Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

“…The trial is conducted with blinded outcome assessors and statistical analysts. 66 inactive older adults with hypertension aged 60–80 years without a history of major adverse cardiovascular events will be randomly assigned to one of the following groups: (1) HIIT (3 months; 3× week); (2) MICT (3 months; 3× week); (3) health education programme (control; 3 months; 1× week). Exercise training sessions involve rating of perceived exertion-based outdoor moderate walking, brisk walking and/or jogging. …”
Get full text

Key CT markers for predicting haemorrhagic transformation after ischaemic stroke: a prospective cohort study in China by Ming Liu, Qian Wu, Yanan Wang, Junfeng Liu, Chenchen Wei

“…The early hypodensity >1/3 of the middle cerebral artery (MCA) territory, Alberta Stroke Programme Early CT Score≤7, midline shift, hyperdense middle cerebral artery sign (HMCAS), poor collateral circulation, infarct core and penumbra was independently associated with the increased risk of HT (all p < 0.05). …”
Get full text

Variation in changes in the incidence of colorectal cancer by age and association with screening uptake: an observational study by Annie S Anderson, Callum G Fraser, Judith A Strachan, Robert JC Steele, Gavin RC Clark, Thomas G Godfrey

“…In addition, linkage between the Scottish Bowel Screening Database and the SCR allowed investigation of any association between screening participation and CRC incidence.Setting Scotland and the Scottish Bowel Screening Programme, in which guaiac faecal occult blood test screening was piloted from March 2000 and fully rolled by December 2009.Participants From the introduction of screening in 2000 through to 2017, 2 395 172 were invited to participate, of whom 1 487 999 participated at least once.Main outcome measures Incidence of CRC.Results In the screening age range (50–74 years), CRC incidence peaked at 156.5 cases per 100 000 in 2010 after full roll-out of screening across Scotland but fell to 123.9 per 100 000 in 2017. …”
Get full text

Mental health and working constraints of first-year PhD students in health and science in a French university: a cross-sectional study in the context of occupational health monitor... by Barbara Charbotel, Emmanuel Fort, Saloua Ahalli, Yamina Bridai, Nicole Baborier

“…It seems relevant to generalise the medical follow-up of all PhD students as soon as they enter the doctoral programme in order to detect and treat their health problems and psychological disorders at an early stage.…”
Get full text

Understanding the work-related challenges of organ and tissue donation coordinators during the COVID-19 pandemic: a mixed-method study by Sonny Dhanani, Ken Lotherington, Vanessa Silva e Silva, Amina Silva, Alessandra Minervini, Kendra-Lee Dupuis

“…Objectives This study aimed to explore the perceptions of donation coordinators in Canada and understand how the COVID-19 pandemic impacted their work activities.Design A sequential mixed-method design incorporating a cross-sectional survey investigating demographic data, substance use and abuse and perceived stress related to the pandemic and semistructured qualitative interviews to further investigate those.Setting Organ donation organisations across Canada.Participants Canadian organ and tissue donation coordinators working within deceased donation programmes. Participants were recruited using a purposive sampling technique for the survey and qualitative interviews. …”
Get full text

HISS: Snakemake-based workflows for performing SMRT-RenSeq assembly, AgRenSeq and dRenSeq for the discovery of novel plant disease resistance genes by Thomas M. Adams, Moray Smith, Yuhan Wang, Lynn H. Brown, Micha M. Bayer, Ingo Hein

“…Abstract Background In the ten years since the initial publication of the RenSeq protocol, the method has proved to be a powerful tool for studying disease resistance in plants and providing target genes for breeding programmes. Since the initial publication of the methodology, it has continued to be developed as new technologies have become available and the increased availability of computing power has made new bioinformatic approaches possible. …”
Get full text

Modern perspective of the Rice Diet for hypertension and other metabolic diseases by Anthony Kuo, Pao-Hwa Lin, Yi-Ju Li, Friedrich C Luft, David López, Romeo Sommerfeld, Paul Ermler, Jana Fehr, Benjamin Bergner, Scott Sanoff, Francis Neelon, William McDowell, Smilla Fox, Abdullatif Ghajar, Elena Gensch, Cedric Lorenz, Martin Preiss, Tom Richter, Philip Klemmer, Anastacia Bohannon, Christoph Lippert

“…Background In the early 1940s, before antihypertensive drugs were available, the Rice Diet Programme (RDP) was developed to treat severe hypertension and, later, diabetes and obesity. …”
Get full text

HIV/AIDS epidemic in India and predicting the impact of the national response: Mathematical modeling and analysis by Arni S. R. Srinivasa Rao, Kurien Thomas, Kurapati Sudhakar, Philip K. Maini

“…After two phases of AIDS control activities in India, the thirdphase of the National AIDS Control Programme (NACP III) was launchedin July 2007. Our focus here is to predict the number of peopleliving with HIV/AIDS (PLHA) in India so that the results can assistthe NACP III planning team to determine appropriate targets to beactivated during the project period (2007-2012). …”
Get full text

Knowledge, Attitudes, Motivations, Expectations, and Systemic Factors Regarding Antimicrobial Use Amongst Community Members Seeking Care at the Primary Healthcare Level: A Scoping... by Nishana Ramdas, Johanna C. Meyer, Natalie Schellack, Brian Godman, Eunice Turawa, Stephen M. Campbell

“…Data management and extraction were facilitated using the Covidence platform, with the Critical Appraisal Skills Programme (CASP) qualitative checklist applied for qualitative studies. …”
Get full text

Voices from the Amazon: exploring implementor and user perceptions of non-invasive malaria diagnostics in Peru by Lauren Nussbaum, Emma Ortega, E. Jennifer Ríos López, Alfonso Simoné Vizcarra, Jhonny J. Córdova López, Serafina Calarco, Elena Marbán-Castro, Kevin Tetteh, Sonjelle Shilton, Amy C. Morrison, Vanessa Fargnoli, Valerie A. Paz-Soldán

“…As manufacturers evaluate the efficacy and effectiveness of these non-invasive diagnostic tools, international recommendations should be created to ensure their agile integration into national malaria programmes.…”
Get full text

Mental health and substance use among rehabilitation sciences students during the COVID-19 pandemic by Itumeleng Ntatamala, Saajida Khan, Zenzo Chakara

“…A mental health diagnosis in the past 12 months was significantly associated with alcohol use (AOR [adjusted odds ratio] = 4.02, 1.06–15.23), prescription medication used to manage academic/social stress (AOR = 5.74, 1.68–19.69), COVID-19 diagnosis (AOR = 5.51, 1.60–18.92) and physiotherapy programme (AOR = 12.35, 1.21–126.44). Barriers to accessing mental health support included academic commitments (61.90%) and the lack of time to attend student wellness services (36.19%). …”
Get full text

Changes in household food security, access to health services and income in northern Lao PDR during the COVID-19 pandemic: a cross-sectional survey by Jennifer R Head, Phetsavanh Chanthavilay, Helen Catton, Ammaline Vongsitthi, Kelley Khamphouxay, Niphone Simphaly

“…Local food production and safety net programmes that offset income losses may help.…”
Get full text

Defining indicators for disease burden, health outcomes, policies and barriers and facilitators to health services for migrant populations in the Middle East and North African regi... by Charles Agyemang, Ali Ardalan, Farah Seedat, Bouchra Assarag, Nuria Casamitjana, Kolitha Wickramage, Sally Hargreaves, Ana Requena-Mendez, Fouad M Fouad, Dominik Zenner, Anna Deal, Stella Evangelidou, Wafa Saidi, Chiaki Ito, Oumnia Bouaddi, Moudrick Abdellatifi, Alba Cuxart-Graell, Hassan Edries, Eman Elafef, Taha Maatoug, Anissa Ouahchi, Liv Mathilde Pampiri, Sara Arias, Adel Abdelkhalek, Ahmed Hamed Arisha, Ibrahim Ahmed Bani, Aasmaa Chaoui, Wafa Chemao-Elfihri, Kenza Hassouni, Mahmoud Hilali, Mohamed Khalis, Wejdene Mansour, Ali Mtiraoui, MENA Migrant Health Working Group, Asad Adam, Adnene Ben Haj Aissa, Salma Altyib, Hanen Ben Belgacem, Imane Belkhammar, Thomas Calvot, Luciana Ceretti, Nelly Chavassieux, Hassan Chrifi, Mohamed Douagi, Algdail Elnil, Gonzalo Fanjul, Ahmed Hamed, Abdedayem Khelifi, Lora Makhlouf, Maissa Mokni, Davide Olchini, Tarik Oufkir, Nasong Park, Giuseppe Raffa, Sandra Santafé, Alice Sironi, Fatma Temimi, Zeineb Turki

“…Data are needed to support regional elimination and control targets for key diseases and the design and delivery of programmes to improve health outcomes in these groups. …”
Get full text

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol by Michael Doherty, Roshan das Nair, Ana Valdes, Reuben Ogollah, Paul Greenhaff, Bonnie Millar, Michelle Hall, Amy Fuller, Polykarpos Angelos Nomikos, David A Walsh, A Abhishek

“…The feasibility and acceptability of the intervention, and feasibility of undertaking a future cohort randomised controlled trial (RCT) will be explored.Methods and analysis In phase 1, we will develop a training programme for nurses and evaluate the fidelity and acceptability of the non-pharmacological element of the intervention. …”
Get full text

Longitudinal examination of young married women’s fertility and family planning intentions and how they relate to subsequent family planning use in Bihar and Uttar Pradesh India by Niranjan Saggurti, Lisa Calhoun, Priya Nanda, Ilene S Speizer, A J Francis Zavier, Gwyn Hainsworth

“…Having any children and being pregnant at wave 1 were both related to FP use at wave 2.Conclusions It is important to reach young, married women prior to a first pregnancy with nuanced messages addressing their fertility and FP intentions. Programmes targeting women at antenatal and postpartum visits are important for young women to help support them to use FP to address their desires to delay or limit future childbearing for the health and well-being of themselves and their children.…”
Get full text

Appraisal of cowpea cropping systems and farmers’ perceptions of production constraints and preferences in the dry savannah areas of Nigeria by Saba Baba Mohammed, Daniel Kwadjo Dzidzienyo, Muhammad Lawan Umar, Mohammad Faguji Ishiyaku, Pangirayi Bernard Tongoona, Vernon Gracen

“…Hence, breeding for resistance to insect pests and high yield is recommended as an important priority of cowpea breeding programmes in the region.…”
Get full text

Improved cattle farm classification: leveraging machine learning and linked national datasets by Guy-Alain Schnidrig, Guy-Alain Schnidrig, Rahel Struchen, Sara Schärrer, Dagmar Heim, Daniela Hadorn, Gertraud Schüpbach-Regula, Giulia Paternoster

“…A better differentiation of cattle production types would be beneficial for the planning and evaluation of surveillance programmes for cattle diseases and for the benchmarking antibiotic consumption. …”
Get full text

Forecasting models for leprosy cases: a scoping review protocol by Bruna Oliveira Ascef, Gustavo Laine Araújo de Oliveira, Carmelita Ribeiro Filha Coriolano, Haliton Alves De Oliveira Junior

“…Mathematical models and statistical methodologies could play an important role in decision-making and help maintain the gains in elimination programmes. Various models for predicting leprosy cases have been reported in the literature, but they have different settings and distinct approaches to predicting the cases. …”
Get full text

Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial by Martin R Cowie, Stephen Morris, Gregory Lip, Richard J McManus, Stephen Sutton, Jonathan Mant, Simon J Griffin, Sarah Hoare, Jenni Burt, Rachel Johnson, Mark Lown, Alison Powell, Natalie Armstrong, FD Richard Hobbs, Trudie Lobban, Rakesh Narendra Modi, Ben Freedman, David A Fitzmaurice, Stephen Kaptoge, Jenny Lund, Duncan Edwards, Kate Williams, H Thom, Francesco Fusco, Michael J Sweeting, Andrew Dymond, The SAFER Authorship Group

“…Consequently, no countries recommend national screening programmes for AF. The Screening for Atrial Fibrillation with ECG to Reduce stroke (SAFER) trial aims to determine whether screening for AF is effective at reducing risk of stroke. …”
Get full text

Associations between mental illness, TB risk and migrant status by S.E. Hayward, K.L. Kristensen, A. Deal, J.H. Petersen, T. Lillebaek, S. Hargreaves, M. Norredam, J.S. Friedland

“…CONCLUSIONS: People with mental illnesses, particularly psychotic and substance use disorders, have increased TB incidence and represent a high-risk population for targeted screening and treatment. TB programmes should integrate holistic mental health care.…”
Get full text