Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease by Sheetal Verma, Tamisha Vaughan, Kevin D. Bunting

“…The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signaling pathways through p85 and SHP-2. …”
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Discovery of novel tepovirus genomes with a nucleic acid-binding protein homolog by systematic analysis of plant transcriptome data by Dongjin Choi, Hyerin Park, Seungwoo Baek, Myeung Seok Choi, Sylvain Legay, Gea Guerriero, Jean-François Hausman, Yoonsoo Hahn

“…Previously, no members of the genus Tepovirus within this family were known to possess a NABP homolog. In this study, we identified the genome sequences of 21 novel Betaflexiviridae viruses: 17 represent new members of Tepovirus, and four may be founding members of a new genus closely related to the genus Vitivirus. …”
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Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases by Ballazhi Lulzime, Popovski Emil, Jashari Ahmed, Imeri Faik, Ibrahimi Ibrahim, Mikhova Bozhana, Mladenovska Kristina

“…The results demonstrated dose- and time-dependent activity, with the most potent molecules having a thiazole moiety, without or with additional methyl group(s) attached to the carbon(s) at position(s) 5 and/or 4 in the thiazole ring. These molecules possessed significantly higher potency against both test cell lines compared to 4-hydroxycoumarin…”
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Photocells based on silicide Schottky barrier contacts PtSi-n-Si and PdSi-n-Si by A. I. Blesman, R. B. Burlakov

“…This characteristic of the designed photocell will allow to increase its application. Photocell possesses a simple structure and technology with a time of its fabrication in the interval (2,5–3) of the hour.…”
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Glioma Stem Cells: Signaling, Microenvironment, and Therapy by Brandon D. Liebelt, Takashi Shingu, Xin Zhou, Jiangong Ren, Seul A. Shin, Jian Hu

“…GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are capable of de novo tumor formation when implanted in xenograft models. Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. …”
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Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field by Zhikai Yu, Binghao Yang, Penghu Wei, Hang Xu, Yongzhi Shan, Xiaotong Fan, Huaqiang Zhang, Changming Wang, Jingjing Wang, Shan Yu, Guoguang Zhao

“…The resultant model possesses the capability to function as a feedback trigger program for electrical stimulation systems of the feedback variety, specifically within the domain of neural modulation in epilepsy.…”
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Advancing Middle Level Leadership: Middle School Principal Preparation Programs and Approaches to Leadership by Toni M. Williams, W. Keith Burgess

“…Middle school principals are essential to creating a successful learning environment. They should possess expertise in adolescent development, foster a diverse and equitable school community, and invest in teacher development. …”
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Ethnopharmacology of Psychotria: Potential Use of P. malayana Jack Leaves as Antidiabetic Agent by Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat Soád, Qamar Uddin Ahmed, Zalikha Ibrahim

“…The focus is on the species’ ethnomedicinal applications, their potential as an antidiabetic agent, the pharmacologically active antidiabetic compounds possessed, and their toxicological profiles. The escalating global prevalence of diabetes underscores the need for alternative therapeutic agents. …”
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Polyphenol Content and Antioxidant Evaluation of Kawista (Limonia acidissima) Leaf Extract by Muammar Fawwaz, Mamat Pratama, Rais Razak, Yusrianti Andika, Elvina Astika, Feralia Feralia

“…These findings suggest that L. acidissima leaf extract possesses potent antioxidant properties, which may be attributed to its flavonoid and phenolic content. …”
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Intrinsic Gene Expression Correlates of the Biophysically Modeled Diffusion Magnetic Resonance Imaging Signal by Ajay P. Singh, Michael Fromandi, Daniel Pimentel-Alarcón, Donna M. Werling, Audrey P. Gasch, John-Paul J. Yu

“…Using rat genetic models of autism spectrum disorder, we show that image texture–processed neurite orientation dispersion and density imaging (NODDI) diffusion MRI possesses an intrinsic relationship with gene expression that corresponds to the biophysically modeled cellular compartments of the NODDI diffusion signal. …”
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Biosafety Protocols in Dental Care: a Bibliographical Review by Gianela Lorleyn Sánchez Erazo, Karen Estefanía Chicaiza Bonilla, Gissele Alejandra Villarruel Andrade, Pedro Leonardo Padilla Proaño

“…At the doctor's office does not possess all of the level of requisite information to achieve the effectiveness of the protocols so that a revision of the existent bibliography prevails over the theme to complement its implementation. 23 documentary sources was consulted, 18 of them in Spanish and 5 in English among primary sources and secondaries as well as another one back up acceded by means of the principal managers of quest.…”
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The history, current state and perspectives of aerosol therapy by ROSPOND BARTŁOMIEJ, KRAKOWSKA AGATA, MUSZYŃSKA BOŻENA, OPOKA WŁODZIMIERZ

“…It enables drugs administration through the lung and possesses very fast onset action. Therefore, various drugs prescribed in respiratory diseases (such as corticosteroids, β-agonists, anticholinergics) are present on the market in a form of an aerosol.…”
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Management and Reconstruction of a Gastroesophageal Junction Adenocarcinoma Patient Three Years after Pancreaticoduodenectomy: A Surgical Puzzle by Dionysios Dellaportas, James A. Gossage, Andrew R. Davies

“…This clinical scenario possesses numerous difficulties for the surgeon, since surgical resection is the mainstay of treatment for both malignancies. …”
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A FEMININE OF NO ONE’S OWN IN CHARLOTTE TÁBUA RASA by Eider Madeiros, Letícia Simões Velloso Schuler, Mariana Pinheiro Ramalho, Hermano de França Rodrigues

“…Based on the contributions of Bento (2008), Jorge and Travassos (2018), from the brief precepts of Lacanian psychoanalysis, and on an interview with Leonardo Valente, the author of Charlotte Tábua Rasa (2016), we intend to discuss insofar how the body of a trans woman in a Brazilian politics fictional scenario would be able to draw the difficult boundaries on the discourses, possessions and the domains of language between the self and the other towards the trans-sexualities which dedicate their efforts to reinscriptions and the fissures that are celebrated through the transgressive resilience of the feminine. …”
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Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats by Sebastian Marciniak, Artur Wnorowski, Katarzyna Smolińska, Beata Walczyna, Waldemar Turski, Tomasz Kocki, Piotr Paluszkiewicz, Jolanta Parada-Turska

“…Kynurenic acid (KYNA), a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. …”
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Recent advancements in additively manufactured hip implant design using topology optimization technique by Abdulla All Noman, Mohd Shamil Shaari, Hassan Mehboob, Abdul Hadi Azman

“…Porous additive-manufactured hip implants possess various advantages, including patient-specific implant design, reduced production cost, mass reduction, and a longer implant life by alleviating stress shielding. …”
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Alanine with the Precipitate of Tomato Juice Administered to Rats Enhances the Reduction in Blood Ethanol Levels by Shunji Oshima, Sachie Shiiya, Yoshimi Tokumaru, Tomomasa Kanda

“…We previously demonstrated that water-insoluble fractions, mainly comprising dietary fiber derived from many types of botanical foods, possessed the ability to absorb ethanol-containing aqueous solutions. …”
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The Clinical Trials of Mesenchymal Stromal Cells Therapy by Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon

“…Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. …”
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Metallocene Polyolefins Reinforced by Low-Entanglement UHMWPE through Interfacial Entanglements by Xin Tang, Jinheng Xing, Xiang Yan, Chunlin Ye, Letian Zhang, Yu Zhang, Baoqiang Shu, Jingshan Mu, Wei Li, Jingdai Wang, Yongrong Yang

“…It originates from interdiffusion and entanglement forming of polyethylene segments across the interface, endowing the material with different aggregated and defect structures. For instance, EPDM possesses a higher optimal dosage of UHMWPE particles reflected in good interfacial interdiffusion with UHMWPE particles, leading to significant optimized mechanical performance.…”
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Activities of Amphioxus GH-Like Protein in Osmoregulation: Insight into Origin of Vertebrate GH Family by Mengyang Li, Chengyan Jiang, Yu Zhang, Shicui Zhang

“…We have shown that amphioxus possesses a single GH-like hormone (GHl) gene encoding a functional protein capable of promoting growth. …”
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