Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…BDNF and NGF have demonstrated the ability to improve functional recovery in preclinical and to a lesser extent clinical studies. …”
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Pharmacological Studies on the Antidiabetic, Antioxidant, and Antimicrobial Efficacies of Commiphora myrrha Resin in Streptozotocin-Induced Diabetes in Rats: A Preclinical Study by Rasha A. Mansouri, Aftab Ahmad, null Roushdy M. M., Huda F. Alshaibi, Mahmoud Ragab

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Dental Students’ Didactic and Psychomotor Skills Performance in Dental Anatomy and Preclinical Operative Dentistry Courses in a Saudi Governmental School by Afnan O. Al-Zain, Adel M. Abdel-Azim, Hisham I. Othman

“…A weak, positive, and significant correlation existed between the preclinical operative didactic and psychomotor silks (p<0.05). …”
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...A content analysis of narrative comments on clinical skills during preclinical training ... by Linda Bergeron, Patricia Blanchette, Molk Chakroun, Élisabeth Boileau, Isabelle Boulais, Martine Chamberland, Christina St-Onge

“… Introduction: The progression from preclinical medical training to clerkship is a pivotal yet steep transition for medical students. …”
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Evaluating the Impact of Preclinical and Clinical Exposure to the Pediatric Pulpotomy Procedure on Confidence Among Senior Dental Students: An Analytical Survey Study by Alzain I, Albqmi SS, Alkatheeri SM

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Osteogenic Potential of Dental Mesenchymal Stem Cells in Preclinical Studies: A Systematic Review Using Modified ARRIVE and CONSORT Guidelines by Murali Ramamoorthi, Mohammed Bakkar, Jack Jordan, Simon D. Tran

“…The purpose of this review is to systematically assess the preclinical in vivo and in vitro studies which have evaluated the efficacy of dental stem cells on bone regeneration. …”
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Unveiling the potential: Patient-derived organoids in cancer research and treatment by Zhan Wang

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Promotion of nitric oxide production: mechanisms, strategies, and possibilities by Marcos Gonzalez, Sarah Clayton, Eric Wauson, Daniel Christian, Quang-Kim Tran

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Systematic review of innate immune responses against Mycobacterium tuberculosis complex infection in animal models by Luisa Maria Nieto Ramirez, Carolina Mehaffy, Karen Marie Dobos

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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Combining IL-2-based therapies with immune checkpoint inhibitors (ICIs), anti-angiogenic agents, or radiotherapy has demonstrated synergistic potential. Preclinical and clinical studies highlight reduced toxicity and enhanced anti-tumor efficacy, overcoming TME-driven immune suppression. …”
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Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial by Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang

“…Methods The CD33-targeting domain was selected by CAR-T cells, and this optimized CAR construct was subsequently transduced into umbilical cord-derived NK cells via a retroviral vector. Preclinical efficacy and safety studies were conducted both in vitro and in vivo. …”
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Dental Pulp Mesenchymal Stem Cells Attenuate Limb Ischemia via Promoting Capillary Proliferation and Collateral Development in a Preclinical Model by Youfeng Li, Yuning Zhang, Hua Wang, Chengfeng Sun, Dongmei Liu, Hongying Liu, Jia He, Furong Chen, Weiting Wang, Xi Jiang, Chu-tse Wu, Yuefeng Yang

“…In this study, we compared the therapeutic effects of MSCs derived from different sources in a femoral artery-ligated preclinical ischemic model. We found that treatments with MSCs, including bone marrow- (BM-), adipose- (AD-), dental pulp- (DP-), and umbilical cord- (UC-) derived MSCs, improved limb functions, reduced inflammatory responses, increased angiogenesis, and promoted regeneration of muscle fiber. …”
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Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases by James J. Cody, Pietro Scaturro, Alan B. Cantor, G. Yancey Gillespie, Jacqueline N. Parker, James M. Markert

“…We have previously described an oncolytic herpes simplex virus (HSV), designated M002, which lacks both copies of the γ134.5 neurovirulence gene and carries a murine interleukin 12 (IL-12) expression cassette, and have validated its antitumor efficacy in a variety of preclinical models of primary brain tumors. However, M002 has not been yet evaluated for use against metastatic brain tumors. …”
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Therapeutic potential of short-chain fatty acids for acute lung injury: a systematic review and meta-analysis of preclinical animal studies by Liying Xie, Linyan Wang, Yongxin Liao, Miaoen Yao, Miaoen Yao, Miaoen Yao, Tong Mai, Rongrong Fan, Rongrong Fan, Rongrong Fan, Yun Han, Yun Han, Yun Han, Gengbiao Zhou, Gengbiao Zhou, Gengbiao Zhou

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The Therapeutic Potential of Inflamed Gingiva-Derived Mesenchymal Stem Cells in Preclinical Studies: A Scoping Review of a Unique Biomedical Waste by Gamilah Al-Qadhi, Sarah Al-Rai, Layla Hafed

“…Included studies were assessed using a combination tool, including the guidelines for reporting preclinical in vitro studies on dental materials, which were based on the modification of the Consolidated Standards of Reporting Trial checklist and the guidelines for animal research: reporting of in vivo experiments. …”
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Stem cell-derived exosome treatment for acute spinal cord injury: a systematic review and meta-analysis based on preclinical evidence by Chunlin Mou, Ziyao Xia, Ziyao Xia, Ziyao Xia, Xiujuan Wang, Xunan Dai, Jiaxian Wang, Chun Zhang, Chun Zhang, Yongsheng Xu, Yongsheng Xu, Yongsheng Xu

“…BackgroundThe study aims were to systematically review and analyze preclinical research on the efficacy of exosomes derived from various mesenchymal stem cell sources (MSC-exos) for the treatment of spinal cord contusion injury (SCI) in small animal models.MethodsWe conducted a systematic search of PubMed, Embase and Google Scholar databases from their inception through February 29, 2024, to identify eligible English-language studies based on predefined inclusion and exclusion criteria. …”
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A Comparison of Dental Students&rsquo; Self-Assessment and Instructors&rsquo; Assessment in Competency Examinations in a Preclinical Operative Dentistry Course by Alghilan MA, Munaga S, Aldakhil A

“…This study compared dental students’ self-assessments and instructors’ assessments in competency examinations and evaluated the progress and potential predictors of self-assessment performance, including achievement level and gender, in a Preclinical Operative Dentistry course.Methods: The preclinical operative dentistry assessment and self-assessment records by instructors and students, respectively, were collected retrospectively from intra-semester and final examination assessment rubrics. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Adverse events were mild and manageable, with no reports of severe anaphylaxis. Discussion Preclinical and clinical evidence signifies that Pegmolesatide is a unique, potent PEGylated EPO-memetic peptide (EMP) with a prolonged PD efficacy and PK half-life and a good safety-tolerability profile. …”
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Therapeutic potential of Cinnamomum burmannii bark extract in reducing Malondialdehyde (MDA) levels in MSG-induced wistar rats: a preclinical study by Dina Afrianti, Wahyudi, Ririh Jatmi Wikandari, Rodhi Hartono, Erisa Febriyani, Egy Sunanda Putra

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Therapeutic effect of mesenchymal stem cell-derived exosome therapy for periodontal regeneration: a systematic review and meta-analysis of preclinical trials by Liping Zhou, Wenjia Cai, Yuhan Zhang, Wenjie Zhong, Ping He, Jingsong Ren, Xiang Gao

“…Abstract Background To assess the therapeutic effects of mesenchymal stem cell (MSC)-derived exosome therapy on periodontal regeneration and identify treatment factors associated with enhanced periodontal regeneration in recent preclinical studies. Methods Searches were conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases until October 10, 2024. …”
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