Pharmacotherapy for AMD: state-of-the-art by I.A. Koroleva, A.A. Gvetadze, T.B. Romanova

“…Agents which prevent neovascularization by inhibiting vascular endothelial growth factor (VEGF) are currently used to manage this rapidly progressing type of AMD. It was demonstrated that VEGF inhibiting prevents the development of choroidal neovascular membrane, reduces the sizes of pre-existing membrane, and decreases vascular leakage from new vessels. …”
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Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Abstract Background Osteoarthritis (OA), characterized by progressive degeneration of cartilage and reactive proliferation of subchondral bone, stands as a prevalent condition in orthopedic clinics. …”
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Concurrent versus sequential immunotherapy with chemoradiotherapy for unresectable stage III non-small-cell lung cancer: a retrospective study by Zhou Meng-Xi, Fan Wen-Jie, Zhang Ning, Zhu Li-Yang, Wang Hong-Yan

“…Patients were grouped based on concurrent or sequential administration of ICIs with chemoradiotherapy. Median progression-free survival (mPFS), median overall survival (mOS), 1 and 2-year PFS rates, 2 and 3-year OS rates, objective remission rate (ORR), and disease control rate (DCR) were evaluated. …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…BackgroundIdiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease of unknown etiology, remains incurable with current therapies, which fail to halt disease progression or restore lung function. However, Feibi Recipe No. 2 (FBR2), a clinically validated traditional Chinese medicine formula, exhibits potential as an IPF treatment.ObjectiveThis study aimed to investigate the regulatory effect of FBR2 on ferroptosis through the SIRT3/p53 pathway and its therapeutic potential in improving IPF.MethodsPulmonary fibrosis was induced in C57BL/6J mice by intratracheal instillation of Bleomycin (BLM), followed by FBR2 treatment via gavage. …”
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« Pas de retour à nos maisons sans satisfaction de nos revendications ». Le Hirak du Rif en actes face au Makhzen by Ahmed Chapi

“…Our main argument is that while the movement's activists employed initially (and above all) the most routine tactics of protest (such as demonstrations whose times and locations were publicly announced in advance), they progressively innovated tactically (through, for example, surprise demonstrations known as "chen-ten" and pot-banging protests), moved to new protest sites (such as the various districts of Al Hoceima and the beaches) and encouraged the involvement of heterogeneous protest profiles (many of whom are young and/or have a distant connection to the activist universe) ; these processes fostered the movement's continuity and gave it a disruptive character. …”
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Risk of Dysglycemia in Pregnancy amongst Kenyan Women with HIV Infection: A Nested Case-Control Analysis from the STRiDE Study by Sonak D. Pastakia, Wycliffe K. Kosgei, Astrid Christoffersen-Deb, Benson Kiragu, John N. Hector, Gertrude Anusu, Ponnusamy Saravanan

“…With the growing awareness of the role HIV plays in the progression of noncommunicable diseases and the disproportionate HIV burden African countries like Kenya face, investigating the potential role HIV plays in increasing dysglycemia amongst pregnant women with HIV is an important area of study. …”
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Gut Microbiome and Metabolite Characteristics Associated With Different Clinical Stages in Non-Small Cell Lung Cancer Patients by Liu F, Lu X, Tang M, Chen Y, Zheng X

“…Fan Liu,1 Xingbing Lu,2 Mengli Tang,2 Yuzuo Chen,2 Xi Zheng3,4 1Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Xi Zheng, Lung Cancer Center, Department of Thoracic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu, Sichuan Province, People’s Republic of China, Tel +86-28-86298113, Email zhengxi@scu.edu.cnObjective: Our research has pinpointed the gut microbiome’s role in the progression of various pathological types of non-small cell lung cancer (NSCLC). …”
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Gene prediction of immune cells association between gut microbiota and colorectal cancer: a Mendelian randomization study by Yan Zhong, Guanglei Chen, Menglu Chen, Junsong Cui, Qianren Tan, Zhenghua Xiao

“…BackgroundAn increasing number of studies have revealed that gut microbiota influences the development and progression of Colorectal cancer (CRC). However, whether a causal relationship exists between the two remains unclear, and the role of immune cells in this context is not well understood.ObjectiveTo elucidate the causal relationship between gut microbiota and CRC and to explore the potential mediating role of circulating immune cells.Materials and methodsTo analyze the causal relationship between gut microbiota and CRC, we employed a univariable Mendelian randomization (UVMR) approach. …”
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Social and Humanitarian Factor in South Korea's External Relations and The Korean Question by O. S. Pugacheva

“…Conservative administrations put an emphasis on information pressure on the DPRK while the development of inter-Korean relations was conditioned by the denuclearization of North Korea. Progressive administrations prefer engaging the DPRK in social, humanitarian and economic interactions. …”
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CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…Other more common causes of pancreatitis were ruled out during the progression of this patient, and an elevated lipase with high CMV viral load points towards CMV pancreatitis. …”
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Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter by Huiwen Yan, Dongdong Zhou, Dongdong Zhou, Xiaoli Liu, Peng Wang, Tingting Jiang, Zhiyun Yang

“…Portal hypertension, the most common outcome of cirrhosis progression, has a high incidence. Platelet count/spleen diameter ratio (PSL) with a cut-off value of 909 can predict the presence of esophagogastric varices and thus portal hypertension, which is also an independent risk factor for early recurrence and late recurrence of hepatocellular carcinoma after resection. …”
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Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…Primary congenital glaucoma (PСG) is a visual organ pathology that leads to progressive blindness and poor vision in children. Its main cause is an anomaly of the anterior chamber angle. …”
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Clinical and molecular characteristics and long-term outcomes of pediatric intracranial meningiomas: a comprehensive analysis from a single neurosurgical center by Leihao Ren, Jiaojiao Deng, Hiroaki Wakimoto, Qing Xie, Ye Gong, Lingyang Hua

“…Targeted next generation sequencing was used to detect alterations in meningioma relevant genes. Progression-free survival (PFS) was compared between PMs and adult meningiomas (AMs). …”
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Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…Activated T cells, particularly from the Jurkat cell line, significantly inhibited NSCLC progression, reducing both proliferation and invasion capabilities of A549 and H1299 lung cancer cell lines. …”
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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…Abstract Background Postoperative cognitive dysfunction (POCD) represents a post-surgical complication that features progressive cognitive impairment and memory loss, often occurring in elderly patients. …”
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Anthelmintic Resistance in Sheep Across Ireland and the UK: a literature review of the in vivo versus in vitro methods by Megan Tumulty

“…Conclusion: The extensive use of anthelmintics on sheep production systems has led to the rapid progression of anthelmintic resistance across Ireland and the UK, particularly to the broad-spectrum anthelmintics. …”
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Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study by Rafael Scaf de Molon, Rogier M. Thurlings, Birgitte Walgreen, Monique M. Helsen, Peter M. van der Kraan, Joni Augusto Cirelli, Marije I. Koenders

“…Specialized proresolving mediators (SPRM), which arise from n-3 long-chain polyunsaturated fatty acids (n-3FA), promote resolution of inflammation and may help to prevent progression of an acute inflammatory response into chronic inflammation in patients with arthritis. …”
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Dietary supplementation of Astragalus polysaccharide or its nanoparticles enhances testicular hemodynamics, echotexture, scrotal circumference, concentration of testosterone, estra... by Eman Fayez, Ali Salama, Mohamed Ahmed Ismail, Fady Sayed Youssef, Zaher Mohamed Rawash, MR Oshba, Haney Samir

“…Increases (P < 0.05) were noticed in the mass motility, progressive motility %, live sperm %, and membrane integrity % in nano APS and APS groups, compared to the control. …”
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Immunological mechanisms of tuberculosis susceptibility in TB-infected individuals with type 2 diabetes mellitus: insights from mycobacterial growth inhibition assay and cytokine a... by Bindu Dasan, Anuradha Rajamanickam, Arul Nancy Pandiarajan, Sivakumar Shanmugam, Sujatha Nott, Subash Babu

“…By demonstrating that T2DM individuals exhibit a weakened ability to control M.tb growth and a compromised cytokine profile, the research underscores the need for better diagnostic tools, such as the mycobacterial growth inhibition assay (MGIA), to identify those at greater risk of progression to active TB. The findings also highlight the importance of integrated care strategies for managing both T2DM and TB, particularly in TB-endemic regions, and point to the need for further research to develop more effective interventions tailored to this vulnerable population.…”
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S’unir au Prophète. L’expérience matérielle, esthétique et dévotionnelle du Dalā’il al-Khayrāt au Maroc. Approches codicologique et anthropologique by Hiba Abid, Anouk Cohen

“…At the same time, the material and aesthetic forms of the manuscripts of the Dalā’il were progressively adapted to frequent uses. The miniaturisation of manuscripts allows them to be recited at any moment of the day or week and in all situations. …”
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