Progression-free survival as a surrogate endpoint in myeloma clinical trials: an evolving paradigm by Charlotte Pawlyn, Fredrik H. Schjesvold, David A. Cairns, L. J. Wei, Faith Davies, Omar Nadeem, Haifaa Abdulhaq, Maria-Victoria Mateos, Jacob Laubach, Katja Weisel, Heinz Ludwig, S. Vincent Rajkumar, Pieter Sonneveld, Graham Jackson, Gareth Morgan, Paul G. Richardson

“…Surrogate endpoints of OS, such as progression-free survival (PFS) and response to treatment, have contributed to approval decisions by the Food and Drug Administration (FDA) and European Medicines Agency as endpoints demonstrating clinical benefit, and the FDA has recently supported the use of minimal residual disease (MRD) as an accelerated approval endpoint in multiple myeloma. …”
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Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan by Urwah Rasheed, Minahil Khalid, Aneeqa Noor, Umar Saeed, Rizwan Uppal, Saima Zafar

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NIPAL1 as a prognostic biomarker associated with pancreatic adenocarcinoma progression and immune infiltration by Youlong Zhu, Zongze Qi, Shaoqi Zu, Fangchao Yang, Yanming Wang, Lei Zhu, Xintong Li, Ruixue Li, Hong Zhu

“…Recent genetic studies have revealed that the abnormal expression and functional dysregulation of various genes are involved in the occurrence and progression of pancreatic cancer. NIPA-like proteins (NIPAs) are expressed in a variety of cancer types, yet the role of NIPAL1 in cancer remains unclear. …”
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Dam-busting Flood Evolutionary Progression Mathematical Model Research and Application in Dajingshan Reservoir by YAO Zhijian, CHEN Wenlong

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Application Progress of Transcranial Direct Current Stimulation in Rehabilitation of Chronic Low Back Pain by SHI Jian, WAN Ruihan, WANG Yafei, GONG Chen, WANG Yuling

“…This article reviews the current domestic and international research progress of tDCS in CLBP rehabilitation in recent years and discusses the factors that affect its curative effect (e.g., stimulation target, frequency, and synergistic treatment scheme) and possibly effective treatment modes. …”
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Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome by Mimouni, Nour El Houda, Giacobini, Paolo

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Corrigendum: Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery by Fanda Meng, Xinyu Qiao, Chenglong Xin, Xiaoli Ju, Meilin He

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Small Interfering RNA Targeted to ASPP2 Promotes Progression of Experimental Proliferative Vitreoretinopathy by Xiao-Li Chen, Yu-Jing Bai, Qin-Rui Hu, Shan-Shan Li, Lv-Zhen Huang, Xiao-Xin Li

“…ASPP2 knockdown promoted EMT of ARPE-19 cells in vitro and exacerbated the progression of experimental PVR in vivo, possibly via inflammatory and fibrosis cytokines.…”
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A morphometric signature to identify ductal carcinoma in situ with a low risk of progression by Marcelo Sobral-Leite, Simon P. Castillo, Shiva Vonk, Hendrik A. Messal, Xenia Melillo, Noomie Lam, Brandi de Bruijn, Yeman B. Hagos, Myrna van den Bos, Joyce Sanders, Mathilde Almekinders, Lindy L. Visser, Emma J. Groen, Petra Kristel, Caner Ercan, Leyla Azarang, Jacco van Rheenen, E. Shelley Hwang, Yinyin Yuan, Grand Challenge PRECISION Consortium, Renee Menezes, Esther H. Lips, Jelle Wesseling

“…Abstract Ductal carcinoma in situ (DCIS) may progress to ipsilateral invasive breast cancer (iIBC), but often never will. …”
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Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism by Lijun Zhao, Haonan Qi, Weiting Liu, Huiying Lv, Peixian Li, Wenyue Liu, Ruili Sun, Qiongzi Wang, Xiangpeng Wang

“…In summary, our study validates PDHB as an oncogenic drug resistance-related gene capable of predicting HCC tumor progression. PDHB and Isoacteoside could be potential avenues for targeted and combination therapies in liver cancer.…”
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Role of alpha-fetoprotein in complex diagnostics of progressing course of chronic hepatitis B and C by I. A. Belavina, O. P. Dudanova

“…To determine the role of alpha-fetoprotein (AFP) in complex diagnostics of progressing course of chronic hepatitises B and C. Material and methods. …”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…This study investigates how the progression of acute systemic inflammatory disease influences NP corona compositions and the corresponding effects on innate immune cell interactions, phenotypes, and cytokine responses. …”
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The relationship between spiritual well-being and fear of cancer progression in Iranian cancer patients by Amir Hossein Goudarzian, Amir Hossein Goudarzian, Seyed Amirhossein Mazhari, Pooria Sobhanian, Bahar Farhadi, Soheyla Kalantari, Mozhgan Taebi

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David Cameron and the Web in the Run-up to the 2010 Election: A Parallel and Intricate Progression by Géraldine Castel

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Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression by Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin

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Focused Review: Insight and Updates on COVID-19 from Progress in Microbes and Molecular Biology by Angel Yun-Kuan Thye, Jodi Woan-Fei Law

“…Progress in Microbes and Molecular Biology…”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…We evaluated real-world treatment patterns and outcomes to investigate factors associated with post-progression survival (PPS). Methods: In this multicenter, international, retrospective study, we examined clinical characteristics and outcomes of patients with advanced HCC who progressed on first-line A/B. …”
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Recent progress in triboelectric platforms: engineering materials to industrial applications from the perspective of manufacturing by Yoonsang Ra, Minjun Song, Donghan Lee, Sunmin Jang, Yu-seop Kim, Joonmin Chae, Sumin Cho, Dongik Kam, Donghyun Lee, Gibeom Lee, Younghoon Lee, Dongwhi Choi

“…The use of a proper manufacturing process enables cutting-edge technology in a lab-scale stage to progress to commercialization and popularization with scalability, availability, commercial advantage, and consistent quality. …”
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Progress in Thin Film Solar Cells Based on Cu2ZnSnS4 by Hongxia Wang

“…Cu2ZnSnS4 (CZTS) semiconductor material has emerged as one of the most promising candidates for this aim and has attracted considerable interest recently. Significant progress in this relatively new research area has been achieved in the last three years. …”
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Corrigendum to “Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy” by Nwe Ni Than, Hannah C. Jeffery, Ye H. Oo

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