Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling by Ghada H. Elsayed, Asmaa M. Fahim

“…The mRNA expression levels of PI3K, AKT, mTOR, and CCND1 were examined in PC3-treated cells by using QRT-PCR, and the results demonstrated that, by down-regulating the expression levels of these genes, chitosan salicylaldehyde/CuFe2O4 significantly affected prostate cancer cell proliferation, progression, and autophagy more than chitosan salicylaldehyde. …”
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Evaluating the Protective Effects of MitoQ and Antifreeze Protein III on Cryopreserved Canine Sperm by Abbas Farshad, Emilia Diel, Axel Wehrend

“…The results showed significant (<i>p</i> < 0.05) improvements in motility rate, progressive motility, VAP, VSL, VCL, ALH, and BCF with MitoQ or AFP alone. …”
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Mechanical behavior and micro-crack propagation mode of fault stick–slip under various roughness conditions by Qianbai Zhao, Yong Zhao, Tianhong Yang, Shuhong Wang

“…As the roughness of the fault surface increases, the failure progressively extends into the rock at the distal end of the fault. …”
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Laminin-5 γ2 Chain Expression Correlates with Unfavorable Prognosis in Colon Carcinomas by C. Lenander, J. K. Habermann, Å. Öst, B. Nilsson, H. Schimmelpenning, K. Tryggvason, G. Auer

“…The results indicate that laminin-5 γ2 chain expression is up-regulated during the progression of human colon cancer and that it plays a role in the aggressiveness of these tumors. …”
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Identification of Two Novel Mutations of ABCD1 Gene in Pedigrees with X-Linked Adrenoleukodystrophy and Review of the Literature by Bingzi Dong, Wenshan Lv, Lili Xu, Yuhang Zhao, Xiaofang Sun, Zhongchao Wang, Bingfei Cheng, Zhengju Fu, Yangang Wang

“…However, both of the cases progressed as neurological symptoms and signs after decades. …”
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Neutrophil membrane biomimetic delivery system (Ptdser‐NM‐Lipo/Fer‐1) designed for targeting atherosclerosis therapy by Wei Li, Chang Liu, Sichuan Wang, Naifeng Liu

“…Abstract Atherosclerosis is a progressive inflammatory disease characterised by excessive lipid accumulation and inflammatory cell infiltration and is the basis of most cardiovascular diseases and peripheral arterial diseases. …”
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Understanding and Minimizing Perimeter Losses of Silicon-Based Monolithic Tandem Solar Cells – A Simulation Study by Andreas Fell, Martin Bivour, Mario Hanser, Martin Schubert

“…An understanding of perimeter loss mechanisms and design rules for their minimization is therefore important for effectively progressing high efficient tandem solar cells in R&D. …”
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Integrating human resource management in urban workforce development: A focus on salary increments by L. Yu, A. Santos

“…Crucially, skill enhancement correlated strongly with salary progression, and structured professional development was linked to high employee satisfaction. …”
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The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity. by Liam C Hunt, Michelle Curley, Kudzai Nyamkondiwa, Anna Stephan, Jianqin Jiao, Kanisha Kavdia, Vishwajeeth R Pagala, Junmin Peng, Fabio Demontis

“…UBE2D/eff is key for proteostasis also in skeletal muscle: eff protein levels decline with aging, and muscle-specific eff knockdown causes an accelerated buildup in insoluble poly-ubiquitinated proteins (which progressively accumulate with aging) and shortens lifespan. …”
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One Parent Type Family and Social Welfare: A Case Study of Nyarusiza Sub-County Kisoro District. by Duhimbaze, Emmanuel

“…We should keep in mind that we want to live in a peaceful life and to look forward to a progressive society despite the nature of the family.…”
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Record Disaster Management in Local Government: A Case Study of Nyakagyeme Sub-County Rukungiri District. by Kayesu, Carolyne

“…The study recommends that there is a need for the management to enhance career progression by facilitating staff to go for further training in records management. …”
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The development and maintenance of immunity against visceral leishmaniasis by Rahul Tiwari, Awnish Kumar, Vishal Kumar Singh, Rajneesh, Shashi Bhushan Chauhan, Shyam Sundar, Susanne Nylén, Christian Engwerda, Rajiv Kumar

“…CD4+ T helper (Th) cells orchestrate immune responses in leishmaniasis and IFNγ+ Tbet+ CD4+ T (Th1) cells are required for the activation of phagocytes to kill captured or resident parasites, while other Th cell subset, including FoxP3+ natural regulatory T cells and Th2 cells can promote disease progression by suppressing the activities of Th1 cells. …”
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Enhanced recovery after surgery society’s recommendations for liver surgery reduces non surgical complications by Robert Oehring, Eriselda Keshi, Karl-Herbert Hillebrandt, Pia F. Koch, Matthäus Felsenstein, Simon Moosburner, Wenzel Schöning, Nathanael Raschzok, Johann Pratschke, Jens Neudecker, Felix Krenzien

“…The effect of the ERAS program progressively improved over the years, highlighting the need for continuous effort to maintain and further enhance outcomes.…”
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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms by Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova

“…Conclusions Our findings demonstrate the parallel dysregulation of TEs and piRNAs in HR-MDS patients, highlighting their potential role in MDS progression and indicating that the PIWIL2 level is a promising molecular marker for prognosis. …”
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Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection by Citlali Vázquez, Rusely Encalada, Isabel Jiménez-Galicia, Rogelio Gómez-Escobedo, Gildardo Rivera, Benjamín Nogueda-Torres, Emma Saavedra

“…<b>Results:</b> The antidiabetic drugs in monotherapy showed antiparasitic effects in preventing infection progression (trypomastigotes release), with an IC₅₀ of 8.4–14.3 µM in comparison to that of BNZ (0.26 µM) in vitro. …”
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Multinational retrospective analysis of bridging therapy prior to chimeric antigen receptor t cells for relapsed/refractory acute lymphoblastic leukemia in children and young adult... by Maike Breidenbach, Peter Bader, Andishe Attarbaschi, Claudia Rossig, Roland Meisel, Markus Metzler, Marion Subklewe, Fabian Mueller, Paul-Gerhardt Schlegel, Irene Teichert von Lüttichau, Jean-Pierre Bourquin, Gabriele Escherich, Gunnar Cario, Peter Lang, Ramona Coffey, Arend von Stackelberg, Semjon Willier, Brigitte Strahm, Christina Peters, Tobias Feuchtinger

“…In conclusion, in this retrospective cohort, high-intensity bridging therapy has not improved the outcome in terms of overall and progression-free survival in comparison to a low-intensity therapy. …”
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FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A‐Demethylation of PIK3R3 mRNA by Bingxin Chen, Liming Wang, Xiaomin Li, Ci Ren, Chun Gao, Wencheng Ding, Hui Wang

“…N6‐methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity‐associated gene (FTO) works as the m6A demethylase. …”
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Composites in high-pressure hydrogen storage: A review of multiscale characterization and mechanical behavior by Imen Feki, Mohammadali Shirinbayan, Samia Nouira, Robert Tie Bi, Jean-Baptiste Maeso, Cedric Thomas, Joseph Fitoussi

“…Key failure mechanisms, such as matrix cracking, fiber breakage, and delamination, are explored to elucidate their progressive development and impact on the structural integrity of composites. …”
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Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle by Fang-Hui Li, Yan-Ying Liu, Fei Qin, Qing Luo, Hai-Ping Yang, Quan-Guang Zhang, Timon Cheng-Yi Liu

“…This indicates that LLLI has potential to decrease progression of myocyte apoptosis in sarcopenic muscles.…”
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In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosom... by Khyber Shinwari, Mikhail A. Bolkov, Muhammad Yasir Akbar, Liu Guojun, Svetlana S. Deryabina, Irina A. Tuzankina, Valery. A. Chereshnev

“…This research sheds light on how ELANE failure upon mutation results in disease progression, including congenital neutropenia, and validation of these novel predicted nsSNPs is required through the wet lab.…”
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