Evolución del paciente hospitalizado con gripe durante 2016–2020 según su estado vacunal by Jacobo Martín Ramos, Francisco Javier Cuevas Fernández, Álvaro Torres Lana, Armando Aguirre Jaime

“…Using multivariable binary logistic regression, the risk of progression to severity associated with influenza vaccination status was estimated. …”
Get full text

New Sources and Old Methods. Reconstructing and Applying the Music-Theoretical Paratext of Johann Sebastian Bach’s Compositional Pedagogy by Derek Remeš

“…In contrast to many modern harmonic perspectives, chordal roots and root progressions played little to no role in the pre-Rameau thoroughbass tradition. …”
Get full text

Evaluation of Learners’ Satisfaction with Open Flexible and Distance Learning Services at the University of Lagos Distance Learning Institute by Adenike Oladipo, Esther O. Oladele, Oladipupo Ajeyalemi, Folashade Afolabi, Peter O. Olayiwola, Johnson A. Adewara, Andrew Akala, Uchenna Udeani

“…Les résultats de cette étude ont révélé que la DLI a moins de marge de progression pour satisfaire les apprenants aux stades de la préinscription, du processus et du produit, avec des réponses moyennes de 7,27, 5,63 et 6,87 respectivement. …”
Get full text

Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…The primary endpoints were safety, tolerability and efficacy including objective response rate (ORR), disease control rate (DCR), duration of response (DoR), progression-free survival (PFS) assessed by RECIST v1.1 and overall survival (OS). …”
Get full text

Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort st... by Kai Guo, Qi Wang, Lin Zhang, Rui Qiao, Yujia Huo, Lipeng Jing, Xiaowan Wang, Zixuan Song, Siyu Li, Jinming Zhang, Yanfang Yang, Jinli Mahe, Zhengran Liu

“…Participants with persistently second-lowest to the highest TyG-BMI changes (β = 0.15, 0.38 and 0.76 respectively) and those experiencing the third to fourth cumulative TyG-BMI (β = 0.25 and 0.56, respectively) demonstrated accelerated FI progression. A U-shaped association was observed between TyG-BMI levels and both rapid FI trajectory and higher frail risk, with BMI being the primary factor. …”
Get full text

Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain by M. Llaneza, G. Fontes, L. Benedito-Palos, E. Moral

“…Introduction: Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood. …”
Get full text

Barriers and Facilitators to Adherence to a Healthy Diet Across the Spectrum of Chronic Kidney Disease by Trigueros-Flores XB, Luna-Hernández G, Santos-Lopez MF, Pérez-Galván L, Flores-Camacho KJ, Díaz-Canchola LM, Cueto-Manzano AM, Chávez-Chávez HE, Cerrillos-Gutiérrez JI, Rojas-Campos E, Martín-del-Campo F

“…A healthy diet has been associated with lower progression of kidney disease and helps to prevent complications; however, adherence to nutritional recommendations is frequently low. …”
Get full text

Evaluation of Learners’ Satisfaction with Open Flexible and Distance Learning Services at the University of Lagos Distance Learning Institute by Adenike Oladipo, Esther O. Oladele, Oladipupo Ajeyalemi, Folashade Afolabi, Peter O. Olayiwola, Johnson A. Adewara, Andrew Akala, Uchenna Udeani

“…Les résultats de cette étude ont révélé que la DLI a moins de marge de progression pour satisfaire les apprenants aux stades de la préinscription, du processus et du produit, avec des réponses moyennes de 7,27, 5,63 et 6,87 respectivement. …”
Get full text

An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Kaplan-Meier curves demonstrated that patients with low INPP4B expression had significantly better progression-free survival (PFS) than those with high expression (HR=2.874, 95% CI: 1.262-6.544, P=0.013). …”
Get full text

Serum biomarkers in the metabolic dysfunction-associated steatotic liver fibrosis diagnosis in children by Yu.M. Stepanov, N.Yu. Zavhorodnia, I.A. Klenina, O.M. Tatarchuk, O.P. Petishko

“…One of the unresolved problems associated with MASLD is the identification of individuals at risk of rapid disease progression and development of irreversible liver changes. …”
Get full text

IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…Management algorithms for glaucoma which consider disease progression include three major principles, i.e., IOP lowering to achieve target IOP, maintenance and improvement of ocular blood flow, and neural retinal protection. …”
Get full text

Multiplex immunohistochemistry to explore the tumor immune microenvironment in HCC patients with different GPC3 expression by Mingzhen Zhou, Ziyan Zhou, Lina Hu, Sidong Chen, Fanyan Meng, Jun Chen, Jie Shen

“…This methodology provides valuable insights into the complex interactions and spatial organization of immune cells in the context of hepatocellular carcinoma progression. Low GPC3 expression in HCC patients indicates potential benefits from combined targeted and immunotherapy. …”
Get full text

Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

“…Summary: Background: Prior studies suggest prevalence of heart failure (HF) has remained steady or progressively decreased over past 30 years in the general population. …”
Get full text

Association of depression in multiple sclerosis with fatigue, sleep disturbances, disability, and health-related quality of life: Outcomes of a cross-sectional study by E. Aparicio-Castro, A. Candeliere-Merlicco, C.M. Santa, R. Villaverde-González

“…It can worsen the symptoms of MS, influence disability progression, and significantly reduce the quality of life (QoL). …”
Get full text

Features of expression of immunohistochemical markers in local and generalized clear cell kidney cancer by E. M. Frantsiyants, A. N. Shevchenko, E. A. Dzhenkova, N. S. Karnaukhov, T. A. Gudtskova, A. A. Breus, E. V. Filatova, D. A. Shvyrev

“…One of the main markers of extracellular matrix degradation MMP‑9 was approximately at the same level at both stages: at local‑50±6% and 49.6±7.2% at generalized, the difference in indicators is not reliable (P<0.05).Conclusion. Progression of clear cell kidney cancer from local to generalized forms is accompanied by hyperexpression of cyclin D1, a decreased e‑cadherin expression while increasing vimentin expression (increasing signs of epithelial-mesenchymal transformation), an increase in CD44 and VEGF expression.…”
Get full text

The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis by Xue Gu, Bingfeng Chen, Shengcan Zhang, Xinyu Zhai, Ying Hu, Hui Ye

“…CCL17 high-expression was significantly positively associated with age and advanced N classification, suggesting that CCL17 could accelerate tumor progression by promoting the lymph node metastasis. …”
Get full text

Le Proyecto Mono Tocon : recherche, éducation et conservation, au Pérou by Audrey Gaultier, Rosario Huashuayo‑Llamocca, Antonio Boveda‑Penalba, Jan Vermeer

“…Les conséquences de cela sont bien sûr la disparition progressive de nombreuses espèces endémiques, mais également la destruction ou pollution des sources d’eau présentes dans les forêts et l’appauvrissement des communautés humaines. …”
Get full text

Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…Increased lifespan was accompanied by a slowdown in tumor progression, as evidenced by a reduction in the growth of hepatoma and pancreatic cancer tumors under treatment with GAS strains in mice. …”
Get full text

A simple staging system using biomarkers for wild‐type transthyretin amyloid cardiomyopathy in Japan by Naoya Nakashima, Seiji Takashio, Mami Morioka, Masato Nishi, Toshihiro Yamada, Kyoko Hirakawa, Masanobu Ishii, Noriaki Tabata, Kenshi Yamanaga, Koichiro Fujisue, Daisuke Sueta, Hisanori Kanazawa, Tadashi Hoshiyama, Shinsuke Hanatani, Satoshi Araki, Hiroki Usuku, Eiichiro Yamamoto, Mitsuharu Ueda, Kenichi Matsushita, Kenichi Tsujita

“…This system can objectively evaluate the disease progression of ATTRwt‐CM and may be useful for patient selection for disease‐modifying therapy.…”
Get full text

Sex differences in the peripheral levels of cytokines during 12-month antipsychotic treatment in a drug-naïve schizophrenia spectrum cohort by I. Ratke, A. Torsvik, C.A. Bartz-Johannessen, F. Fathian, I. Joa, S.M. Klæbo Reitan, E.M. Løberg, M. Rettenbacher, S. Skrede, V.M. Steen, E. Johnsen, R.A. Kroken

“…There were significant sex differences in progression of cytokine levels at weeks 3 (IL-6: p = 0.046), 6 (IL-4: p = 0.022, IL-6: p = 0.015), 12 (IL-6: p = 0.01), 26 (IL-4: p < 0.001, IL-6: p = 0.015, TNF-α: p = 0.026), 39 (IL-4: p = 0.003, TNF-α: p = 0.023) and 52 (IL-4: p < 0.001, TNF-α: p = 0.009). …”
Get full text