Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies by Antonia Reale, Assunta Melaccio, Aurelia Lamanuzzi, Ilaria Saltarella, Franco Dammacco, Angelo Vacca, Roberto Ria

“…EPCs are recruited from the bone marrow under the stimulation of growth factors and cytokines and reach the sites of neovascularization in both physiological and pathological conditions such as malignancies where they contribute to the “angiogenic switch” and tumor progression. An implementation of circulating EPCs in the bloodstream of patients with haematological malignancies has been demonstrated. …”
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Progressive loss of upper limb function as a presenting feature of glenohumoral metastasis from a primary tongue malignancy by Adarsh Kudva, Vasantha Dhara, Asmita Unadkat

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Recent Progress in the Identification of the X-Linked Infantile Spinal Muscular Atrophy (Xl-SMA) Gene: Implications for Neuronal Apoptosis by L. L. Baumbach, D. Dressman, H. Basterrechea, M. E. Ahearn, N. T. Bech-Hansen, R. D. Clark, A. Meind, E. Hoffman

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Recent Progress on the Description of Relativistic Spin: Vector Model of Spinning Particle and Rotating Body with Gravimagnetic Moment in General Relativity by Alexei A. Deriglazov, Walberto Guzmán Ramírez

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Association between chronic diseases and severe periodontal disease progression: A retrospective cohort study in a city of Japan by Sayaka Nin, Yu Sun, Takami Maeno, Chihiro Nishiura, Kento Taira, Kenji Fujimoto, Jun Hamano, Sachiko Ozone, Tetsuhiro Maeno

“…Abstract Background Chronic periodontal disease primarily causes tooth loss and oral frailty and is linked to chronic conditions such as diabetes mellitus. However, its progression and broader studies on chronic diseases have not been well explored. …”
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Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era by Ayotola Fatola, Michael D. Evans, Jenna Brown, Elizabeth Davis, Andrew Johnson, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Susan Eubanks, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Ming Y. Lim, Nicole K. Kocher, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Marshall Mazepa, Shruti Chaturvedi

“…In the prospective cohort, overall RFS progressively shortened after each episode of rituximab treatment with the first episode having the longest RFS (2.8 years; interquartile range, 2.0-6.0) and this loss of response durability was most pronounced in Black patients. …”
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Three-Dimensional Assessment of Dental Enamel Microcrack Progression After Orthodontic Bracket Debonding Using Optical Coherence Tomography by Ahmed Haj Hamdan, Sm Abu Saleah, Daewoon Seong, Naresh Kumar Ravichandran, Ruchire Eranga Wijesinghe, Sangyeob Han, Jeehyun Kim, Mansik Jeon, Hyo-Sang Park

“…The current study aimed to quantify the length progression of enamel microcracks (EMCs) after debonding metal and ceramic brackets, implementing OCT as a diagnostic tool. …”
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Clustering Large-Scale Biomedical Data to Model Dynamic Accumulation Processes in Disease Progression and Anti-Microbial Resistance Evolution by Kazeem A. Dauda, Olav N. L. Aga, Iain G. Johnston

“…We demonstrate this ‘Cluster-based HyperHMM’ (CHyperHMM) pipeline for synthetic data, clinical data on disease progression in severe malaria, and genomic data for anti-microbial resistance evolution in Klebsiella pneumoniae, reflecting two global health threats.…”
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The N1‐methyladenosine methyltransferase TRMT61A promotes bladder cancer progression and is targetable by small molecule compounds by Jianjian Yin, Xin Fan, Qi Chang, Yuanheng Dai, Tao Wang, Lei Shi, Linlin Yang, Xiaoming Yang, Xudong Zhang, Lei Jin, Tao Liu, Fengmin Shao, Lirong Zhang, Dongkui Song

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IUCrJ on passing its tenth anniversary and entering its second decade: progress, current status and prospects for the future by Andrew. J. Allen

“…This Editorial briefly celebrates the history and progress of IUCrJ in its first decade, reviews its present status, and suggests some pointers for the future.…”
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Myeloid cell-derived apCAFs promote HNSCC progression by regulating proportion of CD4+ and CD8+ T cells by Feilong Ren, Lin Meng, Shize Zheng, Jiasen Cui, Shaoyi Song, Xing Li, Dandan Wang, Xing Li, Qilin Liu, Wenhuan Bu, Hongchen Sun

“…In vivo experiments have demonstrated that apCAFs could facilitate tumor progression. Furthermore, apCAFs could modulate ratio of CD4+ T cells/CD8+ T cells, such as higher ratio of CD4+ T cells/CD8+ T cells could promote tumor progression. …”
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Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States by Zanthia Wiley, Sujan Reddy, Kara M. Jacobs Slifka, David C. Brandon, John Jernigan, Gilbert J. Kersh, Paige A. Armstrong

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Stimulative Effects of Low Intensity He-Ne Laser Irradiation on the Proliferative Potential and Cell-Cycle Progression of Myoblasts in Culture by Cui-Ping Zhang, Shao-Dan Li, Yan Chen, Yan-Ming Jiang, Peng Chen, Chang-Zhen Wang, Xiao-Bing Fu, Hong-Xiang Kang, Ben-Jian Shen, Jie Liang

“…The aim of the present study was to study the effect of LILI on the growth potential and cell-cycle progression of the cultured myoblasts. Primary myoblasts isolated from rat hind legs were cultured in nutrient-deficient medium for 36 hours and then irradiated by helium-neon laser at a certain energy density. …”
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State of the art progress of Evolvulus alsinoides in pharmacological activity and plant tissue culture: A potent Chinese medicinal plant by Collince Omondi Awere, Valentine Chikaodili Anadebe, Rakkammal Kasinathan, Pandiyan Muthuramalingam, Ramesh Manikandan

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Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…Objective: This article aims to study the effect of phosphate and tension homolog deleted on chromosome ten (PTEN) knockdown on colon cancer progression and macrophage polarization in the cancer environment. …”
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Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma by Pengxiang Gao, Qiuping Liu, Ziye Luo, Wenjun Pu, Wenjun Pu

“…Identifying critical biomarkers and molecular targets is needed for early diagnosis, prognosis, and therapy of these diseases.MethodsIn this study, we explored the gene expression and metabolism in the liver tissues of LC, HCC, and healthy controls, to analyse and identify potential biomarkers of disease progression. Mass spectrometry imaging was used to evaluate the spatial distribution of key metabolites.Results and discussionThe results revealed significant changes in gene expression and metabolic pathways along with disease progression. …”
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Estimation for Akshaya Failure Model with Competing Risks under Progressive Censoring Scheme with Analyzing of Thymic Lymphoma of Mice Application by Tahani A. Abushal, Jitendra Kumar, Abdisalam Hassan Muse, Ahlam H. Tolba

“…Since the cause of failure may be dependent or independent, in this work, we discuss the competing risk lifetime model under progressive type-II censored where the removal follows a binomial distribution. …”
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Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma by Zhengyan Li, Wei Chen, Shu Yao, Zuxiang Peng, Hongming Liu, Yongliang Tang, Yi Feng

“…However, mitophagy did not seem to affect the effectiveness of immunotherapy.ConclusionThis study provides evidence that mitophagy within the HCC TME modulates intercellular communication, influencing tumor progression and patient prognosis. Targeting mitophagy may offer a promising approach to improve the long-term prognosis of HCC patients.…”
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Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: the need for rigor by Joshua D. Grill, Daniel Gillen

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NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression by Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang

“…Mechanistically, NPC1 significantly promotes HCC progression by modulating the TGF-β pathway, independent of its traditional role in cholesterol transport. …”
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