Lipoprotein(a) and thromboembolism: current state of knowledge and unsolved issues by Małgorzata Konieczyńska, Joanna Natorska, Michał Ząbczyk, Anetta Undas

“…Elevated Lp(a) levels, found in about 20% of Europeans, are strongly linked to higher rates of myocardial infarction, major adverse cardiac events, accelerated plaque progression, ischemic stroke (especially in younger adults), and calcific aortic valve disease. …”
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THE EFFECT OF PROPANOLOL ON C-REACTIVE PROTEIN IN PATIENTS WITH SEVERE BURNS AT DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA by Muhammad Aulia U H, Iswinarno Doso Saputro, Magda Rosalina Hutagalung

“…Abstract: Introduction: The incidence of burns in Indonesia progressively  increases with the increase in its population and industries. …”
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Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines by Amrita Ulhe, Prerna Raina, Amol Chaudhary, Ruchika Kaul-Ghanekar

“…Dietary fatty acids, especially omega-3, reduce the risk of cancer by preventing or reversing the progression through a variety of cellular targets, including epigenetic regulation. …”
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Prevalence of Nonalcoholic Steatohepatitis and Associated Fibrosis Stages Among US Adults Using Imaging-Based vs Biomarker-Based Noninvasive Tests by Jesse Fishman, Tom O'Connell, Christina M. Parrinello, Jonathan J. Woolley, Eric Bercaw, Michael R. Charlton

“…Therapies are under development for nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, such that the prevalence of NASH with liver fibrosis, which is likely to require treatment, may be of interest to healthcare decision makers. …”
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Pulsed Light Accelerated Crosslinking versus Continuous Light Accelerated Crosslinking: One-Year Results by Cosimo Mazzotta, Claudio Traversi, Anna Lucia Paradiso, Maria Eugenia Latronico, Miguel Rechichi

“…Methods. 20 patients affected by progressive keratoconus were enrolled in the study. 10 eyes of 10 patients underwent an epithelium-off pl-ACXL by the KXL UV-A source (Avedro Inc., Waltham, MS, USA) with 8 minutes (1 sec. on/1 sec. off) of UV-A exposure at 30 mW/cm2 and energy dose of 7.2 J/cm2; 10 eyes of 10 patients underwent an epithelium-off cl-ACXL at 30 mW/cm2 for 4 minutes. …”
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Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Denis Dekugmen Yar

“…However, ineffective regulatory systems in resource-limited settings can lead to the infiltration of poor-quality and counterfeit antimalarial medicines into the pharmaceutical supply chain, causing treatment failures, prolonged illness, and disease progression. The objective of the study was to assess the quality of selected brands of fixed-dose combination (FDC) AL tablets and suspensions marketed in Kumasi, Ghana. …”
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Minimizing the Diagnostic Delay in Amyotrophic Lateral Sclerosis: The Role of Nonneurologist Practitioners by Martin Matharan, Stéphane Mathis, Sarah Bonabaud, Louis Carla, Antoine Soulages, Gwendal Le Masson

“…Overall, diagnostic delay accounted for 40% of the total duration of the disease progression. Conclusion. In relation to total survival time, the diagnostic delay of ALS appears to be proportionately very long, sometimes longer than that observed in previous studies (because it also included the total delay to diagnostic or treatment initiation). …”
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Gender and age features in adults with congenital heart disease by I.G. Lebid

“…The annual number of examined patients with CHD progressively increased (from 221 in 2011 to 418 patients in 2015). …”
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Clinically approved treatments for refractory glaucoma by Т.А. Zhigalskaya, O.I. Krivosheina

“…More than 70 million patients suffer from glaucoma worldwide. Its incidence progressively increases thus resulting in the steady growth of disability. …”
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Revolutionizing load harmony in edge computing networks with probabilistic cellular automata and Markov decision processes by Dinesh Sahu, Nidhi, Rajnish Chaturvedi, Shiv Prakash, Tiansheng Yang, Rajkumar Singh Rathore, Lu Wang, Sabeen Tahir, Sheikh Tahir Bakhsh

“…Besides optimizing resource exploitation, load harmony in edge computing networks helps provide efficient work progression and minimize latency, thereby contributing to the advancement of the field with respect to real-time applications such as self-driving vehicles and the Internet of Things. …”
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DIFFERENT HUMAN IMAGES AND ANTHROPOLOGICAL COLISSIONS OF POST-MODERNISM EPOСH: BIOPHILOSOPHICAL INTERPRETATION by S. К. Коstyuchkov

“…The author's vision of the anthropological collision of the Post-Modernism era is caused by the fact that the issues of a postmodern man acquire a special urgency at the end of the ХХ – early XXI century. A progressive disproportion between a human being, whose abilities as a representative of the species Homo sapiens are biologically limited, and the human community, which sees no limits in its information and technological expansion, is of current interest. …”
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Effects of an 8-week pre-season targeted training on sprinting performance, agility and lower limb muscular asymmetries in elite soccer players by Artur Gołaś, Przemysław Pietraszewski, Robert Roczniok, Artur Terbalyan, Adam Maszczyk, Rafał Opaliński, Adam Zając

“…The training included 6 bodyweight exercises (Bird Dog, Single-Leg Glute Bridge, Dead Bug, Side Plank, Reverse Lunge, and Clamshell), performed unilaterally in 5 sets of 10 repetitions of each exercise. The load progression included an additional set in each successive week of the experiment. …”
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Cost-Effective Autonomous Drone Navigation Using Reinforcement Learning: Simulation and Real-World Validation by Tomasz Czarnecki, Marek Stawowy, Adam Kadłubowski

“…A vital component of this approach is creating a multi-stage training environment that accurately replicates actual flight conditions and progressively increases the complexity of scenarios, ensuring a robust evaluation of algorithm performance. …”
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Impact of PARP inhibitor maintenance therapy in newly diagnosed advanced epithelial ovarian cancer: A meta-analysis. by Banghyun Lee, Suk-Joon Chang, Byung Su Kwon, Joo-Hyuk Son, Myong Cheol Lim, Yun Hwan Kim, Shin-Wha Lee, Chel Hun Choi, Kyung Jin Eoh, Jung-Yun Lee, Dong Hoon Suh, Yong Beom Kim

“…<h4>Results</h4>The two-year progression-free survival (PFS) was significantly better in the PARPi group than the placebo (Hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.41 to 0.68). …”
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m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder by Shuang Zhu, Peng Wang, Jian Hu

“…Long noncoding RNA (lncRNA) are essential for modulating the onset and progression of alcohol use disorder (AUD). In this study, we investigated the molecular pathways through which lncRNA may contribute to AUD development. …”
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Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung Adenocarcinoma by Zhengyang Fan, Song Wu, Hongyang Sang, Qianping Li, Shaofei Cheng, Hongling Zhu

“…In this study, following an examination of the TGCA datasets, we found that GPD1L displayed a dysregulated state in a wide variety of cancers; this led us to believe that GPD1L is an essential regulator in the progression of malignancies. In addition, we found that the expression of GPD1L was much lower in LUAD tissues when compared with nontumor specimens. …”
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Effectiveness and Safety of Dupilumab and Tralokinumab for Treating Atopic Dermatitis and Pruritic Skin Disorders in Oncological Patients: A Narrative Review by Lauletta G, Potestio L, Patruno C, De Lucia M, Napolitano M

“…In conducting this narrative review, Medical Subject Headings (MeSH) terms and medical terminology related to clinical trials and real-life studies were employed, focusing on the pharmacological agents dupilumab, and tralokinumab.Discussion: Patients with active or past cancer are typically excluded from clinical trials of new medications, complicating the evaluation of cancer progression or recurrence risks in these patients setting. …”
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Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study by Yunyi Yan, Nozomi Kondo, Kentaro Oniki, Hiroshi Watanabe, Tadashi Imafuku, Yuki Sakamoto, Takuro Shigaki, Akari Maruyama, Hitomi Nakazawa, Tetsuya Kaneko, Ayami Morita, Akira Yoshida, Hitoshi Maeda, Toru Maruyama, Hideaki Jinnouchi, Junji Saruwatari

“…Visit-to-visit variability of HbA1c was calculated as the internal standard deviation of HbA1c (HbA1c-SD), the coefficient of variation of HbA1c (HbA1c-CV), the HbA1c change score (HbA1c-HVS), and the area under the HbA1c curve (HbA1c-AUC) with 3-year serial HbA1c measurement data, and the associations between these indices and the development/progression of DKD were examined. Results. Cox proportional hazards models showed that the HbA1c-SD and HbA1c-AUC were associated with the incidence of microalbuminuria, independently of the HbA1c level. …”
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Analysis of changes in the chemokine CXC ligand 13 in serum and cerebrospinal fluid of patients with neuromyelitis optica by Juan Zhou, Shalin Luo, Xiaoxi Yao, Haipeng Li, Ying Wen

“…Abstract To determine correlation between the Extended Disability Status Scale(EDSS) grade and the progression of neuromyelitis optica(NMO) patients’ levels of the chemokine CXC ligand 13 (CXCL13) in their serum and cerebrospinal fluid. …”
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Synthesis, Characterization, and In Vivo Cytokinome Profile of IL-12-Loaded PLGA Nanospheres by Ryan A. Lacinski, Justin E. Markel, Jabeen Noore, Hillary G. Pratt, Brock A. Lindsey

“…Similar trends were observed with IL-1β and CXCL-1, suggesting a decreased likelihood of progression to a systemic inflammatory response syndrome-like state. …”
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