Paediatric nephroblastoma at a South African tertiary hospital: A 21-year retrospective analysis by E Brits, E Gerber, I Iroka, L Mgidlana, J Willoughby, S Dhlamini, P Nxumalo, S Sefadi, A Mthembu, J B Sempa

“…This study highlights the need for collaboration between SA and Lesotho healthcare providers to improve outcomes by addressing diagnostic delays, treatment defaults and response variations in resource-limited settings through community health education, improving access to primary care, offering care-provider training, improving diagnostic resources and addressing socioeconomic barriers. …”
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Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals by Dimitrios V. Vavoulis, Anthony Cutts, Nishita Thota, Jordan Brown, Robert Sugar, Antonio Rueda, Arman Ardalan, Kieran Howard, Flavia Matos Santo, Thippesh Sannasiddappa, Bronwen Miller, Stephen Ash, Yibin Liu, Chun-Xiao Song, Brian D. Nicholson, Helene Dreau, Carolyn Tregidgo, Anna Schuh

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Preventive Adolescent Health Care in Family Practice: A Program Summary by Barry Knishkowy, Moshe Schein, Alexander Kiderman, Aliza Velber, Richard Edman, John Yaphe

“…A Community-Oriented Primary Care (COPC) program targeted all adolescent patients aged 12—18 years in two Israeli family practices. 321 teenagers were invited to participate. …”
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Prolonged Survival following Repetitive Stereotactic Radiosurgery in a Patient with Intracranial Metastatic Renal Cell Carcinoma by Ethan A. Ferrel, Andrew T. Roehrig, Wayne T. Lamoreaux, Alexander R. Mackay, Robert K. Fairbanks, Jason A. Call, Jonathan D. Carlson, Benjamin C. Ling, John J. Demakas, Barton S. Cooke, Aaron Wagner, Christopher M. Lee

“…This 64-year-old female patient initially presented to her primary care physician 22 months after a left nephrectomy for RCC with complaints of mild, intermittent headaches and difficulty with balance. …”
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Suspicion, screening, and diagnosis of wild‐type transthyretin amyloid cardiomyopathy: a systematic literature review by Katrine Bay, Finn Gustafsson, Michael Maiborg, Anne Bagger‐Bahnsen, Anne Mette Strand, Trine Pilgaard, Steen Hvitfeldt Poulsen

“…Three articles discussed the importance of primary care providers in terms of patient entry, while the remaining articles had the cardiovascular setting as point of departure. …”
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Impact of moral distress on burn-out: a cross-sectional survey of front-line family physicians during the initial wave of the COVID-19 pandemic by John Billimek, Johanna Shapiro, Cynthia Haq, Tan Nguyen, Avital Sabrina Fischer, Reece Fenning, John Michael Robb, Allison Slater, Uyen Mai, Tien Lam, Jan Paolo De La Cruz

“…Objectives Primary care clinicians are especially prone to burn-out. …”
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Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol by Angus G K McNair, Nicholas Turner, Alan Richardson, Elizabeth Coulthard, Jemima Dooley, Julie Clayton, Sam Harding, Sarah Rudd, Victoria Grace Gabb, Winsome Barrett-Muir, Natalie Woodward, Sophie Alderman, Joseph Webb

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Treatment and counselling preferences of postpartum women with and without symptoms of (childbirth-related) PTSD: findings of the cross-sectional study INVITE by Rosa Hannele Horstmann, Lara Seefeld, Julia Schellong, Susan Garthus-Niegel

“…The City Birth Trauma Scale (City BiTS) was used to assess CB-PTSD, while the Primary Care Posttraumatic Stress Disorder Screen for DSM-5 (PC-PTSD-5) was used to assess gPTSD. …”
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The Transcultural Diabetes Nutrition Algorithm: A Canadian Perspective by Réjeanne Gougeon, John L. Sievenpiper, David Jenkins, Jean-François Yale, Rhonda Bell, Jean-Pierre Després, Thomas P. P. Ransom, Kathryn Camelon, John Dupre, Cyril Kendall, Refaat A. Hegazi, Albert Marchetti, Osama Hamdy, Jeffrey I. Mechanick

“…The Canadian version of tDNA supports and targets behavioural changes to improve nutritional quality and to promote regular daily physical activity consistent with Canadian Diabetes Association CPG, as well as channelling the concomitant management of obesity, hypertension, dyslipidemia, and dysglycaemia in primary care. Assessing glycaemic index (GI) (the ranking of foods by effects on postprandial blood glucose levels) and glycaemic load (GL) (the product of mean GI and the total carbohydrate content of a meal) will be a central part of the Canadian tDNA and complement nutrition therapy by facilitating glycaemic control using specific food selections. …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England by Derek G Cook, Frank J Kelly, Iain M Carey, H Ross Anderson, David P Strachan, Richard W Atkinson, Sean D Beevers, David Dajnak, John Gulliver

“…Objective To investigate whether the incidence of dementia is related to residential levels of air and noise pollution in London.Design Retrospective cohort study using primary care data.Setting 75 Greater London practices.Participants 130 978 adults aged 50–79 years registered with their general practices on 1 January 2005, with no recorded history of dementia or care home residence.Primary and secondary outcome measures A first recorded diagnosis of dementia and, where specified, subgroups of Alzheimer’s disease and vascular dementia during 2005–2013. …”
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Incidence and risk factors for clinical omphalitis among neonates in Eastern Uganda using chlorhexidine gel for cord care: a community-cohort study by John Wogabaga, Kathy Burgoine, Abel Kakuru, Brendah Nambozo, Martin Chebet, Josephine Tumuhamye, Benon Wanume, Faith Oguttu, Milton W. Musaba, Agnes Napyo, Solomon Wani, Peter Olupot-Olupot, Andrew D. Weeks, Thorkild Tylleskär, David Mukunya

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Suicidal ideation and suicide attempt among pregnant adolescent girls in Ghana: a cross-sectional study by Kwaku Oppong Asante, Emmanuel Nii-Boye Quarshie, Erica Danfrekua Dickson, Sandra Naa-Shasha Quarshie, Sophia Ewuenye Adwoa Kpebu

“…The evidence also highlights a need for both routine antepartum primary care mental health screening for suicidality and related risks and targeted prevention and intervention programmes.…”
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Prediction model study focusing on eHealth in the management of urinary incontinence: the Personalised Advantage Index as a decision-making aid by Huibert Burger, Henk van der Worp, Marco H Blanker, Marjolein Y Berger, Anne Martina Maria Loohuis, Nienke Wessels, Janny Dekker, Alec GGA Malmberg

“…Objective To develop a prediction model and illustrate the practical potential of personalisation of treatment decisions between app-based treatment and care as usual for urinary incontinence (UI).Design A prediction model study using data from a pragmatic, randomised controlled, non-inferiority trial.Setting Dutch primary care from 2015, with social media included from 2017. …”
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Deriving and validating a risk prediction model for long COVID-19: protocol for an observational cohort study using linked Scottish data by Jennifer K Quint, Aziz Sheikh, Chris Robertson, Srinivasa Vittal Katikireddi, Emily Moore, Colin R Simpson, Luke Daines, Eleftheria Vasileiou, Syed Ahmar Shah, Rachel H Mulholland, Vicky Hammersley, Steven Kerr, Ting Shi, David Weatherill, Elisa Pesenti

“…We will identify potential indicators for long-COVID by identifying patterns in primary care data linked to information from out-of-hours general practitioner encounters, accident and emergency visits, hospital admissions, outpatient visits, medication prescribing/dispensing and mortality. …”
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A model based cost-utility analysis of Embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 d... by Melanie J Davies, Alan Brennan, Danielle H Bodicoat, Daniel John Pollard, Anju Keetharuth, Michelle Hadjiconstantinou, Agnieszka Glab, Joesph P Mensa, Alison Northern

“…Objectives To conduct a cost-utility analysis of an implementation package that has been developed aiming to embed the referral of people with type 2 diabetes mellitus (T2DM) to structured self-management education (SSME) from primary care into routine practice compared with usual care.Design Model-based cost-effectiveness analysis using the School for Public Health Research type 2 diabetes treatment model. …”
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Impact of pandemic service changes on ethnic inequalities in maternal and perinatal outcomes in England: a population-based study by Andrew Judge, Erik Lenguerrand, Tim Draycott, Stamatina Iliodromiti, Asma Khalil, Buthaina Ibrahim, Jennifer Elizabeth Jardine

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Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study by Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg

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Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Rand... by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…Despite the attention given to subthreshold symptoms and the interventions for subthreshold symptoms being efficient in preventing the transition to psychiatric disease in primary care, reports on specific interventions are insufficient. …”
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Experiencing the risk of overutilising opioids among patients with chronic non-cancer pain in ambulatory care (ERONA): the protocol of an exploratory, randomised controlled trial by Odette Wegwarth, Joerg J Meerpohl, Norbert Donner-Banzhoff, Claudia Spies, Christine Schmucker, Erika Schulte, Edris Nury, Dirk Brockmann, Stefan Wind, Eva Goebel, Wolf-Dieter Ludwig, Ralph Hertwig

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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial longitud... by Danielle Mazza, Angela Taft, Kevin McGeechan, Kathleen Mcnamee, Natalie Amos, Kirsten I Black, Cathy J Watson, Marion Haas, Jeffrey F Peipert, Jayne Lucke

“…We will analyse data using binary regression models with generalised estimating equations and robust standard errors to account for clustering.Discussion Demonstration of sustained use, effectiveness at reducing unwanted pregnancies and cost-effectiveness of this strategy among this cohort of Australian primary care patients, will strengthen the policy and programme urgency of addressing wider dissemination of these strategies and replicating the study elsewhere.Ethics and dissemination The ACCORd Study received approval from the Monash University Human Research Ethics Committee: CF16/188-201000080. …”
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