Testing the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial by Andreas Blomqvist, Maria Bäck, Leonie Klompstra, Anna Strömberg, Tiny Jaarsma

“…MethodsIn this pilot clinical randomized controlled trial (RCT), patients with HF who were already using Optilogg to enhance self-care behavior were recruited from 5 primary care health centers in Sweden. Participants were randomized to either have their mHealth tool updated with the Activity Coach app (intervention group) or a sham version (control group). …”
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General practitioner-centered rural obesity management: Design, protocol and baseline data of the German HAPpEN pragmatic trial by Marika Haderer, Reiner Hofmann, Tina Bartelmeß, Laura König, Constanze Betz, Mirna Al Masri, Alisa Bader, Natascha von Schau

“…The trial aims to inform primary care obesity management guidelines, focusing on improving health literacy, patient engagement, and long-term clinical benefits. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…AMA Ethics. 2005;7(7):522-524.; Eskew PM, Klink K. Direct primary care: Practice distribution and cost across the nation. …”
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Women Empowered to Connect With Addiction Resources and Engage in Evidence-Based Treatment (WE-CARE)—an mHealth Application for the Universal Screening of Alcohol, Substance Use, D... by Krystyna Isaacs, Autumn Shifflett, Kajal Patel, Lacey Karpisek, Yi Cui, Maayan Lawental, Golfo Tzilos Wernette, Brian Borsari, Katie Chang, Tony Ma

“… BackgroundWomen of childbearing age (aged 18-44 years) face multiple barriers to receiving screening and treatment for unhealthy alcohol and substance use, depression, and anxiety, including lack of screening in the primary care setting and lack of support in accessing care. …”
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Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications? by Irene Ruiz-Tamayo, Josep Franch-Nadal, Manel Mata-Cases, Dídac Mauricio, Xavier Cos, Antonio Rodriguez-Poncelas, Joan Barrot, Gabriel Coll-de-Tuero, Xavier Mundet-Tudurí

“…Electronic medical records were retrieved from all T2DM subjects who attended primary care centers pertaining to the Catalan Health Institute in Catalonia in 2013 and were pharmacologically treated with any NIAD alone or in combination. …”
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Immunogenicity of the 9-valent human papillomavirus vaccine: Post hoc analysis from five phase 3 studies by Anna R. Giuliano, Joel M. Palefsky, Stephen E. Goldstone, Jacob Bornstein, Ilse De Coster, Ana María Guevara, Ole Mogensen, Andrea Schilling, Pierre Van Damme, Corinne Vandermeulen, Misoo C. Ellison, Susan Kaplan, Jianxin Lin, Rachael Bonawitz, Alain Luxembourg

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Yorkshire Enhanced Stop Smoking (YESS) study: a protocol for a randomised controlled trial to evaluate the effect of adding a personalised smoking cessation intervention to a lung... by Richard D Neal, David Baldwin, Sarah Lewis, John Britton, Rachael L Murray, Qi Wu, Kate Brain, Samantha L Quaife, Matthew EJ Callister, Philip A J Crosbie, Harriet D Quinn-Scoggins, Grace M McCutchan, Alex Ashurst, Suzanne Rogerson, Rebecca Thorley

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Comparison of specialist ataxia centres with non-specialist services in terms of care access and organisation, health services resource utilisation and costs in Germany using patie... by Julie Vallortigara, Julie Greenfield, Barry Hunt, Holm Graessner, Carola Reinhard, Andreas Nadke, Bart-Jan Schuman, Deborah Hoffman, Steve Morris, Paola Giunti

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Clinical and ultrasound characteristics in patients with sars-cov-2 pneumonia, associated with hospitalization prognosis. e-covid project by Noemí Fàbrega Ramon, Marta Ortega Bravo, Gerard Torres Cortada, Joaquim Sol Culleré, Mònica Solanes Cabús, Jose María Palacín Peruga

“…However, access was limited in the hospital setting and patients treated in Primary Care (PC) could only access the chest x-ray as an imaging test. …”
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A perinatal psychiatry access program to address rural and medically underserved populations using telemedicine by Courtney King, Marie Hayes, Lizmarie Maldonado, Elizabeth Monter, Rubin Aujla, Erin Phlegar, Claire Smith, Liz Parker, Kerry Blome, Amanda Sandford, Edie Douglas, Constance Guille

“…Methods This model has been adapted in South Carolina to include direct access to mental health treatment in response to inadequate maternity care and mental health services, including a large proportion of rural, Medically Underserved Areas in Primary Care and Mental Health Healthcare Provider Shortage Areas throughout the state. …”
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Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on Use of Probiotics, Prebiotics, Synbiotics and F... by V. T. Ivashkin, I. V. Maev, D. I. Abdulganieva, S. A. Alekseenko, A. V. Gorelov, I. N. Zakharova, O. Yu. Zolnikova, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammayev, E. A. Poluektova, A. S. Trukhmanov, D. V. Usenko, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, I. V. Berezhnaya, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, S. V. Nikolaeva, N. G. Sugyan, A. I. Ulyanin

“…The practical guidelines are intended for primary care physicians, general practitioners, paediatricians, gastroenterologists and general internists to advance the treatment and prevention of gastroenterological diseases in adults and children in therapies with probiotics, prebiotics, synbiotics and their enriched functional foods.Key points. …”
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Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease by Aaron King, Xi Tan, Neil Dhopeshwarkar, Rhonda Bohn, Katherine Dea, Charles E. Leonard, Adam de Havenon

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From Clinical Trial Evidence to Clinical Guidelines: Perspectives on REWIND from Clinicians in the Gulf and Levant Region by Talal Ashour, Sami Azar, Akram Echtay, Muhammad Farooqi, Tarek Fiad, Mohamed Hassanein, Ahmed Hassoun, Abdul Jabbar, Amin Jayyousi, Kari Ranta, Hani Sabbour, Fatih Tangi, Ibrahim Turfanda

“…This trial – REWIND – is the only GLP-1 RA-based CVOT that recruited patients with a CVD prevalence (31%) that is similar to the estimated prevalence in primary care T2D populations in the Gulf and Levant region. …”
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Scoping review of costs of implementation strategies in community, public health and healthcare settings by Hongmei Wang, Jungyoon Kim, Tzeyu L Michaud, Emiliane Pereira, Gwenndolyn Porter, Caitlin Golden, Jennie Hill, Cindy Schmidt, Paul A Estabrooks

“…Predominant topic, setting, country and research design in the included studies were mental health (19%), primary care settings (44%), the US (35%) and observational (42%). …”
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The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction by Junjie Hang, Junjie Huang, Siyuan Zhou, Lixia Wu, Yingwei Zhu, Lina Zhu, Hanyu Zhou, Kequn Xu, Hua Jiang, Xuguang Yang

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Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

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Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study by Natalia Ortega, Nick J. Mueller, Abbas Dehghan, Tosca O. E. de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O. Chocano-Bedoya

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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

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Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…This study developed machine learning models to classify positron emission tomography (PET) Aβ-positivity in participants with preclinical and prodromal AD using data accessible to primary care physicians. Methods This retrospective observational study assessed the classification performance of combinations of demographic characteristics, routine blood test results, and cognitive test scores to classify PET Aβ-positivity using machine learning. …”
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Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. by Alvin Richards-Belle, Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Al Richards, Kenneth K C Man, Neil M Davies, Elvira Bramon, Joseph F Hayes, David P J Osborn

“…<h4>Methods and findings</h4>We conducted an observational emulation of a head-to-head trial of aripiprazole versus olanzapine, quetiapine, and risperidone in UK primary care using data from the Clinical Practice Research Datalink. …”
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