Potential Infectious Complications in Pig Xenograft Donors and Recipients by Nicolas J. Mueller, Linda Scobie

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Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials by Jingyun Yang, Weiqi Hong, Huashan Shi, Cai He, Hong Lei, Yanan Zhou, Hao Yang, Aqu Alu, Zimin Chen, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Jiong Li, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhaoming Su, Yuquan Wei, Qiangming Sun, Shuaiyao Lu, Zhenling Wang, Youchun Wang, Guangwen Lu, Weimin Li, Xiawei Wei

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Correlation Analysis between Nerve Fiber Layer Thickness and Peripapillary Vessel Density and Influencing Factors of Peripapillary Vessel Density in Preclinical Diabetic Retinopathy by Donghui Li, Qichang Wang

“…The duration of diabetes and HbA1c are risk factors for peripapillary vessel density reduction in patients with preclinical DR.…”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Based on this rigorous preclinical evaluation, our validated clinical grade lintuzumab-CD28/CD3ζ CD33CART immunotherapy is now under evaluation in a first-in-child/first-in-human phase 1 clinical trial for children and adolescents/young adults with relapsed/refractory AML.Trial registration number clinicaltrials.gov; NCT03971799.…”
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Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…The most influential predictors were educational level, total medication count, age, sbp and BMI.Conclusions The proposed classifier can help guide preclinical screening of AD in the elderly population.…”
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…Our results assessed the feasibility and safety of ICO injection at the preclinical level and evaluated its efficacy in animal models of stroke. …”
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Synergistic enhancement of spinal fusion in preclinical models using low-dose rhBMP-2 and stromal vascular fraction in an injectable hydrogel composite by Hye Yeong Lee, Seong Bae An, Sae Yeon Hwang, Gwang Yong Hwang, Hye-Lan Lee, Hyun Jung Park, Joongkyum Shin, Keung Nyun Kim, Sung Won Wee, Sol Lip Yoon, Yoon Ha

“…Through a series of in vitro studies and preclinical models involving rats and minipigs, we demonstrated that the hydrogel system enables the sustained release of rhBMP-2, resulting in significantly improved bone density and integration, alongside reduced inflammatory responses. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

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Distinct gut microbial signature and altered short chain fatty acid metabolism at disease onset in a rat preclinical model of superimposed preeclampsia by Moumen M. Alhasan, María S. Landa, Silvia I. García, Roman G. Gerlach, Hani Harb, Fabian B. Fahlbusch, Melanie L. Conrad, Gabriela Barrientos

“…In this study, we assessed the gut microbiome in a rat model of superimposed preeclampsia to characterize the microbial signature associated with defective placentation processes identified at the preclinical disease stage. The blood pressure profile, renal function parameters and fetal phenotype were evaluated in pregnant Stroke-prone Spontaneously Hypertensive Rats (SHRSP) and their normotensive controls. …”
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A dual-phase biologic augmentation of rotator cuff healing in a preclinical rat model using interleukin-17F and low-dose lithium by Manisha R. Mistry, MD, MSc, Yufa Wang, MD, MSc, Cari M. Whyne, PhD, David M. Phillips, MSc, Wendy Oakden, PhD, Paul Marks, MD, Jimmy Tat, MD, MSc, Diane Nam, MD, MSc

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The Gingiva from the Tissue Surrounding the Bone to the Tissue Regenerating the Bone: A Systematic Review of the Osteogenic Capacity of Gingival Mesenchymal Stem Cells in Preclinical Studies by Gamilah Al-Qadhi, Iman Aboushady, Niyaz Al-Sharabi

“…The current review aims to systematically assess the osteogenic capacity of gingiva-derived mesenchymal stem cells (GMSCs) in preclinical studies. A comprehensive electronic search of PubMed, Embase, Web of Science, and Scopus databases, as well as a manual search of relevant references, was performed in June 2020 without date or language restrictions. …”
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Corrigendum to “Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from Scutellaria baicalensis and Acacia catechu” by Mesfin Yimam, Bruce P. Burnett, Lidia Brownell, Qi Jia

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Editorial: Modelling esophageal adenocarcinoma by Hisham F. Bahmad, Farah Ballout

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Preparing healthcare leaders of the digital age with an integrative artificial intelligence curriculum: a pilot study by Soo Hwan Park, Roshini Pinto-Powell, Thomas Thesen, Alexander Lindqwister, Joshua Levy, Rachael Chacko, Devina Gonzalez, Connor Bridges, Adam Schwendt, Travis Byrum, Justin Fong, Shahin Shahsavari, Saeed Hassanpour

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Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus by Chan Yew Low, Wei Ling Gan, Su Jeat Lai, Rachel Su-May Tam, Jie Fei Tan, Stefanie Dietl, Lay Hong Chuah, Nicolas Voelcker, Athirah Bakhtiar

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Differentiating Between Perfluorohexyloctane Ophthalmic Solution and Water-Free Cyclosporine Ophthalmic Solution 0.1% for Dry Eye Disease: A Review of Preclinical and Clinical Characteristics by Laura M. Periman, Darrell E. White, Douglas Katsev

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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

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Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations by Shuo Ding, Juan Chen, Yanchao Wu, Huiru Lin, Qiqiang Liang, Gaoqin Teng, Zhenjie Liu, Man Huang

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Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

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