Blood-based biomarkers in patients with non-small cell lung cancer treated with immune checkpoint blockade by Yo-Ting Tsai, Jeffrey Schlom, Renee N. Donahue

“…These investigations have unveiled compelling correlations between the peripheral immune status of patients both before and during ICI therapy and patient outcomes, which include response rates, progression-free survival, and overall survival. There is need for rigorous validation and standardization of these blood-based assays for broader clinical application. …”
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Eco-biofabrication of silver nanoparticles from Azadirachta indica, Gymnema sylvestre, and Moringa oleifera for lung cancer treatment by Tanya Muthu, Ravi Adusumalli, Sathish Kumar Vemuri, M. Indira Devi, P. Pavan Kumar, Rajkiran Reddy Banala, A. V. Gurava Reddy

“…Gene expression analysis revealed significant downregulation of VEGF and CYCLIN-D1, suggesting inhibitory effects on angiogenesis and cell cycle progression. The synthesized AgNPs exhibited potent cytotoxic activity against A549 cells, with enhanced efficacy compared to the leaf extracts alone. …”
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SOX-9 as a prognostic marker in gastric adenocarcinoma by Efe Yetişgin, Aysun Gökçe, Kutsal Doğan

“…These findings suggest that SOX9 staining intensity and expression are associated with increased tumor malignancy and disease progression. Therefore, SOX9 may serve as a prognostic pathological indicator in GC patients. …”
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Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review by Ren Y, Chen G, Hong Y, Wang Q, Lan B, Huang Z

“…This review summarizes the functional role of the gut microbiota in the development and progression of CIRI and the therapeutic effects of TCM on CIRI by improving gut microbiota dysbiosis, affecting gut microbiota metabolism, and maintaining host immunity. …”
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Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study by Monika M, Rudhra K, Vennila K, Elanchezhiyan, Sri Harini P, S. Shakeron

“…Background and objective: Periodontitis and dental caries are among the most prevalent oral diseases, with chronic periodontitis being a multifactorial, infectious condition that leads to inflammation in the supporting structures of the teeth, progressive attachment loss, and bone resorption. Chronic periodontitis is driven by a consortium of pathogenic microorganisms. …”
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MUC5B regulates alterations in the immune microenvironment in nasopharyngeal carcinoma via the Wnt/β-catenin signaling pathway by Hongming Wang

“…Conclusions Mucin 5B, oligomeric mucus/gel-forming regulates the immune escape of nasopharyngeal carcinoma cells and participates in tumor progression by mediating the Wnt/β-catenin signaling pathway.…”
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Potential for eliminating COVID-19 in Thailand through third-dose vaccination: A modeling approach by Pannathon Kreabkhontho, Watchara Teparos, Thitiya Theparod

“…The model incorporates key epidemiological parameters, vaccination rates, and disease progression stages to assess the effectiveness of different vaccination strategies in curbing disease transmission. …”
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Acoustic Emission and Failure Modes for Coal-Rock Structure under Different Loading Rates by Ning Wang, Yingqian Xu, Dengyuan Zhu, Nan Wang, Benfu Yu

“…According to the damage characteristics and AE parameters for combined samples, an brittle model for coal-rock structure with mutation characteristics was proposed, and three basic failure modes for the combined structure with the increase of loading rate were progressive shear failure, splitting failure, and structural failure, respectively.…”
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Molecular genetics of idiopathic pulmonary fibrosis by R. N. Mustafin

“…Idiopathic pulmonary fibrosis (IPF) is a severe progressive interstitial lung disease with a prevalence of 2 to 29 per 100,000 of the world’s population. …”
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Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping by Shansong Huang, Huiying Wang, Jiaqing Cao, Qiang Pang

“…Abstract Hypoxia and lipid metabolism play crucial roles in the progression of colorectal cancer (CRC). However, the specific functions of hypoxia- and lipid metabolism-related genes (HLPG) in CRC and their relationships with patient prognosis remain unclear. …”
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Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations by Maria Del Valle Estopinal, Lavinia P. Middleton, Bita Esmaeli, Keyur P. Patel, Sara Nowroozizadeh, Michelle D. Williams

“…Mutations in CDH1, PIK3CA, and TP53 genes could induce E-cadherin dysfunction which takes part in the development and progression of this malignancy.…”
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Successful Antiviral Treatment with Direct-Acting Antivirals for Hepatitis C Virus Infection during Peritransplant Period in a Kidney Transplant Recipient by Giovanni Varotti, Ferdinando Dodi, Ernesto Paoletti, Andrea Bruno, Iris Fontana

“…After a transient delay graft function, creatinine levels progressively decreased. From postoperative day 3, tacrolimus reached target levels and remained stable. …”
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PREDISPOSITION FACTORS ANALYSIS FOR FOURNIER'S GANGRENE DEFECTS CLOSURE COMPLICATION by Bayu Fasi Bermani, Sitti Rizaliyana, Ira Handriani

“…Abstract: Introduction:  Fournier's gangrene is a rare and rapidly progressive, necrotizing fasciitis affecting the external genitalia and perineum. …”
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A novel bladder cancer surveillance schedule using bladder Cx for patients on annual surveillance by Arjun Guduguntla, Thomas Whish‐Wilson, Lauren Chandler, Dennis Gyomber

“…All of the tumour recurrences diagnosed after a negative CxM were non‐invasive, thus there was no progression to muscle‐invasive disease. All suitable patients consented to continuing with the CxM protocol. …”
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Histological changes in clıick bursa fabricii during postembryonic period by Nazlı Kocaöz, İlhami Çelik, Sadettin Ünsal

“…The early histological evidence ot involution such as intraepithelial and intralobular cysts were first observed in 12 th week ot posthatching period. As the age progressed, the cysts enlarged and int raf olive ular cysts occupied medullae ot the follicles. …”
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Neutrophil to Lymphocyte Ratio as a Predictive Factor in Iraqi Patients with Thyroid Cancer by Fatima Falah Hassan, Wafaa Fadhil Hamed, Luma Yousif Mehdi

“…It has been shown that there is an association between some biomarkers and the progression of thyroid cancer. In this study, we aim to assess the Neutrophil to Lymphocyte Ratio (NLR) levels and Thyroid function test (TSH, T3, T4) in patients with thyroid cancer. …”
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MOG associated autoimmune encephalomyelitis with active disease dynamic in imaging examinations and minimal clinical manifestation by E. Tilindytė, I. Muliuolis, R. Samaitienė

“…Most often, the disease first manifests as acute disseminated encephalomyelitis, less often as optic neuritis. Progressive encephalopathy and multiple focal neurological symptoms are characteristic to this disease: irritability, disturbed consciousness, weakness, sensory disorders, bowel, bladder dysfunction, spasticity, hyperreflexia, positive Babinsky reflex, paresis, cerebral ataxia, cerebral neuropathy, and spinal cord dysfunction (transverse myelitis). …”
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Survival Outcomes of a Large Cohort of Acral Melanoma Patients Treated at a South African Referral Hospital by Bianca Tod, Tonya Esterhuizen, Willem Visser, Maritha Kotze, Anne Bowcock, Johann Schneider, Henriette Burger

“…The main outcomes of interest were survival time in months (overall and progression-free, OS and PFS). Survival outcomes were analyzed using Kaplan–Meier survival curves. …”
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Correlation of physicochemical properties with antioxidant activity in phenol and thiophenol analogues by R. Bernadett Vlocskó, Maxim Mastyugin, Béla Török, Marianna Török

“…Abstract Oxidative stress, associated with excessive production of reactive oxygen and nitrogen species (ROS, RNS), contributes to the development and progression of many ailments, such as aging, cardiovascular diseases, Alzheimer’s disease, Parkinson’s disease, diabetes, cancer, preeclampsia or multiple sclerosis. …”
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Tyrosine phosphatase SHP2 accelerated ovarian cancer via modulating integrin/ E-Cadherin/ ZEB1 induced EMT by Xiaofei Li, Haibo Zhang, Jianan Dong, Juan Wang

“…Detection of expression of p-SHP2, ZEB1, E-Cadherin, α3-integrin, p-Src, p-SMAD2, Snail, Slug and SKOV3 cells of migration and invasion abilities were detected using Western blot method and cell scratch assay and Transwell assay; Progression of ovarian cancer was detected using subcutaneous tumor transplantation assay in nude mice and HE staining method and immunocyto. …”
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