Anticancer properties of Dillenia suffruticosa (Griffith Ex. Hook. F. & Thomsom) Martelli by Ika Rahayu, Susana Elya Sudrajat, Kris Herawan Timotius

“…The herbal plant Dillenia suffruticosa shows potential in combating cancer progression. Objectives: This review aims to evaluate the anticancer effects of D. suffruticosa, including its extracts and bioactive compounds, on cellular responses, subcellular (mitochondrial) functions, and molecular aspects, as well as the associated molecular pathways. …”
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The “Heretics” Hermeneutics: Bosnia and Balkan Bogomils in the Mirror of Modern Hungarian Literature As Potential(Borrowed?) Theaters of Multidimensional Orientalism by Marton Ivanyi

“…Hungary has experienced distinct phases in its history: as a medieval middle power, later as a territory under Austrian rule, and subsequently as a state-forming entity within the Austro-Hungarian Monarchy. This progression has shaped Hungary’s perception of its neighbors and its role within European ideological currents, particularly those influenced by Orientalist discourses. …”
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Hybrid learning strategies: integrating supervised and reinforcement techniques for railway wheel wear management with limited measurement data by Jessada Sresakoolchai, Chayut Ngamkhanong, Sakdirat Kaewunruen

“…The supervised learning model, developed from validated simulations, predicts wear progression, while reinforcement learning improves maintenance decision-making using basic operational data without regular measurements. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…We examined the effects of topical FTY720 injections on mechanical force-induced HS progression. Methods. Mechanical force-induced HSs were generated in C57BL6/J mice by suturing a dorsal incision and applying a stretching device on Days 6, 8, 10, and 12. …”
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EXamining the feasibility of exerCisE to manage symptoms of Lupus (EXCEL): a protocol for a randomised controlled pilot study by John Reynolds, Katie Hesketh, Matthew Cocks, Megan Quickfall, Alex J Wadley, Scott Green, Jet Veldhuijzen Van Zanten

“…EXCEL will examine the feasibility of conducting a large-scale randomised controlled trial comparing the effects of a remotely monitored, home-based, exercise programme with standard of care for individuals with SLE.Methods and analysis 30 females with SLE will be recruited, and those randomised into Exercise (SLE-Ex) will codesign a progressive training plan with support from the research team. …”
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Immunopathological Changes of Streptococcus pneumoniae Causing Respiratory Infection in Lambs by Abbas A Hamzah, Zainab I Ibrahim

“…By day 14, these changes progressed to marked epithelial vacuolation and necrosis in the trachea, with lung sections revealing perivascular cuffing, peri bronchiolitis, mild bronchiectasis, atelectasis, and alveolar collapse. …”
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Self /other recognition and distinction in adolescents with anorexia nervosa: A pilot study using a double mirror paradigm. by Nathalie Lavenne-Collot, Emilie Maubant, Stéphanie Déroulez, Guillaume Bronsard, Moritz Wehrmann, Michel Botbol, Alain Berthoz

“…This innovative device allows the progressive morphing of one's own face to that of another and vice versa between two subjects that interact on opposite sides of the device. …”
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Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…ObjectiveMitochondrial metabolic reprogramming in macrophages is crucial in the development and progression of inflammation. Given vitamin A’s antioxidant properties and its therapeutic effects on inflammation, this study aims to elucidate how vitamin A influences mitochondrial metabolic reprogramming in inflammatory states, specifically in periodontitis, through genetic bioinformatics and experimental methods.MethodThe study utilized the GSE16134 dataset from the Gene Expression Omnibus (GEO) database, focusing on human periodontitis. …”
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Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Cli... by Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P. Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, Momir Mikov

“…Thus, UDCA could attenuate the progression and complications of diabetes and should be considered as an adjuvant to other diabetes treatment modalities. …”
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Reclaiming Subsidized Land: An Evaluation of Coal Gangue Interlayers by Yuling Gong, Zhenqi Hu, Kevin McSweeney

“…Group 1 treatments (T1–T3) had a 15 cm layer of subsoil immediately below the topsoil, underlain, respectively, by progressively thicker gangue layers (20, 30, and 40 cm) overlying another 15 cm subsoil layer, in turn underlain by gangue. …”
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Gastrostomy uptake in motor neurone disease: a mixed-methods study of patients’ decision making by Natalie James, Emma Power, Anne Hogden, Julie Labra, Victoria M Flood

“…Gender, site of onset and rate of disease progression were observed to contribute to uptake. Age and symptom duration did not. …”
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Real-world treatment patterns and survival outcomes in men with metastatic castration-resistant prostate cancer in Finland: a national, population-based cohort study by Antti Rannikko, Olivia Hölsä, Trude Ågesen, Mattias Ekman, Riikka Mattila

“…Results: Of a total of 31,307 patients with prostate cancer, 2,475 progressed to mCRPC during 2013–2021. Those who received no life-prolonging treatment(s) (28% overall) were older with more comorbidities than treated patients. …”
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Matching plus regression adjustment for the estimation of the average treatment effect on survival outcomes: a case study with mosunetuzumab in relapsed/refractory follicular lymph... by Danilo Di Maio, S. A. Mitchell, S. Batson, E. Keeney, Howard H. Z. Thom

“…Endpoints included overall survival (OS) and progression-free survival (PFS). Sensitivity analyses were performed to test robustness to different distributional assumptions (log-normal, log-logistic and exponential) or model specifications (second, third and fourth lowest AIC) for event times. …”
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Effects of Delayed Metamorphosis on Larval Survival, Metamorphosis, and Juvenile Performance of Four Closely Related Species of Tropical Sea Urchins (Genus Echinometra) by M. Aminur Rahman, Fatimah Md. Yusoff, A. Arshad, Tsuyoshi Uehara

“…Juveniles from larvae of all four species that metamorphosed soon after becoming competent tended to have higher growth rates (test diameter and length of spines) than juveniles from larvae that metamorphosed after a prolonged period of competence with progressively slower growth the longer the prolonged period. …”
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Correlation of serum C - reactive protein with clinical parameters in diabetic patients having chronic periodontitis before and after treatment by Arkhawan Ali Abdulhaq, Ziwar Ahmed Salih, Solaf Abdulqadir Mustafa

“… Background and Objectives: Chronic periodontitis is an infectious disease characterized by inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. C-reactive protein, are acute phase proteins monitored as a marker of inflammatory status. …”
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Reasons for disengagement in first-episode psychosis – perspectives from service users and their caregivers by Yi Chian Chua, Kumarasan Roystonn, K. Pushpa, Swapna Verma, Charmaine Tang

“…A total of five categories each with subthemes were identified from the reasons for service user disengagement – individual factors, stigma, progression, treatment factors, and external factors. …”
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Papillary Carcinoma of Breast: Clinicopathological Characteristics, Management, and Survival by Bushra Rehman, Anam Mumtaz, Barka Sajjad, Namra Urooj, Sameen Mohtasham Khan, M. Toqeer Zahid, Huma Mannan, M. Zulqarnain Chaudhary, Amina Khan, M. Asad Parvaiz

“…HER-2 Neu was positive in 3 patients only, out of which 2 died of progressive disease (one EPC and one IPC). LN metastasis was present in 3 (5%) patients (one in each of 1st three types) and only one died of bone metastasis that was also Her-2Neu positive. …”
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Comorbidity in in patients with relapsing-remitting multiple sclerosis by O.V. Somilo, S.O. Makarov, O.I. Kalbus

“…Comorbidity in multiple sclerosis is an urgent problem of modern neurology, since it can influence such factors as the time of diagnosis, the rate of disease progression and the rate of patient disability, the number of exacerbations and the patient’s quality of life. …”
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Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations by Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehury

“…R47H and R62H in TREM2 may affect the development and progression of AD. Our knowledge-based and machine-learning guided docking and physics-based simulations study unveils deep insights into the endogenous ligand recognition by the positive surface ligand binding site and distant core site pave the way for exploration of other small molecules towards development of novel therapeutics against Alzheimer's disease.…”
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Correlation of Platelet Indices with Severity of Gastroesophageal Varices in Patients of Liver Cirrhosis: A Research Protocol by Parav Tantia, Sourya Acharya

“…While various parameters have been explored to predict the progression and severity of these varices, platelet indices have not been extensively studied in cirrhosis patients with gastroesophageal varices in India. …”
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