Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

“…BackgroundAnti-citrullinated peptide antibodies (ACPA)-negative (ACPA−) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive cellular and metabolic profiles for more targeted interventions.MethodsSingle-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) and synovial tissues of patients with ACPA− and ACPA+ RA, as well as healthy controls, were analyzed. Immune cell populations were classified based on clustering and marker gene expression, with pseudotime trajectory analysis, weighted gene co-expression network analysis (WGCNA), and transcription factor network inference providing further insights. …”
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Older adults’ Internet use behavior and its association with accelerometer-derived physical activity by Yen-Yu Chung, Jiaren Chen, Mei-Chun Lin, Ruo-Lan Liu, Jenn-Bang Wu, Hsin-Chang Tsai, Ting-Fu Lai, Ting-Fu Lai, Yung Liao, Yung Liao, Jong-Hwan Park, Jong-Hwan Park, Jong-Hwan Park

“…ObjectiveThe aging population is thriving worldwide, and it is critical to improve the health of older adults through physical activity (PA). …”
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Manejo en atención primaria de las infecciones de transmisión sexual (III). Hepatitis víricas e infección por el VIH by Ricard Carrillo Muñoz, Cristina Agustí Benito, Mariam de la Poza Abad, Juanjo Mascort Roca

“…Abstract: Routinely obtaining a sexual history is a necessary first step to identify which patients have specific sexual behaviours that may put them at risk and use appropriate protective measures, especially in vulnerable populations. However, late diagnosis of HIV infection remains very high. …”
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The Timing of Infarction Pain in Patients with Acute Myocardial Infarction after Previous Revascularization by Predrag M. Mitrovic, Branislav Stefanovic, Zorana Vasiljevic, Mina Radovanovic, Nebojsa Radovanovic, Gordana Krljanac, Dubravka Rajic, Predrag Erceg, Vladan Vukcevic, Ivana Nedeljkovic, Miodrag Ostojic

“…The subgroups with specific clinical characteristics exhibited different patterns that determined these peaks in all populations. In patients older than 70 years of age, in both sexes, in smokers, diabetics, in patients with hypertension, in those undergoing beta-blocker therapy, and in patients without previous angina, two nearly equal peaks were observed, with higher evening peaks, except in those patients with hypertension and without angina. …”
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Increases in the susceptibility of human endometrial CD4+ T cells to HIV-1 infection post-menopause are not dependent on greater viral receptor expression frequency by Landon G. vom Steeg, Zheng Shen, Jane Collins, Mickey V. Patel, Fiona D. Barr, Daniel C. Hopkins, Christina Ochsenbauer, Charles R. Wira

“…These findings contribute to our understanding of how advanced age alters HIV infection risk which will become increasingly important as the human population continues to age.…”
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The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers by Terkimbi Dominic Swase, Ilemobayo Victor Fasogbon, Ifie Josiah Eseoghene, Ekom Monday Etukudo, Solomon Adomi Mbina, Chebet Joan, Reuben Samson Dangana, Chinyere Anyanwu, Comfort Danchal Vandu, A. B Agbaje, Tijjani Salihu Shinkafi, Ibrahim Babangida Abubarkar, Patrick Maduabuchi Aja

“…The expression of cervical cancer biomarker such as p16INK4a and Ki-67 emphasized target screening and early detection strategy in high-risk population. However, there was no direct impact of HPV/HIV co-infection reported on these biomarkers and required to be studied more especially in people living with HIV.…”
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Predicting the Global Distribution of <i>Nitraria</i> L. Under Climate Change Based on Optimized MaxEnt Modeling by Ke Lu, Mili Liu, Qi Feng, Wei Liu, Meng Zhu, Yizhong Duan

“…This study can provide a theoretical basis for determining the scope of <i>Nitraria</i> L. habitat protection, population restoration, resource management and industrial development in local areas.…”
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Validation of the role of apolipoproteins in coronary artery disease patients with impaired kidney function for prognosis: a prospective cohort study in China by Zixiang Ye, Enmin Xie, Zhangyu Lin, Chenxi Song, Rui zhang, Haoyu Wang, Yongbao Zhang, Kefei Dou

“…These results emphasize the need for incorporating apolipoprotein measurements in secondary prevention strategies for this high-risk population.…”
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Inferior vena cava diameter in patients with chronic heart failure and chronic kidney disease: a retrospective study by Jianan Li, Chi Wang, Hui wu Dong, Jing Qi, Chongyou Rao, Qiuyang Li, Kunlun He

“…Abstract Background Chronic kidney disease (CKD) carries the highest population attributable risk for mortality among all comorbidities in chronic heart failure (CHF). …”
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Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial by Todd Molfenter, Jessica Vechinski, Jee-Seon Kim, Jingru Zhang, Lionel Meng, Jessica Tveit, Lynn Madden, Faye S. Taxman

“…Results Jail sizes ranged from 24% with < 100 and 24% with > 500 daily population, and community-based treatment providers ranged from 63% with < 50 and 7% with > 500 average monthly OUD intakes. …”
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Effect of Kind and Dosage of Enrichment Materials on the Nutritional Quality of Rotifers Especially n3-HUFA by Muhammad Agus Suprayudi

“…In addition Nannochloropsis oculata as an enrichment material showed the highest population density of rotifers during enrichment periods.  …”
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Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…In addition, our data point to the pathogenic potential of the conversion of conventional adaptive B cells, which are the most common population of mature B cells, into innate-like B cells and the production of autoreactive IgA antibodies during homeostatic proliferation. …”
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Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus by Petra Borilova Linhartova, Hana Poskerova, Marie Tomandlova, Jirina Bartova, Katerina Kankova, Antonin Fassmann, Lydie Izakovicova Holla

“…Although IL-1β levels were measured significantly higher in mononuclear cells after stimulation by mitogens, HSP70, or selected periodontal bacteria than in unstimulated cells, IL-1 genotypes did not correlate with circulating IL-1β levels. In the Czech population, significant associations between the IL-1B polymorphism with CP and the IL-1RN variant with T1DM were found. …”
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Hubungan Pemberian Makanan Tambahan Dini terhadap Status Gizi Bayi Usia 4-6 Bulan di Daerah Pantai Kota Padang Tahun 2013 by Fenny Oktrina Fauthrisna, Masrul , Eva Chundrayetti

“…This research is using a cross sectional study’ method,<br />however the entire population is mothers with  infants aged 4-6 months in the district of West Padang, North Padang and Koto Tangah, Padang city and the total sample of 126 people. …”
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Enhancing pathogens detection in suspected geriatric bloodstream infections using Nanopore-targeted sequencing by Menghui Zhao, Yan Ouyang, Junchi Mei, Hang Liu

“…This study highlights the need for further research to validate the routine clinical integration of NTS for managing BSIs in geriatric populations.IMPORTANCEBloodstream infections (BSIs) in elderly patients pose substantial diagnostic and therapeutic challenges due to the limitations of traditional blood culture methods, which are hampered by slow turnaround times and false-negatives. …”
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Gender-based Morphometric Analysis of the Human Orbital Aperture Profile using 3D Reconstruction Computed Tomography: A Cross-sectional Retrospective Study by Muhammad Omer Afzal Bhatti, Mujeeb Ur Rehman Parrey, Muhammad Ikram Ali, Allah Rakhyo Shoro, Abdulkrem Ahmed Alenazi, Rayan Alhumaidi Alruwaili

“…Aim: To measure and compare orbital apertures between males and females using 3D Computed Tomography (CT) in a sample from the Saudi population. Materials and Methods: A cross-sectional retrospective study was conducted from January to June 2024 in the Radiology Department of Tower Hospital, Arar, Kingdom of Saudi Arabia, following the acquisition of ethical approval from the Local Bioethics Committee at Northern Border University. …”
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Adolescent Youth Survey on HIV Prevention and Sexual Health Education in Alabama: Protocol for a Web-Based Survey With Fraud Protection Study by Henna Budhwani, Ibrahim Yigit, Josh Bruce, Christyenne Lily Bond, Andrea Johnson

“…ConclusionsIf the study is successful, it will yield information on HIV knowledge, PrEP awareness, PrEP preferences, and related outcomes among sexual and gender minority teenagers in Alabama, an underserved, hard-to-reach, but also high-priority population for public health efforts to Ending the HIV Epidemic. …”
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Hubungan antara Harga Diri dan Kepercayaan Diri dengan Motivasi Berprestasi Siswa SMA by Yeniar Indriana, Muhammad Dzikron Fadhlurrohman

“…The purpose of this study is to determine the relationship between self-esteem and self-confidence to achievement motivation and also to find out the effective contribution given by the independent variable to the dependent variable. The study population consists of high school students majoring in science in grade XI, aged between 17 and 19 years. …”
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The Acute VertEbRal AugmentaTion (AVERT) study: protocol for a randomised controlled, feasibility trial of spinal medial branch nerve block in hospitalised older patients with vert... by Avril Drummond, Opinder Sahota, Simon Bishop, Dritan Pasku, Apostolos Fakis, Anastasios Bastounis, Chia Wei Tan, Maribel Cameron, Yuriy Arlachov, Michal Czernicki

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Health literacy status and associated factors among residents in Anhui Province, China: a cross-sectional study by Yuansheng Fu, Jianrong Xie, De Xu, Yuanrui Xia, Zhimin Wang, Yinguang Fan

“…Improving HL stands as one of the most essential, cost-effective, and efficacious strategies for enhancing the overall health of the population. This study aims to analyze the status of HL among urban and rural residents in Anhui Province, explore the associated factors, and provide a scientific basis for the formulation of targeted health education and promotion strategies.MethodsA cross-sectional survey was conducted on 16,080 non-collective residents in Anhui Province from July to September 2022. …”
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