The value of fixed segment mobility in posterior dynamic stabilization: a single-center retrospective study by Yulu Sun, Jianbin Guan, Hao Chen, Xiaojie Sun, Kaitan Yang, Qing Fang

“…Conclusion Compared to the first-generation, less mobile Isobar TTL, the second-generation, more mobile Isobar EVO offers superior preservation of the surgical segment and slows the progression of degeneration in the upper adjacent segments. …”
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Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration by Daxue Zhu, Zhaoheng Wang, Shijie Chen, Yanhu Li, Xuewen Kang

“…Chemical screening identified Glucosyringic acid (GA) as a direct inhibitor of POSTN, which delayed IDD progression. Conclusion The study elucidates the pivotal role of POSTN in mediating NP cell pyroptosis through the NLRP3 inflammasome and highlights GA as a promising therapeutic candidate for IDD. …”
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Characteristics and Clinical Course of Patients with Acute Myocardial Infarction and ST-segment Elevation with and without Interatrial Block by Francisco de Jesús Valladares Carvajal, Verónica Mercedes Carretero Acosta, Raimundo Carmona Puerta, Aymara Marcia Hernández Cardoso, Ernesto Julio Bernal Valladares

“…<br /><strong>Methods:</strong> a descriptive and correlational study was carried out in progressive care units of the Dr. Gustavo Aldereguía Lima University General Hospital in Cienfuegos. 169 subjects with a diagnosis of ST-segment elevation myocardial infarction divided into two groups with and without interatrial block were selected. …”
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Sky High or Grounded: Nest Site Selection of Herons and Egrets in a Mixed‐Species Colony by Farrah Samraoui, Riad Nedjah, Abdennour Boucheker, Hamed A. El‐Serehy, Boudjéma Samraoui

“…Both vertical and horizontal stratification were observed, with nests progressively moving higher and further from the tree trunk as the breeding season advanced. …”
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Prevalence of gentle herpes simplex type 2 in Babylon province for last 3 years: A retrospective descriptive data analysis by Ammar Abbas Shalan, Nada Khazal K. Hindi, Mohammed Malih Radhi, Zainab Adil Ghani Chabuck

“…The findings further illuminated a progressive rise in mild herpes prevalence with advancing age. …”
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Instability Mode and Control Technology of Surrounding Rock in Composite Roof Coal Roadway under Multiple Dynamic Pressure Disturbances by Peng Wang, Nong Zhang, Jiaguang Kan, Xingliang Xu, Guangzhen Cui

“…The geological conditions of gas control roadway in the 22301 working face of Tunlan coal mine are taken as examples, and this study is carried out based on the analysis of roof instability conditions of composite roof coal roadway. The progressive crack development characteristics in composite roof coal roadway and the instability failure mode of surrounding rock under multiple dynamic pressure disturbances were revealed, and the control mechanism and support scheme were put forward. …”
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Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas. by Mengqing Mo, Can Hou, Huangbo Yuan, Renjia Zhao, Mingyang Chen, Yanfeng Jiang, Kelin Xu, Tiejun Zhang, Xingdong Chen, Chen Suo

“…We identified six novel index SNPs in the progression of SCCs, which were also strongly interacted with fresh fruit intake. …”
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DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model by Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher

“…Insulin desensitization has been observed in the brains of patients with Parkinson’s disease (PD), which is a progressive neurodegenerative disorder for which there is no cure. …”
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Mechanism of Radix Bupleuri and Hedysarum Multijugum Maxim drug pairs on liver fibrosis based on network pharmacology, bioinformatics and molecular dynamics simulation. by Lefei Yu, Pan Yu, Yongchang Cao, Weiya Cao

“…In conclusion, RB-HMM drug pairs can affect the progression of liver fibrosis through multiple components, multiple targets and multiple pathways, and treat liver fibrosis possibly through anti-inflammatory and affecting cell apoptosis.…”
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Development and validation of a tool for advising primiparous women during early labour: study protocol for the GebStart Study by Mechthild M Gross, Susanne Grylka-Baeschlin, Antonia N Mueller, Jessica Pehlke-Milde

“…However, primiparous women often contact the hospital before labour progresses because they encounter difficulties coping with symptoms of onset of labour on their own. …”
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In the mirror of transitology: The politics of power alternation in the Caucasus and Central Asia by S. A. Pritchin

“…According to the paradigm of transitology, the political development of a state since the departure from the authoritarian regime entails progressive liberalization and democratization of political processes. …”
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A Cost-effectiveness Analysis of Brentuximab Vedotin in Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma by Margaret Hux, Denise Zou, Esprit Ma, Peter Sajosi, Andreas Engstrom, Ross Selby, Eugene Benson, Andrew Briggs, Vijayveer Bonthapally

“…**Results:** Based on statistical extrapolation, brentuximab vedotin was associated with 3.1 years longer duration in the progression-free survival health state and an overall survival improvement of 5.4 years, prior to discounting. …”
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CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53 by Hongqiang Gao, Ran Xie, Rong Huang, Chonglin Wang, Yue Wang, Dongdong Wang, Kaimin Liu, Conghui Yang, Qingxiong Yang, Long Chen

“…Pancreatic cancer is one of the most malignant gastrointestinal tumors, and it is of great significance to explore the molecular mechanism of its progression and find new biological therapeutic targets. …”
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Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain.Future plans By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. …”
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Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution by Xuan Yu, Yongfu Shao, Haotian Dong, Jianing Yan, Xinjun Zhang, Guoliang Ye

“…GPX3, PLAT, and CAV1 were identified as key prognostic genes related to apoptosis in GC, with a focus on their impact on disease progression-related pathways. Furthermore, PCR assays validated that these three key genes exhibited significantly low expression levels in both GC cell lines and tissues. …”
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MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer by Xiaoyu He, Fu Gan, Yongjian Lin, Guoqing Liu, Yunhua Lin, Dongxu Chen

“…Accumulating studies have shown that the initiating and progressing multiple human diseases were closely related to the expression of MAIP. …”
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Correlation between Post-Thaw Spermatozoa Quality of the Endangered Javan Banteng with OPN Gene Expression by Vincentia Trisna Yoelinda, Raden Iis Arifiantini, Dedy Duryadi Solihin, Muhammad Agil, Dedi Rahmat Setiadi, Tulus Maulana, Bambang Purwantara, Yohana Tri Hastuti, Jansen Manansang, Dondin Sajuthi

“…The OPN gene showed positive correlations with the progressive motility (r = 0.711, p = 0.048), viability (r = 0.822, p = 0.012), and acrosomal integrity (r = 0.665, p = 0.072) of Javan banteng spermatozoa after thawing. …”
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Stability Analysis of Slopes Under Seismic Action with Asynchronous Discounting of Strength Parameters by Ruipeng Wang, Hongye Yan, Junkai Yao, Zhuqing Li

“…By establishing a homogeneous slope model and comparing and analyzing the progressive instability failure modes of slopes under static and seismic conditions, the stability and potential slip surface differences of slopes under two different working conditions are explored. …”
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Analysis of MicroRNA -155-5p Expression in Patients with Primary Myelofibrosis. by Sarah I. Khaleel, Jaffar N. AlAlsaidissa

“…This results in extramedullary hematopoiesis, variable blood cell deficiencies, hepatosplenomegaly, general symptoms, progression to leukemia, and a reduced lifespan. Myelofibrosis can occur as a de novo myeloproliferative neoplastic disorder or evolve from other myeloproliferative neoplasms, including Polycythemia Vera or Essential Thrombocytosis. …”
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Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients by Zhaoyue Yan, Yushuai Gao, Jinliang Yu, Zhiyuan Shen, Xingyao Bu

“…As a hallmark of cancers, inflammatory responses are crucial for their progression. The present study is aimed at exploring the prognostic value of inflammatory response-related genes (IRRGs) and constructing a prognostic IRRG signature for gliomas. …”
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