Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy by Yan Qin, Xiao-Jing Sun, Yi-Fang Hu, Meng Jing, Xiao-Juan Yu, Ming-Hui Zhao, Ying Tan

“…Following the confirmation of LPG diagnosis, treatment with angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) was initiated, and the disease progressed slowly.Conclusion LPG is histologically characterized by lamellated lipoprotein thrombi in glomeruli, and kidney biopsy is essential for diagnosis. …”
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Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function by Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang

“…Administration of IL-22Ab significantly reduced the progression of aGVHD in B6D2F1 recipients of B6 grafts. …”
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Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease by Ziyi Yuan, Zhaodi Huang, Chaojun Li, Shengrong Li, Qingguo Ren, Xiaona Xia, Qingjun Jiang, Daoqiang Zhang, Qi Zhu, Xiangshui Meng, Xiangshui Meng

“…Efficient automated diagnosis facilitates the early and accurate detection of MCI and timely intervention and treatment to delay or prevent disease progression.…”
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Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease by Wenhao Chen, Wanliang Yang, Bin Meng, Xingkun Wang, Heng Duan, Qian Xu, Hao Li

“…Conclusion The study suggested the potential roles of ferroptosis-related genes in IVDD and further revealed the role of PDK4 in the progression of IVDD.…”
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Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina by Ling-Dan Dong, Jie Chen, Fang Li, Feng Gao, Jihong Wu, Yanying Miao, Zhongfeng Wang

“…Moreover, expression of Cdk5, p35 and ratio of p-NR2AS1232/NR2A progressively increased with time in both strains, suggestive of activated Cdk5/p35 signaling pathway. …”
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Advancing the understanding of Naegleria fowleri: Global epidemiology, phylogenetic analysis, and strategies to combat a deadly pathogen by Awadh Alanazi, Sonia Younas, Hasan Ejaz, Muharib Alruwaili, Yasir Alruwaili, Bi Bi Zainab Mazhari, Muhammad Atif, Kashaf Junaid

“…The pathogen induces primary amoebic meningoencephalitis (PAM), a rapidly progressive and almost always fatal life-threatening brain infection. …”
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Constructing individualized follow-up strategies for locally advanced esophageal squamous cell carcinoma patients based on dynamic recurrence risk changes by Yibin Cai, Jianming Ding, XiaoJun Cai, Weikun Su, Guibin Weng, Xinlong Zheng, Shijie Chen, Lin Chen, YiJin Lin, Qiwei Yao, Chunkang Yang

“…Kaplan–Meier curves showed that conditional locoregional recurrence-free survival and distant metastasis-free survival of patients in different risk groups and clinical stages progressively increased with survival time, whereas local recurrence and distant metastasis annual recurrence rates decreased yearly with increasing survival time. …”
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Knockdown of hexokinase 2 results in a decreased expression level of the glycolytic enzymes PFKP, BPGM, and GPI in RKO cell line by M. S. Fedorova, I. Y. Karpova, A. V. Lipatova, E. A. Pudova, Z. G. Guvatova, D. V. Kochetkov, A. V. Chaika, B. Y. Alekseev, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva, A. V.  Snezhkina

“…The study of the key aspects of colorectal cancer formation and progression is necessary to develop new approaches to its therapy, as well as to search for new diagnostic, prognostic and predictive biomarkers of CRC. …”
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Pterostilbene protects against lipopolysaccharide-induced inflammation and blood–brain barrier disruption in immortalized brain endothelial cell lines in vitro by Yan Zhou, Yifan Yang, Rui Tian, Wai San Cheang

“…The disruption of BBB is associated with the progression of cerebral diseases. Pterostilbene is a natural compound found in blueberries and grapes with a wide range of biological activities, including anti-inflammatory, antioxidant, and anti-diabetic effects. …”
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Analysis of ADR reports of cetuximab based on the FDA adverse event reporting system database by Shuai Zhao, Yan Wang, Xiaoli Deng, Xi Chen, Zhaoyi Lu

“…Some AEs were not on the drug label: speech disorder, intervertebral discitis, glomerulonephritis rapidly progressive and disseminated intravascular coagulation. …”
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Association between Lipid Profiles and Serum Urate: A Cross-Sectional Study in Southwestern China by Jiying Qi, Xiaojuan Dai, Binbin Zhou, Yang Su, Zhen Xie, Dongmei Liu

“…After adjusting for confounders, the differences in serum urate progressively increased with raising serum triglycerides quartiles. …”
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Optimising subsurface integrity and surface quality in mild steel turning: A multi-objective approach to tool wear and machining parameters by Muhammad Imran, Suo Shuangfu, Bai Yuzhu, Wang Yuming, Naveed Raheel

“…Finally, this study employs Grey Relational Analysis (GRA), Data Environment Analysis Ranking (DEAR), and Multi-objective Optimization based on Ratio Analysis Method (MOORA) optimization techniques with S/N ratios to refine 3D surface roughness (Sa, Sz, Sq) and material removal rates (MRR) in mild steel turning using a CVD-coated carbide tool.Key findings reveal that increasing Vc reduces surface roughness and improves morphology, while higher f and ap deteriorate both. Tool wear progresses through three stages, with the poorest surface quality occurring in the final stage. …”
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Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

“…Recent developments in single-cell multi-omics technologies have provided the ability to identify diverse cell types and decipher key components of the tumor microenvironment (TME), leading to important advancements toward a much deeper understanding of how tumor microenvironment heterogeneity contributes to cancer progression and therapeutic resistance. These technologies are able to integrate data from molecular genomic, transcriptomic, proteomics, and metabolomics studies of cells at a single-cell resolution scale that give rise to the full cellular and molecular complexity in the TME. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. Phytoceuticals offer a promising alternative as they act on the many-sidedness of DN pathophysiology, multitargeting its intricacies. …”
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Multi-dimensional performance-based intelligent optimization of atrium building prototype with informed approach by Yiquan Zou, Yanyan Li, Han Chen, Benlin Xiao, Zhou Li

“…However, as the design process advanced, the potential to optimize building physical properties, space, and related performance gradually diminished, and the costs to achieve the same benefits were progressively increased. In this study, an enclosed atrium-style office space was chosen as a case study, and an intelligent optimization method for the atrium prototype space was proposed. …”
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Acute therapeutic effects and pathophysiology of eosinophilic granulomatosis with polyangiitis neuropathy by Fumitaka Shimizu, Mariko Oishi, Toshihiko Maeda, Yukio Takeshita, Hideaki Nishihara, Ryota Sato, Takashi Kanda, Masayuki Nakamori, Michiaki Koga, Miwako Fujisawa, Yuki Mizumoto, Nanami Yamanaka, Takashi Nawata, Tatsuya Okafuji, Susumu Fujikawa, Kinya Matsuo, Joe Nemoto, Masaya Honda

“…Intrafascicular oedema was found in 95% of all patients.Discussion Our results suggest three pathological pathways: (1) ischaemic peripheral nerve due to vasculitis mainly in ANCA-positive cases, (2) direct infiltration and degranulation of eosinophils in ANCA-negative cases and (3) progression of axonal ischaemia due to intrafascicular oedema in both cases. …”
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Multiangle Correlation Feature Extraction and Disease Prediction Model Construction for Patients With Post-Stroke Dysarthria by Ting Zhu, Shufei Duan, Huizhi Liang, Fujiang Li, Wei Zhang

“…The clinical diagnosis and treatment of motor dysarthria in post-stroke patients is often subjective and neglects the impact of psychological and emotional disorders on disease progression. This study aims to analyze the correlation among emotional expression, psychological state, facial expression, and dysarthria disease severity and is dedicated to the construction of a dysarthria prediction model. …”
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Impact of DLL3 Expression as Prognostic Factor in Extensive Stage of Small Cell Lung Cancer Treated With First‐Line Chemotherapy by Hohyung Nam, Soon‐Hee Jung, Jii Bum Lee, Jee Hyun Kong, Seungtaek Lim

“…In addition, tissue specimen should be available for immuno‐histochemical staining for DLL3, and their clinico‐pathologic data, including progression‐free survival (PFS) and overall survival (OS), were obtained. …”
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Development and validation of risk models to predict chronic kidney disease among people living with HIV: protocol for a systematic review by A P Kengne, Adesola Z Musa, Babatunde L Salako, Nasheeta Peer, Oluwatosin Olaseni Odubela, Nkiruka Odunukwe

“…A predictive model showing an individual’s risk of prevalent and/or progression to kidney failure is useful for initiating timely interventions that prevent further worsening of kidney function. …”
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Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway by Zilin Yu, Chunyang Fan, Yubo Mao, Xiexing Wu, Haiqing Mao

“…These findings suggest a potential therapeutic target for mitigating IVDD progression.…”
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