Evaluation of the effects of asymmetric lumbosacral transitional vertebra on pelvic morphology in dogs using ventrodorsal radiographs by Jon Andre Berg, Bente Kristin Saevik, Frode Lingaas, Catrine Trangerud

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Bioactive compounds of Calotropis gigantea for cancer treatment by Jayalekshmi C, Nishanth Mohan Das, Rajiv Periakaruppan

“…These challenges include optimizing drug delivery systems, conducting comprehensive preclinical and clinical studies, and ensuring compliance with regulatory standards. …”
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Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xeno... by Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey

“…Patient-derived xenograft (PDX) models are increasingly being used for preclinical testing of novel treatment modalities. A novel approach involving targeted error-corrected RNA sequencing using ArcherDX HemeV2 kit was employed to compare 25 primary pediatric acute leukemia samples and their corresponding PDX samples. …”
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Effect of Dietary Combination of Methionine and Fish Oil on Cellular Immunity and Plasma Fatty Acids in Infectious Bursal Disease Challenged Chickens by Elham Maroufyan, Azhar Kasim, Goh Yong Meng, Mahdi Ebrahimi, Loh Teck Chwen, Parvaneh Mehrbod, Behnam Kamalidehghan, Abdoreza Soleimani Farjam

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Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases by Luca Perico, Federica Casiraghi, Fabiane Sônego, Marta Todeschini, Daniela Corna, Domenico Cerullo, Anna Pezzotta, Patricia Isnard-Petit, Silvia Faravelli, Federico Forneris, Kader Thiam, Ariela Benigni, Giuseppe Remuzzi

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Melanin-like nanoparticles as a potential novel therapeutic approach in ADPKD by Laura Cassina, Alessandra Boletta

“…In this issue of EMBO Molecular Medicine, Sun and colleagues report the development of a novel therapeutic approach, and preclinical proof-of-concept evidence of its efficacy, for Autosomal Dominant Polycystic Kidney Disease (ADPKD) (Sun et al, 2024).…”
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

“…This research contributes to the ongoing efforts in developing targeted therapies for conditions involving NLRP3-mediated inflammation, opening avenues for further preclinical and clinical investigations.…”
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Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury by Lanqing Meng, Qing Huang, Xuebin Li, Ping Liang, Yueyong Li, Xiaohua Huang, Jingjie Zhao, Qiuping Chen, Rong Qiu, Lan Li, Chongdong Jian, Hongfei Yao, Jianmin Huang, Xionglin Tang, Zechen Wang, Zhongheng Wei, Jun Wu, Liuzhi Wei, Qiuju Wei, Qianli Tang, Lu Huang, Jihua Wei, Dinggui Lu, Qunqiang Luo, Kegong Xie, Yang Ouyang, Jian Chen, Genliang Li, Linxue Luo, Linbo He, Chenyi Zhuo, Anding Xu, Lingzhang Meng

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Think Stop before Going 'Off-Label' by Gerald Y Minuk

“…Only after careful and extensive review of all available safety and efficacy data derived from preclinical and clinical trials will a regulatory body approve the licensing of a drug for a specific medical condition ('indication'). …”
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Effects of Standardized Natural Citrus Extract on Growth, Gut Health, Carcass Quality, and Welfare of Broiler Chickens by Sekhou Cisse, Arkadiusz Matuszewski, Damian Bień, Patrycja Ciborowska, Anna Zalewska, Jakub Urban, Monika Michalczuk, Marta Mendel, Urszula Latek, Joanna Polak, Małgorzata Sobczak-Filipiak, Paweł Konieczka, Mohammed El Amine Benarbia

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Electromyography as a Means of Assessing Masticatory Muscle Activity in Patients with Pain-Related Temporomandibular Disorders by Liliana Szyszka-Sommerfeld, Monika Machoy, Mariusz Lipski, Krzysztof Woźniak

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Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation by Vera Mekers, Mirjam de Visser, Karijn Suijkerbuijk, Clemens Bos, Chrit Moonen, Roel Deckers, Gosse Adema

“…We report on the effect of M-HIFU on soluble immune modulators and immune cells in different preclinical models, and potential contributions to the anti-tumor immune response. …”
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Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. by Lucy Phillips, Ross Thomson, Tom Coleman-Haynes, Sue Cooper, Felix Naughton, Lisa Mcdaid, Joanne Emery, Tim Coleman

“…<h4>Introduction</h4>Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how nicotine may adversely affect the developing fetus. …”
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Experimental approach to obtaining subcutaneous xenograft of non-small cell lung cancer by E. A. Lukbanova, M. V. Mindar, E. A. Dzhenkova, A. Yu. Maksimov, A. S. Goncharova, Yu. S. Shatova, A. A. Maslov, A. V. Shaposhnikov, E. V. Zaikina, Yu. N. Lazutin

“…The created PDX models can be recommended as test systems for preclinical studies of the effectiveness of new pharmacological substances with potential antitumor activity.…”
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Assessing Familiarity, Usage Patterns, and Attitudes of Medical Students Toward ChatGPT and Other Chat-Based AI Apps in Medical Education: Cross-Sectional Questionnaire Study by Safia Elwaleed Elhassan, Muhammad Raihan Sajid, Amina Mariam Syed, Sidrah Afreen Fathima, Bushra Shehroz Khan, Hala Tamim

“…There were 236 (80.5%) responses from preclinical students and 57 (19.5%) from clinical students, respectively. …”
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Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma by Assem Barakat, Fardous F. El-Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria

“…<b>Conclusions:</b> This study presents a novel, safe, and effective chemical entity of spirooxindole derivatives for further preclinical and clinical studies.…”
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New Therapeutic Targets for Mood Disorders by Rodrigo Machado-Vieira, Giacomo Salvadore, Nancy DiazGranados, Lobna Ibrahim, David Latov, Cristina Wheeler-Castillo, Jacqueline Baumann, Ioline D. Henter, Carlos A. Zarate

“…Here we describe a number of targets/compounds that clinical and preclinical studies suggest could result in putative novel treatments for mood disorders. …”
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Efficacy of vaccines based on chimeric or multiepitope antigens for protection against visceral leishmaniasis: A systematic review. by Karine Ferreira Lopes, Mariana Lourenço Freire, Silvane Maria Fonseca Murta, Edward Oliveira

“…<h4>Conclusions</h4>Vaccine formulations containing various chimeric or multiepitope antigens have been developed and evaluated in different preclinical trials, with only one advancing to clinical trials and commercialization. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…There is strong evidence supporting the transplantation of stem cells or their derivatives in HD animal models, even if stem-cell-based preclinical and clinical trials are still in their early stages. …”
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Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma by Chun Wai Wong, Rotem Leshem, Kieran Neil Sefton, I-Hsuan Lin, Dervla Tamara Isaac, Mario Niepel, Adam Hurlstone

“…PARP14 inhibition prolongs PD-1 blockade responses in preclinical models, but fails to achieve full tumor clearance, suggesting the involvement of additional resistance mechanisms.Methods We identified a robust PARP14 catalytic inhibitor gene signature and evaluated its association with patient survival. …”
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