Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

“…ABSTRACT Campylobacter is a serious health threat because of the rapid progressive evolution of antimicrobial resistance and efficient transmission from zoonotic as well as human sources. …”
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Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects by Yi-Jing Hsiao, Min-Shu Hsieh, Gee-Chen Chang, Yin-Chen Hsu, Chia-Yu Wang, Yan-Ming Chen, Yi-Ling Chen, Pan-Chyr Yang, Sung-Liang Yu

“…Stromal M1 TAMs were positively correlated with disease progression and smoking history. In contrast, islet M1/M2 TAMs were predominantly found in tumors with wild-type TP53 (wtp53) but not associated with EGFR status. …”
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MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Abstract Background Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and a high risk of progression to acute myeloid leukemia. Elucidating the mechanism underlying the dysfunction of MDS-HSCs is crucial for exploring the pathogenesis of the syndrome. …”
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Integrating Two-Tier Optimization Algorithm With Convolutional Bi-LSTM Model for Robust Anomaly Detection in Autonomous Vehicles by Moneerah Alotaibi, Manal Abdullah Alohali, Khalid Mahmood, Asma A. Alhashmi, Jehad Saad Alqurni, Sultan Refa Alotaibi, Ahmad A. Alzahrani, Imene Issaoui

“…Machine learning (ML) and deep learning (DL) based anomaly recognition has progressed as a new study track in autonomous driving. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin remodeling, in pancreatic tumors progression is becoming increasingly recognized. Moreover, in PDAC these aberrant epigenetic mechanisms can also limit therapy efficacy. …”
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A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Patients treated with RC48 MT or RC48 combined with anti-PD-1 IT from July 2021 to April 2023 were recruited for the study. The progression-free survival (PFS), overall survival (OS), objective-response rate (ORR), disease-control rate (DCR), and safety were studied. …”
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CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation by Hussain Z, Abdulrahim Abdul Moti L, Jagal J, Thu HE, Khan S, Kazi M

“…Moreover, the lowest cell viability depicted in MCF-7 (~25%), SK-BR-3 (~20%), and RAW 264.7 cells (~20%), induction of apoptosis, cell cycle arrest, enhanced cell internalization, and alleviation of MCF-7 and SK-BR-3 migration proved the superior anticancer potential of HA-PTX-TMX-CS-NPs compared to unfunctionalized NPs and other control medicines.Conclusion: HA-functionalization of NPs is a promising multiprong strategy for CD44-receptors-mediated targeting of BC cells and TAMs to mitigate the progression, metastasis, and relapse in the BC. Keywords: paclitaxel, tamoxifen, hyaluronic acid, polymeric nanoparticles, CD44-receptors, breast cancer, cell uptake, anticancer efficacy…”
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…A major challenge in managing PrCa is the early identification of aggressive cases for targeted treatment, while avoiding unnecessary interventions in slow-progressing cases. Therefore, there is a critical need for genetic biomarkers that can distinguish between aggressive and non-aggressive PrCa cases. …”
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Bank collapse-landslide failure mechanism of typical reverse rock bank slope in Three Gorges Reservoir area by Yang LI, Hailin ZHAO, Bolin HUANG, Honglin LI, Kaikai XU

“…At present, most of the reverse rock slope toppling instability failure is interpreted as a progressive overall instability failure controlled by dip angle and structural plane. …”
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Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma by Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe

“…The correlations of the EV concentration and size distribution in ascites and plasma with treatment outcome, progression-free survival (PFS) and overall survival (OS) were analysed. …”
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The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…We can conclude that our nanocomplex is a potent effector that prevents tumoral progression by activating three main immunological strategies: switching the surface expression profile of the activated macrophages into a proinflammatory M1-like phenotype, downregulating the expression of proinflammatory cytokines, and upregulating the expression level of anti-inflammatory cytokines.…”
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Conditional diffusion-generated super-resolution for myocardial perfusion MRI by Changyu Sun, Changyu Sun, Neha Goyal, Yu Wang, Darla L. Tharp, Senthil Kumar, Talissa A. Altes

“…The forward diffusion process introduces Gaussian noise incrementally, while the reverse process employs a U-Net architecture to progressively denoise the images, conditioned on the low-resolution input image.ResultsWe trained and validated the model on a retrospective dataset of dynamic contrast-enhanced (DCE) perfusion MRI, consisting of both stress and rest images from 47 patients with heart disease. …”
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Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study by Bo-Ning Cao, Cai-Yan Zhang, Zhen Wang, Yao-Xian Wang, Yao-Xian Wang

“…The bacterial microbiota involved in fatty acid oxidation is associated with diabetic kidney disease (DKD) progression, positively correlated with glycocholenate sulfate levels, and negatively correlated with the phosphate linoleyl-tetraenyl-glycerol (18:2 to 20:4) ratio. …”
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Comparison of radiation esophagitis associated with daytime versus evening radiotherapy in patients with esophageal carcinoma by Yun Xing, Yutian Yin, Liang Yu, Cong Zhang, Guangjin Chai, Bo Lyu, Bin Wang, Lina Zhao, Geng Xiang

“…There was no difference in the overall survival (OS), locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and progression-free survival (PFS) (all p > 0.05) between the daytime treatment group and evening treatment group. …”
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Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis by Leonie Ruths, Jana Hengge, Graciosa Q. Teixeira, Melanie Haffner-Luntzer, Anita Ignatius, Jana Riegger

“…Overall, targeting TCC formation could be a future approach to attenuate OA progression.…”
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Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Rand... by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…This suggests that nonguided ICBT may be effective in preventing SI and SD from progressing to the full threshold. However, appropriate definitions of subthreshold symptoms are necessary. …”
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Virtual Reality Interventions for Older Adults With Mild Cognitive Impairment: Systematic Review and Meta-Analysis of Randomized Controlled Trials by Qin Yang, Liuxin Zhang, Fangyuan Chang, Hongyi Yang, Bin Chen, Zhao Liu

“… BackgroundAlzheimer disease is incurable, but it is possible to intervene and slow down the progression of dementia during periods of mild cognitive impairment (MCI) through virtual reality (VR) technology. …”
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Optic nerve sheath diameter in chronic myeloproliferative disorders by E.M. Yunusova, T.R. Mukhamadeev, B.A. Bakirov

“…For patients with chronic MPD, it is recommended to have more detailed follow-up to prevent vision loss and life-threatening complications in the central nervous system due to disease progression, in particular, those with an increase in ONSD. …”
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Exploring practical experience with different treatments in NSCLC patients with MET-deregulated: a retrospective analysis from the real world by Mengmeng Li, Jiuyan Huang, Ruyue Xing, Xinyang Du, Chunhua Wei, Huijuan Wang

“…Results Among METex14 skipping mutations patients (n = 57), median progression free survival (PFS) was: Chemotherapy 7.64 m, Crizotinib 8.5 m, Savolitinib 9.3 m, and Immunotherapy 3.87 m. …”
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The Prognostic Value of CRP/Alb Ratio in Predicting Overall Survival for Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Combined with Molecular-Targeted... by Huang X, Peng G, Kong Y, Cao X, Zhou X

“…Prognostic factors for progression-free survival (PFS) and overall survival (OS) were identified using univariate and multivariate Cox regression analyses. …”
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