Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…Nine of 14 patients (64%) achieved disease remission, with eight partial responses and one stringent complete response. Median progression-free survival was 6.0 months (range, 2.1 to>16.8 months). …”
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Systemic Inflammatory Markers for Predicting Overall Survival in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis by Xiaotong Song, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaocheng Yang, Jinzhu Liu, Yanshuo Han, Zhaozhou Ren

“…Inflammatory markers are associated with tumor genesis and progression, but their prognostic significance in osteosarcoma remains unclear. …”
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Comprehensive profiling of serum microRNAs in normal and non-alcoholic fatty liver disease (NAFLD) patients by Jian-Wei Zhang, Kamran Ullah, Nauman Khan, Hai-Tao Pan

“…Our study suggests that miR-122 plays a key role in the progression of NAFLD and its associated metabolic disturbances, which can increase the risk of cardiovascular disease. …”
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State of the art of glaucoma diagnosis: neural networks and artificial intelligence by A.V. Kuroyedov, G.A. Ostapenko, K.V. Mitroshina, A.B. Movsisyan

“…Movsisyan^2,4</b> </p> <p> <b>¹Mandryka Central Military Clinical Hospital, Moscow, Russian Federation</b> </p> <p> <b>²Pirogov Russian National Research Medical University, Moscow, Russian Federation</b> </p> <p> <b>³Voronezh State Technical University, Voronezh, Russian Federation</b> </p> <p> <b>⁴Hospital for Disabled Veterans No. 2, Moscow, Russian Federation</b> </p> <p> <br> </p> <p> <i>Predicting of the borderline between health and disease as well as determining of minimum characteristics of disease progression in primary open-angle glaucoma still remain high priority for ophthalmologists worldwide. …”
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Evaluation of Renal Gene Expression of Protein Kinase C (PKC) Isoforms in Diabetic and Nondiabetic Proliferative Glomerular Diseases by Salwa Ibrahim, Laila Rashed, Sawsan Fadda

“…This may represent potential therapeutic targets for prevention of progressive kidney injury in diabetic and proliferative glomerular diseases.…”
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Efficacy of small-diameter core decompression with platelet-rich plasma in early osteonecrosis of the femoral head: a retrospective study by Haiwei Tang, Yahao Lai, Enze Zhao, Kai Zhou, Gang Chen, Zongke Zhou

“…However, whether it hinders disease progression in early ONFH and reduces the conversion rate to THA and femoral head collapse remains uncertain. …”
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Change in Atrial Fibrillation Burden over Time in Patients with Nonpermanent Atrial Fibrillation by Philipp Krisai, Stefanie Aeschbacher, Matthias Bossard, Elena Herber, Steffen Blum, Pascal Meyre, Thilo Burkard, Michael Kühne, Stefan Osswald, Beat A. Kaufmann, David Conen

“…Few patients with paroxysmal or persistent AF have AF episodes on yearly 7-day Holter-ECG recordings, and AF progression is rare. AF burden was independently associated with a history of prior stroke and BNP levels.…”
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Performance evaluation of waste glass in soil improvement: Influence of particle size of waste glass on mechanical, microstructural, and durability characteristics by Harun Akoğuz

“…As a result, repeated WD cycles lead to the formation of microcracks, which progressively weaken soil aggregation and reduce the overall strength of the samples. …”
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Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/... by Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

“…PTCD1 regulated ccRCC progression via various cancer mechanisms including PI3K-Akt signaling, focal adhesion, PD-L1 expression, and PD-1 checkpoints in cancer. …”
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Growth response of <i>Emiliania huxleyi</i> to ocean alkalinity enhancement by G. Faucher, M. Haunost, A. J. Paul, A. U. C. Tietz, U. Riebesell

“…We monitored the species' growth and calcification response to progressively increasing levels of total alkalinity (TA). …”
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Impact of Timing the Combination of Radiotherapy and PD-1 Inhibitors on Outcomes in Patients with Hepatocellular Carcinoma by Zhong L, Peng W, Sun J, Luo Y, Sheng H, Wu Y, Zhou T, Zhou C, Cao C

“…Additionally, we created an experimental tumor model using 6-week-old female mice to validate our findings.Results: In the concurrent group, the median overall survival was indefinite; however, it was 13 months in the sequential group (95% confidence interval [CI] 6.7– 19.3 months, P=0.010). The median progression-free survival was significantly longer in the concurrent group (12 months, 95% CI 9.5– 14.5 months) than in the sequential group (7 months, 95% CI 1.3– 12.7 months; P=0.043). …”
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The Association between Type-2 Diabetes Duration and Major Adverse Cardiac Events after Percutaneous Coronary Intervention by Botey Katamu Benjamin, Chunguang Qiu, Zhanying Han, Wenjie Lu, Guoju Sun, Xiaofei Qin, Xule Wang, Xi Wang, Ran Li, Liang Pan

“…Repeat revascularization was significantly related to the progression of nontreated lesions (De novo lesions 20% vs. 18% and 7.3%, P=0.009) compared to previously treated lesions (target lesion revascularization (TLR) 3% vs. 1.3% and 2%, P=0.774). …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…Extract data on outcome measures such as overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs). …”
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Determinants of Anemia among HIV-Positive Children on Highly Active Antiretroviral Therapy Attending Hospitals of North Wollo Zone, Amhara Region, Ethiopia, 2019: A Case-Control St... by Biruk Beletew, Ayelign Mengesha, Mohammed Ahmed, Awet Fitwi, Mesfin Wudu

“…Anemia is one of the most commonly observed hematological abnormalities and an independent poor prognostic marker of HIV disease. The rate of progression and mortality in this subgroup of patients is high compared to nonanemic patients. …”
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Exploring the correlations between six serological inflammatory markers and different stages of type 2 diabetic retinopathy by Rongjin Deng, Suhui Zhu, Bin Fan, Xiaohu Chen, Hongbin Lv, Yan Dai

“…A close correlation was observed between the SII and PLR and the occurrence and progression of T2DR. The high accuracy of the combined diagnosis of T2DR via various serological inflammatory markers underscores their potential as early biological indicators for the diagnosis of T2DR.…”
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High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses by Mantoani PTS, Micheli DC, Jammal MP, Vieira JH, Michelin MA, Ferreira CGX, Silva HN, Murta EFC, Nomelini RS

“…Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil, Tel +55 34 3318 5326, Fax +55 34 3318 5342, Email rosekeila@terra.com.brBackground: The progression of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer is accompanied by a reduction in the immune response. …”
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Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Moreover, COL17A1 silencing in GEM-resistant PC cells or the incubation of COL17A1-decreased CAF with GEM-resistant PC cells could suppress GEM resistance and cell oncogenic phenotype progression. Mechanistically, COL17A1 interacted with ACTN4 protein, and the anticancer effects mediated by COL17A1-decreased CAFs in resistant PC cells were reversed by ACTN4 overexpression. …”
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Exploring public perceptions and awareness of Parkinson's disease: A scoping review. by Sophie Crooks, Gillian Carter, Christine Brown Wilson, Lisa Wynne, Patrick Stark, Michail Doumas, Matthew Rodger, Emma O'Shea, Gary Mitchell

“…It is characterised by both motor and non-motor symptoms including tremor, slow movement, unsteady gait, constipation and urinary incontinence. As the disease progresses, individuals living with the disease are likely to lose their independence and autonomy, subsequently affecting their quality of life. …”
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Impact of Comorbidities on Prognosis and Treatment Outcomes in Elderly Patients with Hodgkin Lymphoma by Dávid Tóthfalusi, Boglárka Dobó, Fanni Borics, László Imre Pinczés, Árpád Illés, Zsófia Miltényi

“…., hypertension, diabetes, cardiovascular diseases), to assess their impact on overall survival (OS) and progression-free survival (PFS). Diagnostic efficiency was determined via receiver operating characteristic analysis, while the survival outcomes were evaluated using the Cox proportional hazards model. …”
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Correction of Dysbiosis in Diversion Proctitis: Possibilities of Intraluminal Sanitation and the Prevention of Complications after Reconstructive Surgery by V. S. Groshilin, D. V. Martynov, Yu. L. Naboka, M. Yu. Bakulyarov, G. A. Mrykhin

“…Pronounced dysbiotic changes, the progression of catarrhal or erosive diversion colitis and proctosigmoiditis are the risk factors for anastomotic leakage and postoperative bowel dysfunction. …”
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