Identification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking by Xiao-Yao Li, Bei-Yuan Zhang, Xin-Ran Liang, Yan-Yu Han, Min-Hua Cheng, Mei Wei, Ke Cao, Xian-Cheng Chen, Ming Chen, Jian-Feng Duan, Wen-Kui Yu

“…A biogenic analysis was performed to study the population frequency, conservation, and electric potential diagram of the new variant p.K327N. …”
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Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis by Julia M. Scheffler, Christina Drevinge, Catharina Lindholm, Inger Gjertsson, Kristina Lend, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Tuulikki Sokka‐Isler, Dan Nordström, Kim Hørslev‐Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald vanVollenhoven, Hans Carlsten, Mattias Lorentzon, Anna‐Karin Hultgård Ekwall, Anna Rudin, Ulrika Islander

“…The correlations of circulating baseline T helper cell and regulatory T cell populations with trabecular bone changes suggest a potential novel role for these cells in systemic bone homeostasis during early RA.…”
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Co-occurring climate events and environmental justice in California, 2018–2019 by Brittany Shea, Gabriella Y Meltzer, Benjamin B Steiger, Robbie M Parks, Vivian Do, Heather McBrien, Nina Flores, Milo Gordon, Elizabeth M Blake, Joan A Casey

“…Using the CDC/ATSDR Social Vulnerability Index (SVI), we determined whether co-occurring events disproportionately affected vulnerable populations. Nearly every county (97%) experienced at least one day of anomalously warm temperatures, 57% had at least one wildfire burn zone disaster day, and 63% (24/38 counties with available data) had at least one long power outage day. …”
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Prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli over time in Thailand under a One Health approach: A systematic review and meta-analysis by Doan Hoang Phu, Tuempong Wongtawan, Truong Thanh Nam, Dinh Bao Truong, Naparat Suttidate, Juan Carrique-Mas, Niwat Chansiripornchai, Conny Turni, Patrick J. Blackall, Thotsapol Thomrongsuwannakij

“…The highest prevalence of C. jejuni was found in chickens (43.6 %) and chicken products (31.4 %), followed by ducks (16.7 %), the general human population with diarrhea (15.9 %), children with diarrhea (10.7 %). …”
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Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia: a systematic review and meta-analysis by Tekletsadik Tekleslassie Alemayehu, Yilkal Abebaw Wassie, Abaynesh Fentahun Bekalu, Addisu Afrassa Tegegne, Wondim Ayenew, Gebresilassie Tadesse, Demis Getachew, Abebaw Setegn Yazie, Bisrat Birke Teketelew, Mekonnen Derese Mekete, Setegn Fentahun, Tesfaye Birhanu Abebe, Tefera Minwagaw, Gebremariam Wulie Geremew

“…Abstract Background The occurrence of potential drug‒drug interactions (pDDIs) is a serious global issue that affects all age groups, with the elderly population being the most vulnerable. This is due to their relatively high rates of comorbidity and polypharmacy, as well as physiological changes that can increase the potential for DDIs and the likelihood of adverse drug reactions. …”
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Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (D... by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…Unlike other high-risk paediatric populations, standardised routine neurodevelopmental follow-up of PICU survivors is rare, and there is limited knowledge regarding the best methods. …”
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Adverse events of hepatic anti-fibrotic agents in phase 3 and above clinical trials: a descriptive analysis of the WHO-VigiAccess database by Yuwei Liu, Yuwei Liu, Xu Zhao, Xu Zhao, Xinrui Wang, Xinrui Wang, Qiang Zhou, Qiang Zhou

“…Future efforts should focus on improving the pharmacovigilance system, expanding population diversity in trials, and conducting ongoing research and extensive post-marketing surveillance.…”
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Revealing Land-Use Dynamics on Thermal Environment of Riverine Cities Under Climate Variability Using Remote Sensing and Geospatial Techniques by Nazia Iftakhar, Fakhrul Islam, Mohammad Izhar Hussain, Muhammad Nasar Ahmad, Jinwook Lee, Nazir Ur Rehman, Saleh Qaysi, Nassir Alarifi, Youssef M. Youssef

“…The WCT map showed a general warming trend (cold-to-hot type) from 2000 to 2020, particularly in newly urbanized areas due to a 49.63% population increase, while cooling effects (hot-to-cold type) emerged in the newly developed agricultural lands with a 46.46% rise in vegetation. …”
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Serum advanced glycation end products as a putative biomarker in Type2 DKD patients’ prognosis by Ze-Hou Wang, Ze-Hou Wang, Zong-Jin Zhang, Yue-Fen Wang, Jin Xie, Jin Xie, Yi-Min Li, Cun Shen, Yuan Meng, Wen-Jing Zhao, Lu-Ying Sun, Wei Jing Liu

“…These findings should be validated in broader populations in future research.…”
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Country economic status is strongly associated with burn survival - validation of the (modified) ABSI by Julia Elrod, Christoph Mohr, Ludvik Branski, Joshua M. Peterson, Fionna M. Wood, Dale W. Edgar, Pius Agbenorku, Shobha Chamania, Anant Sharma, Flavio N. Novaes, Jean Bosco Katabogama, Michael Boettcher, Konrad Reinshagen, Ingo Koenigs

“…Significant variations in population demographics, sample sizes, total body surface area (TBSA), and age distributions across the studied regions were noted. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Improvements in pain, fatigue, physical function and health-related quality of life were sustained.Conclusions The safety profile of bimekizumab after 5 years of treatment remained consistent with previous reports, with no new safety signals identified. 5-year efficacy was sustained in this r-axSpA population following robust disease control achieved at Week 48.Trial registration numbers NCT02963506; NCT03355573.…”
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Sharing of cmeRABC alleles between C. coli and C. jejuni associated with extensive drug resistance in Campylobacter isolates from infants and poultry in the Peruvian Amazon by Kerry K. Cooper, Evangelos Mourkas, Francesca Schiaffino, Craig T. Parker, Tackeshy N. Pinedo Vasquez, Paul F. Garcia Bardales, Pablo Peñataro Yori, Maribel Paredes Olortegui, Katia Manzanares Villanueva, Lucero Romaina Cachique, Hermann Silva Delgado, Matthew D. Hitchings, Steven Huynh, Samuel K. Sheppard, Ben Pascoe, Margaret N. Kosek

“…We investigated the population structure of genes in the cmeRABC operon and identified a potential genetic bottleneck for the cmeA and cmeB genes. …”
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Characteristics and outcomes of patients with LAM receiving sirolimus in France based on real-life data by Vincent Cottin, Vincent Cottin, Antoine Cases, Virginie Bourdin, Martine Reynaud-Gaubert, Sandrine Hirschi, Mallorie Kerjouan, Rémi Diesler, Rémi Diesler, Brieux Chardès, Stéphane Fiévez, Nada Assi, Aurélie Schmidt, Hélène Denis, Lidwine Wémeau-Stervinou, Yurdagul Uzunhan

“…Even though some of the results should be interpreted cautiously in the light of limitations related to the use of claims database, evolution of the disease and missing safety data, the information retrieved in this study is very valuable, as few studies provide real-world information on LAM populations.…”
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Ambient air pollution and Alzheimer’s disease and other dementias: a global study between 1990 and 2019 by Cui Guo, Dongze Wu, Jun Yang, Xingcheng Lu, Xiang Yan Chen, Jun Ma, Changqing Lin, Alexis K. H. Lau, Yingzhao Jin, Ruiyun Li, Shenjing He

“…Conclusions The burden of dementia is expected to increase globally, given the continuously expansion of the ageing population. Air pollution was found to be significantly associated with a higher burden of AD and dementia. …”
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Potential role of particulate matter in the spreading of COVID-19 in Northern Italy: first observational study based on initial epidemic diffusion by Alessandro Miani, Annamaria Colao, Prisco Piscitelli, Leonardo Setti, Fabrizio Passarini, Gianluigi De Gennaro, Pierluigi Barbieri, Sabina Licen, Maria Grazia Perrone, Andrea Piazzalunga, Massimo Borelli, Jolanda Palmisani, Alessia Di Gilio, Emanuele Rizzo

“…In addition to the number of exceedances of the daily limit value of PM10, we also considered population data and daily travelling information for each province.Results Exceedance of the daily limit value of PM10 appears to be a significant predictor of infection in univariate analyses (p<0.001). …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition by Dongsheng Di, Haolong Zhou, Zhangbo Cui, Jianli Zhang, Qian Liu, Tingting Yuan, Tingting Zhou, Xiao Luo, Danyang Ling, Qi Wang

“…Introduction: The growing prevalence of osteoporosis (OP) in an aging global population presents a significant public health concern. …”
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Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

“…Background and Aims: Refractory celiac disease type II (RCDII) is characterized by a clonally expanded aberrant cell population in the small intestine. The role of other tissue-resident immune subsets in RCDII is unknown. …”
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One Health interventions and challenges under rural African smallholder farmer settings: A scoping review by Evanson R. Omuse, Honest Machekano, Bonoukpoè M. Sokame, Daniel M. Mutyambai, Thomas Dubois, Sevgan Subramanian, Frank Chidawanyika

“…The global human population is rapidly increasing, escalating interactions of people, animals and the environment. …”
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Molecular Data Confirm the Occurrence of the Allochthonous <i>Gambusia holbrooki</i> (Pisces: Poeciliidae) in Sicily and the Maltese Archipelago by Luca Vecchioni, Mirko Liuzzo, Arnold Sciberras, Jeffrey Sciberras, Justin Formosa, Alan Deidun, Gabriele Giacalone, Vincenzo Arizza, Marco Arculeo, Federico Marrone, Francesco Paolo Faraone

“…<i>affinis</i> in Italy and Malta, we conducted extensive sampling in Sicily (Italy) and in the Maltese archipelago, aiming to verify the identity of <i>Gambusia</i> populations occurring in the study area. Based on sequences of the mitochondrial cytochrome b gene, we consistently observed the occurrence of only <i>G. holbrooki</i> in the investigated area, finding, almost exclusively, the most common haplotype known for the species in the whole invaded range (i.e., “HOL1”).…”
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Ultrasound and histopathological assessment of benign, borderline, and malignant thyroid tumors in pediatric patients: an illustrative review and literature overview by Dominika Januś, Dominika Januś, Monika Kujdowicz, Monika Kujdowicz, Aleksandra Kiszka-Wiłkojć, Aleksandra Kiszka-Wiłkojć, Konrad Kaleta, Anna Taczanowska-Niemczuk, Anna Taczanowska-Niemczuk, Jan Radliński, Kamil Możdżeń, Zuzanna Nowak, Wojciech Górecki, Wojciech Górecki, Jerzy B. Starzyk, Jerzy B. Starzyk

“…However, given that not all solid thyroid nodules are malignant, a more conservative approach may also be appropriate in certain cases.ObjectiveThis study aims to present an illustrative analysis of the pathological foundations underlying the sonographic appearance of benign, borderline, and malignant thyroid nodules in the pediatric population at a single tertiary thyroid center.MethodsA total of 47 well-documented pediatric patients referred for thyroid surgery between 2010 and 2023 were analyzed. …”
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