Mechanical Ventilator-Associated Pneumonia in the COVID-19 Pandemic Era: A Critical Challenge in the Intensive Care Units by Mircea Stoian, Adina Andone, Sergiu Rareș Bândilă, Danusia Onișor, Sergiu Ștefan Laszlo, Gabriela Lupu, Alina Danielescu, Dragoș-Florin Baba, Anca Meda Văsieșiu, Andrei Manea, Adina Stoian

“…This study compares patients with VAP in COVID-19 and non-COVID-19 groups, examining the clinical progression, duration of ventilation and hospitalization, mortality, pathogen distribution, and the emergence of multidrug-resistant strains. …”
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The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer by Vesna Ćeriman Krstić, Dragana Jovanović, Natalija Samardžić, Milija Gajić, Jelena Kotur Stevuljević, Aleksandra Klisic, Ivan Soldatović, Damir Radončić, Marina Roksandić Milenković, Biljana Šeha, Nikola Čolić, Katarina Lukić, Milan Savić

“…Results: We found that progression-free survival (PFS) was 18 months, 95% CI (11.1–24.9), for patients with low sPD-L1 and 25 months, 95% CI (8.3–41.7), for patients with high sPD-L1. …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Overall, the median progression-free survival was 5.3 months in the trilaciclib and 4.9 months in the placebo group. …”
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Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer by Xiao Xiao, Fangyi Long, Shaolan Yu, Wengjuan Wu, Dayan Nie, Xiaoyan Ren, Wen Li, Xujuan Wang, Ling Yu, Pinghan Wang, Gang Wang

“…Moreover, COL1A1 expression showed a significant correlation with immune cell infiltration and the expression of immune-related genes within the TME.Further analyses revealed that COL1A1 and its co-expressed genes were primarily enriched in key signaling pathways involved in OC invasion, metastasis, and angiogenesis, indicating its potential role in driving OC progression.ConclusionsOur study found that upregulation of COL1A1 expression is significantly associated with lymph node metastasis of OC and can affect the immune microenvironment. …”
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Identification of Differentially Expressed Genes in Metastatic and Non-Metastatic Nasopharyngeal Carcinoma Cells by Suppression Subtractive Hybridization by Xu-Yu Yang, Cai-Ping Ren, Lei Wang, Hui Li, Chun-Jie Jiang, Hong-Bo Zhang, Ming Zhao, Kai-Tai Yao

“…Flotillin-2, fli-1, pim-3 and ezrin have previously been reported to be associated with tumor metastasis and progression. The remaining up-regulated genes identified in this study have not been reported to be markers of metastasis and may represent new candidates of NPC metastasis-related genes. …”
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CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation by Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He

“…Conclusions CircHipk3 serves a dual role in augmenting macrophage pyroptosis by interaction with Stat3, increase the NLRP3 level, and by binding Snd1 to promote Ptbp1 mRNA degradation to inhibit autophagy, thereby inducing aneurysm formation and progression. Key points CircHipk3 is significantly upregulated in abdominal aortic aneurysms (AAA) compared to normal arteries, contributing to macrophage pyroptosis. …”
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Single-cell transcriptomics reveals the heterogeneity and function of mast cells in human ccRCC by Xiyu Song, Xiyu Song, Xiyu Song, Jianhua Jiao, Jianhua Jiao, Jiayang Qin, Wei Zhang, Weijun Qin, Weijun Qin, Shuaijun Ma, Shuaijun Ma

“…Although the proportion of activated MCs was not significantly altered in ccRCC tissues compared with normal tissues, this finding highlights a shift in the MC phenotype from CTSGhighMCs to more activated VEGFA+MCs, providing a potential therapeutic target for inhibiting ccRCC progression.…”
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Exploring Dance as a Therapeutic Approach for Parkinson Disease Through the Social Robotics for Active and Healthy Ageing (SI-Robotics): Results From a Technical Feasibility Study by Roberta Bevilacqua, Elvira Maranesi, Marco Benadduci, Gabriella Cortellessa, Alessandro Umbrico, Francesca Fracasso, Giovanni Melone, Arianna Margaritini, Angela La Forgia, Pierpaolo Di Bitonto, Ada Potenza, Laura Fiorini, Carlo La Viola, Filippo Cavallo, Alessandro Leone, Andrea Caroppo, Gabriele Rescio, Mauro Marzorati, Amedeo Cesta, Giuseppe Pelliccioni, Giovanni Renato Riccardi, Lorena Rossi

“… Abstract BackgroundParkinson disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms. …”
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Time without PSA recurrence after radical prostatectomy as a predictor of future biochemical recurrence, metastatic disease and prostate cancer death: a prospective Scandinavian co... by Mats Steinholtz Ahlberg, Hans-Olov Adami, Hans Garmo, Lars Holmberg, Anna Bill-Axelson, Ove Andren, Gunnar Steineck, Jan-Erik Johansson

“…Objective Although surveillance after radical prostatectomy routinely includes repeated prostate specific antigen (PSA)-testing for many years, biochemical recurrence often occurs without further clinical progression. We therefore hypothesised that follow-up can be shortened for many patients without increasing the risk of prostate cancer death. …”
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Ovarian Reserve: A Critical Indicator of Female Reproductive Health by Julia Ufnal, Anna Wolff, Maria Morawska, Dominika Lewandowska, Dominika Rosińska-Lewandoska, Marcelina Szewczyk, Klaudia Kożuchowska, Dawid Pilarz, Kinga Jarosz, Szymon Gruszka

“…The finite pool of oocytes established in utero declines progressively throughout life, which is a natural process but may result in diminished ovarian reserve (DOR) in some women. …”
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A Green Approach to Landfill Remediation: The Efficacy of Indigenous Zygophyllum coccineum L. and Leptadenia pyrotechnica L. in Phytoremediating a Heavy Oil Flay Ash-contaminated L... by Samir G.M. Al-Solaimani, Abdulrahman Alkurashi, Refaat A. Abohassan, Omer H.M. Ibrahim, Magdi A.A. Mousa

“…The results showed that vegetation within the landfill exhibited the lowest overall fresh and dry biomass values of aerial and root parts. However, growth progressively improved with the increasing distance, with maximum growth reached at 1000 m from the landfill. …”
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The efficacy and safety of induction chemotherapy combined with sintilimab followed by concurrent chemoradiotherapy plus sintilimab sequencing maintaining with sintilimab for patie... by Ruifeng Wang, Tianhui Guo, Qi Wang, Wen Gao, Yimiao Yu, Jun Zhang, Wenqian Fu, Haiji Wang, Biyuan Zhang

“…The primary endpoints included progression-free survival (PFS) and PFS rates at 6, 12, and 18 months. …”
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Interplay between physical activity volume and intensity with modeled life expectancy in women and men: A prospective cohort analysis by Francesco Zaccardi, Alex V. Rowlands, Paddy C. Dempsey, Cameron Razieh, Joe Henson, Jonathan Goldney, Benjamin D. Maylor, Atanu Bhattacharjee, Yogini Chudasama, Charlotte Edwardson, Jari A. Laukkanen, Ulf Ekelund, Melanie J. Davies, Kamlesh Khunti, Thomas Yates

“…At 60 years, life expectancy was progressively longer for higher physical activity volume and intensity profiles, reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity, corresponding to 3.4 additional years (95% confidence interval (95%CI): 2.4–4.4) in women and 4.6 additional years (95%CI: 3.6–5.6) in men compared to those at the 10th centiles. …”
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Early Effects of Bronchoscopic Cryotherapy in Metastatic Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Single-Center Prospective Study by Gediminas Vasiliauskas, Evelina Žemaitė, Erika Skrodenienė, Lina Poškienė, Gertrūda Maziliauskienė, Aurimas Mačionis, Skaidrius Miliauskas, Donatas Vajauskas, Marius Žemaitis

“…<b>Conclusions:</b> Our study demonstrated that combined bronchoscopic cryotherapy and immunotherapy with or without chemotherapy may reduce the rate of progressive disease in metastatic non-small cell lung cancer patients while maintaining a satisfactory safety profile.…”
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Evolution characteristics of overburden structure in inclined fully mechanized caving under residual coal pillars of the upper layer by LIU Yong, WANG Hongwei, WU Xuesong, TIAN Chengpeng, GUAN Rongfu, NIE Yunxiao, FAN Zhiwei, CAO Peipei

“…The roof structure within the disturbed zone evolved progressively into a composite structure of "low-level inverted step cantilever beams and high-level large masonry beams". …”
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Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis by Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang

“…These changes in the levels of intact N-glycopeptides are associated with various aspects of SSc, including diffuse SSc (dSSc), interstitial lung disease (ILD), disease progression, cardiovascular involvement and C-reactive protein in the peripheral blood. …”
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Biotechnological Effects of <i>Lactobacillus plantarum</i>, Cellulase, and Xylanase on Nutritional Quality and Microbial Community Structure of Corn Stover Silage by Jianliang Liu, Mingjian Liu, Panjie Sheng, Chaoran Song, Weiqin Ma, Baochao Bai, Jiayu Zhao, Shuai Du, Gentu Ge, Zhijun Wang, Yushan Jia

“…The findings revealed that the nutritional quality of corn stover silage improved progressively with fermentation time. Compared to the control group, the addition of <i>Lactobacillus plantarum</i>, cellulase, and xylanase significantly increased the abundance of lactic acid bacteria, reduced the pH value, and effectively suppressed the proliferation of spoilage microorganisms. …”
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Does Sex Matter in Obesity-Induced Periodontal Inflammation in the SS^LepR Mutant Rats? by Abdulmohsin Alhashim, Kim Capehart, Jocelyn Tang, Karim M. Saad, Rafik Abdelsayed, Marion A. Cooley, Jan M. Williams, Ahmed A. Elmarakby

“…Obesity has been shown to exacerbate the progression of periodontal disease. Studies suggest a sex difference in periodontitis, whereby males are more sensitive to periodontal inflammation compared to females. …”
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Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre... by Julia Katharina Schleifenbaum, Janis Morgenthaler, Shachi Jenny Sharma, Jens Peter Klußmann, Philipp Linde, Simone Wegen, Johannes Rosenbrock, Christian Baues, Emmanouil Fokas, Richard Khor, Sweet Ping Ng, Simone Marnitz, Maike Trommer

“…Overall survival (OS), progression-free survival (PFS) and toxicities according to Common Terminology Criteria for Adverse Events (CTCAE) v5.0 were assessed. …”
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Prevalence of Diabetes, Prediabetes, and Associated Factors in an Adult Chinese Population: Baseline of a Prediabetes Cohort Study by Xinjie Yu, Fang Duan, Da Lin, Hai Li, Jian Zhang, Qiuyu Wang, Xianglong Wang, Qian Zhao, Jiayu Deng, Guangwei Song, Qingqing Ji, Haihua Zheng, Xiang Chen, Guoyi Zhou

“…To report baseline information of a prediabetes mellitus (PDM) cohort with the aim of exploring related factors for the progression of PDM and its complications. Methods. This study is an exploratory and cross-sectional analysis of the baseline data from a cohort study. …”
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