Quantitative Evaluation of Top Coal Caving Methods at the Working Face of Extra-Thick Coal Seams Based on the Random Medium Theory by Shi Jiulin, Zhang Quntao, Gao Xiaojin, Xue Jisheng

“…The results show the following: (1) The coal-rock settlement and the caving body demonstrate clear axial symmetrical features along the working face; the size of the caving body increases as the caving height grows and its shape turns progressively from semicircular to semielliptical with a lower foot of the coal-rock settlement. (2) The caving interval is derived using the sum of the radii of the coal-rock settlement curves formed by the two largest caving bodies. (3) The symmetrical caving approach provides a symmetrical space for the subsequent movement of the broken top coal, which enables a uniform development of the caving body. (4) Compared with the traditional sequential coal caving method with the same number of supports, the interval symmetrical caving method results in a 21.7% of coal production increase, 17% caving rate promotion, and a shortened caving time by 23.4%. (5) The interval symmetrical caving method is found to improve the controllability of the caving process at the fully mechanized top coal caving working face. …”
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Efficacy and safety of camrelizumab combined with chemotherapy as second-line treatment for locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma by Yinfang Gu, Xiaofang Zou, Junlin Zhu, Guowu Wu

“…We evaluated short-term efficacy, including overall response rate (ORR) and disease control rate (DCR), as well as survival outcomes, including progression-free survival (PFS) and overall survival (OS). …”
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Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…We conclude the anti-rat IAP antibody disrupts IAP/SHPS-1 association and attenuates aberrant IGF-I signaling thereby preventing or reversing the progression of retinal pathophysiological changes.…”
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Association of Prehypertension with Renin Angiotensin System: A Cross-Sectional Study on Tribal Population of Northern India by Vani Kandpal, Mohinder Pal Sachdeva, Kallur Nava Saraswathy

“…Evaluating the prevalence of prehypertension is imperative to prevent disease progression. Prehypertension, alike HTN, is a complex disorder that manifests when genes are triggered by the environment. …”
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The winding road to health: A systematic scoping review on the effect of geographical accessibility to health care on infectious diseases in low- and middle-income countries. by Fleur Hierink, Emelda A Okiro, Antoine Flahault, Nicolas Ray

“…Timely access to health facilities can prevent disease progression and enables disease notification through surveillance systems. …”
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NLRP3 is a BMI-independent mediator of stable COPD by Yonca Gungor, Selin Ercan, Saliha Selin Özuygur Ermiş, Yiğit Kozalı, Gizem Kursunluoglu, Ceyda Sahan, Aylin Ozgen Alpaydin, Hulya Ayar Kayali

“…The NLRP3/caspase-1/interleukin (IL)-1β pathway might be involved in the progression of COPD with increasing body mass index. …”
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Study on Catastrophe Instability of Support System in Gypsum Goaf Based on Energy Dissipation Theory by Yuejin Zhou, Xiaoding Xu, Xiaotong Li, Meng Li, Yugui Yang

“…The evolution from the static state in bottom page to the static state in top page is not progressive, but catastrophic. The redundant energy released in this process leads to mechanical instability of the support system. …”
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Dietary diversity and opportunistic infections among adults living with human immunodeficiency virus on antiretroviral therapy in Kumasi metropolis; a facility-based cross-sectiona... by Charles Apprey, Hammond Yaw Addae, Monica Osei, Irene Danquah, Reginald Annan

“…Adequate nutrition remains an essential factor that positively influences disease progression and the occurrence of OIs. In Ghana, no study has evaluated the association between dietary diversity and OI occurrence among adults with HIV. …”
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Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3 by Huiny Miriane Tienoue Fotso, Mary-Ann Mbong Angie, Françoise Raïssa Ntentie, Inelle Makamwe, Ferdinand Lanvin Edoun Ebouel, Emmerencia Kenjing Ndansack, Enyong Julius Oben

“…AE-Ac showed inhibitory effects on the expression of genes involved in cancer progression making it a potential health intervention agent that can be exploited in cancer therapy protocols.…”
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Genetic Gain in Wheat Grain Yield and Nitrogen Use Efficiency at Different Nitrogen Levels in an Irrigated Hot Environment by Izzat Sidahmed Ali Tahir, Elfadil Mohamed Elyayeb Elbashier, Mohamed Ahmed Salih Ibrahim, Abu Sefyan Ibrahim Saad, Osman Suliman Abdalla

“…This gain was associated with progresses in harvest index (HI) at N43, N86, and N129 but not at N0. …”
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Saffron therapy for the ongoing treatment of age-related macular degeneration by Peter J McCluskey, Thomas Hong, Andrew A Chang, John Grigg, Geoffrey K Broadhead, Timothy E Schlub, Eugenia Chu

“…Mean BCVA was 1.6 letters worse (p<0.05) with no difference between those on AREDS supplements or not, and this may have been related to cataract progression. No saffron-related serious adverse events were detected.Conclusion Saffron supplementation modestly improved mfERG responses in participants with AMD, including those using AREDS supplements. …”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development by N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

“…To elucidate how these signs develop, we used a nextgeneration RNA sequencing technique (RNA-Seq) to study the prefron­tal-cortex transcriptome of OXYS rats during the manifestation of AD signs (at an age of 5 months) and during their active progres­sion (at an age of 18 months), using age-matched Wistar rats (parental strain) as controls. …”
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Requiem – Alàgbà, Dr., Prince, Mosọbalájé Ajíbádé Àkàndé Adébáyọ̀ Fálétí, OON, DLitt., FNAL, JP, a.k.a ‘Pa Fálétí’ to Some; ‘Bàbá Fálétí’ to all and Sundry.... by Pamela J. Olubunmi Smith

“…It is a testament to everything relational, from the ceremonial to the conventional to the familial! The progression from ‘Knowing of a person’ (mímọ ẹnì kan); ‘knowing something about that person’ (mímọ nǹkan nípa ẹni náà, mímọ ẹni náà); to ‘knowing that person well, personally’ (mímọ ènìyàn náà dáadáa) describes the various levels and depths of measuring knowledge of and/or familiarity with that person. …”
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Modeling COVID-19 dynamics in the Basque Country: characterizing population immunity profile from 2020 to 2022 by Bechir Naffeti, Zeineb Ounissi, Akhil Kumar Srivastav, Nico Stollenwerk, Joseba Bidaurrazaga Van-Dierdonck, Maíra Aguiar

“…Results The COVID-19 epidemic in the Basque Country progressed through three distinct phases, each shaped by dynamic interactions between virus transmission, public health interventions, and vaccination efforts. …”
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Metastatic pancreatic cancer now in remission: a case report and literature review by Charles W. Shi, Thomas J. VanderMeer, Anita Pudusseri

“…Despite a stage IV diagnosis, the primary tumor was resected in order to mitigate the risk for mutation and progression. Although rare, greater hope for patients with PDAC of the tail with favorable tumor biology responsive to FOLFIRINOX may contribute to increased surgical resection rates and improve survival rates.…”
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hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…While hERG channel is notoriously regarded as an off-target due to drug-induced cardiotoxicity, its therapeutic potential as a drug target remains largely unexplored.MethodsThis study investigated the role of hERG in breast cancer progression and its impact on patient survival. The anti-proliferative, anti-migratory, anti-invasive and pro-apoptotic effects of hERG activators were evaluated using the Cell Counting Kit-8, wound healing assay, transwell assay and cell apoptosis assay, respectively. …”
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Relationship between dietary intake and atherogenic index of plasma in cardiometabolic phenotypes: a cross-sectional study from the Azar cohort population by Shirin Soheilifard, Elnaz Faramarzi, Reza Mahdavi

“…Abstract Background Cardiovascular diseases are a leading cause of global mortality, with diet playing a key role in their progression. The Atherogenic Index of Plasma (AIP) is a predictive marker for cardiovascular risk, but its association with dietary intake across cardiometabolic phenotypes remains underexplored. …”
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Hormonal-Receptors-Positive and HER2-Negative Patients with Metastatic Breast Cancer Treated with First-Line Palbociclib and Hormonal Therapy: Impact of First-Cycle Neutropenia and... by Khaled Abd Elaziz Ahmed Elnaghi, Hosam Ali Alghanmi, Shereef Ahmed Elsamany, Fathia Almarzoki, Mohamed Elsafty, Mohammad Jaffal

“…Dose reduction was recorded in 46.7% of patients and it was more common in patients with higher Allred scores (scores 7–8). The median progression-free survival (PFS) of the study group was 22 months. …”
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The challenges of independence: ontogeny of at-sea behaviour in a long-lived seabird by Delord, Karine, Weimerskirch, Henri, Barbraud, Christophe

“…Patterns of activity parameters in juveniles after independence suggested a progressive change of foraging performances during the first two months after fledging. …”
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Real-world clinical validation of the Qatar pre-diabetes risk score: a cross-sectional study by Mohamed Ahmed Syed, Narjiss Sallahi, Abduljaleel Abdullatif Zainel, Halima None Bensmail, Abdelilah Arredouani

“…Introduction Pre-diabetes stands as a prominent, independent risk factor for the onset of type 2 diabetes (T2D), with 5%–10% of individuals with pre-diabetes progressing to T2D annually. The effectiveness of rigorous lifestyle interventions in averting the transition from pre-diabetes to T2D has been substantiated across multiple investigations and populations. …”
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