PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2− breast cancer by Eduardo Terán, Rebeca Lozano, César A. Rodríguez, Mar Abad, Luis Figuero, José Antonio Muñoz, Belén Cigarral, Aline Rodrígues, Magdalena Sancho, M. Asunción Gómez, Daniel Morchón, Juan Carlos Montero, José María Sayagués, M. Dolores Ludeña, Emilio Fonseca

“…A subanalysis was carried out based on exons 9 and 20, which showed a statistically poorer PFS in PIK3CAm exon 9 versus 20 population (9.7 m vs. 30.3 m; HR = 2.84; p = 0.024). …”
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Attention speed and anterior cingulate cortex volume in female and male veterans with suicide ideation and attempts by Erin C. McGlade, Erin C. McGlade, Erin C. McGlade, James R. Yancey, James R. Yancey, James R. Yancey, Keenan E. Roberts, Keenan E. Roberts, Keenan E. Roberts, Audrey Elias, Audrey Elias, Chelsea Carson, Chelsea Carson, Chelsea Carson, Jiyoung Ma, Jiyoung Ma, Margaret R. Legarreta, Margaret R. Legarreta, Deborah A. Yurgelun-Todd, Deborah A. Yurgelun-Todd, Deborah A. Yurgelun-Todd

“…Attentional processes have emerged as a possible predictor of suicide behaviors (SB), yet associated neural correlates remain understudied, particularly in the Veteran population.MethodsThe current study examines sustained and selective attention performance as indexed by the Ruff 2 & 7 Selective Attention Test and anterior cingulate cortex (ACC) volume as they relate to SB in Veterans. …”
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Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…New strategies such as total neoadjuvant therapy (TNT) and neoadjuvant immunotherapy have shown great promise in certain patient populations. Currently, there is an urgent need to stratify patients before treatment to adopt the appropriate neoadjuvant strategies. …”
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Prevalence and temporal trends in myopia and high myopia children in China: a systematic review and meta-analysis with projections from 2020 to 2050Research in context by Wei Pan, Seang-Mei Saw, Tien Yin Wong, Ian Morgan, Zhikuan Yang, Weizhong Lan

“…Methods: A systematic review and meta-analysis searching several databases in both English and Chinese: PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI), Wanfang, China Science and Technology Journal Database (CSTJ) with date limits from 01/01/2010 to 11/23/2024 was conducted. We included population-based or school-based studies in China that determined the myopia prevalence, based on the cycloplegic refraction, in children under 20. …”
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Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…Therefore, we investigated if these symptoms are helpful for triage and diagnosis of ACS in females and males with acute chest discomfort.Design Cross-sectional study.Setting Nine out-of-hours service in primary care (OHS-PC) in the Netherlands participated, covering both rural and urban areas, serving a total population of 1.5 million people.Participants 2195 patients were selected calling the OHS-PC with acute chest discomfort, 55.4% were females. …”
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Real-world outcomes of Defocus Incorporated Multiple Segments lenses on retarding axial elongation in myopic children and adolescents by Rachel K. M. Chun, Rachel K. M. Chun, Rachel K. M. Chun, Kryshell Y. Q. Wong, Carly S. Y. Lam, Carly S. Y. Lam, Carly S. Y. Lam, Chi-ho To, Chi-ho To, Chi-ho To, Chi-ho To, Kenneth K. K. Liu, Yin-zhi Wong, Wing-chun Tang, Nicole Chan, Dora Kwok, Max Cheung, David Yung, Andrew K. C. Lam, Andrew K. C. Lam, Andrew K. C. Lam

“…PurposeThis study aimed to examine the effect of Defocus Incorporated Multiple Segments (DIMS) lenses on myopia progression and axial elongation in a clinical population.MethodsA retrospective study was conducted using clinical data from 489 and 156 patients aged 3 to 17 years old who were prescribed DIMS and single vision (SV) lenses, respectively at the Optometry Clinic of The Hong Kong Polytechnic University between July 2018 and August 2019. …”
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Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults: A systematic review and meta-analysi... by Ben Singh, Cristina Cadenas-Sanchez, Bruno G.G. da Costa, José Castro-Piñero, Jean-Philippe Chaput, Magdalena Cuenca-García, Carol Maher, Nuria Marín-Jiménez, Ryan McGrath, Pablo Molina-García, Jonathan Myers, Bethany Gower, Francisco B. Ortega, Justin J. Lang, Grant R. Tomkinson

“…Estimated CRF could provide a practical and robust alternative to objectively measured CRF for assessing mortality risk across diverse populations. Our findings underscore the health-related benefits of higher CRF and advocate for its integration into clinical practice to enhance risk stratification.…”
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Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa by Katrien F.M. Bracké, Laura Monteiro Rente Dias, Marisha N. Meijer, Cathelijne P.M. Steegers, Laurinde F. den Heijer, Tess van der Harst, Marjolein H.G. Dremmen, Meike W. Vernooij, Gwen C. Dieleman, Tonya White

“…Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN. …”
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Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision m... by Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu, the SEARCH 010/RV254 study group

“…Conclusions Persistent eGFRcre decrease to < 90 ml/min/1.73 m2 after switch to DTG was common in this Thai population. eGFRcystC was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…Future studies should be designed to further interrogate our findings, while accommodating for nuances specific to the paediatric deceased-donor population and their families. …”
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Hypertension moderates the relationship between plasma beta-amyloid and cognitive impairment: a cross-sectional study in Xi’an, China by Ziyu Liu, Yaoli He, Simeng Cui, Liangjun Dang, Binyan Zhang, Jin Wang, Wenhui Lu, Kang Huo, Yu Jiang, Chen Chen, Ling Gao, Shan Wei, Yi Zhao, Ningwei Hu, Jingyi Wang, Hong Lv, Hong Lv, Qiumin Qu, Qiumin Qu, Suhang Shang

“…Multivariate logistic regression examined the relationship between plasma Aβ and CI in total population, the hypertension subgroup and the non-hypertension subgroup.Results737 participants (49.5%) had hypertension and 189 participants (12.7%) had CI. …”
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Diagnostic Value of Sodium, White Blood Cell, Neutrophil Levels; White Blood Cell/Sodium and Neutrophil/Sodium Ratios in Appendicitis in Pediatric Patients by Cem Kaya, Gökhan Arkan, Fatma Nur Aracıer Uçaner, Leyla Nur Türker, Alparslan Kapısız, Ramazan Karabulut, Zafer Türkyılmaz, Kaan Sönmez

“…Further research is warranted to explore their utility in larger populations.…”
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From ocean to cage: evaluating the culture feasibility of Black-spotted croaker (Protonibea diacanthus) by Shubhadeep Ghosh, Gyanaranjan Dash, Biswajit Dash, Rajesh Kumar Pradhan, Sekar Megarajan, Pralaya Ranjan Behera, Ritesh Ranjan, Swatipriyanka Sen, Madhumita Das, Vettath Raghavan Suresh, Achamveetil Gopalakrishnan, Joykrushna Jena

“…The growth performance index (ϕ’) was calculated at 1.91, surpassing values reported for wild populations. Polyculture with P. diacanthus did not significantly affect the growth or feed utilization of T. mookalee (P &gt; 0.05).Discussion and conclusionThe results indicate that P. diacanthus exhibits superior growth under marine cage culture conditions, with a high growth performance and compatibility in polyculture systems. …”
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Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease by Rui Wang, Yuanyuan Li, Yuting Jiang, Xiaona Liu, Hongqi Feng, Zhe Jiao, Bingyun Li, Chang Liu, Yuncheng Shen, Fang Chu, Chenpeng Zhu, Dianjun Sun, Wei Zhang

“…Conclusions Alleles and genotypes of the CRP/FCAR/FCGR2A gene can increase the susceptibility to COPD in the northern Chinese population. For the first time, environmental exposure to the CRP/FCAR/FCGR2A/FCGR2B genes has been shown to have synergistic or antagonistic effects on COPD susceptibility on genotypes or haplotypes.…”
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The impact of war on people with type 2 diabetes in Ukraine: a survey studyResearch in context by Oksana Sulaieva, Viktoriia Yerokhovych, Sergii Zemskov, Iuliia Komisarenko, Vitalii Gurianov, Volodymyr Pankiv, Oleksandr Tovkai, Tetyana Yuzvenko, Violetta Yuzvenko, Andrii Tovkai, Zlatoslava Shaienko, Tetyana Falalyeyeva, Nadiya Skrypnyk, Taras Romaniv, Nadiya Pasyechko, Taras Krytskyy, Solomiia Danyliuk, Andrii Klantsa, Dmytro Krasnienkov, Oleksandr Gurbych, Nazarii Kobyliak

“…Summary: Background: Although the number of studies reporting war-induced effects on the health of the Ukrainian population has been growing, there are still little data on assessing patients with type 2 diabetes (T2D) during the war. …”
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Which Measure of Stone Burden is the Best Predictor of Interventional Outcomes in Urolithiasis: A Systematic Review and Meta-analysis by the YAU Urolithiasis Working Group and EAU... by Robert Geraghty, Amelia Pietropaolo, Lazaros Tzelves, Riccardo Lombardo, Helene Jung, Andreas Neisius, Ales Petrik, Bhaskar K. Somani, Niall F. Davis, Giovanni Gambaro, Romain Boissier, Andreas Skolarikos, Thomas Tailly

“…We considered all studies reporting prognostic accuracy statistics on any intervention for kidney stones (extracorporeal shockwave lithotripsy [ESWL], ureterorenoscopy [URS], or percutaneous nephrolithotomy [PCNL]; Population) using multiplane measurements of stone burden (area in mm2 or volume in mm3; Intervention) in comparison to single-plane measurements of stone burden (size in mm; Intervention) for the study-defined stone-free rate (Outcome) in a PICO-framed question. …”
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Increased Early‐Mortality in Children With Solid Tumors During the COVID‐19 Pandemic in a Middle‐Income Country by Oscar Ramirez, Vivian Piedrahita, Santiago Bolivar, Karina Grillo, Adriana Linares, Carlos Pardo, Martha Piña, Amaranto Suarez, Carlos A. Portilla, Jesus Ardila, Viviana Lotero, Luz A. Urcuqui, Angela Trujillo, Patricia Montenegro, Luis E. Bravo, Paula Aristizabal, VIGICANCER Working Group

“…Early‐mortality was higher in patients with public insurance, a vulnerable population that warrants attention.…”
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Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis by Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Arkaitz Mucientes, Arkaitz Mucientes, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Rocío Redondo-Rodriguez, Rocío Redondo-Rodriguez, Laura Cano-García, Laura Cano-García, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…A Cox multivariate analysis was performed to identify factors related to D2T RA.ResultsThe study population comprised 39 patients: 13 (33%) with D2T RA and 26 (66%) with E2T RA. …”
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The burden of headache disorders among medical students in Vietnam: estimates from a cross-sectional study with a health-care needs assessment by Dung Viet Nguyen, Hieu Trung Vo, Khoi Hong Vo, Lam Tung Duong, Lam Que La, An Bao Hoang, Phu Hong Vo, Thao Thu Tran, Binh Van Phan, Huong Thi Thu Pham, Hai-Anh Nguyen, Nga Thi Bui, Phuc Duy Phan, Thang Xuan Pham, Cong-Hoang Nguyen, Ngoc-Linh Thi Pham, Luc Tien Trinh, Duong Thi Ha, Ha-An Phan, Thanh-Thuy Ho, Loi Thi Dinh, Le Thi Bich Nguyen, Linh Hue Nguyen, Toan Van Phan, Thuy Thanh Truong, Quy Huu Ha, Hoai Thi Thu Nguyen

“…In the present study, we provide estimates of the associated symptom burden and impaired participation, utilizing these estimates to assess headache-related healthcare needs within this population. Methods The study followed the standardized methodology established by the Global Campaign against Headache. …”
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Beta-variant recombinant SARS CoV-2 vaccine induces durable cross-reactive antibodies against Omicron BA variants by Odile Launay, Rachna Gupta, Tifany Machabert, Eleine Konate, Alexandra Rousseau, Claire Vigne, Francois Beckers, Louis Devlin, Elisabeth Botelho-Nevers, Marine Cachanado, Christian Chidiac, Dominique Deplanque, Bertrand Dussol, Inès Ben Ghezala, Marie Lachatre, Karine Lacombe, Fabrice Laine, Liem Binh Luong Nguyen, Patricia Pavese, Catherine Schmidt-Mutter, Marie-Pierre Tavolacci, Roman M. Chicz, Bogdana Coudsy, Saranya Sridhar, Amel Touati, Eric Tartour, Tabassome Simon

“…Results Across the whole population, MVB.1.351 vaccine induces highest NAbs titers against Omicron BA.1 and BA.4/5 variants at D28 and M3 post-booster. …”
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