3-Hydroxyanthranic acid inhibits growth of oral squamous carcinoma cells through growth arrest and DNA damage inducible alpha by Guifang Gan, Xinxia Zhou, Qiaoping Zheng, Xianfu Gao, Xu Chen, Han Zhang, Jinghao Liu, Zhaopeng Shi, Fuxiang Chen

“…Results: 3-HAA was selectively down-regulated in OSCC patients and the decreasing level intensified with pathological progression. Higher expression of kynurenine 3-monooxygenase (KMO) and kynureninase (KYNU), which can increase the content of 3-HAA, was associated with poorer prognosis of OSCC patients. …”
Get full text

A new and automated risk prediction of coronary artery disease using clinical endpoints and medical imaging-derived patient-specific insights: protocol for the retrospective GeoCAD... by Louisa Jorm, Daniel Moses, Dona Adikari, Ramtin Gharleghi, Shisheng Zhang, Arcot Sowmya, Sze-Yuan Ooi, Susann Beier

“…The ‘anatomy of risk’ hypothesis recognises that adverse anatomical features of coronary arteries enhance atherogenic haemodynamics, which in turn mediate the localisation and progression of plaques. We propose a new risk prediction method predicated on CT coronary angiography (CTCA) data and state-of-the-art machine learning methods based on a better understanding of anatomical risk for CAD. …”
Get full text

LncRNA SNHG17 Contributes to Proliferation, Migration, and Poor Prognosis of Hepatocellular Carcinoma by Yue Luo, Junhao Lin, Jiakang Zhang, Zhenghui Song, Dayong Zheng, Fengsheng Chen, Xuefen Zhuang, Aimin Li, Xinhui Liu

“…Broadly, our findings illustrate that SNHG17 acts as a noncoding oncogene in HCC progression, suggesting its potential value as a novel target for HCC therapy.…”
Get full text

Acute Infusion-Related Side Effects of Amphotericin B Lipid Complex (ABLC) in Oncohematological Patients: Real-World Data from Brazilian Reference Centers by Francelise Bridi Cavassin, Marcello Mihailenko Chaves Magri, Ariela Victoria Borgmann, Isabela Dombeck Floriani, Marina Rachid Barreto, Tania Zaleski, Fabianne Altruda de Moraes Costa Carlesse, Giovanni Luís Breda, Fábio de Araújo Motta, Diego Rodrigues Falci, Ana Verena Almeida Mendes, Hugo Paz Morales, Patrícia Silva Montes, Mariane Taborda, Talita Teles Teixeira Pereira, João Luiz Baú-Carneiro, Flávio Queiroz-Telles

“…Seventy-nine (34.5%) developed some IRSE, 5.1% of which progressed in severe form to discontinuation of treatment. …”
Get full text

The age-adjusted international prognostic index 2 (A-FLIPI2) for elderly patients with follicular lymphoma by Jiesong Wang, Junlei Jia, Jingwei Yu, Jing Liu, Meng Gao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Bin Meng, Wenchen Gong, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Among the four scoring systems evaluated, A-FLIPI2 showed the highest AUC for predicting risk of death (0.793) and disease progression (0.678). And the performance of A-FLIPI2 is validated in an external validation cohort. …”
Get full text

Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…Recent research emphasizes the role of the tumor microenvironment (TME) and immune modulation in glioma progression and resistance. Despite these advances, a comprehensive bibliometric analysis of research trends in glioma chemoradiotherapy resistance over the past two decades is lacking. …”
Get full text

BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…The findings reveal that exposure to BPZ leads to a reduction in early embryo quality and hinders developmental progression. RNA sequencing analysis has identified 593 differentially expressed genes as a result of BPZ exposure, highlighting considerable changes in early embryonic gene expression. …”
Get full text

Real world experience with [99mTc]Tc-HYNIC-iPSMA SPECT prostate cancer detection: interim results from the global NOBLE registry by Pete Tually, Virginia García Quinto, Yehia Omar, Fuad Novruzov, Ryan Yudistiro, Mike Sathekge, Geoffrey Currie, Paul Galette, Neel Patel, Tracey Brown, Gabriel Bolland, Rebecca Lo Bue, David Cade

“…Patients were followed until disease progression, death, serious or intolerable adverse events, registry termination by the sponsor, patient withdrawal, or lost to follow-up. …”
Get full text

Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer by Haruka Suzuki, Kohei Hamada, Junzo Hamanishi, Akihiko Ueda, Ryusuke Murakami, Mana Taki, Rin Mizuno, Koichi Watanabe, Hanako Sato, Yuko Hosoe, Hiroaki Ito, Koji Yamanoi, Hiroyuki Yoshitomi, Nobuyuki Kakiuchi, Ken Yamaguchi, Noriomi Matsumura, Seishi Ogawa, Hideki Ueno, Masaki Mandai

“…We identified them as proximal or distal to the tumor margin and demonstrated that patients with distal TLSs (dTLSs) had significantly prolonged overall survival and progression-free survival (PFS) across multiple cohorts [hazard ratio (HR), 0.56; 95% confidence interval (CI), 0.36–0.88; p = 0.01 for overall survival; HR, 0.58; 95% CI, 0.40–0.84; p = 0.004 for PFS]. …”
Get full text

Recurrent Pneumothorax in a Critically Ill Ventilated COVID-19 Patient by Lucas Rehnberg, Robert Chambers, Selina Lam, Martin Chamberlain, Ahilanandan Dushianthan

“…Despite the insertion of ICDs, the hydropneumothorax persisted over months and initially progressed in size on serial scans needing multiple ICDs. …”
Get full text

Three-dimensional ultrasound fusion imaging in precise needle placement for thermal ablation of hepatocellular carcinoma by Jiaming Liu, Yuqing Guo, Yueting Sun, Ming Liu, Xiaoer Zhang, Ruiying Zheng, Longfei Cong, Baoxian Liu, Xiaoyan Xie, Guangliang Huang

“…The rate of adequate ablative margin, complete response (CR), local tumor progression (LTP), disease-free survival (DFS), and overall survival (OS) was evaluated.Results According to postoperative contrast-enhanced CT or MR imaging, the complete response rate was 100% (60/60), and 83% of tumors (30/36) achieved adequate ablative margin (>5 mm) three-dimensionally. …”
Get full text

A high offset stem design does not increase stem migration under full weight bearing in cementless total hip arthroplasty: a model-based RSA study by Tobias Reiner, Robert Sonntag, Jan Philippe Kretzer, Michael Clarius, Eike Jakubowitz, Stefan Weiss, Stefan Kinkel, Tilman Walker, Tobias Gotterbarm, Timo Albert Nees

“…After minimal initial subsidence (SL-PLUS Standard: up to −0.54 mm; SL-PLUS Lateral: up to −0.73 mm), no further progressive migration was observed. A significant difference in stem anteversion was noted between the groups at six months (P = 0.021) and two years (P = 0.001). …”
Get full text

Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study by Zi-Han Yin, Qiong-Nan Bao, Ya-Qin Li, Yi-Wei Liu, Zi-Qi Wang, Fang Ye, Xia He, Xin-Yue Zhang, Wan-Qi Zhong, Ke-Xin Wu, Jin Yao, Zi-Wen Chen, Ling Zhao, Fan-Rong Liang

“…Growing evidence suggest that alterations in the microbiota-gut-brain (MGB) axis contribute to the development and progression of aMCI. However, little is known about whether and how acupuncture change the MGB axis of aMCI individuals. …”
Get full text

Association of smoking with amyotrophic lateral sclerosis: A systematic review, and meta-analysis, including dose-response analysis by Kihun Kim<sup>+<sup/>, Dai Sik Ko<sup>+<sup/>, Jin-Woo Kim, Dongjun Lee, Eunjeong Son, Hyun-Woo Kim, Tae-Jin Song<sup>+<sup/>, Yun Hak Kim

“…Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting the voluntary motor nervous system. …”
Get full text

Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study by Robert Landewé, Désirée van der Heijde, Filip van den Bosch, Maxime Dougados, Anna Molto, Stefan Siebert, Juergen Braun, Yuko Kaneko, Adeline Ruyssen-Witrand, Martin Soubrier, Atsuo Taniguchi, Masato Okada, Alain Cantagrel, Shigeto Kobayashi, Jon Packham, Philippe Goupille, Rene-Marc Flipo, Alain Saraux, Philippe Gaudin, Roberto Caporali, Raj Sengupta, James Cheng-Chung Wei, Tetsuya Tomita, Fernando Pimentel-Santos, Alberto Ortiz, Gaëlle Varkas, Alejandro Martínez, Shigeyoshi Tsuji, Alejandro Alvarellos, José Maldonado-Cocco, Yoshinori Taniguchi, Fadoua Allali, Raquel Almodovar González, Elena Alonso Blanco-Morales, Maria Aparicio Espinar, Pamir Atagunduz, Pauline Bakker, Leila Benbrahim, Bahia Benchekroun, Alberto Berman, Pedro Carvalho, Gustavo Casado, Francisco Colombres, Eugenio del Miguel Mendieta, Vanesa Duarte, Cristina Fernandez Carballido, Manuel Fernandez-Prada, Pilar Font Ugalde, Dolors Grados Cánovas, Jordi Gratacós Masmitjá, Vittorio Grosso, Naomi Ichikawa, Hisashi Inoue, Taku Kawasaki, Manjari Lahiri, Hernán Maldonado-Ficco, Kazuo Matsui, Ramón Mazzuchelli Esteban, Corinne Micelli, Chisun Min, Mitsuhiro Morita, Juan Mulero Mendoza, Gisela Pendón, Dora Pereira, Hanan Rkain, Oscar Rillo, Carlos Rodriguez Lozano, Adrián Salas, Carlos Salinas-Ramos, Amelia Santosa, Caroline Spiegel, Carmen Stolwijk, Kurisu Tada, Naoho Takizawa, Chung Tei Chou, Lay-Keng Teoh, Wen-Chan Tsai, Olga Tsyplenkova, Kiana Vakil-Gilani, Rafael Valle-Oñate, Virginia Villaverde, Ai Yap, Pedro Zarco Montejo, Juan C Barreira, Juan D Diaz-Garcia, Michel De Bandt, Astrid van Tubergen, Rodolfo Pérez-Alamino, T Marhadour, Christian Waimann, Mari CruzFernandez Espartero, Jose Raul NogueraPons, José A PereiradaSilva

“…Diagnostic delay showed a progressive decrease during the last decades, patients with disease onset after 2010 showed a shorter delay in diagnosis than those with disease onset during 2000–2010 (m 2.00 vs 0.41 years, p&lt;0.01). …”
Get full text

Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk by Xiaoye Liu, Kaiyang Liu, Jie Yang, Hui Qiao, Lai-Yu Kwok, Wenyi Zhang

“…We used Probio-M9 as the sole inoculant for milk fermentation, collecting samples at 1.5- to 3-h intervals to monitor fermentation progression. Moreover, the metabolomics changes of the fermented milk were investigated after a 28-d storage period to evaluate post-storage stability. …”
Get full text

Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease by Yue Xu, Yue Xu, Durong Chen, Meiqi Dong, Yun Zhang, Yun Zhang, Hongmei Yu, Hongmei Yu, Hongmei Yu, Yanqing Han, Yanqing Han, Yanqing Han

“…ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database were included in this study, and depression, cognitive function, and ADL were measured using the Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment Scale (MoCA), and Unified Parkinson’s Disease Rating Scale, Part II (UPDRS II) respectively. …”
Get full text

Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint by Yan Wang, Xiaoye Jin, Rui Qiu, Bo Ma, Sheng Zhang, Xuyang Song, Jinxi He

“…Application to TCGA data successfully predicted clinical outcomes, including a significant association with 6-month progression-free survival (PFS, P = 0.007, AUC = 0.793).DiscussionThe model demonstrates strong performance across preclinical datasets, showing its potential for real-world application in personalized cancer therapy. …”
Get full text

Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review by Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang

“…Surgical resections and additional pathological examinations support the diagnosis of CCAU (palliative resection for case 1 and transurethral resection for case 2). Case 1 undergone progression 6 months after initial treatment with transurethral resection and chemotherapy with a 15-month overall survival. …”
Get full text

Using a digital health intervention “INTERCEPT” to improve secondary prevention in coronary heart disease (CHD) patients: protocol for a mixed methods non-randomised feasibility st... by Catriona Jennings, Irene Gibson, Marissa Corcoran, John William McEvoy, Lis Neubeck, Lisa Hynes, Faisal Sharif, David Wood, Andrew W Murphy, Molly Byrne

“…Using pre-defined feasibility criteria, including recruitment, retention and engagement rates, together with data on intervention acceptability, will determine the appropriateness of progressing to a definitive trial. Discussion This study will provide important insights to help inform the feasibility of conducting a definitive trial of “INTERCEPT” among coronary heart disease patients in a critical health care setting.…”
Get full text