One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States by Christopher M. Blanchette, Emily Zacherle, Joshua M. Noone, Bryce A. Van Doren, Debosree Roy, Reuben Howden

“…Future research should assess other differences between AATD and the general COPD population such as natural history of disease, treatment responsiveness and disease progression.…”
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Weighted Gene Coexpression Network Analysis Identifies TBC1D10C as a New Prognostic Biomarker for Breast Cancer by Huiying Qiao, Rong Lv, Yongkui Pang, Zhibing Yao, Xi Zhou, Wei Zhu, Wenqing Zhou

“…We downloaded raw data from several databases including TCGA and MDACC to identify TME hub genes associated with overall survival (OS) and the progression-free interval (PFI) by WGCNA. Correlations between hub genes and either tumor-infiltrating immune cells or immune checkpoints were conducted by ssGSEA. …”
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Geospatial visualization and seasonal variation of heavy metals in river sediments by D. Justus Reymond, K. Sudalaimuthu

“…Industrialization and agricultural developments are progressively causing ecological concerns, which must be addressed. …”
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The Value of Immune-Related Genes Signature in Osteosarcoma Based on Weighted Gene Co-expression Network Analysis by Xin Wang, Li Gan, Ju Ye, Mengjie Tang, Wei Liu

“…This study is aimed at obtaining immune-related genes (IRGs) associated with the progression and prognosis of OS. Method. Expression profiling data and clinical data for OS were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. …”
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Efficacy of an Emergency Cervical Cerclage Using Absorbable Monofilament Sutures by Yuka Sato, Nobuhiro Hidaka, Takahiro Nakano, Saki Kido, Masahiro Hachisuga, Yasuyuki Fujita, Kiyoko Kato

“…Among the 23 patients (18 singleton and five twin pregnancies) evaluated, ultrasound-indicated (progressive cervical length shortening) were eight (35%) and physical examination-indicated (fetal membranes that prolapsed into the vagina or dilated cervix) were 15 patients (65%). …”
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Application of Surgical Protocols for the Treatment of Highly Irregular Astigmatism with Topographic Guided Ablation in a Case of Post-LASIK Ectasia by Motwani M, Agu E, Xu A, Yung M

“…Epithelium-off corneal cross-linking was performed at 3.0 mW/cm for 30 minutes.Results: The patient initially presented with a remote history of LASIK and progressive left eye blurring. His uncorrected distance visual acuity (UDVA) was 20/40, with a corrected distance visual acuity (CDVA) of 20/25 with a manifest refraction of − 1.25 +1.75 × 180. …”
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Molecular and serological investigation of hepatitis B virus in patients with acute undifferentiated febrile illness at Tha Song Yang hospital, Tak Province, Thailand by Narin Thippornchai, Anon Sae-Oueng, Akanitt Jittmittraphap, Wang Nguitragool, Pornsawan Leaungwutiwong

“…Abstract Background Hepatitis B virus (HBV) infection is associated with hepatitis, often progressing to liver cirrhosis or cancer, posing a significant public health challenge, particularly in Thailand. …”
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The potential of stem cell therapy in Multiple Sclerosis treatment: a review by Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

“…Most current clinical trials continue to focus on establishing the safety and efficacy of adipose derived stem cell-based therapeutics, with promising results becoming progressively evident. This review reports stem cell-based therapies as potential therapeutic approaches in the treatment and management of Multiple Sclerosis. …”
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Impact of Comorbidities on the Severity of Disease & Outcome in Children with COVID 19 at a Tertiary Care Pediatric Hospital, Rawalpindi. by Rai Muhammad Asghar, Muddassar Sharif, Khalid Saheel, Isfandyar Khan, Abid Hussain, Rai Rijjal Ashraf

“…It is considered that COVID-19, in those with underlying health conditions or co-morbidities, has an increasingly rapid and severe progression, often leading to death. This study is designed to evaluate the impact of co-morbidities on the severity and outcome of COVID-19 infection in children. …”
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Early referral to nephrological care improves long-term survival and hospitalization after dialysis initiation, independent of optimal dialysis start – a call for harmonization of... by Mathias Haarhaus, Lavinia O. Bratescu, Nicolae Pana, Emanuela M. Gemene, Eliana M. Silva, Carla Alexandra R. Santos Araujo, Fernando Macario

“…Early treatment of kidney disease can slow disease progression and reduce the increased risk of mortality associated with end-stage kidney disease. …”
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Interferon (IFN)-gamma (γ) inducible protein 10 (IP-10) in the diagnosis of latent and active tuberculosis in Bacille Calmette Guerin (BCG)-vaccinated pediatric population. by Magdalena Druszczynska, Michał Seweryn, Sebastian Wawrocki, Anna Pankowska, Anastasiia Kulbachko, Magdalena Jurczak, Magdalena Kowalewska-Pietrzak

“…Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.tb) infection (LTBI) that have a high risk of progressing to active TB disease remains a significant diagnostic hurdle.…”
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Influence of Dry Beach on the Dynamic Stability of Ash Storage Field: A Numerical Analysis by Fangtao She, Chang Liu, Xiangang Zhou, Changjun Qi, Jiulong Ding

“…As the length of the dry beach increases, the maximum horizontal displacements show a certain decrease, but they occur progressively further away from the third subdam, so that, under dynamic action, the dams become safer. …”
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Integrative Bioinformatics Analysis Unravel the Association between Intracerebral Hemorrhage and Cellular Apoptosis through Immune Infiltration by Pandi Chen, Gengfan Ye, Jia Li, Kuan Feng, Guangyao Zhu, Maosong Chen, Wei Chen

“…Through bioinformatics analysis, we identified PPP1R15A, IL1R1, and TYROBP as crucial genes in the occurrence and progression of ICH, with the potential involvement of Activated dendritic cells and CD56dim natural killer cells in these processes.…”
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PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Hitesh Gandhi, Norbert Feigler, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…The US COPD population was modeled with 1000 simulations of patient progression over 10 years. Agent characteristics were based on literature and claims analysis of the 2016-2018 Medicare 100% fee-for-service and IBM MarketScan^®^ databases. …”
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Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats by Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan

“…The 28 days of DCXD (5 g/kg) treatment significantly reduced the increased BP effectively, inhibited the enhanced heart index, kidney index, and 24 h urinary protein, and improved the progressive pathological changes of heart and kidney, which was comparable to that of the positive control amlodipine. …”
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Fatty acid metabolism-related signature suggests an oncogenic role of TEKT1 in endometrial cancer by Zhikai Xiahou, Hong Xiao, Yafeng Song, Xin Xu

“…Objective: The study aims to construct a prognostic signature to detect the molecular interaction between the fatty acid metabolism and the progression of endometrial cancer. Materials and methods: A total of 309 fatty acid metabolism relative genes were analyzed in the endometrial cancer cohort from The Cancer Genome Atlas. …”
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Administration of a Next-Generation Probiotic Escherichia coli Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes by Jie Luo, Yilin Fang, Zhanghua Qi, Fengyang Cui, Hong Hu, Shengjie Li, Tingtao Chen, Hongyan Zhang

“…Diabetes mellitus (DM) is a persistent and steadily progressing metabolic condition distinguished by unregulated high levels of blood glucose. …”
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To study the role of tofacitinib and betamethasone pulse in the treatment of vitiligo at a tertiary care centre: an observational comparative study by Rashmi Singh, Surabhi Shandilya, Kamalpreet Kaur Bhaikhel, Gopi Krishna Maddali

“…The new oral biologic tofacitinib, which is a Janus kinase inhibitor, is a new addition to the armamentarium of immunosuppressive therapy to halt disease progression in vitiligo. Tofacitinib is also known to inhibit IFN-γ mediated inflammation, which is an important step in the development of vitiligo lesions. …”
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Three-dimensional conformal radiation therapy for the osteoarthritis of knee joint: the radiobiological background, dose distribution analysis by М. V. Маkаrоvа, M. Yu. Vаlkov, D. Yu. Tretjakov

“…The technique of three-dimensional conformal radiation therapy of the knee joint in OA with progressive pain syndrome can potentially lead to an increase in the analgesic effect due to greater coverage with a dose of bone elements of the joint, which are a potential source of pain. …”
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Efficiency of the Stool-PCR Test Targeting NADH Dehydrogenase (Nad) Subunits for Detection of Opisthorchis viverrini Eggs by Wansika Phadungsil, Supaporn Pumpa, Kridsada Sirisabhabhorn, Amornrat Geadkaew-Krenc, Rudi Grams, Mathirut Mungthin, Toon Ruang-Areerate, Poom Adisakwattana, Nipawan Labbunruang, Pongsakorn Martviset

“…The early diagnosis of O. viverrini infection may interrupt the progression of the opisthorchiasis and other related illnesses, especially CCA. …”
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