Hiperoxaluria secundaria: causas y consecuencias de la enfermedad renal crónica by Loreto Mariscal de Gante, Laura Salanova, Mariel Valdivia Mazeyra, Rosario Serrano Pardo, Borja Quiroga

“…At present, we do not have specific treatments for secondary hyperoxaluria, so early diagnosis and measures aimed at preventing the progression of kidney failure are currently the main therapeutic tools.…”
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Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock by Julia Garcia Mancebo, Kristen Sack, Padraic Romfh, Yifeng Peng, John Kheir

“…In two rat models of hemorrhagic shock, we quantified (1) The correlation of RRS-measured ShbO2 to SvO2 during progressive hemorrhage (n=20) and (2) The value of these metrics to predict near-term mortality in fixed, severe hemorrhage (mean blood pressure =25 mm Hg; n=18).Results In model 1, eShbO2 (r=0.705, p<0.0001) and tShbO2 (r=0.724, p<0.0001) correlated well with SvO2 and with serum lactic acid (eShbO2-lactate r=0.708, p<0.0001; tShbO2-lactate r=0.830, p<0.0001). hShbO2 correlated poorly with both SvO2 and lactic acid. …”
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ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization by Zeyu Guan, Xiaogao Wang, Chao Xu, Ran Lu

“…Further analysis revealed that ALKBH5 can alleviate the progression of lower extremity atherosclerosis and promote the polarization of M2 macrophages. …”
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Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

“…Patients with thyroid dysfunction had longer overall survival, progression-free survival, and distant metastasis-free survival at both one and two years compared to patients with normal thyroid function, but the difference was not statistically significant (p > 0.05). …”
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Efficacy and safety of nivolumab plus ipilimumab in gastrointestinal cancers: a systematic review and meta-analysis by Bowen Dai, Jiaping Jiang, Xiaoyu Yu, Haihua Zhan, Zhengchuan Hu

“…We extracted data from 10 randomized controlled trials and utilized a random effects model to assess the objective response rate (ORR), median progression-free survival (mPFS), median overall survival (mOS), median duration of response (mDOR), and treatment-related adverse events (TRAEs). …”
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Lipid analysis of tear fluid as a diagnostic tool for meibomian gland dysfunction by L.R. Takhauova, A.A. Guseva, A.A. Krylova, O.I. Krivosheina

“…</p> <p> Lipid mapping analyzes the lipid composition of biological samples, such as tear fluid, to study the mechanisms of the development and progression of various ocular surface diseases, including dry eye syndrome, MGD, and recurrent blepharoconjunctivitis. …”
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Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation by Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y

“…TNF-α-stimulated HaCaT keratinocytes were used for in vitro analyses, including apoptosis, cell cycle progression, and inflammatory gene expression via RT-qPCR. …”
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Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…Abstract Prostate cancer presents a major health issue, with its progression influenced by intricate molecular factors. …”
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Mixed Comparative Evaluation of a Training Program Dedicated to Cystic Fibrosis Reference Centers: Protocol for the Pilot Implementation of Shared Decision-Making in the Treatment... by Nora Moumjid, Constance Gotte, Sophie Hommey, Stéphanie Poupon Bourdy, Julie Haesebaert, Isabelle Durieu, Quitterie Reynaud

“… BackgroundDiabetes affects half of the patients with cystic fibrosis who are aged 30 years and older. Diabetes progresses asymptomatically over a long period of time. …”
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Assessment of root resorption on lateral incisors after primary canine extraction treating mesioangular displaced permanent canines: a randomised controlled trial by Narmin Helal, Reem Naaman, Najlaa Alamoudi, Azza El-Housseiny, Fatima Jadu

“…Severe resorption was observed more frequently in cases involving palatally displaced canines within both groups, but it did not reach statistical significance.ConclusionsLateral incisor root resorption (RR) progressed significantly within a 12-month period irrespective of treatment modality. …”
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Reflexive Methods of Knowledge in Educational Activities: Phenomenological Hermeneutics by T. N. Korneenko

“…Today, lifelong learning and self-education individual skills are of paramount importance for each representative of the society in relation to the world trends of a post-industrial era: economic domination in the innovative sector, progressive increase of intensity of information flows and rates of distribution of high technologies, rapid development of science and industry of knowledge, quickly changing and becoming tougher requirements to professionalism, qualification and creativity of experts irrespective of the sphere of employment. …”
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Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis by Na Aru, Congyu Yang, Yuntian Chen, Jiaming Liu

“…The findings of our meta-analysis demonstrated a significant link between low SMI and progression-free survival [P = 0.002; HR: 1.62, 95% CI: 1.20–2.17]. …”
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The Mediating Role of Cognitive Reappraisal on Bedtime Procrastination and Sleep Quality in Higher Educational Context: A Three-Wave Longitudinal Study by Zhang Y, Rehman S, Addas A, Ahmad M, Khan A

“…Grounded in the Self-Regulation Model of Behavior and the Transactional Model of Stress and Coping, this study examines the mediating role of cognitive reappraisal in the relationship between bedtime procrastination and sleep quality over time.Methods: Employing a longitudinal design, the study examined the progression of bedtime procrastination, cognitive reappraisal, and sleep quality among university students at three distinct time points throughout an academic semester. …”
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Comprehensive characterization of tobacco-induced changes in enamel surface topography by Tamanna Kaur, Ramya Ramadoss, Nitya Krishnasamy, Sandhya Sundar, Suganya Panneer Selvam, Hema Shree K

“…Results: AFM analysis revealed a clear progression of enamel surface roughness from Grade 0 to Grade 3. …”
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…In contrast to the heterogeneity observed from our neuropsychological data-driven approach, diagnostic classifications for this same sample based solely on clinical judgment indicated that 82% of individuals were amnestic-predominant, 9% were non-amnestic, 4% met criteria for Posterior Cortical Atrophy, and 5% met criteria for Primary Progressive Aphasia. Conclusion A neuropsychological data-driven method to phenotype EOAD individuals uncovered a more detailed understanding of the presenting heterogeneity in this atypical AD sample compared to clinical judgment alone. …”
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Construction and validation of prognosis and treatment outcome models based on plasma membrane tension characteristics in bladder cancer by Zhipeng Wang, Sheng Li, Fuchun Zheng, Situ Xiong, Lei Zhang, Liangwei Wan, Chen Wang, Xiaoqiang Liu, Jun Deng

“…Background Plasma membrane tension-related genes (MTRGs) are known to play a crucial role in tumor progression by influencing cell migration and adhesion. …”
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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosisResearch in context by Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong, Ruize Yu, Rong Jiang, Haotian Dai, Jingyuan Zhang, Xiaohua Gu, Yongle Xu, Chunwei Li, Shan Shan, Feng Xu, Yue Hong, Tao Ren

“…This study aimed to elucidate the characteristics of small airway epithelial dysfunction in patients with IPF and explore novel therapeutic interventions to impede IPF progression by targeting the dysfunctional small airways. …”
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Prognostic and clinicopathological role of soluble programmed cell death ligand-1 in patients with diffuse large B-cell lymphoma: a meta-analysis by Hongbin Lu, Lulu Luo, Jie Mi, Min Sun, Huaping Wang, Zheng Wang, Wenwen Ding

“…The value of sPD-L1 in predicting the overall survival (OS) and progression-free survival (PFS) of patients with DLBCL was analyzed by computing the combined hazard ratios (HRs) and 95% confidence intervals (CIs). …”
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Anlotinib in combination with metronomic chemotherapy in HER2-negative metastatic breast cancer: an observational and retrospective study by Jiaxuan Liu, Jiayang Zhang, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Huan Wang, Jing Wang, Xiaoran Liu, Bin Shao, Qiao Li

“…The primary end point was progression free survival (PFS). Secondary end points included objective response rate (ORR), disease control rate (DCR), overall survival (OS) and safety. 48 patients with HER2 negative MBC were enrolled. 19 (39.6%) patients received NVB, 17 (35.4%) patients received CAPE and 12 (25.0%) patients received VP-16. …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

“…BackgroundMyelodysplastic neoplasms (MDS) are characterized by ineffective hematopoiesis, peripheral blood cytopenias, and an increased risk of progression to acute myeloid leukemia. One of the main treatment goals is improving quality of life (QoL), particularly for patients with lower-risk MDS (LR-MDS) who may live longer with compromised QoL. …”
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