previously known as fulminant hepatic failure, has become a common, rapidly progressive, and life-threatening catastrophic hepatic disease in intensive care unit (ICU) due to the continuous increase in drug abuse, viral infection, metabolic insult, and auto-immune cause. …”
Get full text

Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…The paper of Christoph Lumer (University of Siena, Italy) establishes a new criterion for our moral duties, dubbed ‘progressive norm welfarism’, and deduces a principle of ‘no harm to developing countries’ from it. …”
Get full text

Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis by Chuanxin Liu, Xiaobin Huang, Jiao Kong, Xuejiao Li, Yuming Wang, Fangfang Zhang, Jiajia Duan

“…This approach transforms fragmented toxicity indicators into systematic evidence of toxicity, presenting a hierarchical progression of toxicity evidence and avoiding data accumulation in natural drug toxicology. …”
Get full text

Analysis of the current situation and risk factors of frailty in elderly patients with type 2 diabetes (老年2型糖尿病患者衰弱现状及影响因素分析) by LI Li (李莉), YING Yanping (应燕萍)

“…Screening elderly patients with type 2 diabetes for early signs of frailty and addressing risk factors through specific interventions can help slow down the progression of frailty. (目的 调查老年2型糖尿病患者的衰弱现状, 分析潜在影响因素, 以期为相关干预研究提供参考依据。…”
Get full text

Potential Antidepressant Effects of Omeprazole Introduced Through Network Analysis and Systems Biology Should Be Interpreted with Caution in the Clinical Environment by Seyed-Ali Mostafavi

“…Hence, the hypothetical identification of medications like Omeprazole to treat MDD is indeed a progression; however, it is important to take a more careful analysis of such results and findings, and translate such findings into clinics when it is possible. …”
Get full text

Neurotoxicity of aluminium chloride and okadaic acid in zebrafish: Unravelling Alzheimer's disease model via learning and memory function evaluation by S.Z. Raduan, Q.U. Ahmed, M.R.A. Rusmili, A.S.M. Sabere, M.S. Haris, M.F. Shaikh, W.A.W. Sulaiman, M.H. Mahmood

“…Introduction/objectives: Alzheimer's disease (AD) is characterised by a progressive decline in cognitive abilities, especially learning and memory. …”
Get full text

Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Here, we present Non-lethal Sonodynamic Therapy (NL-SDT), in which ultrasound is used to activate locally sonosensitizers, thereby stimulating the production of reactive oxygen species for the purpose of modulating cell function or fate, as a novel methodology to inhibit progression of hypertensive renal fibrosis. To confirm whether NL-SDT can reduce hypertensive renal fibrosis and its mechanism. …”
Get full text

Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…No significant differences between basic and control groups at analysis of paired liver biopsies for fibrosis stage reduction rate, absence of negative changes for fibrosis severity and proportion of patients with fibrosis progression were found. Pegaltevir® and PegIntron® treatment groups were comparable safety profile, adverse events were expected, mainly of mild and moderate severity. …”
Get full text

The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…None of the included studies reported whether renal or cardiovascular disease progression events occurred. Compared with angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) alone, the combination with GBE was more beneficial in improving urinary albumin excretion rate (UAER) [mean difference (MD) = -22.99 μg/min, 95% confidence interval (CI): −27.66 to −18.31, p &lt; 0.01], serum creatinine (SCr) [MD = −8.30 μmol/L, 95% CI: −11.55 to −5.05, p &lt; 0.01], blood urea nitrogen (BUN) [MD = −0.77 mmol/L, 95% CI: −1.04 to −0.49, p &lt; 0.01], 24-hour urinary total protein (24hUTP) [MD = −0.28 g/d, 95% CI: −0.35 to −0.22, p &lt; 0.01], cystatin C (Cys-C) [MD = −0.30 mg/L, 95% CI: −0.43 to −0.17, p &lt; 0.01], total cholesterol (TC) [MD = −0.69 mmol/L, 95% CI: −1.01 to −0.38, p &lt; 0.01], triglyceride (TG) [MD = −0.40 mmol/L, 95% CI: −0.56 to −0.23, p &lt; 0.01], low-density lipoprotein cholesterol (LDL-C) [MD = −0.97 mmol/L, 95% CI: −1.28 to −0.65, p &lt; 0.01], fasting blood glucose (FBG) [MD = −0.30 mmol/L, 95% CI: −0.54 to −0.05, p = 0.02], hematocrit [MD = −4.58%, 95% CI: −5.25 to −3.90, p &lt; 0.01] and fibrinogen [MD = −0.80 g/L, 95% CI: −1.12 to −0.47, p &lt; 0.01]. …”
Get full text

Intersemiotic Translation: From Medieval Poetry to Modern Movie by Leila Nik Nasab

“…The key story elements examined in this movie are as follows:Plot (narrative structure)Character and characterizationStory progressionSetting (time and place)Symbols and signsDialogueThemes and motifsThe story of Sheikh San'an, who fell in love, is one of the beautiful mystical stories, and Sheikh Farid al-Din Attar elegantly narrates it in verse in his Conference of the Birds.Most of the elements of the Sheikh San'an story can be found in The Forbidden Fruit. …”
Get full text

Acute Care Practice in the United States: The Roles of Occupational Therapy and Physical Therapy in Early Rehabilitation by Suzanne E. Holm, Kelly Nelson, Angela Patterson

“…In PT, the emphasis is on promoting and progressing patients'mobility and movement to increase performance and to enhance function, well-being, overall health and quality of life. …”
Get full text

A survey of knowledge about health education and self-management behavior in 118 patients with early diabetic nephropathy (118例早期糖尿病肾病患者健康教育知识水平及自我管理行为现状调查)... by CHEN Furong (陈芙蓉), ZHOU Jianping (周建平), MAO Dandan (毛丹旦), BO Jing (薄静), ZHUANG Ji (庄姬)

“…In addition, the poor self-management behavior among patients with early diabetic nephropathy may indicate poor diabetes self-management as a negative influencing factor of progression of early diabetic nephropathy. (目的 探讨早期糖尿病肾病患者健康教育知识水平及自我管理行为现状, 为制定针对性的健康教育及护理方案提供依据。…”
Get full text

« Just got to keep going » by Jean-Paul Rocchi

“…Miss Jane est prisonnière d’une gangue spatio-temporelle qui, contre la progression même du roman, semble-t-il, la ramène sur ses pas et vers ce statut d’esclave qu’elle voudrait croire obsolète. …”
Get full text