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  1. 781

    Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

    Published 2025-01-01
    “…<b>Methods</b>: In this study, we conducted a further examination of the transcriptomic expression profile of SPP1 (Osteopontin) during the progression of cancer in four human tissues, breast, prostate, renal and skin, in order to understand the circumstances conducive to its activation and dysregulation, the biological pathways and other mechanisms involved as well as differences in its splicing patterns influencing its expression and functionality. …”
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    Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy by Na Liu, Liuqing Xu, Yingfeng Shi, Shougang Zhuang

    Published 2017-01-01
    “…Recent studies suggest that activation of autophagy in podocytes may be a potential therapy to prevent the progression of DN. Here, we review the mechanisms of autophagy in podocytes and discuss the current studies about alleviating proteinuria via activating podocyte autophagy.…”
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  4. 784

    Survival and Disease Progression in Older Adult Patients With Cirrhosis: A Retrospective Study by Khaled Al-Smadi, Ammar Qureshi, Michelle Buitrago, Besher Ashouri, Zeid Kayali

    Published 2024-01-01
    “…A prospective study is needed to further investigate the effect of age and obesity on survival and disease progression in older adult patients with cirrhosis.…”
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  5. 785

    Global asymptotic properties of staged models with multiple progression pathways for infectious diseases by Andrey V. Melnik, Andrei Korobeinikov

    Published 2011-07-01
    “…We consider global asymptotic properties of compartment staged-progression models for infectious diseases with long infectious period, where there are multiple alternative disease progression pathways and branching. …”
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    Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

    Published 2025-02-01
    “…HIF-1α-mediated tumor hypoxia drives angiogenesis, immune suppression, and extracellular matrix remodeling, creating an environment that promotes tumor progression and resistance to immunotherapies. HIF-1α regulates critical pathways, including the expression of vascular endothelial growth factor and immune checkpoint upregulation, leading to tumor-infiltrating lymphocyte dysfunction and recruitment of immunosuppressive cells like regulatory T cells and myeloid-derived suppressor cells. …”
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    Steatohepatitis Is Not Associated with an Increased Risk for Fibrosis Progression in Nonalcoholic Fatty Liver Disease by Hannes Hagström, Olof Elfwén, Rolf Hultcrantz, Per Stål

    Published 2018-01-01
    “…Only NASH and not NAFL has been considered to increase the risk for fibrosis progression. The present study investigates risk factors for fibrosis progression in patients with NAFLD, and if fibrosis progression associates with subsequent mortality. …”
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    The Effect of Corneal Refractive Power Area Changes on Myopia Progression during Orthokeratology by Minfeng Chen, Xinting Liu, Zhu Xie, Pengqi Wang, Miaoran Zheng, Xinjie Mao

    Published 2022-01-01
    “…To investigate the effect of corneal refractive power area changes on myopia progression during orthokeratology. Methods. One hundred and sixteen children who met the inclusion criteria and insisted on wearing orthokeratology lenses for two years were retrospectively assessed. …”
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  13. 793
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    Using progress logs to research the information behaviour of higher education students in prison by Isabel Virgo

    Published 2024-06-01
    “…Development of the method. Progress logs are designed to capture individual-level qualitative data over a period of time, using prompts which build on previous prompts to generate rich data, allow opportunities for participant reflection and provide a narrative of progress. …”
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  15. 795

    Inferences for Generalized Pareto Distribution Based on Progressive First-Failure Censoring Scheme by Rashad M. El-Sagheer, Taghreed M. Jawa, Neveen Sayed-Ahmed

    Published 2021-01-01
    “…In this article, we consider estimation of the parameters of a generalized Pareto distribution and some lifetime indices such as those relating to reliability and hazard rate functions when the failure data are progressive first-failure censored. Both classical and Bayesian techniques are obtained. …”
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