Bone cell differentiation and mineralization in wild-type and osteogenesis imperfecta zebrafish are compromised by per- and poly-fluoroalkyl substances (PFAS) by Francesca Tonelli, Cecilia Masiero, Carla Aresi, Camilla Torriani, Simona Villani, Guido Premoli, Antonio Rossi, Antonella Forlino

“…Addressing this question represents a need for ensuring global health and wellbeing to all individuals in a world facing the progressive increase of aging and aging related diseases. …”
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β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion by Ru Zhang, Weijia Wang, Aitian Li, Huishang Wang, Xiaoyan Liu, Feifei Fan, Ying Wang, Huanyu Zhang, Jingxia Chang, Yinyin Zhang, Hongmin Wang, Lijun Miao, Bo Huang, Li Yang, Li Yang, Li Yang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang

“…Immunosuppressive tumor microenvironment was found to play a substantial role in the progression of MPE, and mainly attributed to tumor-associated macrophages (TAMs). …”
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Environmental trade-offs of meeting nutritional requirements with a lower share of animal protein for adult subpopulations by J. Aubin, F. Vieux, S. Le Féon, M. Tharrey, J.L. Peyraud, N. Darmon

“…A low-animal-protein (LAP) diet was identified for each subpopulation by progressively decreasing the share of animal protein by steps of 5% until the recommended quantity of protein and/or consumption constraints were no longer satisfied. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Periostin (POSTN), a matricellular protein within the tumor microenvironment, has been implicated in the promotion of tumor progression and treatment resistance, particularly through mechanisms such as epithelial-mesenchymal transition (EMT). …”
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Potential Modulatory Role of Phoenixin-14 in Epithelial–Mesenchymal Transition of Endometriotic 12Z Cells by Karolina Iwona Kulinska, Magdalena Wierzbicka, Anna Dera-Szymanowska, Krzysztof Szymanowski, Mirosław Andrusiewicz, Maria Wołuń-Cholewa

“…The epithelial–mesenchymal transition (EMT) is critical to endometriosis progression, where cells lose epithelial traits and gain invasiveness. …”
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The Association Between Neutrophil‐Percentage‐to‐Albumin Ratio (NPAR) and Mortality Among Individuals With Cancer: Insights From National Health and Nutrition Examination Survey... by Xinyang Li, Meng Wu, Minxin Chen, Rufei Liu, Qingxu Tao, Yun Hu, Jinming Yu, Dawei Chen

“…ABSTRACT Background Neutrophils interact with tumor cells, potentially exacerbating cancer progression. Additionally, decreased albumin levels are a marker of poor cancer prognosis. …”
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Toxicological Effects of Commonly Used Mosquito Coil Smoke on Liver and Lung Function in Rats by Hadiza Abubakar, Yahuza Gimba Muhammed, Alhassan Muhammad Wudil, Dayyabu Shehu, Murtala Yaú

“…Additionally, microscopic analysis of lung tissue indicated the presence of histopathological lesions in the exposed rats, suggesting a detrimental impact of mosquito coil smoke exposure in a time-dependent progression.…”
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Evaluation of the merit of ethanolic extract of Annona reticulata as an anti-cancer agent in human colon cancer cell lines (HCT-116) [version 2; peer review: 2 approved, 1 not appr... by Sri Pragnya Cheruku, Krishnananda Prabhu, Akshatha G Nayak, Vijetha Shenoy Belle, Vanishree Rao, Pooja Prakash Rao, Nitesh Kumar

“…The bioinformatics analysis of these phytochemicals showed a high potential to affect the levels of key proteins driving colon cancer progression, inhibiting the enzymes and proteins overexpressed in cancer. …”
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Hepatic arterial infusion chemotherapy combined with systemic therapy sequentially or simultaneously for advanced hepatocellular carcinoma by Yu-zhe Cao, Jia-yu Pan, Guang-lei Zheng, Chao An, Meng-Xuan Zuo

“…We used the Kaplan–Meier method and a log-rank test to compare the overall survival (OS) and progression-free survival (PFS) rates between the SI and SE groups. …”
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Association between systemic immune-inflammation index and the risk of all-cause, cancer and non-cancer mortality in the general population: results from national health and nutrit... by Siyu Wu, Zhao Liu, Xing Li, Shan Gao, Peng Xia

“…Summary Background Inflammation plays an important role in the progression of cancer and other diseases, such as diabetes and cardiovascular and cerebrovascular diseases. …”
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A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights by Junxi Hu, Junxi Hu, Shuyu Tian, Shuyu Tian, Qingwen Liu, Qingwen Liu, Jiaqi Hou, Jiaqi Hou, Jun wu, Jun wu, Xiaolin Wang, Xiaolin Wang, Yusheng Shu, Yusheng Shu

“…BackgroundGlutathione (GSH) metabolism supports tumor redox balance and drug resistance, while long non-coding RNAs (lncRNAs) influence lung adenocarcinoma (LUAD) progression. This study developed a prognostic model using GSH-related lncRNAs to predict LUAD outcomes and assess tumor immunity.MethodsThis study analyzed survival data from The Cancer Genome Atlas (TCGA) and identified GSH metabolism-related lncRNAs using Pearson correlation. …”
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Lenvatinib and tislelizumab versus atezolizumab and bevacizumab in combination with TAE-HAIC for unresectable hepatocellular carcinoma with high tumor burden: a multicenter retrosp... by Hongjie Cai, Song Chen, Shuangyan Tang, Yi Xiao, Feng Shi, Zhiqiang Wu, Ping Ma, Huanwei Chen, Wenquan Zhuang, Wenbo Guo

“…Secondary endpoints included progression-free survival (PFS), tumor response, and adverse events (AEs). …”
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The carcinoid that doesn't select – the role of preoperative echocardiography in carcinoid heart disease by Emese Papp, Mónika Dénes, Anita Zádori, Katalin Takó, Miklós Tóth, Judit Tőke, Jenő Szolnoky, Réka Rácz, Péter Andréka

“…Conclusion: CHD is a progressive condition predominantly associated with severe TR and PR. …”
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The effect of calf muscular vein thrombosis on the prognosis within one year postoperatively of geriatric hip fracture patients: a propensity score-matched analysis by Jiabao Jiang, Fei Xing, Rong Luo, Zhao Chen, Hao Liu, Zhou Xiang, Xin Duan

“…However, patients with CMVT had longer hospital stays, a higher incidence of postoperative complications, and a higher incidence of thrombosis progression than patients without CMVT in the follow-up. …”
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The effects of Lepidium meyenii on MSG-induced subfertility in male Wistar rats: Targeting oxidative stress, pro-inflammatory cytokines, steroidogenic enzymes, and reproductive hor... by Temidayo S. Omolaoye, Surendra Singh Rawat, Naglaa Gamil Shehab, Eslam El Nebrisi, Stefan S. Du Plessis

“…Results: MSG administration significantly reduced total and progressive sperm motility (p < 0.05), decreased total antioxidant capacity (TAC) (p < 0.001), increased mRNA expression of TNF-α, IL-6, IL-1β in the testis and prostate (p < 0.05), protein expression of GP130 in the testis, reduced serum testosterone, and altered expression of steroidogenic markers. …”
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Safety and tumour-specific immunological responses of combined dendritic cell vaccination and anti-CD40 agonistic antibody treatment for patients with metastatic pancreatic cancer:... by Joachim G J V Aerts, Sjoerd H van der Burg, Martijn P Lolkema, Sai Ping Lau, Freek R van ’t Land, Marjolein Y V Homs, Casper H J van Eijck

“…This study will determine the safety of DC/anti-CD40 agonistic antibody combination treatment, and treatment-induced tumour-specific immunological responses.Methods and analysis In this open-label, single-centre (Erasmus Univsersity Medical Center, Rotterdam, Netherlands), single-arm, phase I dose finding study, adult patients with metastatic pancreatic cancer with progressive disease after FOLFIRINOX chemotherapy will receive monocyte-derived DCs loaded with an allogeneic tumour lysate in conjunction with a CD40 agonistic antibody. …”
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CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors by Yi Sun, Eduardo Davila, YuJie Guo, Richard D Schulick, Elliott Yee, Yuki Fujiwara, Kaitlyn Dickinson, Zhiwei Sun, Junyi Hu, Yuwen Zhu

“…T-cell transfer and CD93 blockade synergistically improve tumor vascular maturation, as well as inhibit tumor progression. Anti-CD93 selectively promotes effector T-cell infiltration in a tumorous setting where the CD93 pathway is upregulated. …”
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Multi-scale identification of driving forces for landscape ecological risk: A case study of the basin containing three plateau lakes in Yunnan, China by Shu Wang, Quanli Xu, Junhua Yi

“…From the local perspective, the deteriorated area in the local areas experienced erosion due to high risk, progressing from southwest to northeast from 2000 to 2020. …”
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Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis by Ana Maria Vega-Letter, Cynthia García-Guerrero, Liliana Yantén-Fuentes, Carolina Pradenas, Yeimi Herrera-Luna, Eliana Lara-Barba, Felipe A. Bustamante-Barrientos, Masyelly Rojas, María Jesús Araya, Nicole Jeraldo, Constanza Aros, Francisca Troncoso, Daniela Poblete, Angela Court, Alexander Ortloff, Jose Barraza, Francesca Velarde, Carlos Farkas, Claudio Carril, Noymar Luque-Campos, Gonzalo Almarza, Maximiliano Barahona, Jose Matas, Lucas Cereceda, Rocío Lorca, Jorge Toledo, Karina Oyarce, Rolando Vernal, Andrés Caicedo, Andrea del Campo, Yessia Hidalgo, Roberto Elizondo-Vega, Farida Djouad, Maroun Khoury, Fernando E. Figueroa, Patricia Luz-Crawford

“…Finally, Mito-MSC transplantation yielded significant reductions in joint mineralization, a hallmark of OA progression, as well as improvements in OA-related histological signs, with the lower dose exhibiting better therapeutic efficacy. …”
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Poor outcome despite modern treatments: A retrospective study of 99 patients with primary and secondary plasma cell leukemia by Camille Tessier, Richard LeBlanc, Jean Roy, Sabrina Trudel, Julie Côté, Marc Lalancette, Jean‐Samuel Boudreault, Émilie Lemieux‐Blanchard, Rayan Kaedbey, Michel Pavic

“…Results We identified 99 eligible PCL patients, of whom 33 were pPCL and 66 were sPCL. The median progression‐free survival (PFS) to frontline treatment and overall survival (OS) were, respectively, 4.8 (95% CI, 0.4–9.2) and 18.3 months (95% CI, 0.0–39.0) for pPCL and 0.8 (95% CI, 0.5–1.1) and 1.2 months (95% CI, 0.9–1.5) for sPCL (both p < 0.001). …”
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