Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…We further investigated the impact of DBF4 on the progression of ccRCC cells. Various assays, including assessments of cell proliferation, apoptosis, the cell cycle, cell migration and invasion, and colony formation, and xenograft tumor models were subsequently performed following to the knockdown of DBF4 expression via shRNA. …”
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Medication underuse in real-life practice: the impact of galcanezumab towards achieving very low frequency episodic migraine in a southeast Asian middle-income nation by Wanakorn Rattanawong, Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Auranee Trisataya, Sekh Thanprasertsuk, Alan Rapoport

“…Abstract Background Migraine progression, particularly from episodic to chronic migraine (CM), increases disease burden and healthcare costs. …”
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The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment by Antonia Keck, Julia-Sophia Scheuermann, Petra Scheerbaum, Elmar Graessel, Kirsten R. Müller-Vahl

“…Cannabidiol (CBD) shows potential in slowing MCI progression due to its neuroprotective and anti-inflammatory properties. …”
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Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort by Colin Vendrami, Elena Gonzalez Rodriguez, Guillaume Gatineau, Peter Vollenweider, Pedro Marques-Vidal, Olivier Lamy, Didier Hans, Enisa Shevroja

“… STUDY AIMS: Sarcopenia is a progressive, age-related loss of muscle mass, strength and function. …”
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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis by Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong

“…Thymol sulfate may increases the risk of HD pathogenesis by mediating the evolution of PTK2B genetic variants inducing CD8 + NKT cells in the progression of the immune microenvironment.…”
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Optimizing risk in action: Differences between fixated aim points and movement outcomes in throwing by Stephan Zahno, Damian Beck, Ralf Kredel, André Klostermann, Ernst-Joachim Hossner

“…Analysis of movement trajectories shows that, in penalty conditions, the shifts away from the penalty zone increased progressively until the final phases of the movement. …”
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Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfu... by Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Chong Dong, Qian Sun

“…BackgroundSevere renal ischemia and reperfusion injury (IRI) progresses to renal interstitial fibrosis (RIF) with limited therapeutic strategies. …”
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Burnout in New Zealand resident doctors: a cross-sectional study of prevalence and risk factors by Denys Shay, Susanna Every-Palmer, Alex B Boyle, Tanushk Martyn, Earle Savage, Simon B M MacLean

“…Qualitative data revealed concerns about poor staffing, inadequate remuneration, a focus on service provision over education, slow career progression and difficulty balancing work and specialty examinations.Conclusions Burnout has a high prevalence in New Zealand’s resident doctor workforce. …”
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Prevalence of peripheral artery disease in young coronary artery disease patients by Medikonda Malla Reddy, N. Krishna Geetha, Kakumani Jagadeswar, I. Mariraj, K.I.S.N. Vaishnavi, Fahad Dadu, Gowri Shankar A.

“…Peripheral artery disease (PAD) and coronary artery disease (CAD) are progressive inflammatory conditions caused by arteriosclerosis, typically presenting after the age of 50. …”
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Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol by Dongying Wang, Chunhua Zhao, Li Fu, Yang Liu, Weiyang Zhang, Tianmin Xu

“…One patient died of recurrence 5 months after surgery, and the other patients’ progression-free survival (PFS) ranged from 9 to 59 months. …”
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WORLD EXPERIENCE IN ADMINISTRATIVE AND LEGAL SUPPORT OF FOOD SECURITY by Yuliya Pustovit, Olena Dragan, Alina Berher

“…Based on the research, Ukraine has a unique opportunity to improve the administrative and legal support of food security, using the foreign experience of progressive countries with a high level of the Global Food Security Index. …”
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Corneal nerve abnormalities in early-stage diabetic retinopathy evaluated by corneal confocal microscopy by Yi Zhou, Xiangchen Li, Suhan Shi, Ziwei Guo, Beibei Shan, Linlin Xu, Yixiao Li, Jianxin Guo

“…The morphological score of DCs in the NPDR group (2.6 [2.4–2.8]) was significantly higher than that in the NDR group (1.80 [1.80–2.20]) (all P < 0.001). As diabetes progresses to the stage of diabetic retinopathy, there were significant negative correlations between inferior whorl length (IWL) (rho = -0.802, P < 0.001) and average nerve fiber length ( ANFL) (rho = -0.487, P < 0.001) with the occurrence of DR. …”
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A Live Video Resiliency Dyadic Intervention for Persons With Dementia and Their Care-Partners Early After Diagnosis: Protocol for Open Pilot of Resilient Together for Dementia by Sydney McCage, Kristin Walker, Talea Cornelius, Robert A Parker, Kristen Dams-O'Connor, Brad Dickerson, Christine Ritchie, Ana-Maria Vranceanu, Sarah Bannon

“… BackgroundAlzheimer disease and related dementias (ADRDs) are increasingly common progressive conditions that have a substantial impact on individuals and their primary care partners—together described as a dyad. …”
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Comparison of Efficacy and Safety of First-Line Treatment Options for Unresectable Stage III Non-Small Cell Lung Cancer: A Retrospective Analysis by Luqing Zhao, Zhiting Zhao, Xiaoqi Yan, Fei Wu, Ning Sun, Renhong Guo, Shaorong Yu, Xiao Hu, Jifeng Feng

“…Adverse events and responses were assessed using CTCAE v5.0 and RECIST v1.1. The progression-free survival (PFS) was estimated using the Kaplan–Meier method or the Cox survival regression model and compared using the log-rank test. …”
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Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma by Juan Li, Xuyu Gu, Chanchan Gao, Jun Zhang

“…Our results also identified a lncRNA MEG3/miR-195-3p/RAB1A/TM9SF3 regulatory axis, which may also play an important role in the progression of LUAD. Further study needs to be conducted to verify this result.…”
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Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…Conclusion‍　‍Bergapten can reduce the expression of SASP factors such as IL-6, TNF-α, P16, P21, MMP9 and MMP13 in IL-1β-stimulated chondrocytes, and thus exerts its anti-inflammatory and anti-aging effects in delaying the progression of OA. …”
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PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study by He Z, Chen H, Liang C, Tang X, Jiang L, Xie F, Liu Q, Zheng Y

“…The overall response rate (ORR), progression-free survival (PFS), and overall survival (OS) were compared.Results: After PSM, 80 and 130 patients received AT-HAIC and PLEN-HAIC, respectively. …”
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Hubungan Lama Aktivitas Membaca dengan Derajat Miopia pada Mahasiswa Pendidikan Dokter FK Unand Angkatan 2010 by Mutia Maulud Fauziah, M. Hidayat, Julizar .

“…Reading time can increase risk and progression of myopia. Medical students have the risk of myopia because of long and intensive reading. …”
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The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient by A. Husdal, G. Bukholm, I. R. K. Bukholm

“…The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously evaluated in breast cancer. …”
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Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation by Yuxi Zhang, Qiao Tang, Jiahui Cui, Yanan Li, Heng Xu, Zhen Qiu, Shaoqing Lei, Rui Xue, Qian Sun, Zhongyuan Xia

“…Dysregulation of this pathway has been linked to the progression of multiple pathological conditions, making it an attractive target for therapeutic intervention. …”
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