Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice by Weimin Guo, Nicholas Crossland, Jimmy W. Crott

“…In agreement with human and preclinical data, livers of MED-diet-fed mice were healthier than those fed WRN diets. …”
Get full text

Comparative analyses of the hemostatic efficacy and surgical device performance of powdered oxidized regenerated cellulose and starch-based powder formulations by Marianne Stark, Allen Y. Wang, Brittny Corrigan, Henok G. Woldu, Samar Azizighannad, Gustavo Cipolla, Richard Kocharian, Hector De Leon

Get full text

Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review by Jakub Fiegler-Rudol, Natalia Zięba, Radosław Turski, Maciej Misiołek, Rafał Wiench

“…Inclusion criteria encompassed preclinical in vitro and in vivo studies and clinical trials focusing on HY-PDT for head and neck malignancies and its subtypes. …”
Get full text

Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder by Claudia Fuchs, Laura Gennaccaro, Stefania Trazzi, Stefano Bastianini, Simone Bettini, Viviana Lo Martire, Elisa Ren, Giorgio Medici, Giovanna Zoccoli, Roberto Rimondini, Elisabetta Ciani

“…The lack of detailed behavioral profiling of this model remains a crucial gap that must be addressed in order to advance preclinical studies. Here, we provide a behavioral and molecular characterization of heterozygous Cdkl5 +/− mice. …”
Get full text

The mirror preference test: A reverse translational approach to study anomalous subjective experience in rats by Daria Chestnykh, Liubov S. Kalinichenko, Stephan von Hörsten, Johannes Kornhuber, Christian P. Müller

“…Symptoms related to the misinterpretation of reality are crucial for diagnosis but pose challenges for preclinical research. In humans, a Mirror-Gazing test is used to examine abnormal self-experience and to predict the risk of schizophrenia. …”
Get full text

Structural, Morphological, and Antibacterial Attributes of Graphene Oxide Prepared by Hummers’ and Brodie’s Methods by Vittorio Marsala, Yuriy Gerasymchuk, Maria Luisa Saladino, Emil Paluch, Magdalena Wawrzyńska, Vitalii Boiko, Xiang Li, Cristina Giordano, Dariusz Hreniak, Beata Sobieszczańska

Get full text

Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway by Peng Sun, Sheng Wei, Xia Wei, Jieqiong Wang, Yuanyuan Zhang, Mingqi Qiao, Jibiao Wu

Get full text

Advances in Molecular Imaging with Ultrasound by Ryan Gessner, Paul A. Dayton

“…This new technology, referred to as ultrasonic molecular imaging, is still in its infancy. However, in preclinical studies, ultrasonic molecular imaging has shown promise in assessing angiogenesis, inflammation, and thrombus. …”
Get full text

Associations of Vitamin D With GPX4 and Iron Parameters in Chronic Obstructive Pulmonary Disease Patients: A Case–Control Study by Jun Fei, Ling Liu, Jia-Fei Li, Qiang Zhou, Yu Wei, Ting-Dong Zhou, Lin Fu

Get full text

Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases by Carlotta Magrì, Giuliana Calabrese, Letizia Masi, Sara Troisi, Federica di Vincenzo, Pierluigi Puca, Cristina Graziani, Loris R. Lopetuso, Valentina Petito

“…For each disease group, preclinical data will be presented in addition to clinical trial evidence.…”
Get full text

Virotherapy in Head and Neck Cancer by Zhan Wang

“…Notably, oncolytic virotherapy, viral vector-based vaccines, and viral vector-based gene therapy are key branches of virotherapeutic interventions that have demonstrated potential in preclinical and clinical studies.…”
Get full text

Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…However, despite the substantial preclinical evidence, further large-scale clinical studies are necessary. …”
Get full text

Developing and validating a drug recommendation system based on tumor microenvironment and drug fingerprint by Yan Wang, Xiaoye Jin, Rui Qiu, Bo Ma, Sheng Zhang, Xuyang Song, Jinxi He

“…By bridging preclinical IC50 and clinical BOR endpoints, this approach provides a promising tool for optimizing patient-specific treatments.…”
Get full text

Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs by Alana C. Costa, Arquimedes Gasparotto, Jr., Alana A.K. Garcia, Cícero A.C. Pereira, Emerson L.B. Lourenço, Helena P.G. Joaquim

“…No significant safety concerns have been identified in preclinical studies involving CBD and THC. However, the available data on the toxicity of combined CBD and THC are still inconclusive. …”
Get full text

Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research by Cheol-Kyu Park, MD, PhD, Maryam Khalil, BSc, Nhu-An Pham, PhD, Stephanie Wong, BSc, Dalam Ly, PhD, Adrian Sacher, MD, FRCPC, Ming-Sound Tsao, MD, FRCPC

“…We highlight the various approaches to generate them, factors that are critical to successfully establishing such models, their respective limitations, and considerations in model selection for preclinical lung cancer immuno-oncology research and therapeutic studies.…”
Get full text

Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease by Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, Mark E. Bunnage

“…Here we describe the development of preclinical assays and the discovery of potent and specific APOL1 inhibitors with drug-like properties. …”
Get full text

Detection Performance of 99mTc in Albira SI Small-Animal SPECT-CT by Jie TANG, Dong XU, Qianyue HU, Bo ZHANG, Wei LI, Lizhen WANG, Huixin YU, Fukuan ZHAO

“…Small-animal single-photon emission computed tomography-X-ray computed tomography (SPECT-CT) is an advanced imaging tool for preclinical research of single-photon radiopharmaceuticals. …”
Get full text

Trends in Anti-Epileptic Drug Development by Lennart Gram

“…More recently, increased attention has been focused on the role which excitatory transmitters may play in epileptogenesis, and various substances which decrease excitation are currently being investigated at the preclinical level. Since considerable potential still resides in several of the drugs already on the market, resources have been spent on trying to modify/improve the chemical formula of some of these substances, and a number of new drugs has emerged as a result of this approach. …”
Get full text

Combining Nuclear Medicine With Other Modalities: Future Prospect for Multimodality Imaging by Stephen J. Archibald PhD, Jason P. Holland PhD, Aruna Korde PhD, Andre F. Martins PhD, Adam J. Shuhendler PhD, Peter J. H. Scott PhD

Get full text

Serological evidence of Erysipelothrix rhusiopathiae antibodies in wild boars (Sus scrofa) in Poland by Czyżewska-Dors Ewelina Barbara, Augustyniak Agata, Piekutowska-Nóżka Ewa, Jężak Joanna, Kowalczyk Ewelina, Jabłoński Artur

Get full text