A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine by Nalú Navarro-Alvarez, Beatriz M. M. Gonçalves, Alec R. Andrews, David H. Sachs, Christene A. Huang

“…Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing. …”
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Medical students' exposure to and attitudes about the pharmaceutical industry: a systematic review. by Kirsten E Austad, Jerry Avorn, Aaron S Kesselheim

“…Studies were separated, where possible, into those that addressed preclinical versus clinical training, and were quality rated using a standard methodology. …”
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Fetal and Neonatal Levels of Omega-3: Effects on Neurodevelopment, Nutrition, and Growth by Juliana Rombaldi Bernardi, Renata de Souza Escobar, Charles Francisco Ferreira, Patrícia Pelufo Silveira

“…Evidence from animal models of dietary n-3 LCPUFAs deficiency suggests that these fatty acids promote early brain development and regulate behavioral and neurochemical aspects related to mood disorders (stress responses, depression, and aggression and growth, memory, and cognitive functions). Preclinical and clinical studies suggest the role of n-3 LCPUFAs on neurodevelopment and growth. n-3 LCPUFAs may be an effective adjunctive factor for neural development, growth, and cognitive development, but further large-scale, well-controlled trials and preclinical studies are needed to examine its clinical mechanisms and possible benefits. …”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…To date, many radioprotectors and radiosensitizers have been investigated in preclinical studies, but their use has been hampered by the high toxicity to normal cells or poor tumor radiosensitization effects. …”
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Recent Developments in Ventricular Assist Device Therapy by Angel Moctezuma-Ramirez, Haseeb Mohammed, Austin Hughes, Abdelmotagaly Elgalad

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Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…Results: Preclinical studies showed that GSH improves macrophage antimicrobial function, reduces oxidative stress, and limits <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) growth. …”
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Focused ultrasound for treatment of peripheral brain tumors by Phillip Mitchell Johansen, Payton Yerke Hansen, Ali A. Mohamed, Sarah J. Girshfeld, Marc Feldmann, Brandon Lucke-Wold

“…This treatment method has shown promising results in preclinical trials including minimal adverse effects, increased infiltration of the therapeutic agents into the CNS, decreased tumor progression, and improved survival rates.…”
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Metastatic brain tumors: from development to cutting‐edge treatment by Guilong Tanzhu, Liu Chen, Jiaoyang Ning, Wenxiang Xue, Ce Wang, Gang Xiao, Jie Yang, Rongrong Zhou

“…In recent years, the prognosis for BM patients has improved, and significant advancements have been made in both clinical and preclinical research. This review focuses on BM originating from lung cancer and breast cancer. …”
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Structural and vascular assessment of the optic nerve head and macula in chronic Chagas disease by Cristiana L. M. Agra, Camila V. Ventura, Letícia D. da Fonte, Marcela R. V. Oliveira, Marília Leal, Maria Elisa L. S. M. Assunção, Maria da Glória A. M. Cavalcanti, Silvia M. M. Alves, Ana Karine Soares, Liana O. Ventura, Tiago S. Prata

“…The aim of the present study was to investigate preclinical structural and vascular optic nerve head (ONH) and macular parameters in patients with chronic CD. …”
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The Influence of Resin Infiltration on the Shear Bond Strength of Orthodontic Brackets: A Systematic Review and Meta-Analysis by Sylwia Kiryk, Jan Kiryk, Jacek Matys, Maciej Dobrzyński

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Effects of Elevated Ambient Temperature on Reproductive Outcomes and Offspring Growth Depend on Exposure Time by Huda Yahia Hamid, Md Zuki Abu Bakar Zakaria, Goh Yong Meng, Abd. Wahid Haron, Noordin Mohamed Mustapha

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Olfaction-based learned preference assessment without the use of motivational fear or motivational weight loss by Sara E. Moss, Ekaterina S. McCurdy, Natalya N. Thomas, Danielle Gulick, Angela M. Poff, Dominic P. D'Agostino

“…IntroductionReliable assessments of learning ability in preclinical models are essential for studying neurodegenerative, developmental, and inflammatory disorders. …”
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In Vivo Assessment of Osseous Wound Healing Using a Novel Bone Putty Containing Lidocaine in the Surgical Management of Tooth Extractions by Akshay Kumarswamy, Antonio Moretti, David Paquette, Ricardo Padilla, Eric Everett, Salvador Nares

“…Objective. This preclinical pilot study evaluated the systemic, radiographic, and histological responses to bone putty containing lidocaine in a canine tooth extraction model. …”
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Pediatric Interventions in a Sanfilippo Syndrome Patient Under General Anesthesia: A Case Report by Ahmad Al Malak, Hassan Issawi, Mohammad Hassoun, Mohammad Al Halabi

“…Case Presentation: A 9-year-9-month-old female was presented at our private clinic accompanied with her parents and referred from a general practitioner, and the preclinical examination revealed atypical craniofacial structure and skeletal features such as abnormal posture and movements adding on atypical behavioral manifestations such as temper tantrums, speech difficulties, dementia, and destructive behavior.…”
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Editorial: Animal models of hypertension by Marta Aleksandrowicz, Marta Kuczeriszka, Leszek Dobrowolski, Modar Kassan

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Editorial: Community series in adenosine pathways in cancer immunity and immunotherapy, volume II by Junjiang Fu, Luca Antonioli, Xiaoli Zheng, Ali H. El-Far

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The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice by Tess Yntema, Tim R. Eijgenraam, Niels J. Kloosterhuis, Rick Havinga, Mirjam H. Koster, Milaine V. Hovingh, Jan Freark de Boer, Debby P. Y. Koonen, Folkert Kuipers

“…Based on extensive preclinical mouse studies, BA signaling pathways have been implicated as therapeutic targets for cardiovascular diseases. …”
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Integrating Clinimetric and Psychometric Approaches in Enhancing Osteoarthritis Care by Roxana Maria Sânziana Pavel, Andrei-Flavius Radu, Delia Carmen Nistor-Cseppento, Cosmin-Mihai Vesa, Anamaria Lavinia Purza, Delia Mirela Tit, Ada Radu, Simona Gabriela Bungau

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The protective role of GLP-1 in neuro-ophthalmology by Sohum Sheth, Aashay Patel, Marco Foreman, Mohammed Mumtaz, Akshay Reddy, Ramy Sharaf, Siddharth Sheth, Brandon Lucke-Wold

“…This article identifies the sources and targets of GLP-1 in the brain and review the mechanisms which mediate its neuroprotective effects, as well as implications for Alzheimer’s disease (AD) and Parkinson’s disease (PD). Furthermore, the preclinical works which unravel the effects of GLP-1 in ocular dynamics and the preclinical literature regarding GLP-1RA use in the management of several neuro-ophthalmic conditions, including diabetic retinopathy (DR), glaucoma, and idiopathic intracranial hypertension (IIH) are discussed.…”
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The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells by Xiao Liang, Chang Xu, Wanchun Wang, Xiang Li

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