Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives by Dong Luo, Yunmei Liu, Zhengmao Lu, Lei Huang

“…Targeted therapies against key targets in GC, including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR), have shown remarkable therapeutic efficacies by inhibiting tumor progression and/or blood supply. In particular, markable breakthroughs have been made in HER2-targeting drugs for HER2-positive GC patients. …”
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Anti-VEGF-therapy for pseudoxanthoma elasticum (case reports) by A.D. Chuprov, S.M. Kim, E.A. Pidodniy, A.M. Iserkepova

“…The leading signs of eye disorder are angioid streaks and choroidal neovascularization (CNV). Progressive destruction of Bruch's membrane favors CNV, whereas macular neovascularization is the key reason for a reduction in central vision in PXE. …”
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Cost Effectiveness of Insulin Glargine versus Neutral Protamin Hagedorn Insulin in the Treatment of Type 2 Diabetes Patients in Turkey by Ilhan Satman, Hayley Bennett, Candeger Yilmaz, Sazi Imamoglu, Goksun Ayvaz, Abdurrahman Comlekci, Demet Ozkaya, Toros Sahin

“…**Methods:** A previously published discrete event simulation model of T2DM progression was utilised to characterise the cost-effectiveness of insulin glargine in a Turkish population given the benefits observed in clinical practice. …”
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La villégiature anglaise et l’invention de la Côte d’Azur by Alain Bottaro

“…Finally came « launch time », as the expression goes: that is, the progressive inclusion of local towns in the ranks of top resorts for international travelers. …”
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Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study by L. Guiducci, C. Vassalle, P. Parchi, S. Maffei

“…All BMs, except for total calcium and BALP, progressively decreased over time (P≤0.05). No fractures and significant adverse events were reported. …”
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Molecular subtype of ovarian clear cell carcinoma: an analysis of 80 Chinese patients using the TCGA molecular classification of endometrial cancer by Wei Chen, Lu Yan, Qin Li, Shuling Zhou, Ting Hou, Huijuan Yang, Shuang Ye

“…No significant differences were observed between the molecular subtypes and clinicopathological features. The progression-free survival and overall survival of the entire cohort were closely associated with FIGO stage (p < 0.01), the presence of residual tumour (p < 0.01), and the platinum response (p < 0.01). …”
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Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review by Nidhi Garg, Ananya Sree Kunamneni, Pankaj Garg, Sandeep Sharma, Divakar Sharma, Adinarayana Kunamneni

“…The current recommendation for mild-moderate, nonhospitalized patients who are at a high risk of disease progression is to use Paxlovid as the first-line option. …”
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Alström syndrome: the journey to diagnosis by Akshat Sinha, Kerry Leeson-Beevers, Catherine Lewis, Elizabeth Loughery, Tarekegn Geberhiwot

“…Symptoms include retinal dystrophy, nystagmus, photophobia, hearing loss, obesity, insulin resistance, diabetes and cardiomyopathy. The condition is progressive, but it is important to note that not all the complications associated with AS occur in everyone affected. …”
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Neutrophil Extracellular Trap Production in Patients with Colorectal Cancer In Vitro by J. J. R. Richardson, C. Hendrickse, F. Gao-Smith, D. R. Thickett

“…Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs which have been implicated in cancer progression and in the development of metastases. NETs production in patients with colorectal cancer was investigated to elucidate their role and prognostic significance. …”
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Second-line systemic treatment for metastatic colorectal cancer: A systematic review and Bayesian network meta-analysis based on RCT. by Chengyu Sun, Enguo Fan, Luqiao Huang, Zhengguo Zhang

“…Markov Chain Monte Carlo (MCMC) technique was used in this network meta-analysis (NMA) to generate the direct and indirect comparison results among multiple treatments in progression-free survival (PFS), overall response rate (ORR), overall survival (OS), complete response (CR), partial response (PR), grade 3 and above adverse events (Grade ≥ 3AE), and any adverse events (Any AE). …”
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ERBB3-related gene PBX1 is associated with prognosis in patients with HER2-positive breast cancer by Shufen Mo, Haiming Zhong, Weiping Dai, Yuanyuan Li, Bin Qi, Taidong Li, Yongguang Cai

“…Conclusion PBX1, IGHM and CXCL13 are associated with the expression level of the ERBB3 and are prognostic markers for HER2-positive in BC, which may play an important role in the development and progression of BC.…”
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OUTCOME OF DEVELOPMENTAL THERAPY IN CHILDREN WITH CEREBRAL PALSY CHILDREN: A PROSPECTIVE COHORT by Erum Afzal, Tanveer Ahmad, Muhammad Khalid Iqbal, Kausar Aftab, Rubeena Muein

“… Introduction: Cerebral palsy (CP) is the non-progressive disorder of motor and posture with associated delayed development in areas of cognition, perception, behavior and sensation, due to insult to immature brain. …”
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Circ-ADAM9 Promotes High Glucose-Induced Retinal Pigment Epithelial Cell Injury in DR via Regulating miR-338-3p/CARM1 Axis by Zeyu Liang, Chengzhe Lu, Tingting Feng, Xiang Gao, Yongfang Tu, Wenchao Yang, Yipeng Wang

“…More research is needed to confirm the role and mechanism of circ-ADAM9 in DR progression. Methods. High glucose (HG)-induced RPE cells (ARPE-19) were used to mimic the hyperglycemia condition. …”
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Effect of Preservation Methods on Physicochemical Quality, Phenolic Content, and Antioxidant Activity of Stevia Leaves by Nadia Hidar, Abdelhamid Noufid, Ayoub Mourjan, El Mustapha El Adnany, Safa Mghazli, Mohammed Mouhib, Abderrahim Jaouad, Mostafa Mahrouz

“…Chlorophylls a and b decreased when storage progressed for freeze-dried leaves as well as for gamma-irradiated leaves. …”
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miR-126 Mimic Counteracts the Increased Secretion of VEGF-A Induced by High Glucose in ARPE-19 Cells by Roberta Sanguineti, Alessandra Puddu, Massimo Nicolò, Carlo Enrico Traverso, Renzo Cordera, Giorgio L. Viviani, Davide Maggi

“…These results indicate that reduced levels of miR-126 may contribute to DR progression by increasing expression of VEGF-A in RPE cells. …”
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The neuroendocrine stress-response in insects: the history of the development of the concept by M. A. Eremina, N. E. Gruntenko

“…This reaction is universal and appears in response to stimuli that are unusual not just for living and habitat of the species, but also for each population. Here we review a progressive change of theoretical concepts, approaches and methods of research in this scientific field: beginning with the development of the stress concept by H. …”
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Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…To analyze modern approach to pathogenesis of Crohn's diseases (CD), to determine effect of individual immunogenetic factors on development and progression of disease, in particular, in relation to HLA profile.Summary. …”
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Identification of Key Genes and Prognostic Value Analysis in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis by Meng Wang, Licheng Wang, Shusheng Wu, Dongsheng Zhou, Xianming Wang

“…Emerging evidence indicates that various functional genes with altered expression are involved in the tumor progression of human cancers. This study is aimed at identifying novel key genes that may be used for hepatocellular carcinoma (HCC) diagnosis, prognosis, and targeted therapy. …”
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Aspartate aminotransferase to platelet ratio correlates with poor prognosis and metabolic alterations in Dabie bandavirus infection by Chunxia Guo, Ruixue Li, Xia Wang, Xiulan Peng

“…Alanine, aspartate, and glutamate metabolism are involved in the progression of SFTS.…”
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An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy by Maximilian Hammer, Amanda Ie, Katharina Eibenberger, Gerd Uwe Auffarth, Kanmin Xue

“…Significant cataract progression occurred in all phakic patients. In 25% of pseudophakic cases, posterior capsule opacification was noted. …”
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