Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD by Mark W. Jacobson, Linda K. McEvoy, Anders Dale, Christine Fennema-Notestine

“…Identifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. …”
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Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. by Shi-Hsia Hwa, Yock Ann Lee, Joseph N Brewoo, Charalambos D Partidos, Jorge E Osorio, Joseph D Santangelo

“…We report the immunogenic and safety profile of inactivated, purified EV71 preparations formulated with aluminum hydroxide adjuvant in preclinical studies in mice and rabbits. In mice, the candidate vaccine formulations elicited high neutralizing antibody responses. …”
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The application of procyanidins in diabetes and its complications: a review of preclinical studies by Yongchuang Zhang, Mengna Li, Haoyuan Liu, Yongfu Fan, Huan Huan Liu

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Review of preclinical data on hyperthermia treatment in lymphomas and its potential for clinical application by Moritz V. Scharr, Frederik Damm, Paul Krahl, Anna Dieper, Paraskevi D. Veltsista, Alexander Hansch, Marcus Beck, Dominik Gerster, Anna-Chiara Giovannelli, Lars Bullinger, Daniel Zips, Pirus Ghadjar

“…Included were in vitro studies on lymphoma cell lines and preclinical studies on animal models with lymphoma that were both treated with HT as monotherapy or HT in combination with another treatment, and studies on patients with lymphoma. …”
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Quantitative accuracy of preclinical in ovo PET/MRI: influence of attenuation and quantification methods by Theresa Balber, Katarína Benčurová, Manuela Mayrhofer, Joachim Friske, Martin Haas, Claudia Kuntner, Thomas H. Helbich, Marcus Hacker, Markus Mitterhauser, Ivo Rausch

“…The phantom was placed in a preclinical PET/MRI system and PET acquisitions were performed without, and after subsequently adding the different hardware parts to the setup. …”
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Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

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Ultrasound-guided photoacoustic image annotation toolkit in MATLAB (PHANTOM) for preclinical applications by Allison Sweeney, Aayush Arora, Skye A. Edwards, Srivalleesha Mallidi

Subjects: “…Preclinical imaging…”
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Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson’s disease by Luisa Di Menna, Marika Alborghetti, Maria Ilenia De Bartolo, Marina Borro, Giovanna Gentile, Manuela Zinni, Matteo Bologna, Carolina Cutrona, Giovanna D’Errico, Tiziana Imbriglio, Domenico Bucci, Sara Merlo, Roxana Paula Ginerete, Rosamaria Orlando, Federica Carrillo, Giorgio Fortunato, Milena Cannella, Maria Angela Sortino, Julien Pansiot, Olivier Baud, Ferdinando Nicoletti, Valeria Bruno, Maurizio Simmaco, Francesco Ernesto Pontieri, Edoardo Bianchini, Domiziana Rinaldi, Amalia de Curtis, Giovanni De Gaetano, Licia Iacoviello, Teresa Esposito, Alfredo Berardelli, Giuseppe Battaglia

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Activation of KATP channels in pain modulation: a systematic review of preclinical studies by Signe Schønning Beich, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi

“…Inclusion criteria were preclinical studies measuring pain in vivo upon activation of the KATP channel by administering a stimulator or positive modulator. …”
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Preclinical evaluation of the potential PARP-imaging probe [carbonyl-11C]DPQ by Katarína Benčurová, Theresa Balber, Victoria Weissenböck, Lukas Kogler, Joachim Friske, Verena Pichler, Markus Mitterhauser, Marcus Hacker, Cécile Philippe, Marius Ozenil

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The Relationship between Stress and Preclinical Dental Students’ Performance: A Longitudinal Study by Diva Lugassy, Gil Ben-Izhack, Sara Zissu, Rotem Shitrit Lahav, Ophir Rosner, Nir Uziel, Sarit Naishlos, Asaf Shely

“…The aim of this study was to evaluate the changing levels of stress among dental students during 8 months of a basic manual skills course in the preclinical year and to examine the association between stress and dental performance. …”
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Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease by Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huang

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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

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Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening by Lisa Götz, Jenny Wegert, Alireza Paikari, Silke Appenzeller, Sabrina Bausenwein, Christian Vokuhl, Taryn D. Treger, Jarno Drost, Christin Linderkamp, Dominik T. Schneider, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Nils Welter, Norbert Graf, Sam Behjati, Rhoikos Furtwängler, Manfred Gessler

“…Adherent, spheroid and organoid cultures are also clearly distinguishable by their transcriptome. Preclinical drug screening experiments revealed sensitivity to a range of inhibitors, that are highly effective in other childhood solid tumors. …”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…We developed a new chimeric antigen receptor (CAR) targeting glypican-2 (GPC2) and conducted iterative preclinical engineering of the CAR structure to maximize its anti-tumor efficacy before clinical translation.Methods We evaluated different GPC2-CAR constructs by measuring the CAR activity in vitro. …”
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Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies by Mahdi Fatemizadeh, Esmail Riahi, Gholamreza Hassanzadeh, Anahita Torkaman-Boutorabi, Forough Radfar, Maryam Farahmandfar

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The use of virtual reality in screening for preclinical Alzheimer's disease: A scoping review protocol. by Yuan Tian, Maneesh V Kuruvilla, Mira Park

“…<h4>Introduction</h4>Preclinical Alzheimer's disease (AD) represents the earliest phase of AD, often years before the onset of mild cognitive impairment (MCI). …”
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Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer’s disease by Swetha Ravichandran, Peter J. Snyder, Jessica Alber, Charles F. Murchison, Lauren E. Chaby, Andreas Jeromin, Edmund Arthur

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Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario by F. Salamanna, M. Sartori, G. Barbanti Brodano, C. Griffoni, L. Martini, S. Boriani, M. Fini

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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

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