Increased Circulating Chemerin in Relation to Chronic Microvascular Complications in Patients with Type 2 Diabetes by Ping Gu, Wei Wang, Yue Yao, Yixin Xu, Liping Wang, Pu Zang, Jian Ma, Cuihua Yang, Junya Liang, Bin Lu, Jiaqing Shao

“…Furthermore, the chemerin plasma concentrations increased with the progression of diabetic nephropathy with highest values in macroalbuminuria groups. …”
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Sigma-1 Receptor Modulates CFA-Induced Inflammatory Pain via Sodium Channels in Small DRG Neurons by Yuanlong Song, Zifen Xu, Liangpin Zhang, Linlin Gao

“…Our results revealed several key findings: (1) The expression of Sig-1R was found to be upregulated during the progression of inflammatory pain, with a notable translocation from the cytoplasm to the membrane; (2) Inhibition of peripheral Sig-1R using S1RA resulted in a reduction of CFA-induced allodynia; (3) Activation of Sig-1R through PRE-084 led to a decrease in the fast sodium current in isolated DRG neurons from CFA-treated rats, which was associated with a diminished action potential (AP) peak and maximum depolarizing rate (MDR), as well as an increased rheobase; (4) Furthermore, PRE-084 was observed to enhance the slow component of the sodium current, resulting in hyperpolarization of the threshold potential and an increase in AP firing frequency, alongside an elevation in the mRNA expression of the slow sodium channel Nav1.9 in CFA-treated rats. …”
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Bacterial community assembly of specific pathogen-free neonatal mice by Elizabeth A. Kennedy, James S. Weagley, Andrew H. Kim, Avan Antia, Anna L. DeVeaux, Megan T. Baldridge

“…Microbial community composition has been shown to impact disease progression in these models. Despite this, the maturation of the early-life murine microbiome has not been well-characterized. …”
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Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines... by Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…Pancreatic cancer is one of the most lethal malignancies with an increasing incidence and a high mortality rate, due to its rapid progression, invasiveness, and resistance to anticancer therapies. …”
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Epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England by Pablo N. Perez-Guzman, Edward Knock, Natsuko Imai, Thomas Rawson, Cosmo Nazzareno Santoni, Joana Alcada, Lilith K. Whittles, Divya Thekke Kanapram, Raphael Sonabend, Katy A. M. Gaythorpe, Wes Hinsley, Richard G. FitzJohn, Erik Volz, Robert Verity, Neil M. Ferguson, Anne Cori, Marc Baguelin

“…Abstract As the SARS-CoV-2 pandemic progressed, distinct variants emerged and dominated in England. …”
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PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…Conclusion Our study unveils the oncogenic role of PTOV1 in CRC progression, which was achieved by promoting SQSTM1 directed autophagic degradation of p53. …”
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Advancements and trends in mangrove species mapping based on remote sensing: A comprehensive review and knowledge visualization by Yuqi Wu, Chunyan Lu, Kexin Wu, Wenna Gao, Nuocheng Yang, Jingwen Lin

“…Classification algorithm development has evolved four stages, from pixel-based methods to object-oriented approaches, progressing to approaches incorporating machine learning algorithms, and currently advancing towards ensemble learning and deep learning. …”
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Prevalence and clinical impact of disseminated intravascular coagulation in acute aortic dissection: a nationwide cohort study by Shuhei Murao, Yutaka Umemura, Hirotaka Mori, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Satoshi Fujimi, Kazuma Yamakawa

“…Increased DIC scores correlated with higher in-hospital mortality. With the progression of coagulopathy, characterized by thrombocytopenia, elevated prothrombin time-international normalized ratio, prolonged activated partial thromboplastin time, increased D-dimer, and decreased fibrinogen levels, in-hospital mortality also increased. …”
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Numerical Simulation and Optimization of Outdoor Wind Environment in High-Rise Buildings Zone of Xuzhou City by Huanhuan Fang, Xiang Ji, Jiuxin Wang, Jijun Lu, Mengcheng Yang, Jiajun Li, Zhongcheng Duan

“…The study comprehensively examines the effects of building height, width, orientation, spacing, and layout on the outdoor wind field, progressing from individual building units to clusters. …”
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Inhibiting METTLl3-ATG5 axis-mediated harmful autophagy in macrophages could help reduce airway epithelial inflammation and remodeling in COPD by Chen Guiyang, Xia Zhiwei, Zeng Xianyou, Liu Hanying

“…We investigated the role and underlying mechanisms of methyltransferase-like 3 (METTL3) and autophagy-related protein 5 (ATG5) in the progression of COPD. In a COPD mouse model exposed to cigarette smoke, lung tissues showed increased levels of METTL3, p-p65/ p65, autophagy markers (LC3 and ATG5), inflammatory factors (interleukin-6, IL-8, and TNF-α), and airway remodeling markers (N-cadherin, α-SMA, and Tn-C), while p62 and E-cadherin levels were decreased. …”
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Determining the cultural safety of chronic disease interventions for Aboriginal and Torres Strait Islander Australians: a scoping review by Hannah Woodall, Hannah Woodall, Hannah Woodall, Sarah Larkins, Janani Pinidiyapathirage, Janani Pinidiyapathirage, Raelene Ward, Rebecca Evans

“…Searches included Scopus, Informit, OVID Medline, Emcare and CINAHL including all articles published until September 2023.ResultsSearches identified 2,225 articles. 1,854 articles underwent title and abstract screening, with 97 progressing to full text review. Twenty articles met the inclusion criteria. 75% (n = 15) of articles determined cultural safety based solely on Aboriginal and Torres Strait Islander peoples’ perspectives, with community acceptance as the most common means of determining cultural safety. …”
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Fibrous Dysplasia of the Ethmoid Bone Diagnosed in a 10-Year-Old Patient by Zofia Resler, Monika Morawska-Kochman, Katarzyna Resler, Tomasz Zatoński

“…Surgical intervention is recommended only for patients with severe functional impairment, progressive deformities, or malignant transformation.…”
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Expression of MMP1, MMP3, and TIMP1 in intervertebral discs under simulated overload and microgravity conditions by Xuanyu Chen, Zhangfu Li, Chao Zheng, Ji Wu, Yong Hai

“…MMP1 and MMP3 levels progressively increased with longer exposure durations, showing statistically significant differences (P < 0.01). …”
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High-Dose Toremifene as a Promising Candidate Therapy for Hormone Receptor-Positive Metastatic Breast Cancer with Secondary Resistance to Aromatase Inhibitors by Atsushi Fushimi, Isao Tabei, Azusa Fuke, Tomoyoshi Okamoto, Hiroshi Takeyama

“…The overall response rate (ORR) and clinical benefit rate (CBR) were compared between various clinical subgroups, including patients exhibiting primary or secondary AI resistance as defined by the timing of recurrence or progression. Time to treatment failure (TTF) was estimated by the Kaplan–Meier method and compared between subgroups by the log-rank test. …”
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Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma by Yun Ji, Yue Yin, Weizhen Zhang

“…., extracellular exosome) and signaling pathways that participate in the progression of HCC induced by HBV, serving comprehensive knowledge of the mechanisms regarding HBV-related HCC.…”
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The Impact of Care Upon Alzheimer Patient’s Family Caregiver in Sulaimani City by Farida Abdulqadir Tahir

“…Family Care giving for relatives with Alzheimer, often includes assisting them with one or more activities of daily living, as Alzheimer is one of the progressive impairment diseases in patient’s physical and cognitive ability. …”
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Influence of mode of delivery on infant gut microbiota composition: a pilot study by Li Yu, Yong Guo, Jie-Ling Wu

“…Further comprehensive studies that consider geographical locations are necessary to elucidate the progression of microbiota in infants born via different delivery modes.…”
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KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis by Yonghu Chen, Xilin Wu, Zhe Jiang, Xuezheng Li

“…BackgroundAcute lung injury (ALI) is a severe condition characterized by inflammation, tissue damage, and persistent activation of the cyclic GMP-AMP (cGAS)-stimulator of interferon genes (STING) pathway, which exacerbates the production of pro-inflammatory mediators and promotes the progression of ALI. Specific inhibition of this pathway has been shown to alleviate ALI symptoms. …”
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Climate variability can outweigh the influence of climate mean changes for extreme precipitation under global warming by K. Nordling, K. Nordling, N. L. S. Fahrenbach, B. H. Samset

“…<p>As global warming progresses, weather conditions like daily temperature and precipitation are changing due to changes in their means and distributions of day-to-day variability. …”
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Management of female para-urethral cyst with dyspareunia: a case report by Manoj Kumar Deepak, R. M. Meyyappan, T. Senthil Kumar, J. Saravanan

“…Case presentation We present the case of a 36-year-old, sexually active, Indian (Asian) woman with a 6-month history of progressively worsening lower urinary tract symptoms, consisting of dysuria, post-micturition dribble, increased urination frequency, and significant dyspareunia. …”
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