Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…The long-term safety of upadacitinib in extensive populations remains unexplored. This study evaluates upadacitinib-related adverse events (AEs) utilizing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsWe employed disproportionality analyses, including the proportional reporting ratio (PRR), reporting odds ratio (ROR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayesian geometric mean (EBGM) algorithms to identify signals of upadacitinib-associated AEs for treating inflammatory bowel disease (IBD).ResultsFrom a total of 7,037,004 adverse event reports sourced from the FAERS database, 37,822 identified upadacitinib as the primary suspect drug in adverse drug events (ADEs), including 1,917 reports specifically related to the treatment of inflammatory bowel disease (IBD). …”
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Modulation of local immunity by the vaginal microbiome is associated with triggering spontaneous preterm birth by Yijia Liang, Yijia Liang, Yijia Liang, Changying Zhao, Yan Wen, Dashuang Sheng, Tiantian Wei, Tianqi Hu, Junhui Dai, Guoping Zhao, Guoping Zhao, Guoping Zhao, Sijie Yang, Sijie Yang, Qinghua Wang, Lei Zhang, Lei Zhang

“…ObjectiveThis study aimed to identify immune states associated with a high risk of preterm birth by immunophenotyping in pregnant populations, and to elucidate the characteristics of immune subtypes and their relationships with preterm birth. …”
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Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”? by Fritsch, Clémentine, Appenzeller, Brice M. R., Bertrand, Colette, Coeurdassier, Michael, Driget, Vincent, Hardy, Emilie M, Palazzi, Paul, Schaeffer, Charline, Goydadin, Anne-Claude, Gaba, Sabrina, Bretagnolle, Vincent, Pelosi, Céline

“…On the basis of dose reconstruction approaches and toxicological thresholds from the literature, GLY and GLUF levels may be associated with risk in small mammals and endanger local populations. Our findings raise issues about the omnipresence of GLY, AMPA and GLUF in agricultural landscapes, including in animals from habitats considered refuges, questioning their ecological safety. …”
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On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…An ongoing mosquito dispersal within the Limassol district was detected, suggesting the presence of established, hidden adventive populations. These mosquitoes share a high degree of ancestry with those in the Balkans and parts of northern Italy that border the Adriatic Sea. …”
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Cytotoxicity Potential of Endophytic Fungi Extracts from Terminalia catappa against Human Cervical Cancer Cells by Michèle Stella Majoumouo, Marius Belmondo Tincho, Rufin Marie Kouipou Toghueo, Thureyah Morris, Donavon Charles Hiss, Fabrice Fekam Boyom, Chitra Mandal

“…The percentages of cell populations were increased at late apoptosis (Annexin+/PI+), with the percentages of 27.4 ± 0.3 and 19.2 ± 0.01 obtained, respectively, for 50 µg/ml and 80 µg/ml of the N97 extract and 2.1 ± 0.1 obtained for the control in late apoptosis (Annexin V+/PI+) . …”
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KMO-driven metabolic reconfiguration and its impact on immune cell infiltration in nasopharyngeal carcinoma: a new avenue for immunotherapy by Nijun Chen, Yuan Zong, Chen Yang, Lei Li, Yang Yi, Jiawen Zhao, Xiaoyu Zhao, Xianfei Xie, Xingmei Sun, Ning Li, Liting Jiang

“…Importantly, KMO levels positively correlated with the infiltration of various immune cell populations, including B cells, T cells, and macrophages, as well as inflammatory signatures. …”
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Evaluation of Human Leukocyte Antigen Class I and Class II in End-Stage Renal Disease Occurrence in Indonesian Transplantation Patients by Hani Susianti, Dwi Priyadi Djatmiko, I Komang Adi Widana, Deasy Ayuningtyas Tandio, Catur Suci Sutrisnani, Singgih Pudjo Wahono, Ira Puspitawati

“…Genetic studies of end-stage renal disease (ESRD), including those of human leukocyte antigen (HLA) genes, have been reported in several populations but have not yet been evaluated in Indonesia. …”
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Association between occupational exposure to gasoline and anemia: a retrospective cohort study in China by Lan Lin, Hongmei Cao, Beining Wu, Jin Wang, Lin Song, Weiling Chan, Geyang Li, Li Zhou, Jing Xiao, Lejia Zhu, Yulong Lian

“…Anemia was diagnosed according to WHO guidelines on hemoglobin cutoffs to define anemia in individuals and populations. Occupational exposure concentration of gasoline was measured based on the Chinese national standard (GBZ-T300.62-2017). …”
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Effects of traditional Chinese medicine massage therapy on pain, functional activity, muscle activation patterns and proprioception in knee osteoarthritis: a randomised controlled... by Xin Zhou, Cheng Tang, Bowen Zhu, Yangyang Fu, Min Fang, Sitong Fang, Qingguang Zhu, Yuen Yee Janice Hiew

“…Outcome analyses will be conducted on both intention-to-treat and per-protocol populations. A preliminary analysis will test whether TCM massage, in addition to exercise, has statistically better outcomes.Ethics and dissemination The study protocol has received approval from the Ethics Committee of Shuguang Hospital, Shanghai University of Traditional Chinese Medicine (2023-1357-124-01).All study participants will be required to give written informed consent. …”
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Stature estimation and sex determination from contemporary Northeastern Thai clavicles using discriminant function and linear regression analyses by Chanasorn Poodendaen, Poonikha Namwongsakool, Sitthichai Iamsaard, Nareelak Tangsrisakda, Rarinthron Samrid, Chadaporn Chaimontri, Worrawit Boonthai, Suthat Duangchit

“…High variability of clavicle has significant forensic application in many populations except the modern Northeastern Thais. This study aimed to develop the discriminant function analysis to estimate stature and sex dimorphism from dry clavicles in exploring a potential method for Thai forensic anthropology. …”
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Disease burden of biliary tract cancer in 204 countries and territories, 1990–2021: A comprehensive demographic analysis of the Global Burden of Disease Study 2021 by Xuheng Sun, Jiangmei Liu, Wei Zhang, Yijun Wang, Yan Jiang, Lijun Wang, Yixin Zou, Yuxuan Xiao, Yongbing Xiang, Maolan Li, Maigeng Zhou, Yingbin Liu, Sihan Zhou, Xiuyuan Hao

“…This study provided a comprehensive comparison of differences in the burden of disease across populations and over time, and further presented evidence concerning the formulation of prevention and control policies and etiologic studies for BTCs and proposed logical hypotheses to investigate.…”
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Social capital and physical activity: a literature review up to March 2024 by Zhendong Gao, Chen Soon Chee, Roxana Dev Omar Dev, Yutong Liu, Jianhong Gao, Rui Li, Fangyi Li, Xiaoxiao Liu, Tao Wang

“…When designing public health interventions in the future, it is crucial to tailor strategies to different populations and contexts to better leverage social capital in promoting physical activity.…”
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Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal by Bobby Brooke Herrera, Bobby Brooke Herrera, Bobby Brooke Herrera, Bobby Brooke Herrera, Beth Chaplin, Souleymane MBoup, Adam Abdullahi, Adam Abdullahi, Michelle He, Sydney M. Fisher, Sulaimon Akanmu, Charlotte A. Chang, Donald J. Hamel, Ravindra K. Gupta, Ravindra K. Gupta, Phyllis J. Kanki

“…BackgroundThe COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. …”
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Construction and evaluation of a triage assessment model for patients with acute non-traumatic chest pain: mixed retrospective and prospective observational study by Xuan Zhou, Gangren Jian, Yuefang He, Yating Huang, Jie Zhang, Shengfang Wang, Yunxian Wang, Ruofei Zheng

“…Conclusion We proposed an accurate model to predict the high-risk populations with chest pain, based on which a simple and rapid online tool was developed and provided substantial support for its application as a decision-making tool for the emergency department. …”
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Community-based model for management and follow-up by non-physician healthcare workers to improve awareness, treatment, and control of hypertension: The COTRACO study protocolDetai... by A.J. Lora Mantilla, L.A. Parra Gomez, P.A. Camacho-López, J. Otero-Wandurraga, B. Novella, A. González-Medina, O. Valdez-Tiburcio, F. Lanas, M.C. Rocha-Lezama, J. Alonzo-Arias, C. Rivilla-Piñango, C. Cáceres-Ramírez, S.J. Villabona-Flórez, Y.M. Giraldo-Castrillón, P. López-Jaramillo

“…Propensity Score Matching will be used to select 300 patients in Chile and 1200 in Spain for comparison with standard care in these populations. Expected outcomes: The primary outcome at 12 months of follow-up is the percentage of patients achieving controlled hypertension (defined as systolic BP < 140 mmHg and diastolic BP < 90 mmHg, or < 130 mmHg, and diastolic BP < 80 mmHg for diabetic patients), ensuring it is not inferior to that achieved in the control countries. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…The World Health Organization (WHO) has recently promoted a multidisciplinary approach for pediatric chronic pain, integrating physical, psychological, and pharmacological interventions, given the high prevalence of pain in pediatric populations, affecting up to 46% of children and adolescents. …”
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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

“…BackgroundAnti-citrullinated peptide antibodies (ACPA)-negative (ACPA−) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive cellular and metabolic profiles for more targeted interventions.MethodsSingle-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) and synovial tissues of patients with ACPA− and ACPA+ RA, as well as healthy controls, were analyzed. Immune cell populations were classified based on clustering and marker gene expression, with pseudotime trajectory analysis, weighted gene co-expression network analysis (WGCNA), and transcription factor network inference providing further insights. …”
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Manejo en atención primaria de las infecciones de transmisión sexual (III). Hepatitis víricas e infección por el VIH by Ricard Carrillo Muñoz, Cristina Agustí Benito, Mariam de la Poza Abad, Juanjo Mascort Roca

“…Abstract: Routinely obtaining a sexual history is a necessary first step to identify which patients have specific sexual behaviours that may put them at risk and use appropriate protective measures, especially in vulnerable populations. However, late diagnosis of HIV infection remains very high. …”
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The Timing of Infarction Pain in Patients with Acute Myocardial Infarction after Previous Revascularization by Predrag M. Mitrovic, Branislav Stefanovic, Zorana Vasiljevic, Mina Radovanovic, Nebojsa Radovanovic, Gordana Krljanac, Dubravka Rajic, Predrag Erceg, Vladan Vukcevic, Ivana Nedeljkovic, Miodrag Ostojic

“…The subgroups with specific clinical characteristics exhibited different patterns that determined these peaks in all populations. In patients older than 70 years of age, in both sexes, in smokers, diabetics, in patients with hypertension, in those undergoing beta-blocker therapy, and in patients without previous angina, two nearly equal peaks were observed, with higher evening peaks, except in those patients with hypertension and without angina. …”
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Enhancing pathogens detection in suspected geriatric bloodstream infections using Nanopore-targeted sequencing by Menghui Zhao, Yan Ouyang, Junchi Mei, Hang Liu

“…This study highlights the need for further research to validate the routine clinical integration of NTS for managing BSIs in geriatric populations.IMPORTANCEBloodstream infections (BSIs) in elderly patients pose substantial diagnostic and therapeutic challenges due to the limitations of traditional blood culture methods, which are hampered by slow turnaround times and false-negatives. …”
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